LOCUS       NM_005120               6925 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens mediator complex subunit 12 (MED12), mRNA.
ACCESSION   NM_005120
VERSION     NM_005120.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6925)
  AUTHORS   Chen,J., Wang,T. and Mu,W.
  TITLE     A C->T Variation in 3'-Untranslated Region Elevates MED12 Protein
            Level in Breast Cancer That Relates to Better Prognosis
  JOURNAL   Genet Test Mol Biomarkers 28 (9), 343-350 (2024)
   PUBMED   39166292
  REMARK    GeneRIF: A C->T Variation in 3'-Untranslated Region Elevates MED12
            Protein Level in Breast Cancer That Relates to Better Prognosis.
REFERENCE   2  (bases 1 to 6925)
  AUTHORS   Li,Y., Asif,H., Feng,Y., Kim,J.J. and Wei,J.J.
  TITLE     Somatic MED12 Mutations in Myometrial Cells
  JOURNAL   Cells 13 (17), 1432 (2024)
   PUBMED   39273004
  REMARK    GeneRIF: Somatic MED12 Mutations in Myometrial Cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6925)
  AUTHORS   Maia-Silva,D., Cunniff,P.J., Schier,A.C., Skopelitis,D.,
            Trousdell,M.C., Moresco,P., Gao,Y., Kechejian,V., He,X.Y.,
            Sahin,Y., Wan,L., Alpsoy,A., Liverpool,J., Krainer,A.R.,
            Egeblad,M., Spector,D.L., Fearon,D.T., Dos Santos,C.O.,
            Taatjes,D.J. and Vakoc,C.R.
  TITLE     Interaction between MED12 and DeltaNp63 activates basal identity in
            pancreatic ductal adenocarcinoma
  JOURNAL   Nat Genet 56 (7), 1377-1385 (2024)
   PUBMED   38886586
  REMARK    GeneRIF: Interaction between MED12 and DeltaNp63 activates basal
            identity in pancreatic ductal adenocarcinoma.
REFERENCE   4  (bases 1 to 6925)
  AUTHORS   Khan,N.H., McNally,R., Kim,J.J. and Wei,J.J.
  TITLE     Racial disparity in uterine leiomyoma: new insights of genetic and
            environmental burden in myometrial cells
  JOURNAL   Mol Hum Reprod 30 (3) (2024)
   PUBMED   38290796
  REMARK    GeneRIF: Racial disparity in uterine leiomyoma: new insights of
            genetic and environmental burden in myometrial cells.
            Review article
REFERENCE   5  (bases 1 to 6925)
  AUTHORS   Chuang,T.D., Ton,N., Rysling,S., Boos,D. and Khorram,O.
  TITLE     The Effect of Race/Ethnicity and MED12 Mutation on the Expression
            of Long Non-Coding RNAs in Uterine Leiomyoma and Myometrium
  JOURNAL   Int J Mol Sci 25 (2), 1307 (2024)
   PUBMED   38279317
  REMARK    GeneRIF: The Effect of Race/Ethnicity and MED12 Mutation on the
            Expression of Long Non-Coding RNAs in Uterine Leiomyoma and
            Myometrium.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6925)
  AUTHORS   Briault,S., Hill,R., Shrimpton,A., Zhu,D., Till,M., Ronce,N.,
            Margaritte-Jeannin,P., Baraitser,M., Middleton-Price,H.,
            Malcolm,S., Thompson,E., Hoo,J., Wilson,G., Romano,C., Guichet,A.,
            Pembrey,M., Fontes,M., Poustka,A. and Moraine,C.
  TITLE     A gene for FG syndrome maps in the Xq12-q21.31 region
  JOURNAL   Am J Med Genet 73 (1), 87-90 (1997)
   PUBMED   9375929
REFERENCE   7  (bases 1 to 6925)
  AUTHORS   Margolis,R.L., Abraham,M.R., Gatchell,S.B., Li,S.H., Kidwai,A.S.,
            Breschel,T.S., Stine,O.C., Callahan,C., McInnis,M.G. and Ross,C.A.
  TITLE     cDNAs with long CAG trinucleotide repeats from human brain
  JOURNAL   Hum Genet 100 (1), 114-122 (1997)
   PUBMED   9225980
REFERENCE   8  (bases 1 to 6925)
  AUTHORS   Fondell,J.D., Ge,H. and Roeder,R.G.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8329-8333 (1996)
   PUBMED   8710870
REFERENCE   9  (bases 1 to 6925)
  AUTHORS   Yamagata,K., Takeda,J., Menzel,S., Chen,X., Eng,S., Lim,L.R.,
            Concannon,P., Hanis,C.L., Spielman,R.S., Cox,N.J. and Bell,G.I.
  TITLE     Searching for NIDDM susceptibility genes: studies of genes with
            triplet repeats expressed in skeletal muscle
  JOURNAL   Diabetologia 39 (6), 725-730 (1996)
   PUBMED   8781769
REFERENCE   10 (bases 1 to 6925)
  AUTHORS   Lyons,M.J.
  TITLE     MED12-Related Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301719
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB069668.1, AF117755.1,
            AF071309.1 and BM662470.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_005120.2.
            
            Summary: The initiation of transcription is controlled in part by a
            large protein assembly known as the preinitiation complex. A
            component of this preinitiation complex is a 1.2 MDa protein
            aggregate called Mediator. This Mediator component binds with a
            CDK8 subcomplex which contains the protein encoded by this gene,
            mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase,
            and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II
            interactions and thereby regulates transcription initiation and
            reinitation rates. The MED12 protein is essential for activating
            CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia
            syndrome, also known as FG syndrome, and Lujan-Fryns syndrome.
            [provided by RefSeq, Aug 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2496534.1,
                                           SRR14038191.1615767.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374080.8/ ENSP00000363193.3
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-127               DB069668.1         41-167
            128-214             AF117755.1         107-193
            215-5907            AF071309.1         68-5760
            5908-6772           AF117755.1         5893-6757
            6773-6925           BM662470.1         21-173              c
FEATURES             Location/Qualifiers
     source          1..6925
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq13.1"
     gene            1..6925
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /note="mediator complex subunit 12"
                     /db_xref="GeneID:9968"
                     /db_xref="HGNC:HGNC:11957"
                     /db_xref="MIM:300188"
     exon            1..258
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..6693
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /note="thyroid hormone receptor-associated protein, 230
                     kDa subunit; trinucleotide repeat containing 11
                     (THR-associated protein, 230 kDa subunit); putative
                     mediator subunit 12; activator-recruited cofactor 240 kDa
                     component; CAG repeat protein 45; human opposite paired;
                     OPA-containing protein; trinucleotide repeat-containing
                     gene 11 protein; thyroid hormone receptor-associated
                     protein complex 230 kDa component; mediator of RNA
                     polymerase II transcription, subunit 12 homolog; Kohtalo
                     homolog"
                     /codon_start=1
                     /product="mediator of RNA polymerase II transcription
                     subunit 12"
                     /protein_id="NP_005111.2"
                     /db_xref="CCDS:CCDS43970.1"
                     /db_xref="GeneID:9968"
                     /db_xref="HGNC:HGNC:11957"
                     /db_xref="MIM:300188"
                     /translation="MAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQG
                     FNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNF
                     WLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLI
                     KMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGST
                     IGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLL
                     LPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAP
                     QPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGS
                     PLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAG
                     FTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLC
                     EWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIF
                     QDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDL
                     AFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKP
                     DFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPI
                     PQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVP
                     LNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQI
                     TSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDL
                     VGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCIL
                     AYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPA
                     AHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSL
                     SAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDL
                     IRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCD
                     RHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRR
                     QGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRL
                     MQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSL
                     LENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLP
                     TSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDE
                     QREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQ
                     QTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENK
                     RAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGF
                     DSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLY
                     HTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKK
                     KSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLY
                     TQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQ
                     QQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTG
                     PAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRF
                     SHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQ
                     QQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQ
                     SQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY"
     exon            259..363
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            364..555
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            556..712
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            713..894
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1005
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1260
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1407
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1507
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1644
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1776
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1903
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..2133
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2214
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..2385
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2386..2530
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2531..2581
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2582..2700
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2844
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3008
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3009..3140
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3141..3368
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3369..3513
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3514..3634
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3635..3736
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3737..3850
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            3851..4026
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4027..4206
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4207..4278
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4279..4412
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4413..4574
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4575..4686
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4687..4776
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4777..4886
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            4887..5022
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5023..5184
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5185..5559
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5560..5710
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5711..5907
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5908..5985
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            5986..6203
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6204..6426
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6427..6567
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6568..6649
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     exon            6650..6925
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6903..6908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /note="hexamer: AATACA"
     polyA_site      6925
                     /gene="MED12"
                     /gene_synonym="ARC240; CAGH45; FGS1; HDKR; HOPA; Kto;
                     MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230"
                     /note="major polyA site"
ORIGIN      
        1 agtttccggc aatggtcgag agtttctaac gtgccccctt gttgtctctc ggccgccgtc
       61 ctctcaacca ccgcccccct tttcggctcc ctctccccct tcccgttccc ccagtcagcc
      121 tggccctgct ggtgcctccg gcgctacggg ctgggcaaga tggcggcctt cgggatcttg
      181 agctacgaac accggcccct gaagcggccg cggctggggc ctcccgatgt ttaccctcag
      241 gaccccaaac agaaggagga tgaactgacg gccttgaatg taaaacaagg tttcaataac
      301 cagcctgctg tctctgggga tgagcatggc agtgccaaga acgtcagctt caatcctgcc
      361 aagatcagtt ccaacttcag cagcattatt gcagagaaat tacgttgtaa tacccttcct
      421 gacactggtc gcaggaagcc ccaagtgaac cagaaggata acttctggct ggtgactgca
      481 cgatcccaga gtgccattaa cacttggttc actgacttgg ctggcaccaa gccactcacg
      541 caactagcca aaaaggtccc cattttcagt aagaaggaag aggtgtttgg gtacttagcc
      601 aaatacacag tgcctgtgat gcgggctgcc tggctcatta agatgacctg tgcctactat
      661 gcagcaatct ctgagaccaa ggttaagaag agacatgttg accctttcat ggaatggact
      721 cagatcatca ccaagtactt atgggagcag ttacagaaga tggctgaata ctaccggcca
      781 gggcctgcag gaagtggggg ctgtggttcc acgatagggc ccttgcccca tgatgtagag
      841 gtggcaatcc ggcagtggga ttacaccgag aagctggcca tgttcatgtt tcaggatgga
      901 atgctggaca gacatgagtt cctgacctgg gtgcttgagt gttttgagaa gatccgccct
      961 ggagaggatg aattgcttaa actgctgctg cctctgcttc tccgatactc tggggaattt
     1021 gttcagtctg catacctgtc ccgccggctt gcctacttct gtacacggag actggccctg
     1081 cagctggatg gtgtgagcag tcactcatct catgttatat ctgctcagtc aacaagcacg
     1141 ctacccacca cccctgctcc tcagccccca actagcagca caccctcgac tccctttagt
     1201 gacctgctta tgtgccctca gcaccggccc ctggtttttg gcctcagctg tatcctacag
     1261 accatcctcc tgtgctgtcc tagtgccttg gtttggcact actcactgac tgatagcaga
     1321 attaagaccg gctcaccact tgaccacttg cctattgccc cgtccaacct gcccatgcca
     1381 gagggtaaca gtgccttcac tcagcaggtc cgtgcaaagt tgcgggagat cgagcagcag
     1441 atcaaggagc ggggacaggc agttgaagtt cgctggtctt tcgataaatg ccaggaagct
     1501 actgcaggct tcaccattgg acgggtactt catactttgg aagtgctgga cagccatagt
     1561 tttgaacgct ctgacttcag caactctctt gactcccttt gtaaccgaat ctttggattg
     1621 ggacctagca aggatgggca tgagatctcc tcagatgatg atgctgtggt gtcattgcta
     1681 tgtgaatggg ctgtcagctg caagcgttct ggtcggcatc gtgctatggt ggtagccaag
     1741 ctcctggaga agagacaggc ggagattgag gctgagcgtt gtggagaatc agaagccgca
     1801 gatgagaagg gttccatcgc ctctggctcc ctttctgctc ccagtgctcc cattttccag
     1861 gatgtcctcc tgcagtttct ggatacacag gctcccatgc tgacggaccc tcgaagtgag
     1921 agtgagcggg tggaattctt taacttagta ctgctgttct gtgaactgat tcgacatgat
     1981 gttttctccc acaacatgta tacttgcact ctcatctccc gaggggacct tgcctttgga
     2041 gcccctggtc cccggcctcc ctctcccttt gatgatcctg ccgatgaccc agagcacaag
     2101 gaggctgaag gcagcagcag cagcaagctg gaagatccag ggctctcaga atctatggac
     2161 attgacccta gttccagtgt tctctttgag gacatggaga agcctgattt ctcattgttc
     2221 tcccctacta tgccctgtga ggggaagggc agtccatccc ctgagaagcc agatgtcgag
     2281 aaggaggtga agcccccacc caaggagaag attgaaggga cccttggggt tctttacgac
     2341 cagccacgac acgtgcagta cgccacccat tttcccatcc cccaggagga gtcatgcagc
     2401 catgagtgca accagcggtt ggtcgtactg tttggggtgg gaaagcagcg agatgatgcc
     2461 cgccatgcca tcaagaaaat caccaaggat atcttgaagg ttctgaaccg caaagggaca
     2521 gcagaaactg accagcttgc tcctattgtg cctctgaatc ctggagacct gacattctta
     2581 ggtggggagg atgggcagaa gcggcgacgc aaccggcctg aagccttccc cactgctgaa
     2641 gatatctttg ctaagttcca gcacctttca cattatgacc aacaccaggt cacggctcag
     2701 gtctcccgga atgttctgga gcagatcacg agctttgccc ttggcatgtc ataccacttg
     2761 cctctggtgc agcatgtgca gttcatcttc gacctcatgg aatattcact cagcatcagt
     2821 ggcctcatcg actttgccat tcagctgctg aatgaactga gtgtagttga ggctgagctg
     2881 cttctcaaat cctcggatct ggtgggcagc tacactacta gcctgtgcct gtgcatcgtg
     2941 gctgtcctgc ggcactatca tgcctgcctc atcctcaacc aggaccagat ggcacaggtc
     3001 tttgaggggc tgtgtggcgt cgtgaagcat gggatgaacc ggtccgatgg ctcctctgca
     3061 gagcgctgta tccttgctta tctctatgat ctgtacacct cctgtagcca tttaaagaac
     3121 aaatttgggg agctcttcag cgacttttgc tcaaaggtga agaacaccat ctactgcaac
     3181 gtggagccat cggaatcaaa tatgcgctgg gcacctgagt tcatgatcga cactctagag
     3241 aaccctgcag ctcacacctt cacctacacg gggctaggca agagtcttag tgagaaccct
     3301 gctaaccgct acagctttgt ctgcaatgcc cttatgcacg tctgtgtggg gcaccatgat
     3361 cccgataggg tgaatgacat cgcaatcctg tgtgcagagc tgaccggcta ttgcaagtca
     3421 ctgagtgcag aatggctagg agtgcttaag gccttgtgct gctcctctaa caatggcact
     3481 tgtggtttca acgatctcct ctgcaatgtt gatgtcagtg acctatcttt tcatgactcg
     3541 ctggctactt ttgttgccat cctcatcgct cggcagtgtt tgctcctgga agatctgatt
     3601 cgctgtgctg ccatcccttc actccttaat gctgcttgta gtgaacagga ctctgagcca
     3661 ggggcccggc ttacctgccg catcctcctt caccttttca agacaccgca gctcaatcct
     3721 tgccagtctg atggaaacaa gcctacagta ggaatccgct cctcctgcga ccgccacctg
     3781 ctggctgcct cccagaaccg catcgtggat ggagccgtgt ttgctgttct caaggctgtg
     3841 tttgtacttg gggatgcgga actgaaaggt tcaggcttca ctgtgacagg aggaacagaa
     3901 gaacttccag aggaggaggg aggaggtggc agtggtggtc ggaggcaggg tggccgcaac
     3961 atctctgtgg agacagccag tctggatgtc tatgccaagt acgtgctgcg cagcatctgc
     4021 caacaggaat gggtaggaga acgttgcctt aagtctctgt gtgaggacag caatgacctg
     4081 caagacccag tgttgagtag tgcccaggcg cagcgcctca tgcagctcat ttgctatcca
     4141 catcgactgc tggacaatga ggatggggaa aacccccagc ggcagcgcat aaagcgcatt
     4201 ctccagaact tggaccagtg gaccatgcgc cagtcttcct tggagctgca gctcatgatc
     4261 aagcagaccc ctaacaatga gatgaactcc ctcttggaga acatcgccaa ggccacaatc
     4321 gaggttttcc aacagtcagc agagacaggg tcatcttctg gaagtactgc aagcaacatg
     4381 cccagcagca gcaagaccaa gcctgtgctc agctctctag agcgctctgg tgtatggctg
     4441 gtggcccccc tcattgctaa actgcccacc tcagtccagg gacatgtgtt aaaggctgct
     4501 ggggaagaat tggagaaggg tcagcacctg ggttcctctt cacgcaaaga acgtgatcga
     4561 caaaagcaga agagcatgtc cctattgagc cagcagccct tcttatcgct ggtgctaaca
     4621 tgtctgaaag ggcaggatga acaacgcgag ggactcctta cctccctcta cagccaggtg
     4681 caccagattg tgaataattg gcgagatgac cagtacttag atgattgcaa accaaagcag
     4741 cttatgcatg aggcactcaa actgcggctc aacctggtgg ggggcatgtt tgacacggtg
     4801 cagcgcagca cccagcagac cacggagtgg gccatgctcc tcctggagat catcatcagc
     4861 ggcactgtcg acatgcagtc caacaatgag ctcttcacta ctgtgttgga catgctgagc
     4921 gtgctcatca atgggacatt ggctgcagac atgtctagca tctcgcaagg tagcatggag
     4981 gaaaacaagc gtgcatacat gaacctggcg aagaagttgc agaaggagtt gggggagcgc
     5041 cagtcagaca gtctggaaaa ggttcgccag ctgctgccac tgcccaagca gacccgagat
     5101 gtcatcacgt gtgagccaca gggctccctt atcgatacca agggcaacaa gattgctggc
     5161 ttcgattcca tcttcaagaa ggagggtcta caggtttcca ccaaacagaa gatctcgccc
     5221 tgggatcttt ttgaggggtt gaagccgtca gcaccactct cttggggctg gtttggaaca
     5281 gtccgagtgg accggcgagt ggctcgagga gaggagcagc agcggttgct gctctaccac
     5341 acacacctga ggccccggcc ccgcgcctat tacctggagc cactgccact gcccccagaa
     5401 gatgaggagc cgcctgctcc taccctgcta gagcctgaga aaaaggctcc agagcccccc
     5461 aaaactgaca aaccgggggc tgctccaccc agtactgagg aacgcaagaa gaagtccacc
     5521 aagggcaaga aacgcagcca gccagctacc aagacagagg actatggaat gggcccgggt
     5581 cggagcggcc cttatggtgt gacagtgcct ccggacctcc tgcaccaccc aaaccctggt
     5641 tctataacac accttaacta caggcaaggc tccataggcc tgtacaccca gaaccagcca
     5701 ctacctgcag gtggccctcg tgtggaccca taccgtcctg tgcgcttacc aatgcagaag
     5761 ctgcccaccc gaccaactta ccctggagtg ctgcccacaa ccatgactgg cgtcatgggt
     5821 ttagaaccct cctcttataa gacctctgtg taccggcagc agcaacctgc ggtgccccaa
     5881 ggacagcgcc ttcgccaaca gctccagcag agtcagggca tgttgggaca gtcatctgtc
     5941 catcagatga ctcccagctc ttcctacggt ttgcagactt cccagggcta tactccttat
     6001 gtttctcatg tgggattgca gcaacacaca ggccctgcag gtaccatggt gccccccagc
     6061 tactccagcc agccttacca gagcacccac ccttctacca atcctactct tgtagatcct
     6121 acccgccacc tgcaacagcg gcccagtggc tatgtgcacc agcaggcccc cacctatgga
     6181 catggactga cctccactca aaggttttca caccagacac tgcagcagac acccatgata
     6241 agtaccatga ctccaatgag tgcccagggc gtccaggcag gcgtccgttc aacagccatc
     6301 ctacctgagc agcagcagca gcagcaacag cagcaacagc aacagcagca gcagcagcaa
     6361 cagcaacagc agcagcagca gcagcagtac cacatccggc agcagcagca gcagcagatc
     6421 ctgcggcagc agcagcaaca gcaacagcag cagcagcagc agcagcaaca gcaacagcag
     6481 cagcagcaac agcaacaaca gcaacaccag cagcaacagc agcaacaggc ggctcctccc
     6541 caaccccagc cccagtccca gccccagttc cagcgccagg ggcttcagca gacccagcag
     6601 cagcaacaga cagcagcttt ggtccggcaa cttcaacaac agctctctaa tacccagcca
     6661 cagcccagta ccaacatatt tggacgctac tgagccacct ggaggaactg cttgtgcact
     6721 ggatgtggcc ccaccctttc ctcttaattc ccaatcccat tcctgggcta gcaccagtag
     6781 tggttggggc cctcccctca ggctccattt ttaataagtt tttagtattt ttgttaatgt
     6841 gaggcattga gctgttgggt tttgtatatt atttatatag agaccccaga gctgttgcac
     6901 ccaatacaca gagcttcttt gcaaa
//
