LOCUS       NM_001270875            4702 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens MYST/Esa1 associated factor 6 (MEAF6), transcript
            variant 2, mRNA.
ACCESSION   NM_001270875
VERSION     NM_001270875.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4702)
  AUTHORS   Liu,Y., Cheng,P., Zhao,W., Zhu,L., Sui,J., Dai,Y. and Lai,Y.
  TITLE     MiR-197-3p reduces bortezomib resistance in multiple myeloma by
            inhibiting IL-6 expression in a MEAF6-dependent manner
  JOURNAL   Leuk Res 114, 106785 (2022)
   PUBMED   35074616
  REMARK    GeneRIF: MiR-197-3p reduces bortezomib resistance in multiple
            myeloma by inhibiting IL-6 expression in a MEAF6-dependent manner.
REFERENCE   2  (bases 1 to 4702)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4702)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 4702)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 4702)
  AUTHORS   Foy,R.L., Song,I.Y., Chitalia,V.C., Cohen,H.T., Saksouk,N.,
            Cayrou,C., Vaziri,C., Cote,J. and Panchenko,M.V.
  TITLE     Role of Jade-1 in the histone acetyltransferase (HAT) HBO1 complex
  JOURNAL   J Biol Chem 283 (43), 28817-28826 (2008)
   PUBMED   18684714
REFERENCE   6  (bases 1 to 4702)
  AUTHORS   Doyon,Y., Cayrou,C., Ullah,M., Landry,A.J., Cote,V., Selleck,W.,
            Lane,W.S., Tan,S., Yang,X.J. and Cote,J.
  TITLE     ING tumor suppressor proteins are critical regulators of chromatin
            acetylation required for genome expression and perpetuation
  JOURNAL   Mol Cell 21 (1), 51-64 (2006)
   PUBMED   16387653
REFERENCE   7  (bases 1 to 4702)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
REFERENCE   8  (bases 1 to 4702)
  AUTHORS   Doyon,Y., Selleck,W., Lane,W.S., Tan,S. and Cote,J.
  TITLE     Structural and functional conservation of the NuA4 histone
            acetyltransferase complex from yeast to humans
  JOURNAL   Mol Cell Biol 24 (5), 1884-1896 (2004)
   PUBMED   14966270
REFERENCE   9  (bases 1 to 4702)
  AUTHORS   Cai,Y., Jin,J., Tomomori-Sato,C., Sato,S., Sorokina,I.,
            Parmely,T.J., Conaway,R.C. and Conaway,J.W.
  TITLE     Identification of new subunits of the multiprotein mammalian
            TRRAP/TIP60-containing histone acetyltransferase complex
  JOURNAL   J Biol Chem 278 (44), 42733-42736 (2003)
   PUBMED   12963728
REFERENCE   10 (bases 1 to 4702)
  AUTHORS   Lee,S.Y., Obata,Y., Yoshida,M., Stockert,E., Williamson,B.,
            Jungbluth,A.A., Chen,Y.T., Old,L.J. and Scanlan,M.J.
  TITLE     Immunomic analysis of human sarcoma
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2651-2656 (2003)
   PUBMED   12601173
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC056406.1 and AL034379.8.
            
            On Feb 27, 2020 this sequence version replaced NM_001270875.2.
            
            Summary: This gene encodes a nuclear protein involved in
            transcriptional activation. The encoded protein may form a
            component of several different histone acetyltransferase complexes.
            There is a pseudogene for this gene on chromosome 2. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Aug 2012].
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            coding region, but maintains the reading frame, compared to variant
            1. The encoded isoform (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.2698593.1, AK225598.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296214.10/ ENSP00000296214.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-825               BC056406.1         10-834
            826-4702            AL034379.8         13437-17313         c
FEATURES             Location/Qualifiers
     source          1..4702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..4702
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="MYST/Esa1 associated factor 6"
                     /db_xref="GeneID:64769"
                     /db_xref="HGNC:HGNC:25674"
                     /db_xref="MIM:611001"
     exon            1..110
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..596
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="isoform 2 is encoded by transcript variant 2;
                     Esa1p-associated factor 6 homolog; chromatin
                     modification-related protein MEAF6; sarcoma antigen
                     NY-SAR-91; protein EAF6 homolog; centromere protein 28"
                     /codon_start=1
                     /product="chromatin modification-related protein MEAF6
                     isoform 2"
                     /protein_id="NP_001257804.1"
                     /db_xref="CCDS:CCDS59196.1"
                     /db_xref="GeneID:64769"
                     /db_xref="HGNC:HGNC:25674"
                     /db_xref="MIM:611001"
                     /translation="MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFE
                     GSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSA
                     LAGVQDQLIEKREPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTS
                     SGSHHSSHKKRKNKNRHRIDLKLNKKPRADY"
     exon            111..226
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     exon            227..314
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     exon            315..360
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     exon            361..553
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     exon            554..587
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     exon            588..4702
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1362..1367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="hexamer: AATAAA"
     polyA_site      1384
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="major polyA site"
     regulatory      1495..1500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="hexamer: ATTAAA"
     polyA_site      1517
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="major polyA site"
     regulatory      2098..2103
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="hexamer: AATAAA"
     polyA_site      2118
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
     regulatory      4432..4437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="hexamer: ATTAAA"
     polyA_site      4453
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
     regulatory      4683..4688
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
                     /note="hexamer: AATAAA"
     polyA_site      4702
                     /gene="MEAF6"
                     /gene_synonym="C1orf149; CENP-28; EAF6; NY-SAR-91"
ORIGIN      
        1 gccgcccgcc tcagcccaac atggcgatgc acaacaaggc ggcgccgccg cagatcccgg
       61 acacccggcg ggagctggcg gagctcgtga agcggaagca ggagctggcg gaaacattgg
      121 caaatttgga gcgacagatc tatgcttttg agggaagcta cctggaagac actcagatgt
      181 atggcaatat tattcgtggc tgggatcggt atctgaccaa ccaaaaaaac tccaatagca
      241 aaaatgatcg aaggaaccgg aagtttaagg aagctgagcg gctcttcagt aaatcctcgg
      301 ttacctcagc agctgcagta agtgcattgg caggagttca ggaccagctc attgaaaaga
      361 gggagccagg aagtgggacg gaaagtgaca cttctccaga cttccacaat caggaaaatg
      421 agcccagcca ggaggaccct gaggatctgg atggatctgt gcagggagtg aaacctcaga
      481 aggctgcttc ttctacttcc tcagggagtc accacagcag ccataaaaag cgaaagaata
      541 aaaaccggca caggattgat ctgaagttaa acaaaaaacc acgagctgac tattagaaga
      601 cacattagtg cagaagcttc caggctgtag agccctgctt cccttctctg acctcacaaa
      661 gataaacatc cttcacctga gttcgtggcc atccacctct gctctcccag acccagtgcc
      721 tgtgactttg agtagtttgt tctaaatgtg gtgacaaaca agtcatttct gtaagacatt
      781 gggtcttact ttatgtcatt tttagtaaca gaactgcagg aagatgaaga caatgttgta
      841 atcccagcaa gttgctaact gtgcgtttct cccttcttag aatgaatgtc tcccccaaaa
      901 ctggctggca ccagcttcat ctgtgatacc cttcaagaaa tgttctctgg ttttgtttta
      961 tgctgaaagt agaacacaag tcacatttca gatggaggct gtaaatatct ggcattttct
     1021 tatattgttt tatgttttct tgtttttctc ttgttgtttt tatcttattt tctttggggt
     1081 ttttttgtaa tgcctttgta cagctcatac tttcctgctg acatatctga tcatctcttt
     1141 catgcagttg ccaatattca taactgaaaa taatctggtt tatcataagt aaaatgggaa
     1201 acttgcctct gttttttgca aggggaggta aagagtgttt agtaattacc tatcttaaat
     1261 ctttctgagt tggtagtaga ttcatgttca aggaacagga aaaatggaaa aacataagtt
     1321 taaatcagtt ctttttaaat aactttttat tcttttgtat aaataaaatt tcacaggctt
     1381 caaattctca tgctttactt ttaaacccga gattgttttt tcacttattt attcatatca
     1441 tgccttatgg aaatttcttt ttctgtattt tctctctttg ctggtattca cctgattaaa
     1501 tattgctcta aaaatcacca tggcatatgg aaagtctcaa aattatacca aaagtgataa
     1561 cttatgtcgt tcttaagtgg agtgaaagga tagcatcagt gagagccagt gttgcccacc
     1621 aggtctccct ttcttggagg gcttgttggg gctgaggaat ctgctagtaa tcgttacctg
     1681 cctctagtgc tgtggtgaac ttgcgacagg gtctggctgc acattggaat cacctgagaa
     1741 gctttaaaat actcatgcct ggatcccatc cctagagact ggggtacagc ctagttattg
     1801 ggaatttctt taaaagagtt cctgggattc tgataagaag ccaggttgag aaccactaca
     1861 ttagaagact gaatggttta atttacatcc tatgttatga ttggtctaag ggataagatt
     1921 tggggtctaa cctttccttt cactctagtt agtcatagtc cttgacttat gcctatatct
     1981 ttgtaagaaa tagtatgttt catttgtgat agtattggta gggctgaata tggatggcat
     2041 ctactgtaaa acaagtctac cttgtcagat gtgcaaaagc tttcactctt gttctcaaat
     2101 aaacttttgt gggttttttt tttttttttt ttttgactct ggctatttag atctttgact
     2161 gtgtctttgg tagcagaact ccagtgtcag gatttttaag gaaatagttt cttatattta
     2221 gattattcct taaaaaaaaa aatcctagaa gcattctgta ttttttgtct gttggtctcc
     2281 tttgctggga gggaggagtg ggatgcctac agtttccttc cttttgggga aagcacacag
     2341 cagaccttaa aatatttttg actcttgggc tgggtgcggt ggctcacacc tgtaatccca
     2401 gcactttggg aggccgaagc gggcggatca cgaggtcagg agatcgagac catcctggcg
     2461 aacacagtga aaccccatct ctactaaaaa tgcaaaaaat tagctgagcg tggtggcggg
     2521 tgccggtagt cccagctact cgggaggctg aggcaggaga atggcatgaa cctgggaggc
     2581 ggagcttaca gtgagctgag atagtgccac tgcactccag cctgggcgac agagcgagac
     2641 tccatctcaa aaaaaaaaaa tatttttgac tcttaacagt ttgagattgc tagagatgga
     2701 atagtactgc tctgttgcgc cactgcactc cagcagcctg ggcgacagag cgagactctg
     2761 tcaaaaaaaa aaaaaaaaag aaagaatagt actgctctta aaaagattat ttacgtattt
     2821 atgaaactgc agtgggatgc ctagtttcct tccctctgag gaaagcacac agcagacctt
     2881 aaaatatttt tgactctcat agtttgacat tgctggagac agaatagtac tgctcttaaa
     2941 aagattattt aagtatttat atattttatt tatttattta tttatttatt tatttattga
     3001 caggatcttg ctctgtcacc caggctggag tgcagcggcc tgatcaaagc tcagtgcagc
     3061 ctcgaacttc tggggtcaag ccatcttcct gcttcagcct tactagtacc tgggactata
     3121 ggtgcatgcc accattccca gctaatttaa aacattttta ttttgtaatg atggcttctt
     3181 gctatgttgc ccaggctggc ctcaagcagt cctcctggcc tcaagcagtc cttctgcctt
     3241 ggcctcccaa agtgctggga ttataggtat caagcaattc tcctgcctca gcctccccag
     3301 tagctgggac tacaggcatg caccaccatg cccatctaag ttttgtattt ttagtggaga
     3361 tggggttttg ccatgatggg caggctggtc tcgaactcct gacctcaggt aatccaccca
     3421 cctcagcctc ccaaagtgct gggattacag gcatgagccc tggcacctgg caatatagag
     3481 tattcttgac atcttgacct gtgcagtaaa gaagataatt aaaatgagcg ataaatagtc
     3541 taagcttgaa agttaaagag cctaagcttg aaacactctg tgacttagtt tttgcattta
     3601 ttctgtcttc tatgcccccc aaccttactc caaattaatg aggcattatt ttatttattt
     3661 atttttttga gacagagtct tgctctgtcg tccaggctgg agtgcagtgg cacaatcttg
     3721 gctcactgct acctccgcct ccagggttca agcaattatt ccgcctcagc ctctcgagta
     3781 gctgagacta caggcgcgtg ctaccacacc cagctagttt ttttttattt tcaatagaga
     3841 ccgggtttca ccatattggc caggctggac tcaaactcct gacttcgtaa tccacctgcc
     3901 tcagcctccc aaagtgctag gattacaggc gtgagccact gcacccggcc taatgaggca
     3961 ttattgctta aaaattcaca tcaagctggg catggtgata tgcaccttta gtcccagctg
     4021 cttgggaggc ttagaggcag caggatcgct tgaagccaga agttcaaggc tacagtatgc
     4081 tatgatcatt tctgtgaatg gccactgcac ttcagcctga gtaacgtagc aagacgctgt
     4141 ctccaacaga aaattgacat ctgaagcctt gactacaggg ggactatact ggtttatgtg
     4201 aagtgtgggg agagagcagg attgtgcttc tttgtacaca tttgcttctc ccaggatagt
     4261 gtcatagtgc ctaggaaggt gatgtgtgtg tcagatacaa tgatagtgaa aagaagggat
     4321 tggaattttc atacctgtgt cagtctaaat gagcattacc ttgtctgaat tgtctaagtg
     4381 gtaagcttcg tgatttgaaa cagttttcac tttgaaaaac tgcttccgtg gattaaaagt
     4441 tgtcaccact aaagtgggct gtggtggagt cgatgctgat cctcacttag ggcagtggcc
     4501 tccaagggga agagggcaca caggatggct gggtgggggt gggaagaaaa gattaggcct
     4561 ttgatttata ttcattttga ggctcagcct tatttagttt ctcactttgg atgtatttta
     4621 tatatataca tcaaatatac atcaatatta gttcattagt acatgtaggt cattaattta
     4681 taaataaaag gttgaaccac aa
//
