LOCUS       NM_001386138           10358 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens methyl-CpG binding protein 2 (MECP2), transcript
            variant 9, mRNA.
ACCESSION   NM_001386138
VERSION     NM_001386138.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10358)
  AUTHORS   Tomasello,D.L., Barrasa,M.I., Mankus,D., Alarcon,K.I.,
            Lytton-Jean,A.K.R., Liu,X.S. and Jaenisch,R.
  TITLE     Mitochondrial dysfunction and increased reactive oxygen species
            production in MECP2 mutant astrocytes and their impact on neurons
  JOURNAL   Sci Rep 14 (1), 20565 (2024)
   PUBMED   39232000
  REMARK    GeneRIF: Mitochondrial dysfunction and increased reactive oxygen
            species production in MECP2 mutant astrocytes and their impact on
            neurons.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10358)
  AUTHORS   Fichou,Y., Nectoux,J., Bahi-Buisson,N., Rosas-Vargas,H., Girard,B.,
            Chelly,J. and Bienvenu,T.
  TITLE     The first missense mutation causing Rett syndrome specifically
            affecting the MeCP2_e1 isoform
  JOURNAL   Neurogenetics 10 (2), 127-133 (2009)
   PUBMED   19034540
  REMARK    GeneRIF: Data suggest the important involvement of the N-terminus
            in the function of MeCP2 protein, and provide further evidence for
            the major impact of a specific MeCP2e_1 deficiency in the
            development of intellectual processing.
REFERENCE   3  (bases 1 to 10358)
  AUTHORS   Harvey,C.G., Menon,S.D., Stachowiak,B., Noor,A., Proctor,A.,
            Mensah,A.K., Mnatzakanian,G.N., Alfred,S.E., Guo,R., Scherer,S.W.,
            Kennedy,J.L., Roberts,W., Srivastava,A.K., Minassian,B.A. and
            Vincent,J.B.
  TITLE     Sequence variants within exon 1 of MECP2 occur in females with
            mental retardation
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 144B (3), 355-360 (2007)
   PUBMED   17171659
  REMARK    GeneRIF: polymorphisms within exon 1 of MECP2 occur in females with
            mental retardation.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Am J Med Genet B Neuropsychiatr Genet. 2007 Oct
            5;144(7):969. Srivistava, Anand K [corrected to Srivastava, Anand
            K]]
REFERENCE   4  (bases 1 to 10358)
  AUTHORS   Francke,U.
  TITLE     Mechanisms of disease: neurogenetics of MeCP2 deficiency
  JOURNAL   Nat Clin Pract Neurol 2 (4), 212-221 (2006)
   PUBMED   16932552
  REMARK    GeneRIF: Rett syndrome is caused by heterozygosity for mutations in
            the X-linked gene MECP2, which encodes methyl-CpG binding protein
            2.
            Review article
REFERENCE   5  (bases 1 to 10358)
  AUTHORS   Mnatzakanian,G.N., Lohi,H., Munteanu,I., Alfred,S.E., Yamada,T.,
            MacLeod,P.J., Jones,J.R., Scherer,S.W., Schanen,N.C., Friez,M.J.,
            Vincent,J.B. and Minassian,B.A.
  TITLE     A previously unidentified MECP2 open reading frame defines a new
            protein isoform relevant to Rett syndrome
  JOURNAL   Nat Genet 36 (4), 339-341 (2004)
   PUBMED   15034579
  REMARK    GeneRIF: description of a previously unknown MeCP2 isoform
            Erratum:[Nat Genet. 2004 May;36(5):540]
REFERENCE   6  (bases 1 to 10358)
  AUTHORS   Reichwald,K., Thiesen,J., Wiehe,T., Weitzel,J., Poustka,W.A.,
            Rosenthal,A., Platzer,M., Stratling,W.H. and Kioschis,P.
  TITLE     Comparative sequence analysis of the MECP2-locus in human and mouse
            reveals new transcribed regions
  JOURNAL   Mamm Genome 11 (3), 182-190 (2000)
   PUBMED   10723722
REFERENCE   7  (bases 1 to 10358)
  AUTHORS   Kaur,S. and Christodoulou,J.
  TITLE     MECP2 Disorders
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301670
REFERENCE   8  (bases 1 to 10358)
  AUTHORS   Van Esch,H.
  TITLE     MECP2 Duplication Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301461
REFERENCE   9  (bases 1 to 10358)
  AUTHORS   Klein,C., Lohmann,K., Marras,C. and Munchau,A.
  TITLE     Hereditary Dystonia Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301334
REFERENCE   10 (bases 1 to 10358)
  AUTHORS   Lewis,J.D., Meehan,R.R., Henzel,W.J., Maurer-Fogy,I., Jeppesen,P.,
            Klein,F. and Bird,A.
  TITLE     Purification, sequence, and cellular localization of a novel
            chromosomal protein that binds to methylated DNA
  JOURNAL   Cell 69 (6), 905-914 (1992)
   PUBMED   1606614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC244097.3, AF030876.2 and
            U52112.2.
            
            Summary: DNA methylation is the major modification of eukaryotic
            genomes and plays an essential role in mammalian development. Human
            proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of
            nuclear proteins related by the presence in each of a methyl-CpG
            binding domain (MBD). Each of these proteins, with the exception of
            MBD3, is capable of binding specifically to methylated DNA. MECP2,
            MBD1 and MBD2 can also repress transcription from methylated gene
            promoters. In contrast to other MBD family members, MECP2 is
            X-linked and subject to X inactivation. MECP2 is dispensible in
            stem cells, but is essential for embryonic development. MECP2 gene
            mutations are the cause of most cases of Rett syndrome, a
            progressive neurologic developmental disorder and one of the most
            common causes of cognitive disability in females. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Oct 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2884311.1,
                                           SRR18074969.3345587.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333, SAMEA2159368
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC244097.3         29110-29223         c
            115-238             AC244097.3         23690-23813         c
            239-589             AF030876.2         23679-24029         c
            590-644             AF030876.2         22868-22922         c
            645-3521            AF030876.2         19882-22758         c
            3522-10358          U52112.2           174507-181343       c
FEATURES             Location/Qualifiers
     source          1..10358
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq28"
     gene            1..10358
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /note="methyl-CpG binding protein 2"
                     /db_xref="GeneID:4204"
                     /db_xref="HGNC:HGNC:6990"
                     /db_xref="MIM:300005"
     exon            1..114
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /inference="alignment:Splign:2.1.0"
     exon            115..238
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /inference="alignment:Splign:2.1.0"
     exon            239..589
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /inference="alignment:Splign:2.1.0"
     exon            590..644
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /inference="alignment:Splign:2.1.0"
     exon            645..10358
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /inference="alignment:Splign:2.1.0"
     CDS             773..1564
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /note="isoform 4 is encoded by transcript variant 9;
                     meCp-2 protein"
                     /codon_start=1
                     /product="methyl-CpG-binding protein 2 isoform 4"
                     /protein_id="NP_001373067.1"
                     /db_xref="GeneID:4204"
                     /db_xref="HGNC:HGNC:6990"
                     /db_xref="MIM:300005"
                     /translation="MPFQTSPGGKAEGGGATTSTQVMVIKRPGRKRKAEADPQAIPKK
                     RGRKPGSVVAAAAAEAKKKAVKESSIRSVQETVLPIKKRKTRETVSIEVKEVVKPLLV
                     STLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESPKAPVPLL
                     PPLPPPPPEPESSEDPTSPPEPQDLSSSVCKEEKMPRGGSLESDGCPKEPAKTQPAVA
                     TAATAAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS"
     regulatory      10336..10341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /note="hexamer: GATAAA"
     polyA_site      10358
                     /gene="MECP2"
                     /gene_synonym="AUTSX3; MRX16; MRX79; MRXS13; MRXSL; PPMX;
                     RS; RTS; RTT"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcgctc cctcctctcg gagagagggc tgtggtaaaa gccgtccgga aaatggccgc
       61 cgccgccgcc gccgcgccga gcggaggagg aggaggaggc gaggaggaga gactgctcca
      121 taaaaataca gactcaccag ttcctgcttt gatgtgacat gtgactcccc agaatacacc
      181 ttgcttctgt agaccagctc caacaggatt ccatggtagc tgggatgtta gggctcaggg
      241 aagaaaagtc agaagaccag gacctccagg gcctcaagga caaacccctc aagtttaaaa
      301 aggtgaagaa agataagaaa gaagagaaag agggcaagca tgagcccgtg cagccatcag
      361 cccaccactc tgctgagccc gcagaggcag gcaaagcaga gacatcagaa gggtcaggct
      421 ccgccccggc tgtgccggaa gcttctgcct cccccaaaca gcggcgctcc atcatccgtg
      481 accggggacc catgtatgat gaccccaccc tgcctgaagg ctggacacgg aagcttaagc
      541 aaaggaaatc tggccgctct gctgggaagt atgatgtgta tttgatcaat ccccagggaa
      601 aagcctttcg ctctaaagtg gagttgattg cgtacttcga aaagctccag gaactggcag
      661 aggccgggga cgccccaaag ggagcggcac cacgagaccc aaggcggcca cgtcagaggg
      721 tgtgcaggtg aaaagggtcc tggagaaaag tcctgggaag ctccttgtca agatgccttt
      781 tcaaacttcg ccagggggca aggctgaggg gggtggggcc accacatcca cccaggtcat
      841 ggtgatcaaa cgccccggca ggaagcgaaa agctgaggcc gaccctcagg ccattcccaa
      901 gaaacggggc cgaaagccgg ggagtgtggt ggcagccgct gccgccgagg ccaaaaagaa
      961 agccgtgaag gagtcttcta tccgatctgt gcaggagacc gtactcccca tcaagaagcg
     1021 caagacccgg gagacggtca gcatcgaggt caaggaagtg gtgaagcccc tgctggtgtc
     1081 caccctcggt gagaagagcg ggaaaggact gaagacctgt aagagccctg ggcggaaaag
     1141 caaggagagc agccccaagg ggcgcagcag cagcgcctcc tcacccccca agaaggagca
     1201 ccaccaccat caccaccact cagagtcccc aaaggccccc gtgccactgc tcccacccct
     1261 gcccccacct ccacctgagc ccgagagctc cgaggacccc accagccccc ctgagcccca
     1321 ggacttgagc agcagcgtct gcaaagagga gaagatgccc agaggaggct cactggagag
     1381 cgacggctgc cccaaggagc cagctaagac tcagcccgcg gttgccaccg ccgccacggc
     1441 cgcagaaaag tacaaacacc gaggggaggg agagcgcaaa gacattgttt catcctccat
     1501 gccaaggcca aacagagagg agcctgtgga cagccggacg cccgtgaccg agagagttag
     1561 ctgactttac acggagcgga ttgcaaagca aaccaacaag aataaaggca gctgttgtct
     1621 cttctcctta tgggtagggc tctgacaaag cttcccgatt aactgaaata aaaaatattt
     1681 ttttttcttt cagtaaactt agagtttcgt ggcttcaggg tgggagtagt tggagcattg
     1741 gggatgtttt tcttaccgac aagcacagtc aggttgaaga cctaaccagg gccagaagta
     1801 gctttgcact tttctaaact aggctccttc aacaaggctt gctgcagata ctactgacca
     1861 gacaagctgt tgaccaggca cctcccctcc cgcccaaacc tttcccccat gtggtcgtta
     1921 gagacagagc gacagagcag ttgagaggac actcccgttt tcggtgccat cagtgccccg
     1981 tctacagctc ccccagctcc ccccacctcc cccactccca accacgttgg gacagggagg
     2041 tgtgaggcag gagagacagt tggattcttt agagaagatg gatatgacca gtggctatgg
     2101 cctgtgcgat cccacccgtg gtggctcaag tctggcccca caccagcccc aatccaaaac
     2161 tggcaaggac gcttcacagg acaggaaagt ggcacctgtc tgctccagct ctggcatggc
     2221 taggaggggg gagtcccttg aactactggg tgtagactgg cctgaaccac aggagaggat
     2281 ggcccagggt gaggtggcat ggtccattct caagggacgt cctccaacgg gtggcgctag
     2341 aggccatgga ggcagtagga caaggtgcag gcaggctggc ctggggtcag gccgggcaga
     2401 gcacagcggg gtgagaggga ttcctaatca ctcagagcag tctgtgactt agtggacagg
     2461 ggagggggca aagggggagg agaagaaaat gttcttccag ttactttcca attctccttt
     2521 agggacagct tagaattatt tgcactattg agtcttcatg ttcccacttc aaaacaaaca
     2581 gatgctctga gagcaaactg gcttgaattg gtgacattta gtccctcaag ccaccagatg
     2641 tgacagtgtt gagaactacc tggatttgta tatatacctg cgcttgtttt aaagtgggct
     2701 cagcacatag ggttcccacg aagctccgaa actctaagtg tttgctgcaa ttttataagg
     2761 acttcctgat tggtttctct tctccccttc catttctgcc ttttgttcat ttcatccttt
     2821 cacttctttc ccttcctcca tcctcctcct tcctagttca tcccttctct tccaggcagc
     2881 cgcggtgccc aaccacactt gtcggctcca gtccccagaa ctctgcctgc cctttgtcct
     2941 cctgctgcca gtaccagccc caccctgttt tgagccctga ggaggccttg ggctctgctg
     3001 agtccgacct ggcctgtctg tgaagagcaa gagagcagca aggtcttgct ctcctaggta
     3061 gccccctctt ccctggtaag aaaaagcaaa aggcatttcc caccctgaac aacgagcctt
     3121 ttcacccttc tactctagag aagtggactg gaggagctgg gcccgatttg gtagttgagg
     3181 aaagcacaga ggcctcctgt ggcctgccag tcatcgagtg gcccaacagg ggctccatgc
     3241 cagccgacct tgacctcact cagaagtcca gagtctagcg tagtgcagca gggcagtagc
     3301 ggtaccaatg cagaactccc aagacccgag ctgggaccag tacctgggtc cccagccctt
     3361 cctctgctcc cccttttccc tcggagttct tcttgaatgg caatgttttg cttttgctcg
     3421 atgcagacag ggggccagaa caccacacat ttcactgtct gtctggtcca tagctgtggt
     3481 gtaggggctt agaggcatgg gcttgctgtg ggtttttaat tgatcagttt tcatgtggga
     3541 tcccatcttt ttaacctctg ttcaggaagt ccttatctag ctgcatatct tcatcatatt
     3601 ggtatatcct tttctgtgtt tacagagatg tctcttatat ctaaatctgt ccaactgaga
     3661 agtaccttat caaagtagca aatgagacag cagtcttatg cttccagaaa cacccacagg
     3721 catgtcccat gtgagctgct gccatgaact gtcaagtgtg tgttgtcttg tgtatttcag
     3781 ttattgtccc tggcttcctt actatggtgt aatcatgaag gagtgaaaca tcatagaaac
     3841 tgtctagcac ttccttgcca gtctttagtg atcaggaacc atagttgaca gttccaatca
     3901 gtagcttaag aaaaaaccgt gtttgtctct tctggaatgg ttagaagtga gggagtttgc
     3961 cccgttctgt ttgtagagtc tcatagttgg actttctagc atatatgtgt ccatttcctt
     4021 atgctgtaaa agcaagtcct gcaaccaaac tcccatcagc ccaatccctg atccctgatc
     4081 ccttccacct gctctgctga tgaccccccc agcttcactt ctgactcttc cccaggaagg
     4141 gaaggggggt cagaagagag ggtgagtcct ccagaactct tcctccaagg acagaaggct
     4201 cctgccccca tagtggcctc gaactcctgg cactaccaaa ggacacttat ccacgagagc
     4261 gcagcatccg accaggttgt cactgagaag atgtttattt tggtcagttg ggtttttatg
     4321 tattatactt agtcaaatgt aatgtggctt ctggaatcat tgtccagagc tgcttccccg
     4381 tcacctgggc gtcatctggt cctggtaaga ggagtgcgtg gcccaccagg cccccctgtc
     4441 acccatgaca gttcattcag ggccgatggg gcagtcgtgg ttgggaacac agcatttcaa
     4501 gcgtcacttt atttcattcg ggccccacct gcagctccct caaagaggca gttgcccagc
     4561 ctctttccct tccagtttat tccagagctg ccagtggggc ctgaggctcc ttagggtttt
     4621 ctctctattt ccccctttct tcctcattcc ctcgtctttc ccaaaggcat cacgagtcag
     4681 tcgcctttca gcaggcagcc ttggcggttt atcgccctgg caggcagggg ccctgcagct
     4741 ctcatgctgc ccctgccttg gggtcaggtt gacaggaggt tggagggaaa gccttaagct
     4801 gcaggattct caccagctgt gtccggccca gttttggggt gtgacctcaa tttcaatttt
     4861 gtctgtactt gaacattatg aagatggggg cctctttcag tgaatttgtg aacagcagaa
     4921 ttgaccgaca gctttccagt acccatgggg ctaggtcatt aaggccacat ccacagtctc
     4981 ccccaccctt gttccagttg ttagttacta cctcctctcc tgacaatact gtatgtcgtc
     5041 gagctccccc caggtctacc cctcccggcc ctgcctgctg gtgggcttgt catagccagt
     5101 gggattgccg gtcttgacag ctcagtgagc tggagatact tggtcacagc caggcgctag
     5161 cacagctccc ttctgttgat gctgtattcc catatcaaaa gacacagggg acacccagaa
     5221 acgccacatc ccccaatcca tcagtgccaa actagccaac ggccccagct tctcagctcg
     5281 ctggatggcg gaagctgcta ctcgtgagcg ccagtgcggg tgcagacaat cttctgttgg
     5341 gtggcatcat tccaggcccg aagcatgaac agtgcacctg ggacagggag cagccccaaa
     5401 ttgtcacctg cttctctgcc cagcttttca ttgctgtgac agtgatggcg aaagagggta
     5461 ataaccagac acaaactgcc aagttgggtg gagaaaggag tttctttagc tgacagaatc
     5521 tctgaatttt aaatcactta gtaagcggct caagcccagg agggagcaga gggatacgag
     5581 cggagtcccc tgcgcgggac catctggaat tggtttagcc caagtggagc ctgacagcca
     5641 gaactctgtg tcccccgtct aaccacagct ccttttccag agcattccag tcaggctctc
     5701 tgggctgact gggccagggg aggttacagg taccagttct ttaagaagat ctttgggcat
     5761 atacattttt agcctgtgtc attgccccaa atggattcct gtttcaagtt cacacctgca
     5821 gattctagga cctgtgtcct agacttcagg gagtcagctg tttctagagt tcctaccatg
     5881 gagtgggtct ggaggacctg cccggtgggg gggcagagcc ctgctccctc cgggtcttcc
     5941 tactcttctc tctgctctga cgggatttgt tgattctctc cattttggtg tctttctctt
     6001 ttagatattg tatcaatctt tagaaaaggc atagtctact tgttataaat cgttaggata
     6061 ctgcctcccc cagggtctaa aattacatat tagaggggaa aagctgaaca ctgaagtcag
     6121 ttctcaacaa tttagaagga aaacctagaa aacatttggc agaaaattac atttcgatgt
     6181 ttttgaatga atacgagcaa gcttttacaa cagtgctgat ctaaaaatac ttagcacttg
     6241 gcctgagatg cctggtgagc attacaggca aggggaatct ggaggtagcc gacctgagga
     6301 catggcttct gaacctgtct tttgggagtg gtatggaagg tggagcgttc accagtgacc
     6361 tggaaggccc agcaccaccc tccttcccac tcttctcatc ttgacagagc ctgccccagc
     6421 gctgacgtgt caggaaaaca cccagggaac taggaaggca cttctgcctg aggggcagcc
     6481 tgccttgccc actcctgctc tgctcgcctc ggatcagctg agccttctga gctggcctct
     6541 cactgcctcc ccaaggcccc ctgcctgccc tgtcaggagg cagaaggaag caggtgtgag
     6601 ggcagtgcaa ggagggagca caacccccag ctcccgctcc gggctccgac ttgtgcacag
     6661 gcagagccca gaccctggag gaaatcctac ctttgaattc aagaacattt ggggaatttg
     6721 gaaatctctt tgcccccaaa cccccattct gtcctacctt taatcaggtc ctgctcagca
     6781 gtgagagcag atgaggtgaa aaggccaaga ggtttggctc ctgcccactg atagcccctc
     6841 tccccgcagt gtttgtgtgt caagtggcaa agctgttctt cctggtgacc ctgattatat
     6901 ccagtaacac atagactgtg cgcataggcc tgctttgtct cctctatcct gggcttttgt
     6961 tttgcttttt agttttgctt ttagtttttc tgtccctttt atttaacgca ccgactagac
     7021 acacaaagca gttgaatttt tatatatata tctgtatatt gcacaattat aaactcattt
     7081 tgcttgtggc tccacacaca caaaaaaaga cctgttaaaa ttatacctgt tgcttaatta
     7141 caatatttct gataaccata gcataggaca agggaaaata aaaaaagaaa aaaaagaaaa
     7201 aaaaacgaca aatctgtctg ctggtcactt cttctgtcca agcagattcg tggtcttttc
     7261 ctcgcttctt tcaagggctt tcctgtgcca ggtgaaggag gctccaggca gcacccaggt
     7321 tttgcactct tgtttctccc gtgcttgtga aagaggtccc aaggttctgg gtgcaggagc
     7381 gctcccttga cctgctgaag tccggaacgt agtcggcaca gcctggtcgc cttccacctc
     7441 tgggagctgg agtccactgg ggtggcctga ctcccccagt ccccttcccg tgacctggtc
     7501 agggtgagcc catgtggagt cagcctcgca ggcctccctg ccagtagggt ccgagtgtgt
     7561 ttcatccttc ccactctgtc gagcctgggg gctggagcgg agacgggagg cctggcctgt
     7621 ctcggaacct gtgagctgca ccaggtagaa cgccagggac cccagaatca tgtgcgtcag
     7681 tccaaggggt cccctccagg agtagtgaag actccagaaa tgtccctttc ttctccccca
     7741 tcctacgagt aattgcattt gcttttgtaa ttcttaatga gcaatatctg ctagagagtt
     7801 tagctgtaac agttcttttt gatcatcttt ttttaataat tagaaacacc aaaaaaatcc
     7861 agaaacttgt tcttccaaag cagagagcat tataatcacc agggccaaaa gcttccctcc
     7921 ctgctgtcat tgcttcttct gaggcctgaa tccaaaagaa aaacagccat aggccctttc
     7981 agtggccggg ctacccgtga gcccttcgga ggaccagggc tggggcagcc tctgggccca
     8041 catccggggc cagctccggc gtgtgttcag tgttagcagt gggtcatgat gctctttccc
     8101 acccagcctg ggataggggc agaggaggcg aggaggccgt tgccgctgat gtttggccgt
     8161 gaacaggtgg gtgtctgcgt gcgtccacgt gcgtgttttc tgactgacat gaaatcgacg
     8221 cccgagttag cctcacccgg tgacctctag ccctgcccgg atggagcggg gcccacccgg
     8281 ttcagtgttt ctggggagct ggacagtgga gtgcaaaagg cttgcagaac ttgaagcctg
     8341 ctccttccct tgctaccacg gcctcctttc cgtttgattt gtcactgctt caatcaataa
     8401 cagccgctcc agagtcagta gtcaatgaat atatgaccaa atatcaccag gactgttact
     8461 caatgtgtgc cgagcccttg cccatgctgg gctcccgtgt atctggacac tgtaacgtgt
     8521 gctgtgtttg ctccccttcc ccttccttct ttgcccttta cttgtctttc tggggttttt
     8581 ctgtttgggt ttggtttggt ttttatttct ccttttgtgt tccaaacatg aggttctctc
     8641 tactggtcct cttaactgtg gtgttgaggc ttatatttgt gtaatttttg gtgggtgaaa
     8701 ggaattttgc taagtaaatc tcttctgtgt ttgaactgaa gtctgtattg taactatgtt
     8761 taaagtaatt gttccagaga caaatatttc tagacacttt ttctttacaa acaaaagcat
     8821 tcggagggag ggggatggtg actgagatga gaggggagag ctgaacagat gacccctgcc
     8881 cagatcagcc agaagccacc caaagcagtg gagcccagga gtcccactcc aagccagcaa
     8941 gccgaatagc tgatgtgttg ccactttcca agtcactgca aaaccaggtt ttgttccgcc
     9001 cagtggattc ttgttttgct tcccctcccc ccgagattat taccaccatc ccgtgctttt
     9061 aaggaaaggc aagattgatg tttccttgag gggagccagg aggggatgtg tgtgtgcaga
     9121 gctgaagagc tggggagaat ggggctgggc ccacccaagc aggaggctgg gacgctctgc
     9181 tgtgggcaca ggtcaggcta atgttggcag atgcagctct tcctggacag gccaggtggt
     9241 gggcattctc tctccaaggt gtgccccgtg ggcattactg tttaagacac ttccgtcaca
     9301 tcccacccca tcctccaggg ctcaacactg tgacatctct attccccacc ctccccttcc
     9361 cagggcaata aaatgaccat ggagggggct tgcactctct tggctgtcac ccgatcgcca
     9421 gcaaaactta gatgtgagaa aaccccttcc cattccatgg cgaaaacatc tccttagaaa
     9481 agccattacc ctcattaggc atggttttgg gctcccaaaa cacctgacag cccctccctc
     9541 ctctgagagg cggagagtgc tgactgtagt gaccattgca tgccgggtgc agcatctgga
     9601 agagctaggc agggtgtctg ccccctcctg agttgaagtc atgctcccct gtgccagccc
     9661 agaggccgag agctatggac agcattgcca gtaacacagg ccaccctgtg cagaagggag
     9721 ctggctccag cctggaaacc tgtctgaggt tgggagaggt gcacttgggg cacagggaga
     9781 ggccgggaca cacttagctg gagatgtctc taaaagccct gtatcgtatt caccttcagt
     9841 ttttgtgttt tgggacaatt actttagaaa ataagtaggt cgttttaaaa acaaaaatta
     9901 ttgattgctt ttttgtagtg ttcagaaaaa aggttctttg tgtatagcca aatgactgaa
     9961 agcactgata tatttaaaaa caaaaggcaa tttattaagg aaatttgtac catttcagta
    10021 aacctgtctg aatgtacctg tatacgtttc aaaaacaccc cccccccact gaatccctgt
    10081 aacctattta ttatataaag agtttgcctt ataaatttac ataaaaatgt ccgtttgtgt
    10141 cttttgttgt aaaaatcaag tgattttttc ataaggttct tttactattg gaaaagatgg
    10201 gcagcacgca gttttatttt atttttgtaa gttttttaat acatgtgaaa gcaaagaata
    10261 ctcagcatgc ctttctaagt gacgcgtttg caccttttgt tgggaagtac tgtatcctgt
    10321 gctgttagca ttctcgataa atctctctgt gaaagtga
//
