LOCUS       NM_004229               7996 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens mediator complex subunit 14 (MED14), mRNA.
ACCESSION   NM_004229 XM_936689 XM_942908 XM_942913 XM_942916 XM_942919
            XM_942921
VERSION     NM_004229.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7996)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 7996)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 7996)
  AUTHORS   Hicks,J.A., Li,L., Matsui,M., Chu,Y., Volkov,O., Johnson,K.C. and
            Corey,D.R.
  TITLE     Human GW182 Paralogs Are the Central Organizers for RNA-Mediated
            Control of Transcription
  JOURNAL   Cell Rep 20 (7), 1543-1552 (2017)
   PUBMED   28813667
  REMARK    GeneRIF: Functional analysis implicates TNRC6A, NAT10, MED14, and
            WDR5 in RNA-mediated transcriptional activation.
REFERENCE   4  (bases 1 to 7996)
  AUTHORS   Basel-Vanagaite,L., Smirin-Yosef,P., Essakow,J.L., Tzur,S.,
            Lagovsky,I., Maya,I., Pasmanik-Chor,M., Yeheskel,A., Konen,O.,
            Orenstein,N., Weisz Hubshman,M., Drasinover,V., Magal,N., Peretz
            Amit,G., Zalzstein,Y., Zeharia,A., Shohat,M., Straussberg,R.,
            Monte,D., Salmon-Divon,M. and Behar,D.M.
  TITLE     Homozygous MED25 mutation implicated in eye-intellectual disability
            syndrome
  JOURNAL   Hum Genet 134 (6), 577-587 (2015)
   PUBMED   25792360
REFERENCE   5  (bases 1 to 7996)
  AUTHORS   Cevher,M.A., Shi,Y., Li,D., Chait,B.T., Malik,S. and Roeder,R.G.
  TITLE     Reconstitution of active human core Mediator complex reveals a
            critical role of the MED14 subunit
  JOURNAL   Nat Struct Mol Biol 21 (12), 1028-1034 (2014)
   PUBMED   25383669
  REMARK    GeneRIF: This results from a dramatically enhanced ability of
            MED14-containing complexes to associate with Pol II.
REFERENCE   6  (bases 1 to 7996)
  AUTHORS   Ryu,S., Zhou,S., Ladurner,A.G. and Tjian,R.
  TITLE     The transcriptional cofactor complex CRSP is required for activity
            of the enhancer-binding protein Sp1
  JOURNAL   Nature 397 (6718), 446-450 (1999)
   PUBMED   9989412
REFERENCE   7  (bases 1 to 7996)
  AUTHORS   Gu,W., Malik,S., Ito,M., Yuan,C.X., Fondell,J.D., Zhang,X.,
            Martinez,E., Qin,J. and Roeder,R.G.
  TITLE     A novel human SRB/MED-containing cofactor complex, SMCC, involved
            in transcription regulation
  JOURNAL   Mol Cell 3 (1), 97-108 (1999)
   PUBMED   10024883
  REMARK    Erratum:[Mol Cell 1999 Apr;3(4):following 541]
REFERENCE   8  (bases 1 to 7996)
  AUTHORS   Sun,X., Zhang,Y., Cho,H., Rickert,P., Lees,E., Lane,W. and
            Reinberg,D.
  TITLE     NAT, a human complex containing Srb polypeptides that functions as
            a negative regulator of activated transcription
  JOURNAL   Mol Cell 2 (2), 213-222 (1998)
   PUBMED   9734358
REFERENCE   9  (bases 1 to 7996)
  AUTHORS   Yoshikawa,H., Fujiyama,A., Nakai,K., Inazawa,J. and Matsubara,K.
  TITLE     Detection and isolation of a novel human gene located on
            Xp11.2-p11.4 that escapes X-inactivation using a two-dimensional
            DNA mapping method
  JOURNAL   Genomics 49 (2), 237-246 (1998)
   PUBMED   9598311
REFERENCE   10 (bases 1 to 7996)
  AUTHORS   Fondell,J.D., Ge,H. and Roeder,R.G.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8329-8333 (1996)
   PUBMED   8710870
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC098377.1, AF304448.1 and
            AC093029.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_004229.3.
            
            Summary: The activation of gene transcription is a multistep
            process that is triggered by factors that recognize transcriptional
            enhancer sites in DNA. These factors work with co-activators to
            direct transcriptional initiation by the RNA polymerase II
            apparatus. The protein encoded by this gene is a subunit of the
            CRSP (cofactor required for SP1 activation) complex, which, along
            with TFIID, is required for efficient activation by SP1. This
            protein is also a component of other multisubunit complexes e.g.
            thyroid hormone receptor-(TR-) associated proteins which interact
            with TR and facilitate TR function on DNA templates in conjunction
            with initiation factors and cofactors. This protein contains a
            bipartite nuclear localization signal. This gene is known to escape
            chromosome X-inactivation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF304448.1, AB006651.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000324817.6/ ENSP00000323720.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4782              BC098377.1         11-4792
            4783-6758           AF304448.1         4772-6747
            6759-7996           AC093029.4         73276-74513         c
FEATURES             Location/Qualifiers
     source          1..7996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xp11.4"
     gene            1..7996
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /note="mediator complex subunit 14"
                     /db_xref="GeneID:9282"
                     /db_xref="HGNC:HGNC:2370"
                     /db_xref="MIM:300182"
     exon            1..345
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..4495
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /note="human homolog of yeast RGR1; cofactor required for
                     Sp1 transcriptional activation, subunit 2 (150kD); vitamin
                     D receptor-interacting protein complex component DRIP150;
                     thyroid hormone receptor-associated protein complex
                     component TRAP170; transcriptional co-activator CRSP150;
                     hRGR1; ARC150; RGR1 homolog; CRSP complex subunit 2;
                     activator-recruited cofactor 150 kDa component; vitamin D3
                     receptor-interacting protein complex 150 kDa component;
                     thyroid hormone receptor-associated protein complex 170
                     kDa component"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 14"
                     /protein_id="NP_004220.2"
                     /db_xref="CCDS:CCDS14254.1"
                     /db_xref="GeneID:9282"
                     /db_xref="HGNC:HGNC:2370"
                     /db_xref="MIM:300182"
                     /translation="MAPVQLENHQLVPPGGGGGGSGGPPSAPAPPPPGAAVAAAAAAA
                     ASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLAL
                     VKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDV
                     LTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVA
                     NGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGDGRALVHSMQISFIHQ
                     LVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYHAGKC
                     LSLSVWNQQVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKI
                     DHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENSSIETALPALVVPILEPCGNSE
                     CLHIFVDLHSGMFQLMLYGLDQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQS
                     IKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSY
                     KYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVE
                     SKKTKRAGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAI
                     RLLKIPPCKGITEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQG
                     PSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFS
                     EVRVYNYRKLILCYGTTKGSSISIQWNSIHQKFHISLGTVGPNSGCSNCHNTILHQLQ
                     EMFNKTPNVVQLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHI
                     RLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQD
                     ARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHS
                     TVNQSPSMMHTQSPGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPH
                     GTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPR
                     AGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLC
                     SPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQ
                     LKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIM
                     KLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQ
                     EPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIF
                     AAVRDLMANLTLPPGGRP"
     exon            346..372
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            373..478
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            479..652
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            653..782
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            783..911
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1019
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1152
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1303
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..1415
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1541
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1620
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1780
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1975
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2110
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2187
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..2348
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            2349..2495
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            2496..2587
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            2588..2740
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..3010
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3011..3151
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3263
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3395
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3578
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3579..3814
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3815..3994
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            3995..4102
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            4103..4228
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            4229..4421
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     exon            4422..7996
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      6599
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
     regulatory      6731..6736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /note="hexamer: AATAAA"
     polyA_site      6758
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /note="major polyA site"
     regulatory      7976..7981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
                     /note="hexamer: ATTAAA"
     polyA_site      7996
                     /gene="MED14"
                     /gene_synonym="CRSP150; CRSP2; CSRP; CXorf4; DRIP150;
                     EXLM1; RGR1; TRAP170"
ORIGIN      
        1 ctgttctgag gcggcccggc ggtaggcggt ggcgactctg cccgctcccg tttcggcgcg
       61 gtgaccgagc gcccgggagg ctcgaggacc gcatcgtgtg ccgttgcgcc aagcccggtc
      121 ctgcgccgcc atggccccag tgcagctgga gaaccaccag ctggtcccgc ccggaggcgg
      181 cggcgggggc agcggcggac ccccgtcagc cccagcccct cctcccccgg gagccgccgt
      241 ggcggcggcc gctgcagctg cggctagccc gggctaccgg ctgagcaccc tcattgaatt
      301 tctgctgcac cgggcctact cggagcttat ggtgttgacg gacctactgc caaggaaatc
      361 tgatgtggaa aggaaaatag aaatagtgca gtttgctagc cggacacgcc aactcttcgt
      421 tcgattatta gctttagtga aatgggctaa taatgctggc aaagtggaaa aatgtgcgat
      481 gatttcaagc tttttagatc agcaagccat cctgtttgtg gacactgctg atcgcctggc
      541 ctcgttagct agagatgctc tggtccatgc acgcctgcct agttttgcca tcccatatgc
      601 cattgatgta ctaactactg gatcttaccc acggctgcca acctgcatta gggacaaaat
      661 tattcctcca gacccaatta ccaaaattga aaaacaagcc acactccatc agctgaatca
      721 gattcttaga catcggcttg taaccacaga tcttcctcct cagttagcaa atcttacagt
      781 tgcaaatggc cgggtgaagt ttcgtgttga aggagaattt gaagccacct tgactgtgat
      841 gggagatgac cctgatgttc catggcgtct tctcaagcta gaaattctag ttgaggataa
      901 ggaaacagga gatgggcgag ctttggttca tagcatgcaa atcagcttca tccatcaact
      961 ggtgcagtct aggctctttg ctgatgagaa acctcttcag gatatgtaca actgcctaca
     1021 ttctttctgt ttatcacttc agttagaagt gttacattcc caaactctaa tgttaatccg
     1081 agaacggtgg ggagaccttg tgcaggtgga aaggtatcat gctggaaagt gcctctccct
     1141 ttcagtttgg aatcaacagg ttcttgggag aaaaactgga acagcatctg ttcacaaagt
     1201 tacaattaaa attgatgaga atgatgtctc caagccttta cagatttttc acgatcctcc
     1261 tttgccagct tctgattcca aattagtaga aagagccatg aagatcgacc acttatcaat
     1321 agaaaaactc ctgattgaca gtgtccatgc aagagctcat cagaagctcc aagaactgaa
     1381 ggccattctt agaggcttca atgccaatga aaactcttcc atagagactg cactcccagc
     1441 tcttgttgtt cccatcttgg agccctgtgg taattcagag tgtctgcaca tttttgtaga
     1501 tttacattct ggaatgtttc aattgatgct ttatggactt gaccaggcca ctctggatga
     1561 catggagaag tctgtgaatg atgatatgaa acgaatcata ccctggattc agcaacttaa
     1621 gttttggctt ggacaacagc gttgcaagca gtctataaaa catctgccta cgataagcag
     1681 tgaaacattg cagctttcca attactcaac tcatcctatt ggaaaccttt ctaagaataa
     1741 actgttcatt aaacttaccc gccttccaca atactacatt gttgtggaga tgttggaggt
     1801 tcccaataaa cccacacaac tgtcgtacaa gtactacttt atgtctgtga atgctgcaga
     1861 tcgtgaagac agccctgcaa tggcattgct gctgcagcag ttcaaggaaa acattcagga
     1921 cttggttttt cgtacaaaaa ccgggaaaca gaccagaacc aatgccaagc gcaagttgtc
     1981 tgatgatcca tgtccagtag aatccaagaa aacaaaacga gcaggagaaa tgtgtgcctt
     2041 caataaagtt ttagcccact tcgtcgctat gtgtgataca aatatgccat ttgtaggact
     2101 tcggttggag ttgtccaatc tggagattcc acatcaagga gtgcaagtgg aaggtgatgg
     2161 cttcagccat gcaattcgct tattaaaaat tcctccctgt aagggtataa ctgaggaaac
     2221 ccaaaaggct ctggaccgct ctcttcttga ttgcactttc cgattacaag gtagaaataa
     2281 ccgcacttgg gtagcagagt tagtgtttgc aaattgtcca cttaatggca cttctactag
     2341 ggagcaagga ccatcccggc acgtttacct gacatatgaa aatctgttgt ctgagcctgt
     2401 tggtggtaga aaggtggttg aaatgtttct taatgactgg aatagcattg cacgattata
     2461 tgagtgtgtg ttggaatttg cacgttctct accagacata cctgctcatc taaatatttt
     2521 ctcagaagtt cgtgtttata attaccgaaa acttatcttg tgttatggaa ccaccaaggg
     2581 aagctcaatt agtatccaat ggaattcgat ccatcaaaaa ttccacattt ctttgggaac
     2641 tgttggccca aactcaggtt gcagtaactg tcacaatacc attctccatc agcttcaaga
     2701 aatgttcaac aaaacaccaa atgtggttca gttattacag gtactgtttg atactcaggc
     2761 tccattaaat gccatcaaca aactccccac tgtgccgatg ttgggcttga cccagagaac
     2821 caatactgcc taccagtgct tctccattct gccacagtcg tccacccaca tcagactggc
     2881 cttcaggaac atgtattgca ttgatatata ctgccggagt cgaggtgttg tggcaatacg
     2941 ggatggtgcc tatagtcttt ttgataacag caaactagtt gaaggtttct atcctgcacc
     3001 aggactaaag acgttcctga atatgtttgt tgacagcaat caggatgctc gaagaaggtc
     3061 tgtaaatgag gacgataatc ccccttctcc tataggagga gatatgatgg attctttaat
     3121 atcgcagctc cagccaccac cccagcaaca gccatttcca aagcagccag gaacatcagg
     3181 tgcttatcct cttacttcac cccctacatc ttatcatagc acagtcaatc agtctccctc
     3241 aatgatgcac acacagtctc caggaaatct gcatgctgcc agctccccca gtggggcttt
     3301 gagagcccca tcaccagcgt catttgttcc aactcctccc ccatcctcgc atggaatctc
     3361 aataggacca ggggccagtt ttgctagtcc acatggaact cttgacccta gttccccata
     3421 cactatggtg tcaccaagtg gacgagcagg gaactggcca ggatctcctc aagtgtctgg
     3481 cccctcacca gcagcacgca tgcctggaat gtcaccagcc aacccctcac tacattctcc
     3541 ggttccagat gcttctcatt cccctcgagc tggaacaagt tctcaaacaa tgccaacaaa
     3601 catgcctcca cctcgtaaac tacctcagcg ctcttgggcg gcatccatac ctaccatcct
     3661 cactcacagt gccttgaaca ttttactgct gccctctcca actccaggcc ttgtgcccgg
     3721 cctggcaggt agttaccttt gttctccact tgagagattc cttggatcag tcatcatgag
     3781 acgacatctt caaagaatta ttcaacaaga aacgctgcag ctgataaatt ctaatgaacc
     3841 cggagtgatc atgtttaaga ctgatgcact gaaatgcaga gtagctctta gtcccaaaac
     3901 caaccaaacg cttcagctaa aagtgacacc tgaaaatgca ggacagtgga aacctgatga
     3961 acttcaagtt ttggagaaat tctttgaaac aagagttgca ggaccaccat ttaaagctaa
     4021 tacgttaata gccttcacca agctattagg agctcctaca cacatcctca gggattgtgt
     4081 gcacattatg aagctggagc tgttccctga ccaagcaaca cagctaaaat ggaatgttca
     4141 gttttgcctg acgatccctc ccagcgcgcc gccgattgca cctcctggga cgcctgctgt
     4201 ggtgctgaaa tccaaaatgc tattttttct tcaactaact cagaaaacat cggtccctcc
     4261 ccaagaacct gttagtatta tagttccaat catttatgac atggcttcag gtacaaccca
     4321 gcaggcagac attcccagac agcagaactc ttctgttgct gctcccatga tggtcagcaa
     4381 cattctgaag aggtttgcag agatgaatcc accacgacaa ggtgaatgca caatatttgc
     4441 agctgttcgt gatttaatgg ctaatcttac actgccccct ggtgggcgtc catagacact
     4501 attgttttta aaccaggaag gctgacagat gagacaacaa aaaaaatctg aattcagcct
     4561 tcagtttaaa aaaggaaaag gacttttttt ttaaacttta agagctaaat attctaaact
     4621 ggcaaaaatt ttcagggtgc acttctttca tcaaaatgat catccatctt ttgtataatg
     4681 aacttgtata gtgtgtttaa atgggacaca tttcaaagga aataaatcag tgtccgtttg
     4741 ccagtaataa atttaatatt ctgttttata ctataaagtt atgaaaatgc caaacttgtt
     4801 tatttaattg ttttcttatg ttttgggtgt aatagtcctt ttttggtttt tgttttgttt
     4861 tttaaggcag gtctgtcatt tttgaatact gtaaaactgt gataaacttt atattgaagc
     4921 tgtattttaa tatgaccgct ttgaatcctt acatgaaatg ttctgggagt tgttataaac
     4981 acaccccaag gaagcaatat ttaataaaac taggtcaaaa acaaaacaaa acagtgacac
     5041 tcacttgtgt gtatataaac tctagagaca tcttaggccc tcccttcatc tttaacctgg
     5101 tggatggagc cagttattaa tttataataa tacatgtctg aaatttgacc aaaaacatct
     5161 tctttatgtc aaggttaata tattttcttc agacattcct aacttgacta gtggttaaca
     5221 tttagcacct tggttgtctt tcaatatata ggatttgggt gaaaaataag gaacttagtc
     5281 tttgagaagg gacagtatgt ggttcgtatt gatcaaggat cccaaataat gcaatcattc
     5341 tcatctgttg aggatgtggg aacttttctg tcaggaaaat ttagtttaca gaatacttct
     5401 gcatacaaca ttaattagga aacaaagaac tttaatgctg tacctctgca tgaagtttct
     5461 gtgagctttc tttatcttgc ttaacttatc ctcctttcct tccccaccaa aattgggatt
     5521 gttctaaaca atttcaattt aattcattgt caacaaaacg atagaatgtt ttgcttggaa
     5581 gaaacctggt ccattcccct cattgtgaag aatcccgaat cctgggcctg tccagggtca
     5641 aatggagttt ttggtattaa tacatctctg cagggtttct ttttggagca ctgtgctgtc
     5701 tttcctagtc agtcagggac ttttttaagc ttcaaagaac atggtctgat gcaaaggtct
     5761 tctaccgact tcatggtatt taggaaaaat ttttaagtga taataccatg ccgagttacc
     5821 tggtcactgt aatactggtt ctccattaaa atgtagatgc tttgtctaat tccacttcaa
     5881 gatgatttaa ttgagcttct ataactatca actatcaaat tctagtttca agtatctcac
     5941 tgtacctata tcatatctgt tctcaacttt gtttgattct ccactcattt tcaatcagag
     6001 ttgaagcctt ctttgccttt cttctttgtc ttatttctgc cttcatctcc cacttctcac
     6061 ccaactctgc cactgttcag gagcagttga ctaaactttt atccttcctt taacttaatc
     6121 tttttatcct tctgttttta gttcttacag tggtaatcac atcagtttgg caatctaaga
     6181 tgtctttatc aagggtcagc ccttttctat ttggagctga atcttttctt tcatgtagaa
     6241 atctacatgt atatacaaga aatgtatttt tatctgcagg ataatattgt ttcaaataat
     6301 tttattaaga gttaactttt taggtatttt cccttttaat gtggttttga aatgttaatt
     6361 gcatttttac acatgatgca ttcagtggac actctttttt cctaattata actcatctct
     6421 gaatgcattg tgccaatcaa gagtaagata ggattcagtg cgcaaaattt gcttttgatg
     6481 cttattaaga gtaaacccat gaatttgaat ttttatatta tgcttggtac ttggaattga
     6541 tatatacctt attaaagctt gaaaacattt agcatttgaa tagtaagttt catcacaaat
     6601 catgtctttt gcctcttttg ttacccaggt tcgatcaagg ggactggatg cccaagtgat
     6661 tttctctaat aatcgggttg ggacttaact ttaaggtgtt ttcaatgtga ttttagtatt
     6721 tacagtaata aataaaattt atacaaagtt tcagagaact accaactctc tagttaattt
     6781 tgatgaagat gttttcatta atagtctggt ttagtattaa tttaaccttg aaataagaaa
     6841 ttggtcctga tttgccacct tcatttttcc atctgctgaa atgccatttc agaatgtata
     6901 aaagtacttt cagaattaga agaaaagtga gagcttcagc agaacgtgtc aagtcgctaa
     6961 taacaggagt cgaaccttat gtttgaaaat taactgagtg agttaagtgc aagcataaac
     7021 taaaatttat atgactttga atttaagaac cactaataac tgtgttctaa ttaacacagt
     7081 aatctgttca gccaaaggat actaacagcc attctttgga ctgtggttaa tttgataact
     7141 tcaagaagtt ataactttgc taccctggat tctgatgcaa tttcaatata aaaagttgtt
     7201 cctttcatag tttttccccc caaaagaagt gcctattaca ttttacctta atgtttattt
     7261 atcatccaag tgttcttgat ataaaatcag tatacagaaa attttaagag aacttacatt
     7321 caagggacat agagggaaaa tgttaatgtg tatttcattg tttcttgtgg aatttttttt
     7381 tcattcggtt tgagaatgga cagtgtgtct aaggatgtga tttaaattta cttaggatgg
     7441 atttagcatt gaggttatta agacaaagtt agcagaggcc agccagcact gtgctgcaca
     7501 actccaggaa ctccatggta tgctcacaat tttctgcaag ttgcctccac ttccaagtgg
     7561 ccagtgattt gttaaaatac cttgcccaag aatataactg attgatgaaa gggcatattt
     7621 aggtcaatat aaaataatag caagtattta ctgagagctt actgtgtgct aggcattttc
     7681 ttaatatttc aatgtgtatt taatcctcac aacaacccaa tgtggtaggt tattgatatc
     7741 ctcttcttaa aaatgagtaa atggaggccc agagaaatgt aatttgcctg agatcaaatt
     7801 aaggttgctt aagatcaaac tgctaagaag gggcagtttg agtctgagct agtgctccta
     7861 aacactggac atttttgctg tgaaccacag tcgggaaggt ttaatgttta gactctttcc
     7921 tcagaggctt ttaactacac acaattttga catgttttcc aagctcagaa agctcattaa
     7981 aaacaactaa aactga
//
