LOCUS       NM_001393769           10794 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens mediator complex subunit 12L (MED12L), transcript
            variant 1, mRNA.
ACCESSION   NM_001393769 XM_006713487
VERSION     NM_001393769.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10794)
  AUTHORS   Wu,K., Wang,W., Cheng,Q., Xiao,D., Li,Y., Chen,M. and Zheng,X.
  TITLE     Rare MED12L Variants Are Associated with Susceptibility to Guttate
            Psoriasis in the Han Chinese Population
  JOURNAL   Dermatology 240 (4), 606-614 (2024)
   PUBMED   38735287
  REMARK    GeneRIF: Rare MED12L Variants Are Associated with Susceptibility to
            Guttate Psoriasis in the Han Chinese Population.
REFERENCE   2  (bases 1 to 10794)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 10794)
  AUTHORS   Cai,D.C., Fonteijn,H., Guadalupe,T., Zwiers,M., Wittfeld,K.,
            Teumer,A., Hoogman,M., Arias-Vasquez,A., Yang,Y., Buitelaar,J.,
            Fernandez,G., Brunner,H.G., van Bokhoven,H., Franke,B.,
            Hegenscheid,K., Homuth,G., Fisher,S.E., Grabe,H.J., Francks,C. and
            Hagoort,P.
  TITLE     A genome-wide search for quantitative trait loci affecting the
            cortical surface area and thickness of Heschl's gyrus
  JOURNAL   Genes Brain Behav 13 (7), 675-685 (2014)
   PUBMED   25130324
REFERENCE   4  (bases 1 to 10794)
  AUTHORS   Ong,B.A., Li,J., McDonough,J.M., Wei,Z., Kim,C., Chiavacci,R.,
            Mentch,F., Caboot,J.B., Spergel,J., Allen,J.L., Sleiman,P.M. and
            Hakonarson,H.
  TITLE     Gene network analysis in a pediatric cohort identifies novel lung
            function genes
  JOURNAL   PLoS One 8 (9), e72899 (2013)
   PUBMED   24023788
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10794)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   6  (bases 1 to 10794)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 10794)
  AUTHORS   Joensuu,T., Hamalainen,R., Yuan,B., Johnson,C., Tegelberg,S.,
            Gasparini,P., Zelante,L., Pirvola,U., Pakarinen,L., Lehesjoki,A.E.,
            de la Chapelle,A. and Sankila,E.M.
  TITLE     Mutations in a novel gene with transmembrane domains underlie Usher
            syndrome type 3
  JOURNAL   Am J Hum Genet 69 (4), 673-684 (2001)
   PUBMED   11524702
  REMARK    Erratum:[Am J Hum Genet 2001 Nov;69(5):1160]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108726.9, AC078816.16 and AC024886.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Mar 10, 2021 this sequence version replaced XM_006713487.3.
            
            Summary: The protein encoded by this gene is part of the Mediator
            complex, which is involved in transcriptional coactivation of
            nearly all RNA polymerase II-dependent genes. The Mediator complex
            links gene-specific transcriptional activators with the basal
            transcription machinery. [provided by RefSeq, May 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.3795951.1,
                                           SRR14372080.202860.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2151119
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000687756.1/ ENSP00000508695.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-273               AC108726.9         8373-8645
            274-501             AC108726.9         9507-9734
            502-606             AC078816.16        5032-5136
            607-798             AC078816.16        11477-11668
            799-958             AC078816.16        16519-16678
            959-1128            AC078816.16        44855-45024
            1129-1239           AC078816.16        47383-47493
            1240-1509           AC078816.16        48526-48795
            1510-1659           AC078816.16        52587-52736
            1660-1759           AC078816.16        54114-54213
            1760-1896           AC078816.16        54540-54676
            1897-2028           AC078816.16        74024-74155
            2029-2155           AC078816.16        77048-77174
            2156-2370           AC078816.16        79411-79625
            2371-2475           AC078816.16        81244-81348
            2476-2652           AC078816.16        82184-82360
            2653-2800           AC024886.20        116225-116372       c
            2801-2919           AC024886.20        111192-111310       c
            2920-3063           AC024886.20        110392-110535       c
            3064-3227           AC024886.20        109055-109218       c
            3228-3359           AC024886.20        105826-105957       c
            3360-3587           AC024886.20        101225-101452       c
            3588-3729           AC024886.20        100440-100581       c
            3730-3850           AC024886.20        98665-98785         c
            3851-3952           AC024886.20        98180-98281         c
            3953-4066           AC024886.20        96882-96995         c
            4067-4266           AC024886.20        93665-93864         c
            4267-4455           AC024886.20        90217-90405         c
            4456-4530           AC024886.20        89557-89631         c
            4531-4718           AC024886.20        89253-89440         c
            4719-4880           AC024886.20        88258-88419         c
            4881-4992           AC024886.20        86207-86318         c
            4993-5082           AC024886.20        83686-83775         c
            5083-5192           AC024886.20        82543-82652         c
            5193-5328           AC024886.20        82213-82348         c
            5329-5490           AC024886.20        81240-81401         c
            5491-5853           AC024886.20        78259-78621         c
            5854-6010           AC024886.20        76296-76452         c
            6011-6222           AC024886.20        71564-71775         c
            6223-6312           AC024886.20        57099-57188         c
            6313-6542           AC024886.20        54924-55153         c
            6543-6699           AC024886.20        53136-53292         c
            6700-6810           AC024886.20        50009-50119         c
            6811-6892           AC024886.20        36051-36132         c
            6893-10794          AC024886.20        29778-33679         c
FEATURES             Location/Qualifiers
     source          1..10794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.1"
     gene            1..10794
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /note="mediator complex subunit 12L"
                     /db_xref="GeneID:116931"
                     /db_xref="HGNC:HGNC:16050"
                     /db_xref="MIM:611318"
     exon            1..273
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            274..501
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     CDS             403..6945
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /note="isoform 1 is encoded by transcript variant 1;
                     mediator of RNA polymerase II transcription, subunit 12
                     homolog-like; no opposite paired repeat protein; thyroid
                     hormone receptor-associated-like protein; trinucleotide
                     repeat-containing gene 11 protein-like; mediator complex
                     subunit 12 like"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 12-like protein isoform 1"
                     /protein_id="NP_001380698.1"
                     /db_xref="CCDS:CCDS93408.1"
                     /db_xref="GeneID:116931"
                     /db_xref="HGNC:HGNC:16050"
                     /db_xref="MIM:611318"
                     /translation="MAAFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQG
                     FNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNY
                     WLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLI
                     KMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSTGDGPVP
                     VPPEVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPL
                     MLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSP
                     GPPGPGMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSAN
                     PGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQES
                     TAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVT
                     LLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSSSLAGSSL
                     PVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISR
                     GDLSVTASTRPRSPVGENADEHYSKDHDVKMEEQSIMAHMGIDSGTTNIFDEVDKSDF
                     KTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHL
                     QYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTET
                     GVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTS
                     YHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGL
                     CVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYV
                     SCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSM
                     LGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVL
                     KALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSL
                     LAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQATGKPFPGIRSSCDRHLLAAAHN
                     SIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRCDGNADDIWTASQNPKS
                     CGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQ
                     KLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGS
                     GSVAEMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKT
                     FLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSM
                     SLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHE
                     ALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVL
                     INGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCD
                     VITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWF
                     GTVRVDRRVIKYEEQHHLLLYHTHPMPKPRSYYLQPLPLPPEEEEEEPTSPVSQEPER
                     KSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHP
                     QSTLWGYNLVGQPQQPGFFLQNQSLTPGGSRLDPAGSFVPTNTKQALSNMLQRRSGAM
                     MQPPSLHAITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQGQPGDQAALFAAQARPSP
                     QLPQYPGLQQAQTMPQGYTMYGTQMPLQQTSQQQAGSVVLSPSYNSRAYPAAHSNPVL
                     MERLRQIQQQPSGYVQQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNL
                     PSVPLPQDPMRPRQPQVRQQQRLLQMQQPQQPQPQQPPQPQQSSQSQSQTLGLQAMQP
                     QQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF"
     exon            502..606
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            607..798
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            799..958
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1128
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1239
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            1240..1509
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1659
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1759
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1896
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2028
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..2155
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2156..2370
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2475
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2652
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2800
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2801..2919
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3063
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3064..3227
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3228..3359
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3360..3587
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..3729
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3730..3850
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..3952
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            3953..4066
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4067..4266
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4455
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4456..4530
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4531..4718
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4719..4880
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4881..4992
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            4993..5082
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            5083..5192
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            5193..5328
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            5329..5490
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            5491..5853
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            5854..6010
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6011..6222
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6223..6312
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6313..6542
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6543..6699
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6700..6810
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6811..6892
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     exon            6893..10794
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10789..10794
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /note="hexamer: AATAAA"
     polyA_site      10794
                     /gene="MED12L"
                     /gene_synonym="NIZIDS; NOPAR; TNRC11L; TRALP; TRALPUSH"
                     /note="major polyA site"
ORIGIN      
        1 atgctcagtg cggacgccgc gccgccgtcc gccaactcgg aagctcgcgc tcccgggccg
       61 tgggggcgag aacgccggcg gcgagccggc gtcgctcgcc gcccccagac agtggcaaac
      121 ttcgcggcgt tcccggagct cgtccgggcg aggcagatac cgcacaaata aaatcaaatc
      181 caagtccccc atcccaaccc gaatgatgga ggctgcggcg gccggagtga ccccgccgcc
      241 gccagcccca gcccgctagc cgcggaccaa cagcgccaca gcgagcgagc gagcgaggag
      301 ggggagagag ggagtctgtc tgcaaagtgc tgctccctgg tgctcagagg cggctgctcc
      361 agctccaact ctcattcatt tcgccggtta acatgagaga tcatggccgc cttcgggctt
      421 ctcagctatg agcagagacc gctgaagcgc ccccggctcg ggccgcccga cgtctaccca
      481 caggacccca agcagaagga ggatgaactt actgctgtga atgtaaagca aggcttcaat
      541 aatcagccag ccttcactgg agatgaacat ggctcagcca gaaatattgt aattaaccca
      601 tcaaagattg gagcttattt tagcagcata ttagctgaga aactgaagct taacactttc
      661 caggacacgg gaaagaagaa accacaagtt aatgctaaag ataattattg gctggttact
      721 gctcgatccc agagtgcaat tcatagttgg ttttctgact tagcaggaaa taagccactt
      781 tctattttgg caaaaaaggt tcctatcctt agtaaaaaag aggatgtttt tgcatattta
      841 gctaaatatt ctgtgccaat ggttcgagca acgtggctga tcaagatgac ttgtgcctat
      901 tattctgcta tatctgaagc taaaattaag aaacgtcagg ctcctgatcc gaatttggag
      961 tggacacaga tatctaccag atatcttcga gagcagttgg ccaagatttc tgacttttac
     1021 cacatggcct ccagcacggg cgatggccct gtccctgtgc caccagaggt ggagcaagcc
     1081 atgaagcaat gggaatacaa cgaaaagcta gcatttcaca tgttccagga aggaatgtta
     1141 gaaaaacacg aatatttgac atggatcctg gatgttttag aaaagatcag accaatggat
     1201 gatgatcttc ttaaactctt gctaccacta atgctgcagt attcagatga gtttgttcag
     1261 tcggcctacc tgtctcgtcg tcttgcctac ttttgtgccc ggcgtctttc cttgctgctg
     1321 agcgatagcc ccaacctcct tgctgcccac tcaccccaca tgatgatagg accaaacaac
     1381 tcgagtatcg gggcccccag ccctggcccc cccggccctg gcatgagccc cgtgcagctg
     1441 gccttctcag attttctttc ctgtgcacag catggtcccc tggtttatgg acttagttgt
     1501 atgttgcaga ctgtcactct ctgttgccca agtgccttgg tgtggaatta ttccacaaat
     1561 gaaaataaga gcgcaaaccc aggctcaccc ctggatctgc tgcaggtggc cccgtccagc
     1621 ctccccatgc cgggtgggaa cacggctttc aatcagcagg ttcgggcaag gatttatgaa
     1681 gtagaacaac agataaaaca aagaggccgt gcagtggaag ttcggtggtc atttgacaag
     1741 tgccaagaat ccacagcagg ggtgactatt agtcgggttt tgcacacgtt ggaagttttg
     1801 gatcgtcact gttttgaccg aactgattcc agcaattcca tggagacact ttatcataag
     1861 attttctggg caaaccaaaa caaagataac caagaggttg cgcccaacga tgaagctgtg
     1921 gtgacgctgt tatgtgaatg ggccgtgagc tgcaaacggt ctggcaagca cagggccatg
     1981 gctgtggcaa aactcctgga gaagaggcaa gcagaaattg aggcagagag atgtggtgaa
     2041 tcagaagtct tagatgagaa ggagtctatt tcttcatcct ctcttgctgg atccagtttg
     2101 cctgttttcc agaatgtgct gttaaggttt ttagatacac aggccccctc tttgtcggac
     2161 ccaaacagtg aatgtgaaaa ggtggaattt gtgaacctgg tgctgctctt ctgcgagttc
     2221 atccgccatg atgtcttctc ccatgacgca tacatgtgta ccctcatatc tcgaggagat
     2281 ttgtcagtca ctgcctcaac tcggccgcgg tcaccagtag gggaaaatgc agatgaacac
     2341 tattcaaagg accatgatgt gaaaatggag gaacagagta ttatggcgca tatgggcatt
     2401 gactcaggaa ccactaacat ttttgatgaa gtagacaaga gtgactttaa aactgacttt
     2461 ggttcggaat ttccaatttt ttctcctatg cctggagaat cctgtgagaa tgccaacact
     2521 tcgttgggca gaagaatgtc agttaattgt gagaagttgg tgaagaggga aaagccaagg
     2581 gaattaattt ttccatctaa ttatgacctc cttcgccact tacagtatgc aacacatttt
     2641 cctatacctc tggatgaatc ttcaagtcat gaatgtaacc agcgcacaat ccttctctat
     2701 ggagtcggca aagagcgtga tgaagcaagg catcagctga agaagattac caaagatatc
     2761 ctgaaaattc taaataagaa gagcaccaca gagacagggg ttggggacga aggacaaaaa
     2821 gccaggaaga acaaacagga gacatttcca acactggaga ctgtgttcac taaactccag
     2881 ctcctttcat attttgatca acatcaagtg acatctcaga tttctaacaa tgtgctagaa
     2941 caaatcacaa gctttgcgtc aggaacatcc tatcatctcc ctttggctca ccacattcag
     3001 ctcatctttg atctcatgga gccagcactg aacatcaacg gactaattga cttcgcaata
     3061 cagttactaa atgaactgag tgttgtggaa gctgaactgc tcctaaaatc ctccagcctg
     3121 gcaggaagtt atacaacagg actgtgtgtc tgcatcgtgg ctgttctcag gcgctatcac
     3181 agttgtctaa tcttgaatcc tgatcagaca gcccaggtgt ttgaagggtt gtgtggtgtg
     3241 gtcaagcatg tcgtaaaccc ctcagaatgt tcttcccctg aaagatgcat tttagcctac
     3301 ctctatgatc tctatgtgtc atgtagccac ctcagaagta aatttggaga cctcttcagt
     3361 agtgcctgtt caaaagtaaa gcaaaccata tataataacg tgatgcctgc aaattcgaac
     3421 ttgcgatggg atccagactt catgatggat tttattgaga atccctcagc ccgcagcatc
     3481 aactactcaa tgctgggcaa gatcctcagt gacaatgcgg ccaatcgcta cagctttgtc
     3541 tgcaatacac tcatgaatgt atgtatgggc catcaggatg ctggcaggat taacgacata
     3601 gccaatttct cctctgagct tacggcttgc tgcactgttc ttagttcaga atggctgggg
     3661 gttctgaagg ctctttgttg ttcttcaaat cacgtgtggg ggtttaatga tgtactttgc
     3721 actgtagatg tgagtgacct ttcattccat gattcattag ctactttcat tgctattctg
     3781 atagcacgac agtgtttttc cctggaggac gtcgtgcagc atgtcgcact tccctctctt
     3841 ctagcagcag cttgtgggga tgcggacgcc gagcctgggg cgagaatgac atgccgactc
     3901 ttgcttcatc tcttccgagc tccccaggcc tgcttcttac ctcaagcaac gggcaaacct
     3961 ttccctggaa taagatcatc ttgtgataga cacctcttag ccgctgctca caacagcatt
     4021 gaagtgggag ccgtgtttgc tgtcttaaaa gcaattatga tgcttggaga tgccaaaatt
     4081 ggcaataaca gtgtcagctc tttaaagaat gatgacttca ccatgagagg tttgcgatgt
     4141 gatgggaatg ctgatgatat ctggactgcc tcacaaaatc caaaatcctg tgggaaaagc
     4201 atttccatag aaactgccaa tttaagagaa tacgctagat atgtactgag gactatctgt
     4261 caacaggaat gggtaggaga gcattgctta aaagaacctg aaagattatg tacagacaaa
     4321 gaacttatat tggaccctgt gctttcaaat atgcaagcac agaaattact gcagcttatc
     4381 tgttatcctc atggcattaa agaatgtacc gagggggaca atctgcaaag acagcacatt
     4441 aagcgtattc ttcagaatct tgagcagtgg acactgaggc aatcctggtt agaactccag
     4501 ctaatgatca aacagtgctt gaaggaccct ggctctggtt ctgtggccga aatgaacaac
     4561 ttactggaca atattgcaaa ggcaacaata gaggtattcc agcagtctgc agacctaaat
     4621 aattcttcta attctggcat gagcctcttc aacccaaaca gtattggaag tgctgataca
     4681 agtagcacga gacagaatgg aataaagaca ttcctaagtt cctccgaacg caggggtgta
     4741 tggttggtgg cccccctcat cgccaggttg ccaacttctg tgcaaggaag agtgctgaaa
     4801 gccgctgggg aagagctgga gaagggacag cacttgggtt cttcttccaa aaaggaaagg
     4861 gacagacaga aacagaaaag tatgtctctt ttgagtcaac aacccttcct ctcactggta
     4921 cttacctgcc ttaagggaca agatgaacaa agggaaggcc tcctaacatc tctccagaat
     4981 caagttaacc agattttaag taactggaga gaagaacgat accaagatga cataaaagcg
     5041 cggcagatga tgcacgaagc attgcaactc cgcctaaatt tggtaggagg aatgtttgac
     5101 acggtgcaga ggagcaccca gtggactaca gactgggccc tgctactcct tcagatcatt
     5161 acttcaggaa ctgttgacat gcacactaac aatgaattat tcacaacagt tcttgacatg
     5221 ctgggtgttt taatcaatgg aacgttagcc tctgacctat caaatgcatc ccctggggga
     5281 tctgaagaga acaagcgtgc atacatgaat ttagtaaaga aactgaaaaa agagctagga
     5341 gacaagcgat cagaaagtat tgacaaagtt cgacagttac tacctttgcc gaaacagaca
     5401 tgtgatgtca tcacttgtga acctatgggt tccttgattg acacaaaagg aaacaaaatt
     5461 gctggatttg actctataga taaaaaacag ggtctccagg tctctacgaa gcagaaggtg
     5521 tccccgtggg acttgtttga gggtcagaag aacccagctc ctttgtcctg ggcctggttt
     5581 gggacagtcc gagtggaccg aagagtgatc aagtacgagg agcagcatca cctcctgctg
     5641 tatcacacac accccatgcc caagccccgc agttactacc tccagccact gcccctgcct
     5701 cctgaggagg aagaggaaga gcccacatct ccagtttctc aggaaccaga aaggaagtcc
     5761 gctgagctgt cagatcaggg aaaaaccaca acagatgaag aaaagaaaac aaaaggaagg
     5821 aagcgcaaga cgaaatctag ctcaagagtt gatgaatatc cacagagcaa catataccga
     5881 gtgcctccta attactcgcc tatctcctcc caaatgatgc accatccaca gtccaccttg
     5941 tggggttaca acctcgtggg ccagccccag cagcccggct ttttccttca gaaccaatct
     6001 cttactccag gtggctccag attggaccct gcaggctcct ttgtcccaac caacaccaaa
     6061 caagctctgt caaacatgct acagcggcgc tcaggcgcca tgatgcagcc gccttctctt
     6121 catgcaatca catcgcagca gcagttgata cagatgaagc ttctgcagca gcagcagcaa
     6181 cagcgacttc tcaggcaagc ccagactcgg cctttccaac agggccagcc gggggaccag
     6241 gctgctctct ttgctgcgca agcacggccc tcccctcagc tccctcagta tccagggctg
     6301 cagcaagcac agaccatgcc acagggctat acaatgtatg ggacacagat gcctttgcag
     6361 cagacatcgc agcagcaggc tggcagtgtg gtcctgtctc ccagctataa ctccagagcc
     6421 tatccggccg cacattccaa ccccgtgcta atggaaagac tcagacagat tcagcagcag
     6481 ccgagtggct atgttcagca gcaggcctcg ccgtacctgc agcccctgac tggctctcag
     6541 agactgaacc atcaggctct acagcagagc cctctggtgg gcgggggaat tgatgctgtg
     6601 ctgacttctg cacatccaaa ccttccctcc gtgcccctgc ctcaggatcc catgagaccc
     6661 agacagccgc aagttcgaca gcagcagaga ctcctccaga tgcagcagcc ccagcagccc
     6721 cagccccagc agcctcccca gccccagcag tcctcgcagt cccagagtca gacccttggt
     6781 ctccaagcaa tgcagcccca gcagcccttg tttcccaggc aaggcttgca gcagacccag
     6841 cagcagcagc agacggccgc cttggtgcgg cagctccaga agcagctttc cagcaaccag
     6901 ccacagcaag gagtgactcc gtatgggcat ccttcacact tctgaatctg caagaggaga
     6961 agacatgacg ttttatgttt gcactgaaaa acagaaaatc aaatttaatg cattagtcat
     7021 cttaaaaatg tccctttttt tcatttcttt gacattttac tatattttat gctacatctc
     7081 acaaaaaaaa aaaaaggtgt ttaaacaaaa agccaaggag aagttgtggt ttgattttgt
     7141 tgaattcacc tttaaagtag gtttacaaat gtgaatcatg caggcaggcc tactcccgga
     7201 agagtgtgct agcagacctt ttgaaattgg tgcttttttt gaatctcaca tttctagaaa
     7261 gaatggatta tgatggatct aaggtattta tgtatttcat tcattaatga tgacgttgtt
     7321 tttttttttt taattttatt ttccaaactg tgctggacca aactactgat ttgaaaggca
     7381 tgtcagatct tgacagaaac atggcctgtt tattctgcat tcacctgtga tggtgaaacg
     7441 gacatttatt tgcatcgctc taatttgaaa tgtttgtaat ctcataagca ctttataaac
     7501 tttgttctta tttatgtagg actcttcttt gcttttgttg tggtcaaaag gtgctgaaac
     7561 agattgttgc ttcgtactta aacttcttaa accaagaacc taaaccaagg tttctttgag
     7621 agccgcccta agatgtgcgg aaacctgtta gaagtagctg tactcaaatt tgttttgagg
     7681 caagatcatt gatgagagtc attgtgaagg tacaacatgt aaatcctaaa ggcctgaaag
     7741 aactgcagtg gaatcgtcca actatttatt gccagttttg gttctcctga accttatgcc
     7801 accttaaggg gaaaaaaaaa tccagtagct ggcttgagat tccagtgctc acacttgaca
     7861 tggtttccag agaatctggc cccaaagtcc agaaggctct ggttttcata aaaggtgtat
     7921 ttgctgttta ttttgtatgg taagtatttg ctcttttgaa tttaattatt actgtcagtg
     7981 tcagtcttgg ttgtgtattg catatactgt atttataaat tggtgcaaaa agcacaagta
     8041 aattatacat caaatttatt ataaagaaat agtaactatt ttaactttgt tcaagtatgt
     8101 ggtaatttgc tcctattaga gtaaaaaaga aaccagtaaa ttatcagttt gtgtaactta
     8161 agagtattct atataatatt tttttagatt tagatgcata aaattttgaa tgtgaaaatt
     8221 gcagggcatt ttaaaacata tgtgggggat attttcccat gttctctgtt atttcatttt
     8281 cttttgccat atgattttac atataatata gtcaagcata ctgtgaatag acttgtctat
     8341 aatgagcaga ccatgtaaat ctactttttt taaaatgtag ctagtacaac tttagtagac
     8401 attttctttt gcaaatcatt atctataaat aatttatatc ttcctgggtg agttactcat
     8461 tgcaaagttt gactcatgca aatgacctca aatacatgtc agcttacttt gctgtggcaa
     8521 catccatgtg aactgctttg tacactgtga aaatatttca ctccagcctg cccattttgt
     8581 gtttactctg ggctggaaaa gactttgcca aaacattaaa aactattctt ttcactaaat
     8641 taatagtcta tctgctttca gaagatgtat catctatctg tacacatttt tgctggtttt
     8701 gtatatcaga ttttttcctc tcaagaaaca tacttagata agctaatgaa gttgttttct
     8761 tcaaagtaat atatctatat aatgactgca ttggcaaatc aaccgaaatg tgaatgttgt
     8821 gcctagtgag tgagtcatgt tccatcatta tttctttcca aatttctttg ccagttcagt
     8881 ttgaaccata tattttgtag ctcagcattg caaacaacag taatactgtt ttaagaatga
     8941 gtgttataat tgcatagcat ttgtatgcac tttatacttt gcagaggtga gttaaattat
     9001 taatcatttt gcacatgaaa gctgtggggc atatcttttt tcttttttta ggtgaggaag
     9061 ttatgctacg actctaatta attccacgat tctattgaaa gttgaggaat gctgttttac
     9121 ccctgcgcat tataaagaaa ataactagaa ttactttagt cttcagattt tctccctgtt
     9181 aattctgtat cttgagaggt ttcttttttt tttttttttt tttcttttct tgcaaatgca
     9241 ttcttttgca ttaagatggt cacaaggtaa agccctgtgg cagaacctgg tactttacct
     9301 taccagagga aattacctta gaataagatg gagcgagacc ccagctcccc ttaaagacaa
     9361 gaccttgaaa tcaaatggag tcagctatac ctatcaatca atcacagttc ttggatataa
     9421 gaagcccata gactctcttg tttacactgt aggctttttc ttaatagggt tgcatttgtc
     9481 agtcattgca tttacccttc ttggcctgga agtagaggag atcaatgcgt agctttgacc
     9541 acttccagcc acagggtact aacatcagac ataagttgca accaggtcac attttaggct
     9601 gagatggggc taactgaaag tcagtgtgat gaaaacccaa gggcgctatt ccacatgtct
     9661 caaatgattg gcaggggcta acttattagt aattctcggt tttgtgcact gagatatcta
     9721 agacctatgg catttttttc ccatttataa agctcctata attcttaagt aagtactagg
     9781 tgaatgtttg aatagatgct ggagaaatta cactggaaaa ccccacccct agatttagat
     9841 aagatcaatc atttaatatt ccccaaatta attcaggttg aattaagcat gtaatataaa
     9901 ttcagtgaat tacaaaaaca cattttgtgt aggattgatc agattttaaa tacagtgaaa
     9961 cttcattata tataatagac ctagaccctc ccaagcattt tcccatccca taaagaatta
    10021 atgaaatgaa atgcttatag agcaacgatt cctgctcaga aaaatttcct tataaacagc
    10081 tccaaaccag gggtgcctga gctagatttt aaagttataa agaagtttca ttgtattttt
    10141 aaaacctttt taatgggtgt atttggacaa aaataacccc cttttcacat tttatgatgt
    10201 gcaggtatta cattgctttt tacatgtgga aaagtgagcc tgcatttatt tttaaatgca
    10261 gttattaaaa catttttgta ttccccatca atgaaaattt tcagtgtgaa caaatggtga
    10321 atcataagac agttcagtgc ttattttctg taggttttag caaaaaaatt tataaaccac
    10381 aaaatattta tacatcagga tggtaaattt acatcataaa gattgcagat ttaatatttt
    10441 ccattgtctc tgttctgagt gccatgcttg taacattgat aggaggtgga cactaggcaa
    10501 ctggtattag aagttcattt ttttactgaa aaattcaggt acattagcca tttgttattt
    10561 tatagtgaac cgtttcaatg tttgtttatt gttatttgtt ggcaaaataa aagtgcctta
    10621 agttaaaagt ttgttttgag atccattaaa taaatcagta tcatcagttc ataatgcatt
    10681 tatttacaag tccttttatt ttgcatgttc attgtaaatt taatactgta aatgtattca
    10741 aattcattta catgcctatg gctgcctttg attaaacttc ttccaaaaaa taaa
//
