LOCUS       NM_014623               2018 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens male-enhanced antigen 1 (MEA1), transcript variant 1,
            mRNA.
ACCESSION   NM_014623
VERSION     NM_014623.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2018)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2018)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2018)
  AUTHORS   Ohinata,Y., Sutou,S. and Mitsui,Y.
  TITLE     Peas-Mea1-Ppp2r5d overlapping gene complex: a transposon
            mediated-gene formation in mammals
  JOURNAL   DNA Res 10 (2), 79-84 (2003)
   PUBMED   12755172
REFERENCE   4  (bases 1 to 2018)
  AUTHORS   Ohinata,Y., Sutou,S., Kondo,M., Takahashi,T. and Mitsui,Y.
  TITLE     Male-enhanced antigen-1 gene flanked by two overlapping genes is
            expressed in late spermatogenesis
  JOURNAL   Biol Reprod 67 (6), 1824-1831 (2002)
   PUBMED   12444059
REFERENCE   5  (bases 1 to 2018)
  AUTHORS   Lau,Y.F., Chan,K.M. and Sparkes,R.
  TITLE     Male-enhanced antigen gene is phylogenetically conserved and
            expressed at late stages of spermatogenesis
  JOURNAL   Proc Natl Acad Sci U S A 86 (21), 8462-8466 (1989)
   PUBMED   2813404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136304.10, BQ232807.1 and BM969076.1.
            
            On May 17, 2019 this sequence version replaced NM_014623.3.
            
            Transcript Variant: This variant (1) differs in the 5' UTR and
            coding sequence compared to variant 4. The resulting isoform (1)
            has a shorter and distinct N-terminus compared to isoform 3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.284777.1, BC001754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148093, SAMEA2158188
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000244711.4/ ENSP00000244711.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AL136304.10        31486-31528         c
            44-783              BQ232807.1         12-751
            784-1067            BM969076.1         18-301              c
            1068-2018           AL136304.10        28725-29675         c
FEATURES             Location/Qualifiers
     source          1..2018
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2018
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /note="male-enhanced antigen 1"
                     /db_xref="GeneID:4201"
                     /db_xref="HGNC:HGNC:6986"
                     /db_xref="MIM:143170"
     exon            1..161
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..691
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /note="isoform 1 is encoded by transcript variant 1;
                     Male-enhanced antigen (H-Y structural gene)"
                     /codon_start=1
                     /product="male-enhanced antigen 1 isoform 1"
                     /protein_id="NP_055438.1"
                     /db_xref="CCDS:CCDS4879.1"
                     /db_xref="GeneID:4201"
                     /db_xref="HGNC:HGNC:6986"
                     /db_xref="MIM:143170"
                     /translation="MGPERHLSGAPARMATVVLGGDTMGPERIFPNQTEELGHQGPSE
                     GTGDWSSEEPEEEQEETGSGPAGYSYQPLNQDPEQEEVELAPVGDGDVVADIQDRIQA
                     LGLHLPDPPLESEDEDEEGATALNNHSSIPMDPEHVELVKRTMAGVSLPAPGVPAWAR
                     EISDAQWEDVVQKALQARQASPAWK"
     exon            162..436
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /inference="alignment:Splign:2.1.0"
     exon            437..539
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /inference="alignment:Splign:2.1.0"
     exon            540..2018
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      906..911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /note="hexamer: AATAAA"
     polyA_site      934
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /note="major polyA site"
     regulatory      1047..1052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /note="hexamer: AATAAA"
     polyA_site      1067
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
     regulatory      1335..1340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
                     /note="hexamer: AATACA"
     polyA_site      1358
                     /gene="MEA1"
                     /gene_synonym="HYS; MEA"
ORIGIN      
        1 ctctgcacgt cctgccccgc cggaagtgga ggccgcgggc tctgagcggg tgaggcgcgc
       61 gggaacaccg gcgccgggat tcggatgggg gcgggtgggg gacgctgcag ctggggccat
      121 ttgaggggag cccatggggc ctgaaaggca tctgtcaggc gcccctgccc ggatggcaac
      181 agtagttcta ggaggagaca ccatgggccc tgagcgtatc ttccccaatc agactgagga
      241 actgggacat cagggccctt cagaaggcac tggggattgg agcagtgagg agcctgagga
      301 agagcaggag gaaacggggt cgggcccagc tggctactcc taccagcccc tgaaccaaga
      361 tcctgaacaa gaggaggtgg aactggcacc agtgggggat ggagatgtag ttgctgacat
      421 ccaggatcga atccaggccc tggggcttca tttgccagac ccaccattag agagtgaaga
      481 tgaagatgag gagggagcta cagcgttgaa caaccacagc tctattccca tggacccaga
      541 acatgtagag ctggtgaaaa ggacaatggc tggagtaagc ctgcctgcgc caggggttcc
      601 tgcctgggct cgggagatat cggatgccca gtgggaagat gtggtacaga aagccctcca
      661 agcccggcag gcatcccctg cctggaagtg accacagtga gagctgcctt atattcctac
      721 attccaggcc agaaccagca caggactgaa cacatccctg gttgtaatgt ccatttccat
      781 cttccccgtc tccctttcca catcaaggca catcagactt ctcagagacc cactttattc
      841 agttctgtac atatggggac atcggtccaa gcccaaccca ccttagcatg tatcactctg
      901 tggagaataa agcaccctat gtacacagcc aaaagccgca ctgcctgcgc ccctggaacc
      961 tgggtccggc cttcctcagc ccctggcccc tccaaggtac ctataaggga caagagaagg
     1021 cctgcccagc atagcacaaa caaggaaata aataggtgtt ggcaggagcc atgcttgggg
     1081 caccgctccc tgcttccttc tttctagttt tgggaaccaa cagcacagaa aagcagtcag
     1141 ccccagggtg gtcccttcca tgtctgtgac cccagggctg ctgctcacca aagacagggc
     1201 acggggtagg gtgtttattc atccctcccc ggccccactt ggtccatctg ggccctatat
     1261 tcatcagtta ttgtccacag cctatacttt tctccttttg acctcccttg gtcaggcatg
     1321 gggtaagaag aaataataca accctatctg ccagcacacg gctgggactg gggggcctat
     1381 ttgtgctgca ggggggttgg cttcccttca gctactctgg gaccaatggg gcttgacata
     1441 actttggtga gaataatctc ctgctgttcc ctacatgcct ctgcagggga gagagaggag
     1501 gggagatacc tggcgttcaa atgaggatga agggaagaat agaggagcgt atgtattcct
     1561 gtgtgtactt ctcagagcag cctcaggtag ctgtgggtga ggagcaggta ggggacaggc
     1621 atccccaggt tgtctgagca ctaagcatct tagtgctcag cctgtactag ccacagggag
     1681 gcatgaacac cttttgggga gaagagggac cattctgtgg gtgtccctgc ttcaagtgcc
     1741 cacatccccc tcccttgagt agctagagag gcgctgcctt cccccaagac agccagtagg
     1801 gagcagagta tggagggcca gggcagtgtc ccagggctgt gtgggctgtg gccctgtggt
     1861 aggaacgtga ggggtcagag agcctcctgg ctggcagtta ggaactcttc cgcccgcttg
     1921 tgcgcctcca gtgccttgat ggtgtacacg tcctggggca gctccgactt cctccgcagc
     1981 agcactttct ccttcttgat gtcttttagc atctgtgt
//
