LOCUS       NM_015335               9885 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens mediator complex subunit 13L (MED13L), mRNA.
ACCESSION   NM_015335 XM_034056
VERSION     NM_015335.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9885)
  AUTHORS   Fauqueux,J., Boussion,S., Thuillier,C., Meurisse,E., Lacombe,D.,
            Willems,M., Piton,A., Ait-Yahya,E., Ghoumid,J. and Smol,T.
  TITLE     Splice site variants in the canonical donor site of MED13L exon 7
            lead to intron retention in patients with MED13L syndrome
  JOURNAL   J Med Genet 61 (11), 1040-1044 (2024)
   PUBMED   39181712
  REMARK    GeneRIF: Splice site variants in the canonical donor site of MED13L
            exon 7 lead to intron retention in patients with MED13L syndrome.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9885)
  AUTHORS   Siavriene,E., Petraityte,G., Mikstiene,V., Maldziene,Z.,
            Sasnauskiene,A., Zitkute,V., Ambrozaityte,L., Rancelis,T.,
            Utkus,A., Kucinskas,V. and Preiksaitiene,E.
  TITLE     Molecular and Functional Characterisation of a Novel Intragenic
            12q24.21 Deletion Resulting in MED13L Haploinsufficiency Syndrome
  JOURNAL   Medicina (Kaunas) 59 (7), 1225 (2023)
   PUBMED   37512036
  REMARK    GeneRIF: Molecular and Functional Characterisation of a Novel
            Intragenic 12q24.21 Deletion Resulting in MED13L Haploinsufficiency
            Syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9885)
  AUTHORS   Zhang,N., Song,Y., Xu,Y., Liu,J., Shen,Y., Zhou,L., Yu,J. and
            Yang,M.
  TITLE     MED13L integrates Mediator-regulated epigenetic control into lung
            cancer radiosensitivity
  JOURNAL   Theranostics 10 (20), 9378-9394 (2020)
   PUBMED   32802198
  REMARK    GeneRIF: MED13L integrates Mediator-regulated epigenetic control
            into lung cancer radiosensitivity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9885)
  AUTHORS   Smol,T., Petit,F., Piton,A., Keren,B., Sanlaville,D., Afenjar,A.,
            Baker,S., Bedoukian,E.C., Bhoj,E.J., Bonneau,D., Boudry-Labis,E.,
            Bouquillon,S., Boute-Benejean,O., Caumes,R., Chatron,N., Colson,C.,
            Coubes,C., Coutton,C., Devillard,F., Dieux-Coeslier,A.,
            Doco-Fenzy,M., Ewans,L.J., Faivre,L., Fassi,E., Field,M.,
            Fournier,C., Francannet,C., Genevieve,D., Giurgea,I.,
            Goldenberg,A., Green,A.K., Guerrot,A.M., Heron,D., Isidor,B.,
            Keena,B.A., Krock,B.L., Kuentz,P., Lapi,E., Le Meur,N., Lesca,G.,
            Li,D., Marey,I., Mignot,C., Nava,C., Nesbitt,A., Nicolas,G.,
            Roche-Lestienne,C., Roscioli,T., Satre,V., Santani,A.,
            Stefanova,M., Steinwall Larsen,S., Saugier-Veber,P.,
            Picker-Minh,S., Thuillier,C., Verloes,A., Vieville,G., Wenzel,M.,
            Willems,M., Whalen,S., Zarate,Y.A., Ziegler,A., Manouvrier-Hanu,S.,
            Kalscheuer,V.M., Gerard,B. and Ghoumid,J.
  TITLE     MED13L-related intellectual disability: involvement of missense
            variants and delineation of the phenotype
  JOURNAL   Neurogenetics 19 (2), 93-103 (2018)
   PUBMED   29511999
  REMARK    GeneRIF: Study ascertains missense variations in MED13L as a cause
            for MED13L-related intellectual disability and improves the
            clinical delineation of the condition.
REFERENCE   5  (bases 1 to 9885)
  AUTHORS   Gordon,C.T., Chopra,M., Oufadem,M., Alibeu,O., Bras,M.,
            Boddaert,N., Bole-Feysot,C., Nitschke,P., Abadie,V., Lyonnet,S. and
            Amiel,J.
  TITLE     MED13L loss-of-function variants in two patients with syndromic
            Pierre Robin sequence
  JOURNAL   Am J Med Genet A 176 (1), 181-186 (2018)
   PUBMED   29159987
  REMARK    GeneRIF: Our findings suggest that MED13L-related disorders are a
            possible differential diagnosis for syndromic PRS.
REFERENCE   6  (bases 1 to 9885)
  AUTHORS   Angus,S.P. and Nevins,J.R.
  TITLE     A role for Mediator complex subunit MED13L in Rb/E2F-induced growth
            arrest
  JOURNAL   Oncogene 31 (44), 4709-4717 (2012)
   PUBMED   22249253
  REMARK    GeneRIF: We show that the Mediator complex subunit MED13L is
            required for Rb/E2F control of cell growth, the complete repression
            of cell cycle target genes, and cell cycle inhibition.
REFERENCE   7  (bases 1 to 9885)
  AUTHORS   Peters,U., Hutter,C.M., Hsu,L., Schumacher,F.R., Conti,D.V.,
            Carlson,C.S., Edlund,C.K., Haile,R.W., Gallinger,S., Zanke,B.W.,
            Lemire,M., Rangrej,J., Vijayaraghavan,R., Chan,A.T., Hazra,A.,
            Hunter,D.J., Ma,J., Fuchs,C.S., Giovannucci,E.L., Kraft,P., Liu,Y.,
            Chen,L., Jiao,S., Makar,K.W., Taverna,D., Gruber,S.B., Rennert,G.,
            Moreno,V., Ulrich,C.M., Woods,M.O., Green,R.C., Parfrey,P.S.,
            Prentice,R.L., Kooperberg,C., Jackson,R.D., Lacroix,A.Z.,
            Caan,B.J., Hayes,R.B., Berndt,S.I., Chanock,S.J., Schoen,R.E.,
            Chang-Claude,J., Hoffmeister,M., Brenner,H., Frank,B., Bezieau,S.,
            Kury,S., Slattery,M.L., Hopper,J.L., Jenkins,M.A., Le Marchand,L.,
            Lindor,N.M., Newcomb,P.A., Seminara,D., Hudson,T.J., Duggan,D.J.,
            Potter,J.D. and Casey,G.
  TITLE     Meta-analysis of new genome-wide association studies of colorectal
            cancer risk
  JOURNAL   Hum Genet 131 (2), 217-234 (2012)
   PUBMED   21761138
REFERENCE   8  (bases 1 to 9885)
  AUTHORS   Sato,S., Tomomori-Sato,C., Parmely,T.J., Florens,L., Zybailov,B.,
            Swanson,S.K., Banks,C.A., Jin,J., Cai,Y., Washburn,M.P.,
            Conaway,J.W. and Conaway,R.C.
  TITLE     A set of consensus mammalian mediator subunits identified by
            multidimensional protein identification technology
  JOURNAL   Mol Cell 14 (5), 685-691 (2004)
   PUBMED   15175163
REFERENCE   9  (bases 1 to 9885)
  AUTHORS   Musante,L., Bartsch,O., Ropers,H.H. and Kalscheuer,V.M.
  TITLE     cDNA cloning and characterization of the human THRAP2 gene which
            maps to chromosome 12q24, and its mouse ortholog Thrap2
  JOURNAL   Gene 332, 119-127 (2004)
   PUBMED   15145061
  REMARK    GeneRIF: Transcripts were most abundant in skeletal muscle.
REFERENCE   10 (bases 1 to 9885)
  AUTHORS   Muncke,N., Jung,C., Rudiger,H., Ulmer,H., Roeth,R., Hubert,A.,
            Goldmuntz,E., Driscoll,D., Goodship,J., Schon,K. and Rappold,G.
  TITLE     Missense mutations and gene interruption in PROSIT240, a novel
            TRAP240-like gene, in patients with congenital heart defect
            (transposition of the great arteries)
  JOURNAL   Circulation 108 (23), 2843-2850 (2003)
   PUBMED   14638541
  REMARK    GeneRIF: PROSIT240 shows significant homology to the nuclear
            receptor coactivator TRAP240, suggesting it to be a new component
            of the thyroid hormone receptor-associated protein (TRAP) complex.
            PROSIT240 is involved in early heart and brain development.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC060226.39, AC130895.2,
            AC009321.18 and AC012157.21.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jan 4, 2020 this sequence version replaced NM_015335.4.
            
            Summary: The protein encoded by this gene is a subunit of the
            Mediator complex, a large complex of proteins that functions as a
            transcriptional coactivator for most RNA polymerase II-transcribed
            genes. The encoded protein is involved in early development of the
            heart and brain. Defects in this gene are a cause of transposition
            of the great arteries, dextro-looped (DTGA).[provided by RefSeq,
            Jul 2010].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY338463.1, AF515599.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281928.9/ ENSP00000281928.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-634               AC060226.39        62668-63301         c
            635-872             AC060226.39        23076-23313         c
            873-957             AC130895.2         99195-99279
            958-1041            AC130895.2         113955-114038
            1042-1187           AC009321.18        66948-67093
            1188-1382           AC009321.18        69577-69771
            1383-1571           AC009321.18        70137-70325
            1572-1737           AC009321.18        74275-74440
            1738-1842           AC009321.18        76648-76752
            1843-2574           AC009321.18        80417-81148
            2575-2800           AC009321.18        81913-82138
            2801-2906           AC009321.18        83138-83243
            2907-3031           AC009321.18        83556-83680
            3032-3131           AC009321.18        86447-86546
            3132-3352           AC012157.21        160041-160261       c
            3353-3558           AC012157.21        159507-159712       c
            3559-4496           AC012157.21        154051-154988       c
            4497-4676           AC012157.21        150140-150319       c
            4677-4900           AC012157.21        149297-149520       c
            4901-5093           AC012157.21        147211-147403       c
            5094-5517           AC012157.21        146148-146571       c
            5518-5737           AC012157.21        145415-145634       c
            5738-5926           AC012157.21        143781-143969       c
            5927-6150           AC012157.21        138546-138769       c
            6151-6293           AC012157.21        138202-138344       c
            6294-6452           AC012157.21        135109-135267       c
            6453-6629           AC012157.21        133625-133801       c
            6630-6787           AC012157.21        131971-132128       c
            6788-6949           AC012157.21        129113-129274       c
            6950-7062           AC012157.21        126438-126550       c
            7063-9885           AC012157.21        121607-124429       c
FEATURES             Location/Qualifiers
     source          1..9885
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.21"
     gene            1..9885
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /note="mediator complex subunit 13L"
                     /db_xref="GeneID:23389"
                     /db_xref="HGNC:HGNC:22962"
                     /db_xref="MIM:608771"
     exon            1..634
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     CDS             563..7195
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /note="mediator complex subunit 13 like; thyroid hormone
                     receptor-associated protein 2; thyroid hormone
                     receptor-associated protein complex 240 kDa
                     component-like"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 13-like"
                     /protein_id="NP_056150.1"
                     /db_xref="CCDS:CCDS9177.1"
                     /db_xref="GeneID:23389"
                     /db_xref="HGNC:HGNC:22962"
                     /db_xref="MIM:608771"
                     /translation="MTAAANWVANGASLEDCHSNLFSLAELTGIKWRRYNFGGHGDCG
                     PIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHEL
                     QVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKS
                     EHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNG
                     TLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGV
                     RMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQA
                     ILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSK
                     RSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFS
                     AGPSSSSSLPPPASSKHKTAERQEKGDKLQKRPLIPFHHRPSVAEELCMEQDTPGQKL
                     GLAGIDSSLEVSSSRKYDKQMAVPSRNTSKQMNLNPMDSPHSPISPLPPTLSPQPRGQ
                     ETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGIRPS
                     NPESSEKWWHSYRLPPSDDAEFRPPELQGERCDAKMEVNSESTALQRLLAQPNKRFKI
                     WQDKQPQLQPLHFLDPLPLSQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKD
                     SLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLT
                     QVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGTEDRPLGKDGRAAVPYPP
                     TVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSTQLTEFK
                     MEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSMFAPLKMLPSHCLLPLKIPDACLF
                     RPSWAIPPKIEQLPMPPAATFIRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPA
                     SNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPST
                     TRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVG
                     LYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMC
                     QSTFLPQVEGTKKPQEPPISLLLLLQNQHTQPFASLNFLDYISSNNRQTLPCVSWSYD
                     RVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSS
                     QDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPE
                     PLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKT
                     FFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSGEEND
                     NHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQTPPAAAQGQATPGNAGPLAPNG
                     SAAPPAGSAFNPTSNSSSTNPAASSSASGSSVPPVSSSASAPGISQISTTSSSGFSGS
                     VGGQNPSTGGISADRTQGNIGCGGDTDPGQSSSQPSQDGQESVTERERIGIPTEPDSA
                     DSHAHPPAVVIYMVDPFTYAAEEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQI
                     VPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTL
                     KNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLAS
                     CTDLHGELLETCVVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGR
                     LGRLGHGELKDWSILLGECSLQTISKKLKDVCRMCGISAADSPSILSACLVAMEPQGS
                     FVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNED
                     GFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHS
                     RSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASL
                     HHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTS
                     CLPVHFVVLTQLYNAIMNIL"
     exon            635..872
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            873..957
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            958..1041
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1187
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1382
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1571
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1737
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1842
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..2574
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..2800
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2906
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            2907..3031
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            3032..3131
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            3132..3352
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            3353..3558
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            3559..4496
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            4497..4676
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            4677..4900
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            4901..5093
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5094..5517
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5518..5737
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5738..5926
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            5927..6150
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6151..6293
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6294..6452
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6453..6629
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6630..6787
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6788..6949
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            6950..7062
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     exon            7063..9885
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9864..9869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /note="hexamer: AATAAA"
     polyA_site      9885
                     /gene="MED13L"
                     /gene_synonym="MRFACD; PROSIT240; THRAP2; TRAP240L"
                     /note="major polyA site"
ORIGIN      
        1 attgctgtca gagcaagcga gcccggggag ggaggagaag cgaggctgac tggggaggag
       61 gggggggtgg gggaggaaga ggaaggaggg gacgtcgctc ggctgccggg gtcgcccgct
      121 ggcttcgtcc gcaccccccc cttcgcgagt tcgcgctccg cggcggcggc ggctccgagg
      181 cggcggcggc ggctccgggg ctcgcctccc ctcgcgcgcc ggcgggggcc gagggggagt
      241 cggtggctgg agataaacaa ggcggcggca gcggcagcag cggcggcggc ggcggctgag
      301 gagcagggaa ggcggaggcg gtggccggcc cgcagcgccg gcccggggcg cgcgcccccc
      361 ccgccagccc gggcccgctg cccccggcgc ggcgtcgccg cggcgcctcc cgcctgcccg
      421 ccggccctcg cgccctcccc cggcggcggc ggcggcccgg ccgccccgcg ctccccggcg
      481 aggcgccgcc gcccggcccg gcctcgcctc ggacgcctcg ctccgacatg ccccgctctg
      541 gcggccgggc tcgcggagga tcatgactgc ggcagcgaac tgggtggcga acggggcgag
      601 cctggaggat tgtcactcca acctcttttc gctggctgaa ctcacgggaa tcaaatggcg
      661 taggtacaat tttggagggc atggggactg tggacccata atttcagccc cagcccaaga
      721 tgatccaatt ctgttaagtt tcatccgctg tctgcaagct aacctgcttt gtgtatggcg
      781 tcgtgatgtc aaaccagatt gcaaagagtt atggatattc tggtggggag atgaacccaa
      841 cctagtgggt gtaatacatc atgaactgca ggttgtggaa gaaggactct gggaaaatgg
      901 cctttcctat gaatgtagga cgctgctctt caaagcgatc cacaatctgt tagaaaggtg
      961 cctaatggat aagaacttcg ttaggattgg gaaatggttt gtccgaccct acgaaaagga
     1021 tgaaaagcca gtcaacaaaa gtgagcattt gtcctgtgct ttcacattct ttctgcatgg
     1081 agaaagtaat gtatgcacaa gtgtggagat tgcccagcac cagccaattt atttgatcaa
     1141 tgaggagcat atacacatgg ctcagtcttc acctgcacca tttcaagtac tggtaagtcc
     1201 ttatggctta aatgggacgc taacaggcca agcatacaag atgtcagacc cagccactcg
     1261 taagttgatt gaggaatggc agtatttcta cccgatggtg ctaaaaaaga aagaagaatc
     1321 gaaagaggaa gacgagttgg gatatgatga tgatttccct gtggcagttg aagtaattgt
     1381 tggtggtgtt cggatggttt acccttcagc atttgttttg atctctcaga atgacatccc
     1441 ggttcctcag agtgttgcca gtgctggagg ccacattgca gttgggcagc aagggcttgg
     1501 tagtgtgaag gacccaagta actgtgggat gcctctgacc cctcccacct ctccagaaca
     1561 ggctatccta ggtgagagtg gaggtatgca gagtgctgcc agtcacctgg tttcccaaga
     1621 tggagggatg ataacgatgc acagtccaaa gagatcgggg aagattcctc caaaactcca
     1681 caatcatatg gtccatcgag tctggaagga atgcatcctc aacagaaccc agtccaagag
     1741 gagccaaatg tcaactccaa ctcttgaaga agagcctgct agcaatcctg ctacttggga
     1801 ttttgtggat ccaacccaaa gagtcagctg ttcttgttcc aggcataagc ttttaaaacg
     1861 ttgtgcagtc gggcccaatc gacctcccac agtatctcaa ccagggttca gtgcaggacc
     1921 atcatcatct tcatctttac cacctcctgc ttcttctaag cacaaaacag cagaaagaca
     1981 ggaaaaagga gacaagctgc aaaagagacc cttaatacca tttcaccata ggccctctgt
     2041 ggccgaagaa ttatgcatgg agcaagatac accaggacag aaactagggt tggcagggat
     2101 agactcctcc ttagaggtgt ctagcagtag gaaatatgat aagcaaatgg ccgtgccttc
     2161 cagaaataca agcaagcaaa tgaatctgaa tcctatggat tcacctcatt cccctatatc
     2221 ccctctgcca ccaacactca gccctcagcc acgaggtcag gaaacagaga gtttggaccc
     2281 accatcggtc cctgtgaatc cagcccttta tggaaatgga ctagaactcc agcagttgtc
     2341 tactctggat gacagaactg tcctcgtagg ccaaagactg cctctcatgg cagaggtcag
     2401 cgagacagcc ttatattgtg ggattaggcc ctcgaacccg gagtcatcag aaaagtggtg
     2461 gcatagttat cgtctcccac ccagtgatga tgctgagttc aggcctccag agctccaggg
     2521 tgagagatgt gatgccaaaa tggaggtaaa ctcagagagc actgcattgc aaagactctt
     2581 agcacaacct aacaaacggt ttaaaatctg gcaagacaaa cagccccagt tgcagccact
     2641 ccacttcctt gacccattgc ctctatcaca acaacctgga gacagtttgg gagaagtgaa
     2701 tgacccatat acctttgaag atggtgacat aaaatacatc tttacagcca acaagaaatg
     2761 caaacaaggg acggagaaag attccctgaa aaagaataag tcagaggatg gatttggtac
     2821 caaggatgtc actacaccag gtcattccac gccggtgcct gatgggaaaa atgccatgtc
     2881 tattttcagt tctgctacta aaacagatgt ccggcaggat aatgctgctg gcagagctgg
     2941 ctccagtagc cttacacagg taacagattt ggcaccttcc ctgcatgact tagacaacat
     3001 ctttgataat tctgatgacg acgaacttgg ggctgtatca cctgctctgc gctcatcaaa
     3061 aatgcctgca gttgggacag aagaccgacc tcttgggaag gatggaagag ctgctgttcc
     3121 ttatccacca acagttgcag acttgcaaag gatgtttccc actccaccat ctttggaaca
     3181 gcatcctgca ttttctcctg tgatgaatta taaagatggg atcagctcag agacagtgac
     3241 agcattaggc atgatggaga gccctatggt cagtatggtt tcaacacaac tcacagaatt
     3301 caaaatggaa gtggaagatg gattaggaag tcccaagccc gaggaaatta aggacttttc
     3361 atatgtgcac aaagttccat cctttcaacc ttttgtggga tcctccatgt ttgctccact
     3421 gaagatgttg ccgagccatt gtttgctacc tctgaagata cctgatgcct gtctgtttcg
     3481 gccttcatgg gcaattcctc ctaaaattga acaactgccc atgccccctg cagccacttt
     3541 cattagagat ggctacaata acgtgcctag tgttgggagc ctagcagatc cagactatct
     3601 gaacacacca cagatgaaca cacccgtgac gttgaacagc gctgccccag ccagcaatag
     3661 tggggcagga gtcctaccat ctccagcaac ccctcgcttc tctgtcccca caccacgaac
     3721 ccccaggacc ccaagaactc ccagaggtgg gggcactgcc agtggtcaag ggtctgttaa
     3781 gtatgatagc accgatcaag gatcaccagc ctccaccccc tctactacac ggcccctcaa
     3841 ctctgtggag cccgccacca tgcagccaat tcccgaagcc cacagcctct atgttaccct
     3901 gattctctcc gattccgtga tgaatatctt taaagacaga aactttgaca gctgttgcat
     3961 ctgtgcctgc aacatgaaca tcaaaggggc ggatgtcggg ctttacatcc ccgattcttc
     4021 caatgaggac cagtaccgct gtacctgtgg gtttagtgcg attatgaacc gcaaacttgg
     4081 ctacaattca ggactcttcc ttgaagatga gttggatatt tttgggaaga attctgatat
     4141 tggtcaggct gcagagaggc gcttaatgat gtgtcagtcc accttccttc ctcaggtgga
     4201 aggaaccaaa aaaccccagg agccacccat aagccttctc ctcctcctcc agaatcaaca
     4261 cacacaacct tttgcttcac tgaatttcct ggactacatt tcctctaaca atcgccaaac
     4321 tcttccctgt gtaagctgga gttatgaccg ggtgcaagca gataataatg attactggac
     4381 ggaatgcttt aatgcgttgg agcaggggcg gcagtatgtg gataacccca ctggtggaaa
     4441 agtggacgaa gctctggtga gaagtgccac tgtgcactct tggcctcaca gcaatgtgct
     4501 ggacatcagc atgctctcct cccaggatgt ggttcgtatg ctgttgtccc tgcagccctt
     4561 tctccaagat gccatccaaa agaagcgcac gggcaggacc tgggagaaca tccagcatgt
     4621 gcagggacca ctcacttggc agcagttcca taaaatggca ggacggggaa cctacggttc
     4681 ggaagaatct cctgagccgt tgcccatccc cactctgctg gtaggctatg acaaggattt
     4741 cctcaccatc tcgccattct ccttgccgtt ttgggagagg ctcttgttgg acccatatgg
     4801 gggccaccgt gatgttgcct atattgtggt gtgtccagaa aatgaggcct tgctcgaagg
     4861 agccaaaact ttcttcaggg acttgagtgc tgtatacgag atgtgtaggc ttgggcagca
     4921 caagcccatc tgcaaagtgc tacgtgacgg gatcatgcgc gtgggaaaaa ctgtggcaca
     4981 gaagctgaca gatgagcttg tgagtgagtg gtttaaccag ccttggagcg gcgaggagaa
     5041 tgacaatcat tccagactca aactttatgc gcaagtttgc cgccatcacc tagcacctta
     5101 tttagccact ctgcagcttg atagcagcct attgatacca cctaaatacc agaccccacc
     5161 agcagcagca cagggacaag ctacgccagg gaatgctggg cccttagctc caaatggatc
     5221 agcagctccc ccagctggca gtgcatttaa tcccacctcg aatagtagtt ctacaaatcc
     5281 tgcagcaagt agttctgcat ctggttcctc tgtgccaccg gtctcatcgt ctgcctctgc
     5341 tcctggtatt agccagataa gcactacctc ttcttcagga ttcagtggta gtgttggagg
     5401 gcagaacccc agcactgggg gcatttctgc ggatagaacg caagggaaca taggctgtgg
     5461 tggagacact gaccctgggc agagctcttc tcagccctca caggatggac aagagagtgt
     5521 tacagaaagg gagagaatag gaattcccac ggagcctgac tctgcagaca gccatgccca
     5581 ccctccagct gttgtcattt acatggtgga cccgttcacg tatgctgcag aggaggactc
     5641 cacttctggg aacttttggc tgttgagctt gatgcgctgc tacacagaaa tgctggataa
     5701 tttacctgag catatgagaa attctttcat tctccagatt gtgccttgcc agtacatgct
     5761 gcagacaatg aaggatgagc aagttttcta cattcaatac ttgaagtcca tggcattttc
     5821 agtgtactgc cagtgcaggc gaccactgcc tacacagatc cacattaaat ccctcacggg
     5881 atttgggcct gcagccagca ttgagatgac cctcaagaac cctgagcggc ccagcccaat
     5941 ccagctttac tcccctccct ttatattggc cccaatcaaa gacaagcaga cagagctggg
     6001 agagacgttt ggtgaggcga gccagaaata caatgtgctc ttcgtgggct attgtctgtc
     6061 tcacgaccag cgctggcttt tggcttcctg cactgacctc catggggaat tattagagac
     6121 ctgcgttgta aatattgctt taccaaacag gtcacggagg agtaaagtat ctgcacgtaa
     6181 aattggacta cagaagttat gggagtggtg catagggatt gtccaaatga catctctacc
     6241 ctggagagtt gtaatcgggc gacttgggcg tcttggccat ggggagctta aagattggag
     6301 tatcctcctt ggagaatgtt cactacagac aatcagcaaa aagctcaagg atgtgtgccg
     6361 gatgtgtgga atctctgccg cagactctcc ttctatcctt agtgcctgcc tggttgccat
     6421 ggagccccag gggtcctttg tagtgatgcc agatgctgtc acaatgggct ctgtttttgg
     6481 ccgaagtact gcactgaaca tgcagtcatc tcagctcaac acccctcaag atgcttcttg
     6541 tacacacatc ttggtgttcc caacatcatc aaccatccag gtggctccag ccaactaccc
     6601 caatgaagat gggtttagcc ccaacaatga tgatatgttt gttgaccttc cattcccaga
     6661 tgatatggac aatgatattg gcatattaat gactgggaac ctccattcct ctcccaactc
     6721 ttccccagta ccctccccag gctctccttc tggaattggt gtgggctctc acttccagca
     6781 tagtcggagc cagggtgagc gtcttctttc tagagaagca ccagaggagc taaagcagca
     6841 gcccctggcc cttgggtatt ttgtatcaac tgccaaagct gagaatcttc cccagtggtt
     6901 ttggtcatcg tgtccccagg ctcaaaacca gtgccctctc ttcttaaagg cttcgctgca
     6961 tcaccacatt tcagtagcac agacagacga acttctgcct gccaggaatt ctcagcgggt
     7021 tccacaccct cttgactcca aaaccacgtc ggatgtttta aggtttgttt tggagcagta
     7081 caacgctctg tcctggctca cgtgcaatcc ggccacccag gaccgtactt cctgccttcc
     7141 cgtccacttt gtggtgctca ctcagttgta caatgccatc atgaatatac tttaattgga
     7201 aaagcacttg ttctctctgg ctcagttcct tctccctgca acctcagtcc aaggaacctg
     7261 ctacactctg caaataaccc acatcctttt cttcagacca ctctccacag tcctgcactg
     7321 tgattccttc tcagcaggca catgtcaatt ctgcagtgtt cattaccaga gtgactcctt
     7381 gacacttctc tcatggacct ggaaacttcc ataagtggtg actttcagcc agtgcggtgg
     7441 tgtgtgtagc cccaaccact ggtccccagg aagtggtggt ggttgatggc ttttcagcgg
     7501 gaaacagaag agacagtgtc cttttgcaca agagtctgtg ttttcagcct ctgtatacaa
     7561 ttgagggcag tctagccctt tggatgaaat cctcttagtt actggtgtat ggcctgtggg
     7621 ttacctgaac tccataatct gggacttttt aaaaataaga accagctcaa gtacatggtt
     7681 tcatactggg gtttctgtct ccctagtgtt cccatccaga ttagcatgag tgctttggtt
     7741 gacttcaaac ctgtgtgtca atgcagaagg tctggagaca gcttcatttt gtttatttat
     7801 tttaatttgt tttgtcatat ggtttttgtg actttatttt tttaattcac aaggaccagg
     7861 tacagtagct gaaacccaat tcagatccac cataggattc tttgactaca tacctctgtc
     7921 ctagaagccg gaaaaggagt aaaaacacat tggggagatc atgcctaaaa gtaatatatt
     7981 caaaaccacc cagcagtagg ttttgttaac aacaaactgg attttaaaag ttctgccatg
     8041 ttaagtggcc agcatttcat gaaggataac atttttatac agaaggcagt caagctcaac
     8101 tcagagccat ggaggcaagt accttaatta gttttatata gtcacaacgg aaatatattt
     8161 tctagtgaat tcttattgga agccaggtct ctcctctcat tagatcaaaa gggacttatg
     8221 tacatacaac aattgaaagt gtttgctcat gaaatcagtt ataaatatgg tgaatttttt
     8281 ctggaccata ggaatattat ttcaaagaaa tattacaact taaccattaa attagtactt
     8341 gaagttgagc ctttgtggtg ggacttttta aaaaaatgcc tttttaaagc attaatggct
     8401 aattgaagta ttttatgact cctcattcct ggcccagagg gttgtctttg aaaccctgtt
     8461 tctaaccctt gtgttgtgtg tttctgtctg aggacagtgg gtgtgtactg gcctcccggg
     8521 agccactgtg accaggcctt tgagctcttg tcatctgtgg agagaatcat gcaaatttta
     8581 aaagttcttc caagagactt ccatgtcctg gttattaaca aaaaaggaaa aatgtaataa
     8641 ttgatatgat tttgtaaaag tatttttctt gaaataatct aaagtttaaa acattatatt
     8701 aaaaaaaaag ttgtgtggtg ggaatgtgaa agcagagaaa taacttgtaa atggataatt
     8761 ttgttctctg taccaccagt tgaagggggg gttgactttc gcaatgtata ggataaaaaa
     8821 tctgatatat caaaccattt gtatctaatg tgtacagtgt aaaattgact ttaaaaatat
     8881 tgcagtgcta ttttttctta atcagaaagg aaaattctca aggccttttg aagagcataa
     8941 gaagatgaag attgtaaact tgtataaaat tatcttggtg agaagacaaa ttgtaaagta
     9001 gatatttgta atcttttacc actttggggt tgcttttttc ccggaattca tcagaacttt
     9061 gaattttttt tttaaatggg ctgtttttaa tgcaggggct tttcttccct agaaacccaa
     9121 ttctaagcag aaaaagaaaa aaaacacaaa aaataaaaaa cccctacaaa aaaactttaa
     9181 aaaaaatggc agcaaagggt agttttcatc tggtgtcttt tatttaagtt ttttaagtta
     9241 agaaaagctg gtgacatatt tatacgtttt tgtgcaaaaa taaatgaatg gcaatagatt
     9301 ttaaaaaatc ttattatgta cttctgtgtg aaaaagtctg tataatattt cccttaaata
     9361 tgcattattt tacttgtgag ttttttactg aattaatctg aaatgtacaa gccctggatt
     9421 tgctacagag tgagaagtta ttttattttt ttttattttt aattttggaa attctgcaga
     9481 aatcagaact cttaccatgg tttgaacaaa aaaaggggaa atggggaggg gaaaagggtg
     9541 ggattgtcca gcatgcttgt atgtatattt cagaaccttt tttaaatgta aaagctgtac
     9601 atttctggga agttctgaat ttcttttgtt tccttttttc cttcaagcat tttgcagtga
     9661 gcttctttta tatatagcaa acaatttgaa agaatacaaa aatatgtgaa gttcatttaa
     9721 aaaaataact acagtatagc gctggtacag tacactaaaa gactttgata aaaagaaaca
     9781 ataataaaag gcctccattt taaatgtcat tcatatatac cttgtggatg agagctatat
     9841 acttttacac acttttttag aggaataaat tattgaatta ctgaa
//
