LOCUS       XM_047442117           10773 bp    mRNA    linear   PRI 26-AUG-2024
DEFINITION  PREDICTED: Homo sapiens methyl-CpG binding protein 2 (MECP2),
            transcript variant X4, mRNA.
ACCESSION   XM_047442117
VERSION     XM_047442117.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000023.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
     gene            1..10773
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /note="methyl-CpG binding protein 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 8
                     mRNAs, 21 ESTs, 1707 long SRA reads, 2 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 18 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4204"
                     /db_xref="HGNC:HGNC:6990"
                     /db_xref="MIM:300005"
     CDS             798..1979
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /codon_start=1
                     /product="methyl-CpG-binding protein 2 isoform X2"
                     /protein_id="XP_047298073.1"
                     /db_xref="GeneID:4204"
                     /db_xref="HGNC:HGNC:6990"
                     /db_xref="MIM:300005"
                     /translation="MYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVE
                     LIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSG
                     TTRPKAATSEGVQVKRVLEKSPGKLLVKMPFQTSPGGKAEGGGATTSTQVMVIKRPGR
                     KRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRET
                     VSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHH
                     HHHSESPKAPVPLLPPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESD
                     GCPKEPAKTQPAVATAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERV
                     S"
ORIGIN      
        1 ttccaggacc caggagggag aagcagctgc caggggaagt ctcttcgtag gcggaggtca
       61 ggagtccaag aggagtgagc agagtcacag aagcctctta aagcctcttc ttcccccatc
      121 ccatcaacac atctgctgcc caagaactcc tttgtgattg aatttaacca gagttgattt
      181 ctgttgcttg aaactcagga ccttgatgca gtgtgcaggg tctgggcaag tctagacttg
      241 aatgcaaaca gttcttattg ctaacttacc actagtcacc actaatgaac aaagactatg
      301 aacaggaaat tcataaaaga agagatacag atggccaatg aagataggaa aagagttctg
      361 cctgctggta atcaaagaga tgcaaacgag aacaaaaatg atgccttttc acctaccaaa
      421 tttgtcaaga ttaaaaagaa agcaaagagc cagcgtcagc tgatgttcat acctgcacct
      481 gctcggtagc ttgctaatgt tctgcctgct ccacacgcca ggccagcctc cacggcgcag
      541 ccagggaaga aaagtcagaa gaccaggacc tccagggcct caaggacaaa cccctcaagt
      601 ttaaaaaggt gaagaaagat aagaaagaag agaaagaggg caagcatgag cccgtgcagc
      661 catcagccca ccactctgct gagcccgcag aggcaggcaa agcagagaca tcagaagggt
      721 caggctccgc cccggctgtg ccggaagctt ctgcctcccc caaacagcgg cgctccatca
      781 tccgtgaccg gggacccatg tatgatgacc ccaccctgcc tgaaggctgg acacggaagc
      841 ttaagcaaag gaaatctggc cgctctgctg ggaagtatga tgtgtatttg atcaatcccc
      901 agggaaaagc ctttcgctct aaagtggagt tgattgcgta cttcgaaaag gtaggcgaca
      961 catccctgga ccctaatgat tttgacttca cggtaactgg gagagggagc ccctcccggc
     1021 gagagcagaa accacctaag aagcccaaat ctcccaaagc tccaggaact ggcagaggcc
     1081 ggggacgccc caaagggagc ggcaccacga gacccaaggc ggccacgtca gagggtgtgc
     1141 aggtgaaaag ggtcctggag aaaagtcctg ggaagctcct tgtcaagatg ccttttcaaa
     1201 cttcgccagg gggcaaggct gaggggggtg gggccaccac atccacccag gtcatggtga
     1261 tcaaacgccc cggcaggaag cgaaaagctg aggccgaccc tcaggccatt cccaagaaac
     1321 ggggccgaaa gccggggagt gtggtggcag ccgctgccgc cgaggccaaa aagaaagccg
     1381 tgaaggagtc ttctatccga tctgtgcagg agaccgtact ccccatcaag aagcgcaaga
     1441 cccgggagac ggtcagcatc gaggtcaagg aagtggtgaa gcccctgctg gtgtccaccc
     1501 tcggtgagaa gagcgggaaa ggactgaaga cctgtaagag ccctgggcgg aaaagcaagg
     1561 agagcagccc caaggggcgc agcagcagcg cctcctcacc ccccaagaag gagcaccacc
     1621 accatcacca ccactcagag tccccaaagg cccccgtgcc actgctccca cccctgcccc
     1681 cacctccacc tgagcccgag agctccgagg accccaccag cccccctgag ccccaggact
     1741 tgagcagcag cgtctgcaaa gaggagaaga tgcccagagg aggctcactg gagagcgacg
     1801 gctgccccaa ggagccagct aagactcagc ccgcggttgc caccgccgcc acggccgcag
     1861 aaaagtacaa acaccgaggg gagggagagc gcaaagacat tgtttcatcc tccatgccaa
     1921 ggccaaacag agaggagcct gtggacagcc ggacgcccgt gaccgagaga gttagctgac
     1981 tttacacgga gcggattgca aagcaaacca acaagaataa aggcagctgt tgtctcttct
     2041 ccttatgggt agggctctga caaagcttcc cgattaactg aaataaaaaa tatttttttt
     2101 tctttcagta aacttagagt ttcgtggctt cagggtggga gtagttggag cattggggat
     2161 gtttttctta ccgacaagca cagtcaggtt gaagacctaa ccagggccag aagtagcttt
     2221 gcacttttct aaactaggct ccttcaacaa ggcttgctgc agatactact gaccagacaa
     2281 gctgttgacc aggcacctcc cctcccgccc aaacctttcc cccatgtggt cgttagagac
     2341 agagcgacag agcagttgag aggacactcc cgttttcggt gccatcagtg ccccgtctac
     2401 agctccccca gctcccccca cctcccccac tcccaaccac gttgggacag ggaggtgtga
     2461 ggcaggagag acagttggat tctttagaga agatggatat gaccagtggc tatggcctgt
     2521 gcgatcccac ccgtggtggc tcaagtctgg ccccacacca gccccaatcc aaaactggca
     2581 aggacgcttc acaggacagg aaagtggcac ctgtctgctc cagctctggc atggctagga
     2641 ggggggagtc ccttgaacta ctgggtgtag actggcctga accacaggag aggatggccc
     2701 agggtgaggt ggcatggtcc attctcaagg gacgtcctcc aacgggtggc gctagaggcc
     2761 atggaggcag taggacaagg tgcaggcagg ctggcctggg gtcaggccgg gcagagcaca
     2821 gcggggtgag agggattcct aatcactcag agcagtctgt gacttagtgg acaggggagg
     2881 gggcaaaggg ggaggagaag aaaatgttct tccagttact ttccaattct cctttaggga
     2941 cagcttagaa ttatttgcac tattgagtct tcatgttccc acttcaaaac aaacagatgc
     3001 tctgagagca aactggcttg aattggtgac atttagtccc tcaagccacc agatgtgaca
     3061 gtgttgagaa ctacctggat ttgtatatat acctgcgctt gttttaaagt gggctcagca
     3121 catagggttc ccacgaagct ccgaaactct aagtgtttgc tgcaatttta taaggacttc
     3181 ctgattggtt tctcttctcc ccttccattt ctgccttttg ttcatttcat cctttcactt
     3241 ctttcccttc ctccatcctc ctccttccta gttcatccct tctcttccag gcagccgcgg
     3301 tgcccaacca cacttgtcgg ctccagtccc cagaactctg cctgcccttt gtcctcctgc
     3361 tgccagtacc agccccaccc tgttttgagc cctgaggagg ccttgggctc tgctgagtcc
     3421 gacctggcct gtctgtgaag agcaagagag cagcaaggtc ttgctctcct aggtagcccc
     3481 ctcttccctg gtaagaaaaa gcaaaaggca tttcccaccc tgaacaacga gccttttcac
     3541 ccttctactc tagagaagtg gactggagga gctgggcccg atttggtagt tgaggaaagc
     3601 acagaggcct cctgtggcct gccagtcatc gagtggccca acaggggctc catgccagcc
     3661 gaccttgacc tcactcagaa gtccagagtc tagcgtagtg cagcagggca gtagcggtac
     3721 caatgcagaa ctcccaagac ccgagctggg accagtacct gggtccccag cccttcctct
     3781 gctccccctt ttccctcgga gttcttcttg aatggcaatg ttttgctttt gctcgatgca
     3841 gacagggggc cagaacacca cacatttcac tgtctgtctg gtccatagct gtggtgtagg
     3901 ggcttagagg catgggcttg ctgtgggttt ttaattgatc agttttcatg tgggatccca
     3961 tctttttaac ctctgttcag gaagtcctta tctagctgca tatcttcatc atattggtat
     4021 atccttttct gtgtttacag agatgtctct tatatctaaa tctgtccaac tgagaagtac
     4081 cttatcaaag tagcaaatga gacagcagtc ttatgcttcc agaaacaccc acaggcatgt
     4141 cccatgtgag ctgctgccat gaactgtcaa gtgtgtgttg tcttgtgtat ttcagttatt
     4201 gtccctggct tccttactat ggtgtaatca tgaaggagtg aaacatcata gaaactgtct
     4261 agcacttcct tgccagtctt tagtgatcag gaaccatagt tgacagttcc aatcagtagc
     4321 ttaagaaaaa accgtgtttg tctcttctgg aatggttaga agtgagggag tttgccccgt
     4381 tctgtttgta gagtctcata gttggacttt ctagcatata tgtgtccatt tccttatgct
     4441 gtaaaagcaa gtcctgcaac caaactccca tcagcccaat ccctgatccc tgatcccttc
     4501 cacctgctct gctgatgacc cccccagctt cacttctgac tcttccccag gaagggaagg
     4561 ggggtcagaa gagagggtga gtcctccaga actcttcctc caaggacaga aggctcctgc
     4621 ccccatagtg gcctcgaact cctggcacta ccaaaggaca cttatccacg agagcgcagc
     4681 atccgaccag gttgtcactg agaagatgtt tattttggtc agttgggttt ttatgtatta
     4741 tacttagtca aatgtaatgt ggcttctgga atcattgtcc agagctgctt ccccgtcacc
     4801 tgggcgtcat ctggtcctgg taagaggagt gcgtggccca ccaggccccc ctgtcaccca
     4861 tgacagttca ttcagggccg atggggcagt cgtggttggg aacacagcat ttcaagcgtc
     4921 actttatttc attcgggccc cacctgcagc tccctcaaag aggcagttgc ccagcctctt
     4981 tcccttccag tttattccag agctgccagt ggggcctgag gctccttagg gttttctctc
     5041 tatttccccc tttcttcctc attccctcgt ctttcccaaa ggcatcacga gtcagtcgcc
     5101 tttcagcagg cagccttggc ggtttatcgc cctggcaggc aggggccctg cagctctcat
     5161 gctgcccctg ccttggggtc aggttgacag gaggttggag ggaaagcctt aagctgcagg
     5221 attctcacca gctgtgtccg gcccagtttt ggggtgtgac ctcaatttca attttgtctg
     5281 tacttgaaca ttatgaagat gggggcctct ttcagtgaat ttgtgaacag cagaattgac
     5341 cgacagcttt ccagtaccca tggggctagg tcattaaggc cacatccaca gtctccccca
     5401 cccttgttcc agttgttagt tactacctcc tctcctgaca atactgtatg tcgtcgagct
     5461 ccccccaggt ctacccctcc cggccctgcc tgctggtggg cttgtcatag ccagtgggat
     5521 tgccggtctt gacagctcag tgagctggag atacttggtc acagccaggc gctagcacag
     5581 ctcccttctg ttgatgctgt attcccatat caaaagacac aggggacacc cagaaacgcc
     5641 acatccccca atccatcagt gccaaactag ccaacggccc cagcttctca gctcgctgga
     5701 tggcggaagc tgctactcgt gagcgccagt gcgggtgcag acaatcttct gttgggtggc
     5761 atcattccag gcccgaagca tgaacagtgc acctgggaca gggagcagcc ccaaattgtc
     5821 acctgcttct ctgcccagct tttcattgct gtgacagtga tggcgaaaga gggtaataac
     5881 cagacacaaa ctgccaagtt gggtggagaa aggagtttct ttagctgaca gaatctctga
     5941 attttaaatc acttagtaag cggctcaagc ccaggaggga gcagagggat acgagcggag
     6001 tcccctgcgc gggaccatct ggaattggtt tagcccaagt ggagcctgac agccagaact
     6061 ctgtgtcccc cgtctaacca cagctccttt tccagagcat tccagtcagg ctctctgggc
     6121 tgactgggcc aggggaggtt acaggtacca gttctttaag aagatctttg ggcatataca
     6181 tttttagcct gtgtcattgc cccaaatgga ttcctgtttc aagttcacac ctgcagattc
     6241 taggacctgt gtcctagact tcagggagtc agctgtttct agagttccta ccatggagtg
     6301 ggtctggagg acctgcccgg tgggggggca gagccctgct ccctccgggt cttcctactc
     6361 ttctctctgc tctgacggga tttgttgatt ctctccattt tggtgtcttt ctcttttaga
     6421 tattgtatca atctttagaa aaggcatagt ctacttgtta taaatcgtta ggatactgcc
     6481 tcccccaggg tctaaaatta catattagag gggaaaagct gaacactgaa gtcagttctc
     6541 aacaatttag aaggaaaacc tagaaaacat ttggcagaaa attacatttc gatgtttttg
     6601 aatgaatacg agcaagcttt tacaacagtg ctgatctaaa aatacttagc acttggcctg
     6661 agatgcctgg tgagcattac aggcaagggg aatctggagg tagccgacct gaggacatgg
     6721 cttctgaacc tgtcttttgg gagtggtatg gaaggtggag cgttcaccag tgacctggaa
     6781 ggcccagcac caccctcctt cccactcttc tcatcttgac agagcctgcc ccagcgctga
     6841 cgtgtcagga aaacacccag ggaactagga aggcacttct gcctgagggg cagcctgcct
     6901 tgcccactcc tgctctgctc gcctcggatc agctgagcct tctgagctgg cctctcactg
     6961 cctccccaag gccccctgcc tgccctgtca ggaggcagaa ggaagcaggt gtgagggcag
     7021 tgcaaggagg gagcacaacc cccagctccc gctccgggct ccgacttgtg cacaggcaga
     7081 gcccagaccc tggaggaaat cctacctttg aattcaagaa catttgggga atttggaaat
     7141 ctctttgccc ccaaaccccc attctgtcct acctttaatc aggtcctgct cagcagtgag
     7201 agcagatgag gtgaaaaggc caagaggttt ggctcctgcc cactgatagc ccctctcccc
     7261 gcagtgtttg tgtgtcaagt ggcaaagctg ttcttcctgg tgaccctgat tatatccagt
     7321 aacacataga ctgtgcgcat aggcctgctt tgtctcctct atcctgggct tttgttttgc
     7381 tttttagttt tgcttttagt ttttctgtcc cttttattta acgcaccgac tagacacaca
     7441 aagcagttga atttttatat atatatctgt atattgcaca attataaact cattttgctt
     7501 gtggctccac acacacaaaa aaagacctgt taaaattata cctgttgctt aattacaata
     7561 tttctgataa ccatagcata ggacaaggga aaataaaaaa agaaaaaaaa gaaaaaaaaa
     7621 cgacaaatct gtctgctggt cacttcttct gtccaagcag attcgtggtc ttttcctcgc
     7681 ttctttcaag ggctttcctg tgccaggtga aggaggctcc aggcagcacc caggttttgc
     7741 actcttgttt ctcccgtgct tgtgaaagag gtcccaaggt tctgggtgca ggagcgctcc
     7801 cttgacctgc tgaagtccgg aacgtagtcg gcacagcctg gtcgccttcc acctctggga
     7861 gctggagtcc actggggtgg cctgactccc ccagtcccct tcccgtgacc tggtcagggt
     7921 gagcccatgt ggagtcagcc tcgcaggcct ccctgccagt agggtccgag tgtgtttcat
     7981 ccttcccact ctgtcgagcc tgggggctgg agcggagacg ggaggcctgg cctgtctcgg
     8041 aacctgtgag ctgcaccagg tagaacgcca gggaccccag aatcatgtgc gtcagtccaa
     8101 ggggtcccct ccaggagtag tgaagactcc agaaatgtcc ctttcttctc ccccatccta
     8161 cgagtaattg catttgcttt tgtaattctt aatgagcaat atctgctaga gagtttagct
     8221 gtaacagttc tttttgatca tcttttttta ataattagaa acaccaaaaa aatccagaaa
     8281 cttgttcttc caaagcagag agcattataa tcaccagggc caaaagcttc cctccctgct
     8341 gtcattgctt cttctgaggc ctgaatccaa aagaaaaaca gccataggcc ctttcagtgg
     8401 ccgggctacc cgtgagccct tcggaggacc agggctgggg cagcctctgg gcccacatcc
     8461 ggggccagct ccggcgtgtg ttcagtgtta gcagtgggtc atgatgctct ttcccaccca
     8521 gcctgggata ggggcagagg aggcgaggag gccgttgccg ctgatgtttg gccgtgaaca
     8581 ggtgggtgtc tgcgtgcgtc cacgtgcgtg ttttctgact gacatgaaat cgacgcccga
     8641 gttagcctca cccggtgacc tctagccctg cccggatgga gcggggccca cccggttcag
     8701 tgtttctggg gagctggaca gtggagtgca aaaggcttgc agaacttgaa gcctgctcct
     8761 tcccttgcta ccacggcctc ctttccgttt gatttgtcac tgcttcaatc aataacagcc
     8821 gctccagagt cagtagtcaa tgaatatatg accaaatatc accaggactg ttactcaatg
     8881 tgtgccgagc ccttgcccat gctgggctcc cgtgtatctg gacactgtaa cgtgtgctgt
     8941 gtttgctccc cttccccttc cttctttgcc ctttacttgt ctttctgggg tttttctgtt
     9001 tgggtttggt ttggttttta tttctccttt tgtgttccaa acatgaggtt ctctctactg
     9061 gtcctcttaa ctgtggtgtt gaggcttata tttgtgtaat ttttggtggg tgaaaggaat
     9121 tttgctaagt aaatctcttc tgtgtttgaa ctgaagtctg tattgtaact atgtttaaag
     9181 taattgttcc agagacaaat atttctagac actttttctt tacaaacaaa agcattcgga
     9241 gggaggggga tggtgactga gatgagaggg gagagctgaa cagatgaccc ctgcccagat
     9301 cagccagaag ccacccaaag cagtggagcc caggagtccc actccaagcc agcaagccga
     9361 atagctgatg tgttgccact ttccaagtca ctgcaaaacc aggttttgtt ccgcccagtg
     9421 gattcttgtt ttgcttcccc tccccccgag attattacca ccatcccgtg cttttaagga
     9481 aaggcaagat tgatgtttcc ttgaggggag ccaggagggg atgtgtgtgt gcagagctga
     9541 agagctgggg agaatggggc tgggcccacc caagcaggag gctgggacgc tctgctgtgg
     9601 gcacaggtca ggctaatgtt ggcagatgca gctcttcctg gacaggccag gtggtgggca
     9661 ttctctctcc aaggtgtgcc ccgtgggcat tactgtttaa gacacttccg tcacatccca
     9721 ccccatcctc cagggctcaa cactgtgaca tctctattcc ccaccctccc cttcccaggg
     9781 caataaaatg accatggagg gggcttgcac tctcttggct gtcacccgat cgccagcaaa
     9841 acttagatgt gagaaaaccc cttcccattc catggcgaaa acatctcctt agaaaagcca
     9901 ttaccctcat taggcatggt tttgggctcc caaaacacct gacagcccct ccctcctctg
     9961 agaggcggag agtgctgact gtagtgacca ttgcatgccg ggtgcagcat ctggaagagc
    10021 taggcagggt gtctgccccc tcctgagttg aagtcatgct cccctgtgcc agcccagagg
    10081 ccgagagcta tggacagcat tgccagtaac acaggccacc ctgtgcagaa gggagctggc
    10141 tccagcctgg aaacctgtct gaggttggga gaggtgcact tggggcacag ggagaggccg
    10201 ggacacactt agctggagat gtctctaaaa gccctgtatc gtattcacct tcagtttttg
    10261 tgttttggga caattacttt agaaaataag taggtcgttt taaaaacaaa aattattgat
    10321 tgcttttttg tagtgttcag aaaaaaggtt ctttgtgtat agccaaatga ctgaaagcac
    10381 tgatatattt aaaaacaaaa ggcaatttat taaggaaatt tgtaccattt cagtaaacct
    10441 gtctgaatgt acctgtatac gtttcaaaaa cacccccccc ccactgaatc cctgtaacct
    10501 atttattata taaagagttt gccttataaa tttacataaa aatgtccgtt tgtgtctttt
    10561 gttgtaaaaa tcaagtgatt ttttcataag gttcttttac tattggaaaa gatgggcagc
    10621 acgcagtttt attttatttt tgtaagtttt ttaatacatg tgaaagcaaa gaatactcag
    10681 catgcctttc taagtgacgc gtttgcacct tttgttggga agtactgtat cctgtgctgt
    10741 tagcattctc gataaatctc tctgtgaaag tga
//
