LOCUS       NM_004774               8137 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens mediator complex subunit 1 (MED1), mRNA.
ACCESSION   NM_004774
VERSION     NM_004774.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8137)
  AUTHORS   Li,Z., Sun,M., Yang,R., Wang,Z., Zhu,Q., Zhang,Y., Yang,H.,
            Meng,Z., Hu,L. and Sui,L.
  TITLE     Mediator complex subunit 1 promotes oral squamous cell carcinoma
            progression by activating MMP9 transcription and suppressing CD8+ T
            cell antitumor immunity
  JOURNAL   J Exp Clin Cancer Res 43 (1), 270 (2024)
   PUBMED   39343952
  REMARK    GeneRIF: Mediator complex subunit 1 promotes oral squamous cell
            carcinoma progression by activating MMP9 transcription and
            suppressing CD8[+] T cell antitumor immunity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8137)
  AUTHORS   Chaudhuri,S.M., Weinberg,S.E., Wang,D., Yalom,L.K., Montauti,E.,
            Iyer,R., Tang,A.Y., Torres Acosta,M.A., Shen,J., Mani,N.L.,
            Wang,S., Liu,K., Lu,W., Bui,T.M., Manzanares,L.D., Dehghani,Z.,
            Wai,C.M., Gao,B., Wei,J., Yue,F., Cui,W., Singer,B.D., Sumagin,R.,
            Zhang,Y. and Fang,D.
  TITLE     Mediator complex subunit 1 architects a tumorigenic Treg cell
            program independent of inflammation
  JOURNAL   Cell Rep Med 5 (3), 101441 (2024)
   PUBMED   38428427
  REMARK    GeneRIF: Mediator complex subunit 1 architects a tumorigenic Treg
            cell program independent of inflammation.
REFERENCE   3  (bases 1 to 8137)
  AUTHORS   Shen,Y., Zhou,L., Xu,M., Tan,Z., Yao,K. and Wang,W.
  TITLE     MED1 induces M2 polarization of tumor-associated macrophages to
            aggravate breast cancer
  JOURNAL   Genes Genomics 45 (12), 1517-1525 (2023)
   PUBMED   37594664
  REMARK    GeneRIF: MED1 induces M2 polarization of tumor-associated
            macrophages to aggravate breast cancer.
REFERENCE   4  (bases 1 to 8137)
  AUTHORS   Gao,J., Bao,M., Xing,Y., Ding,Y., Han,T., Wen,E., Liu,J., Yue,S.,
            Wang,R., Wang,L., Liu,J., Zhao,S., Huang,J., Liu,E. and Bai,L.
  TITLE     Mediator subunit MED1 deficiency prevents carbon
            tetrachloride-induced hepatic fibrosis in mice
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 325 (5), G418-G428 (2023)
   PUBMED   37668531
  REMARK    GeneRIF: Mediator subunit MED1 deficiency prevents carbon
            tetrachloride-induced hepatic fibrosis in mice.
REFERENCE   5  (bases 1 to 8137)
  AUTHORS   Wang,M., Roggero,V.R. and Allison,L.A.
  TITLE     Mediator subunit MED1 differentially modulates mutant thyroid
            hormone receptor intracellular dynamics in Resistance to Thyroid
            Hormone syndrome
  JOURNAL   Mol Cell Endocrinol 559, 111781 (2023)
   PUBMED   36191835
  REMARK    GeneRIF: Mediator subunit MED1 differentially modulates mutant
            thyroid hormone receptor intracellular dynamics in Resistance to
            Thyroid Hormone syndrome.
REFERENCE   6  (bases 1 to 8137)
  AUTHORS   Yuan,C.X., Ito,M., Fondell,J.D., Fu,Z.Y. and Roeder,R.G.
  TITLE     The TRAP220 component of a thyroid hormone receptor- associated
            protein (TRAP) coactivator complex interacts directly with nuclear
            receptors in a ligand-dependent fashion
  JOURNAL   Proc Natl Acad Sci U S A 95 (14), 7939-7944 (1998)
   PUBMED   9653119
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1998 Nov 24;95(24):14584]
REFERENCE   7  (bases 1 to 8137)
  AUTHORS   Drane,P., Barel,M., Balbo,M. and Frade,R.
  TITLE     Identification of RB18A, a 205 kDa new p53 regulatory protein which
            shares antigenic and functional properties with p53
  JOURNAL   Oncogene 15 (25), 3013-3024 (1997)
   PUBMED   9444950
REFERENCE   8  (bases 1 to 8137)
  AUTHORS   Zhu,Y., Qi,C., Jain,S., Rao,M.S. and Reddy,J.K.
  TITLE     Isolation and characterization of PBP, a protein that interacts
            with peroxisome proliferator-activated receptor
  JOURNAL   J Biol Chem 272 (41), 25500-25506 (1997)
   PUBMED   9325263
REFERENCE   9  (bases 1 to 8137)
  AUTHORS   Fondell,J.D., Ge,H. and Roeder,R.G.
  TITLE     Ligand induction of a transcriptionally active thyroid hormone
            receptor coactivator complex
  JOURNAL   Proc Natl Acad Sci U S A 93 (16), 8329-8333 (1996)
   PUBMED   8710870
REFERENCE   10 (bases 1 to 8137)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP357374.1, BC131783.1 and
            AC005288.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004774.3.
            
            Summary: The activation of gene transcription is a multistep
            process that is triggered by factors that recognize transcriptional
            enhancer sites in DNA. These factors work with co-activators to
            direct transcriptional initiation by the RNA polymerase II
            apparatus. The protein encoded by this gene is a subunit of the
            CRSP (cofactor required for SP1 activation) complex, which, along
            with TFIID, is required for efficient activation by SP1. This
            protein is also a component of other multisubunit complexes e.g.
            thyroid hormone receptor-(TR-) associated proteins which interact
            with TR and facilitate TR function on DNA templates in conjunction
            with initiation factors and cofactors. It also regulates
            p53-dependent apoptosis and it is essential for adipogenesis. This
            protein is known to have the ability to self-oligomerize. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC131783.1, Y13467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000300651.11/ ENSP00000300651.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               BP357374.1         12-146
            136-5632            BC131783.1         1-5497
            5633-8137           AC005288.1         1823-4327
FEATURES             Location/Qualifiers
     source          1..8137
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..8137
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /note="mediator complex subunit 1"
                     /db_xref="GeneID:5469"
                     /db_xref="HGNC:HGNC:9234"
                     /db_xref="MIM:604311"
     exon            1..226
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            227..333
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            334..412
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            413..467
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            468..600
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            601..629
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            630..701
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..776
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            777..850
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            851..940
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            941..1052
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1177
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1296
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1498
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1594
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1700
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..8137
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8113..8118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /note="hexamer: AATAAA"
     polyA_site      8137
                     /gene="MED1"
                     /gene_synonym="CRSP1; CRSP200; DRIP205; DRIP230; PBP;
                     PPARBP; PPARGBP; RB18A; TRAP220; TRIP2"
                     /note="major polyA site"
ORIGIN      
        1 gaagttccgt tggggaagat ggcggcggcc tcgagcaccc ttctcttctt gccgccgggg
       61 acttcagatt gatccttccc gggaagagta gggactgctg gtgccctgcg tcccgggatc
      121 ccgagccaac ttgtttcctc cgttagtggt ggggaagggc ttatcctttt gtggcggatc
      181 tagcttctcc tcgccttcag gatgaaagct cagggggaaa ccgaggagtc agaaaagctg
      241 agtaagatga gttctctcct ggaacggctc catgcaaaat ttaaccaaaa tagaccctgg
      301 agtgaaacca ttaagcttgt gcgtcaagtc atggagaaga gggttgtgat gagttctgga
      361 gggcatcaac atttggtcag ctgtttggag acattgcaga aggctctcaa agtaacatct
      421 ttaccagcaa tgactgatcg tttggagtcc atagcaagac agaatggact gggctctcat
      481 ctcagtgcca gtggcactga atgttacatc acgtcagata tgttctatgt ggaagtgcag
      541 ttagatcctg caggacagct ttgtgatgta aaagtggctc accatgggga gaatcctgtg
      601 agctgtccgg agcttgtaca gcagctaagg gaaaaaaatt ttgatgaatt ttctaagcac
      661 cttaagggcc ttgttaatct gtataacctt ccaggggaca acaaactgaa gactaaaatg
      721 tacttggctc tccaatcctt agaacaagat ctttctaaaa tggcaattat gtactggaaa
      781 gcaactaatg ctggtccctt ggataagatt cttcatggaa gtgttggcta tctcacacca
      841 aggagtgggg gtcatttaat gaacctgaag tactatgtct ctccttctga cctactggat
      901 gacaagactg catctcccat cattttgcat gagaataatg tttctcgatc tttgggcatg
      961 aatgcatcag tgacaattga aggaacatct gctgtgtaca aactcccaat tgcaccatta
     1021 attatggggt cacatccagt tgacaataaa tggacccctt ccttctcctc aatcaccagt
     1081 gccaacagtg ttgatcttcc tgcctgtttc ttcttgaaat ttccccagcc aatcccagta
     1141 tctagagcat ttgttcagaa actgcagaac tgcacaggaa ttccattgtt tgaaactcaa
     1201 ccaacttatg cacccctgta tgaactgatc actcagtttg agctatcaaa ggaccctgac
     1261 cccatacctt tgaatcacaa catgagattt tatgctgctc ttcctggtca gcagcactgc
     1321 tatttcctca acaaggatgc tcctcttcca gatggccgaa gtctacaggg aacccttgtt
     1381 agcaaaatca cctttcagca ccctggccga gttcctctta tcctaaatct gatcagacac
     1441 caagtggcct ataacaccct cattggaagc tgtgtcaaaa gaactattct gaaagaagat
     1501 tctcctgggc ttctccaatt tgaagtgtgt cctctctcag agtctcgttt cagcgtatct
     1561 tttcagcacc ctgtgaatga ctccctggtg tgtgtggtaa tggatgtgca ggactcaaca
     1621 catgtgagct gtaaactcta caaagggctg tcggatgcac tgatctgcac agatgacttc
     1681 attgccaaag ttgttcaaag atgtatgtcc atccctgtga cgatgagggc tattcggagg
     1741 aaagctgaaa ccattcaagc cgacacccca gcactgtccc tcattgcaga gacagttgaa
     1801 gacatggtga aaaagaacct gcccccggct agcagcccag ggtatggcat gaccacaggc
     1861 aacaacccaa tgagtggtac cactacacca accaacacct ttccgggggg tcccattacc
     1921 accttgttta atatgagcat gagcatcaaa gatcggcatg agtcggtggg ccatggggag
     1981 gacttcagca aggtgtctca gaacccaatt cttaccagtt tgttgcaaat cacagggaac
     2041 ggggggtcta ccattggctc gagtccgacc cctcctcatc acacgccgcc acctgtctct
     2101 tcgatggccg gcaacaccaa gaaccacccg atgctcatga accttcttaa agataatcct
     2161 gcccaggatt tctcaaccct ttatggaagc agccctttag aaaggcagaa ctcctcttcc
     2221 ggctcacccc gcatggaaat atgctcgggg agcaacaaga ccaagaaaaa gaagtcatca
     2281 agattaccac ctgagaaacc aaagcaccag actgaagatg actttcagag ggagctattt
     2341 tcaatggatg ttgactcaca gaaccctatc tttgatgtca acatgacagc tgacacgctg
     2401 gatacgccac acatcactcc agctccaagc cagtgtagca ctcccccaac aacttaccca
     2461 caaccagtac ctcaccccca acccagtatt caaaggatgg tccgactatc cagttcagac
     2521 agcattggcc cagatgtaac tgacatcctt tcagacattg cagaagaagc ttctaaactt
     2581 cccagcacta gtgatgattg cccagccatt ggcacccctc ttcgagattc ttcaagctct
     2641 gggcattctc agagtaccct gtttgactct gatgtctttc aaactaacaa taatgaaaat
     2701 ccatacactg atccagctga tcttattgca gatgctgctg gaagccccag tagtgactct
     2761 cctaccaatc atttttttca tgatggagta gatttcaatc ctgatttatt gaacagccag
     2821 agccaaagtg gttttggaga agaatatttt gatgaaagca gccaaagtgg ggataatgat
     2881 gatttcaaag gatttgcatc tcaggcacta aatactttgg gggtgccaat gcttggaggt
     2941 gataatgggg agaccaagtt taagggcaat aaccaagccg acacagttga tttcagtatt
     3001 atttcagtag ccggcaaagc tttagctcct gcagatctta tggagcatca cagtggtagt
     3061 cagggtcctt tactgaccac tggggactta gggaaagaaa agactcaaaa gagggtaaag
     3121 gaaggcaatg gcaccagtaa tagtactctc tcggggcccg gattagacag caaaccaggg
     3181 aagcgcagtc ggaccccttc taatgatggg aaaagcaaag ataagcctcc aaagcggaag
     3241 aaggcagaca ctgagggaaa gtctccatct catagttctt ctaacagacc ttttacccca
     3301 cctaccagta caggtggatc taaatcgcca ggcagtgcag gaagatctca gactccccca
     3361 ggtgttgcca caccacccat tcccaaaatc actattcaga ttcctaaggg aacagtgatg
     3421 gtgggcaagc cttcctctca cagtcagtat accagcagtg gttctgtgtc ttcctcaggc
     3481 agcaaaagcc accatagcca ttcttcctcc tcttcctcat ctgcttccac ctcagggaag
     3541 atgaaaagca gtaaatcaga aggttcatca agttccaagt taagtagcag tatgtattct
     3601 agccaggggt cttctggatc tagccagtcc aaaaattcat cccagtctgg ggggaagcca
     3661 ggctcctctc ccataaccaa gcatggactg agcagtggct ctagcagcac caagatgaaa
     3721 cctcaaggaa agccatcatc acttatgaat ccttctttaa gtaaaccaaa catatcccct
     3781 tctcattcaa ggccacctgg aggctctgac aagcttgcct ctccaatgaa gcctgttcct
     3841 ggaactcctc catcctctaa agccaagtcc cctatcagtt caggttctgg tggttctcat
     3901 atgtctggaa ctagttcaag ctctggcatg aagtcatctt cagggttagg atcctcaggc
     3961 tcgttgtccc agaaaactcc cccatcatct aattcctgta cggcatcttc ctcctccttt
     4021 tcctcaagtg gctcttccat gtcatcctct cagaaccagc atgggagttc taaaggaaaa
     4081 tctcccagca gaaacaagaa gccgtccttg acagctgtca tagataaact gaagcatggg
     4141 gttgtcacca gtggccctgg gggtgaagac ccactggacg gccagatggg ggtgagcaca
     4201 aattcttcca gccatcctat gtcctccaaa cataacatgt caggaggaga gtttcagggc
     4261 aagcgtgaga aaagtgataa agacaaatca aaggtttcca cctccgggag ttcagtggat
     4321 tcttctaaga agacctcaga gtcaaaaaat gtggggagca caggtgtggc aaaaattatc
     4381 atcagtaagc atgatggagg ctcccctagc attaaagcca aagtgacttt gcagaaacct
     4441 ggggaaagta gtggagaagg gcttaggcct caaatggctt cttctaaaaa ctatggctct
     4501 ccactcatca gtggttccac tccaaagcat gagcgtggct ctcccagcca tagtaagtca
     4561 ccagcatata ccccccagaa tctggacagt gaaagtgagt caggctcctc catagcagag
     4621 aaatcttatc agaatagtcc cagctcagac gatggtatcc gaccacttcc agaatacagc
     4681 acagagaaac ataagaagca caaaaaggaa aagaagaaag taaaagacaa agatagggac
     4741 cgagaccggg acaaagaccg agacaagaaa aaatctcata gcatcaagcc agagagttgg
     4801 tccaaatcac ccatctcttc agaccagtcc ttgtctatga caagtaacac aatcttatct
     4861 gcagacagac cctcaaggct cagcccagac tttatgattg gggaggaaga tgatgatctt
     4921 atggatgtgg ccctgattgg gaattaggaa ccttatttcc taaaagaaac agggccagag
     4981 gaaaaaaaac tattgataag tttataggca aaccaccata aggggtgagt cagacaggtc
     5041 tgatttggtt aagaatccta aatggcatgg ctttgacatc aagctgggtg aattagaaag
     5101 gcatatccag accctattaa agaaaccaca gggtttgatt ctggttacca ggaagtcttc
     5161 tttgttcctg tgccagaaag aaagttaaaa tacttgctta agaaagggag gggggtggga
     5221 ggggtgtagg gagagggaag ggagggaaac agttttgtgg gaaatattca tatatatttt
     5281 cttctccctt tttccatttt taggccatgt tttaaactca ttttagtgca tgtatatgaa
     5341 gggctgggca gaaaatgaaa aagcaataca ttccttgatg catttgcatg aaggttgttc
     5401 aactttgttt gaggtagttg tccgtttgag tcatgggcaa atgaaggact ttggtcattt
     5461 tggacactta agtaatgttt ggtgtctgtt tcttaggagt gactggggga gggaagatta
     5521 ttttagctat ttatttgtaa tattttaacc ctttatctgt ttgtttttat acagtgtttc
     5581 gttctaaatc tatgaggttt agggttcaaa atgatggaag gccgaagagc aaggcttata
     5641 tggtggtagg gagcttatag cttgtgctaa tactgtagca tcaagcccaa gcaaattagt
     5701 cagagcccgc ctttagagtt aaatataata gaaaaaccaa aatgatattt ttattttagg
     5761 agggtttaaa tagggttcag agatcatagg aatattagga gttacctctc tgtggaggta
     5821 ttgacttgta atctcatttt cctttcaaaa aaaaaaaaaa aagctaaggt ggcttgttgg
     5881 gatgtaaaca tgttttcaga tgcagtaagg tttagtgtag gacagccttc ctgacccagt
     5941 ggcatgaaaa ccattacagg attaatagtt ctcctacttc cacaatgtgc caaaagtctg
     6001 catcccagca ttttgtttgc aggagaactg atgccattcc taagagctgg actcactgtt
     6061 tctcttcatc acaaggagaa ggagtccaaa ctttaatcac tccactgtat gctccctgag
     6121 ataaaacagt aaaaaatccg cagccatagt tcacttaaaa caatttcaag ctcacttttg
     6181 aagtaatggg ggcctggaat gctaggtgag catgaagata aacccttgct actatgtagc
     6241 aacccaattg gacctttttg gagaaatagg tctgagtctg gattctgggg gacatcaata
     6301 agagcccttc acataaaaat atagaaatcc aggagactgt ttcgagtgca acagaagttc
     6361 tcagtatttg gagggtcctc tcaaaaattc tgcggcctta ctttgatatt gacacctgca
     6421 ctgtgccatt cctgattatt ccattcagga tctgtatcag cgggatgggg catggtcccc
     6481 agcacaactc ttctgggtta aaaaaaaaaa gccaggtgat tcctttgtgt gttatgtcgt
     6541 aagtggagtg acttcatcat atatggaaga agatttctat attcagcttt ttctgcaggt
     6601 tggagtcagc atagagttgg aaaatcagct ttggctttct ttcctgtctc atttcctcta
     6661 gtgttctcct ttttattgtc atcagctctc aacaactctg ccacttttgt gtcccaaggt
     6721 aataagatgt aggaaacaaa acattgtaaa gtggagcaag aaaagttatc aattaaccac
     6781 atcagagtca aatgtcttgg gtgacactaa ggaggatatg ggcaggtgat accagagtgc
     6841 tttatcttgt gatgttgata cagtagcagc ctctcagaca ttcagccagg ttggatttct
     6901 catgagtttg tcacctagtt ttgaatccta tcccgttggt ttctgcagga aaaaaaaaaa
     6961 aatttatgtg gtttttaaaa tttgttctga gtggggagaa tcttaggggg aatgtactga
     7021 atagtatcat gggctcagct cccccatgca gggccaacaa ataccaaaat gagtaaactg
     7081 ggaagctttt ctctctttct gtcttcatcc cagatcaaag aatcccgagt taggatctgg
     7141 atgaaggata agcccctgaa ttgtcgatgg gctcaccccc acactgaccc agcatctgaa
     7201 cttgcttaac agggagccgg ggctaaactg cttcaccctg cctgagaacc agggagcact
     7261 gcatttctcc acagggtgga ggagaagagg cagaataaac caagcctggg acacctccct
     7321 cctgtctagg tgtactcatt cttctgtttc aaaagaaggc aaggacatga agtcaacttc
     7381 tacctatctt ctgctgctgg tgtcttatgt attctcagtt tgacctgatt cctcttctgt
     7441 cttttgactt aacattaggg gttcttggtc ataacctgct ctgatgtaca taaagatttc
     7501 aggttcaata tcaatgtgtc ttaaaacaga agtattttag cgggtggggg gtggggtggt
     7561 ggggacaaac aacgcaggat ataattgcca aaaccaggct tgaggttggt gactcttgaa
     7621 agattttctt tcttcaggcc tagatcagaa aattaagtgc agcaatatca tgaattctca
     7681 gaagcccttt cagggagcca gtgagtcata cagtatccac agttgagtca cttaaagatg
     7741 tcagtatacg aaacattatt cacaatcctt gggcaatctc attttttttt ccttctcccc
     7801 tcctcccctg ccccccatac atttctatcc ttgagttagt tttggagggg caggaagtac
     7861 ttaacatctc agaagctaga ttgggaaaca tgctcagcta taagaactga gctttaaatt
     7921 ttgagtttaa aaatgtacat caggagcagc tggggagggt ctttttttaa aaaaatcttt
     7981 caaatttggt tttctgtgca tatggccgtt ttgtaaatac tttggggttt ttcatttttt
     8041 tgaaagtaga tgaaatctgt tgtgggattt ttttcccgaa acattacaaa ataacctgtt
     8101 tatttacatg caaataaact tctttgataa aaagtaa
//
