LOCUS       XM_047447691            3841 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens MDS1 and EVI1 complex locus (MECOM),
            transcript variant X19, mRNA.
ACCESSION   XM_047447691
VERSION     XM_047447691.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3841
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..3841
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1;
                     PRDM3; RUSAT2"
                     /note="MDS1 and EVI1 complex locus; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 43 ESTs, 101 long SRA reads, and 100% coverage of
                     the annotated genomic feature by RNAseq alignments,
                     including 96 samples with support for all annotated
                     introns"
                     /db_xref="GeneID:2122"
                     /db_xref="HGNC:HGNC:3498"
                     /db_xref="MIM:165215"
     CDS             253..2439
                     /gene="MECOM"
                     /gene_synonym="AML1-EVI-1; EVI1; KMT8E; MDS1; MDS1-EVI1;
                     PRDM3; RUSAT2"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase MECOM isoform
                     X17"
                     /protein_id="XP_047303647.1"
                     /db_xref="GeneID:2122"
                     /db_xref="HGNC:HGNC:3498"
                     /db_xref="MIM:165215"
                     /translation="MKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPC
                     STPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEERE
                     YKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKQVFTDPSNLQRHIRSQHVGARA
                     HACPECGKTFATSSGLKQHKHIHSSVKPFISFSQSMYPFPDRDLRSLPLKMEPQSPGE
                     VKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGTK
                     LTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKE
                     KYLRPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFNFR
                     APPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSIS
                     SNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELES
                     TGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLD
                     DEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRY
                     KEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSK
                     SQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSISHV"
ORIGIN      
        1 cttgttcctc ctgcgaaacg gtgcggtctg gacacgtctc cggggtgggt cgtccggcct
       61 tcgatcttag acgaatttta caatgtgaag ttctgcatag atgccagtca accagatgtt
      121 ggaagctggc tcaagtacat tagattcgct ggctgttatg atcagcacaa ccttgttgca
      181 tgccagataa atgatcagat attctataga gtagttgcag acattgcgcc gggagaggag
      241 cttctgctgt tcatgaagag cgaagactat ccccatgaaa ctatggcgcc ggatatccac
      301 gaagaacggc aatatcgctg cgaagactgt gaccagctct ttgaatctaa ggctgaacta
      361 gcagatcacc aaaagtttcc atgcagtact cctcactcag cattttcaat ggttgaagag
      421 gactttcagc aaaaactcga aagcgagaat gatctccaag agatacacac gatccaggag
      481 tgtaaggaat gtgaccaagt ttttcctgat ttgcaaagcc tggagaaaca catgctgtca
      541 catactgaag agagggaata caagtgtgat cagtgtccca aggcatttaa ctggaagtcc
      601 aatttaattc gccaccagat gtcacatgac agtggaaagc actatgaatg tgaaaactgt
      661 gccaagcagg ttttcacgga ccctagcaac cttcagcggc acattcgctc tcagcatgtc
      721 ggtgcccggg cccatgcatg cccggagtgt ggcaaaacgt ttgccacttc gtcgggcctc
      781 aaacaacaca agcacatcca cagcagtgtg aagcccttta tctcattctc tcaatcaatg
      841 tacccatttc ctgatagaga cttgagatcg ttacctttga aaatggaacc ccaatcacca
      901 ggtgaagtaa agaaactgca gaagggcagc tctgagtccc cctttgatct caccactaag
      961 cgaaaggatg agaagccctt gactccagtc ccctccaagc ctccagtgac acctgccaca
     1021 agccaagacc agcccctgga tctaagtatg ggcagtagga gtagagccag tgggacaaag
     1081 ctgactgagc ctcgaaaaaa ccacgtgttt gggggaaaaa aaggaagcaa cgtcgaatca
     1141 agacctgctt cagatggttc cttgcagcat gcaagaccca ctcctttctt tatggaccct
     1201 atttacagag tagagaaaag aaaactaact gacccacttg aagctttaaa agagaaatac
     1261 ttgaggcctt ctccaggatt cttgtttcac ccacaattcc aactgcctga tcagagaact
     1321 tggatgtcag ctattgaaaa catggcagaa aagctagaga gcttcagtgc cctgaaacct
     1381 gaggccagtg agctcttaca gtcagtgccc tctatgttca acttcagggc gcctcccaat
     1441 gccctgccag agaaccttct gcggaaggga aaggagcgct atacctgcag atactgtggc
     1501 aagatttttc caaggtctgc aaacctaaca cggcacttga gaacccacac aggagagcag
     1561 ccttacagat gcaaatactg tgacagatca tttagcatat cttctaactt gcaaaggcat
     1621 gttcgcaaca tccacaataa agagaagcca tttaagtgtc acttatgtga taggtgtttt
     1681 ggtcaacaaa ccaatttaga cagacaccta aagaaacatg agaatgggaa catgtccggt
     1741 acagcaacat cgtcgcctca ttctgaactg gaaagtacag gtgcgattct ggatgacaaa
     1801 gaagatgctt acttcacaga aattcgaaat ttcattggga acagcaacca tggcagccaa
     1861 tctcccagga atgtggagga gagaatgaat ggcagtcatt ttaaagatga aaaggctttg
     1921 gtgaccagtc aaaattcaga cttgctggat gatgaagaag ttgaagatga ggtgttgtta
     1981 gatgaggagg atgaagacaa tgatattact ggaaaaacag gaaaggaacc agtgacaagt
     2041 aatttacatg aaggaaaccc tgaggatgac tatgaagaaa ccagtgccct ggagatgagt
     2101 tgcaagacat ccccagtgag gtataaagag gaagaatata aaagtggact ttctgctcta
     2161 gatcatataa ggcacttcac agatagcctc aaaatgagga aaatggaaga taatcaatat
     2221 tctgaagctg agctgtcttc ttttagtact tcccatgtgc cagaggaact taagcagccg
     2281 ttacacagaa agtccaaatc gcaggcatat gctatgatgc tgtcactgtc tgacaaggag
     2341 tccctccatt ctacatccca cagttcttcc aacgtgtggc acagtatggc cagggctgcg
     2401 gcggaatcca gtgctatcca gtccataagc cacgtatgac gttatcaagg ttgaccagag
     2461 tgggaccaag tccaacagta gcatggctct ttcatatagg actatttaca agactgctga
     2521 gcagaatgcc ttataaacct gcagggtcac tcatctaaag tctagtgacc ttaaactgaa
     2581 tgatttaaaa aagaaaagaa agaaaaaaga aactatttat tctcgatatt ttgttttgca
     2641 cagcaaaggc agctgctgac ttctggaaga tcaatcaatg cgacttaaag tgattcagtg
     2701 aaaacaaaaa acttggtggg ctgaaggcat cttccagttt accccacctt agggtatggg
     2761 tgggtgagaa gggcagttga gatggcagca ttgatatgaa tgaacactcc atagaaactg
     2821 aattctcttt tgtacaagat cacctgacat gattgggaac agttgctttt aattacagat
     2881 ttaatttttt tcttcgttaa agttttatgt aatttaaccc tttgaagaca gaagtagttg
     2941 gatgaaatgc acagtcaatt attatagaaa ctgataacag ggagtacttg ttcccccttt
     3001 tgccttctta agtacattgt ttaaaactag ggaaaaaggg tatgtgtata ttgtaaacta
     3061 tggatgttaa cactcaaaga ggttaagtca gtgaagtaac ctattcatca ccagtaccgc
     3121 tgtaccacta ataaattgtt tgccaaatcc ttgtaataac atcttaattt tagacaatca
     3181 tgtcactgtt tttaatgttt atttttttgt gtgtgttgcg tgtatcatgt atttatttgt
     3241 tggcaaacta ttgtttgttg attaaaatag cactgttcca gtcagccact actttatgac
     3301 gtctgaggca cacccctttc cgaatttcaa ggaccaaggt gacccgacct gtgtatgaga
     3361 gtgccaaatg gtgtttggct tttcttaaca ttcctttttg tttgtttgtt ttgttttcct
     3421 tcttaatgaa ctaaatacga atagatgcaa cttagttttt gtaatactga aatcgattca
     3481 attgtataaa cgattataat ttctttcatg gaagcatgat tcttctgatt aaaaactgta
     3541 ctccatattt tatgctggtt gtctgcaagc ttgtgcgatg ttatgttcat gttaatccta
     3601 tttgtaaaat gaagtgttcc caaccttatg ttaaaagaga gaagtaaata acagactgta
     3661 ttcagttatt ttgcccttta ttgaggaacc agatttgttt tctttttgtt tgtaatctca
     3721 ttttgaaata atcagcaagt tgaggtactt tcttcaaatg ctttgtacaa tataaactgt
     3781 tatgcctttc agtgcattac tatgggagga gcaactaaaa aataaagact tacaaaaagg
     3841 a
//
