LOCUS       NM_138476                723 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens magnesium dependent phosphatase 1 (MDP1), transcript
            variant 1, mRNA.
ACCESSION   NM_138476
VERSION     NM_138476.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 723)
  AUTHORS   Zhu,J., Deng,L., Chen,B., Huang,W., Lin,X., Chen,G., Tzeng,C.M.,
            Ying,M. and Lu,Z.
  TITLE     Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor
            of Gastric Cancer
  JOURNAL   Curr Cancer Drug Targets 19 (10), 817-827 (2019)
   PUBMED   31218958
  REMARK    GeneRIF: Magnesium-dependent Phosphatase (MDP) 1 is a Potential
            Suppressor of Gastric Cancer.
REFERENCE   2  (bases 1 to 723)
  AUTHORS   Chen,Y., Lin,J., Yang,M., Xu,C.W., Chen,B.Z., Li,X.J., Zhu,W.F.,
            Fu,W.D., Yu,H., Ying,M.G. and Chen,G.
  TITLE     Expression and prognostic roles of magnesium-dependent
            phosphatase-1 in gastric cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 21 (11), 2617-2625 (2017)
   PUBMED   28678323
  REMARK    GeneRIF: We showed that down-regulation of MDP-1 expression was
            correlated with poorly differentiated carcinoma and later tumor
            stage, and it predicted a significantly poorer disease-free
            survival.
REFERENCE   3  (bases 1 to 723)
  AUTHORS   Fortpied,J., Maliekal,P., Vertommen,D. and Van Schaftingen,E.
  TITLE     Magnesium-dependent phosphatase-1 is a
            protein-fructosamine-6-phosphatase potentially involved in
            glycation repair
  JOURNAL   J Biol Chem 281 (27), 18378-18385 (2006)
   PUBMED   16670083
REFERENCE   4  (bases 1 to 723)
  AUTHORS   Selengut,J.D. and Levine,R.L.
  TITLE     MDP-1: A novel eukaryotic magnesium-dependent phosphatase
  JOURNAL   Biochemistry 39 (28), 8315-8324 (2000)
   PUBMED   10889041
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA287183.1, BC051382.1 and AA918790.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138476.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.54124.1, BU930406.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146236, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288087.12/ ENSP00000288087.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA287183.1         5-35
            32-714              BC051382.1         1-683
            715-723             AA918790.1         34-42               c
FEATURES             Location/Qualifiers
     source          1..723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q12"
     gene            1..723
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /note="magnesium dependent phosphatase 1"
                     /db_xref="GeneID:145553"
                     /db_xref="HGNC:HGNC:28781"
     exon            1..148
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..642
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /EC_number="3.1.3.48"
                     /note="isoform 1 is encoded by transcript variant 1;
                     fructosamine-6-phosphatase"
                     /codon_start=1
                     /product="magnesium-dependent phosphatase 1 isoform 1"
                     /protein_id="NP_612485.2"
                     /db_xref="CCDS:CCDS9620.1"
                     /db_xref="GeneID:145553"
                     /db_xref="HGNC:HGNC:28781"
                     /translation="MARLPKLAVFDLDYTLWPFWVDTHVDPPFHKSSDGTVRDRRGQD
                     VRLYPEVPEVLKRLQSLGVPGAAASRTSEIEGANQLLELFDLFRYFVHREIYPGSKIT
                     HFERLQQKTGIPFSQMIFFDDERRNIVDVSKLGVTCIHIQNGMNLQTLSQGLETFAKA
                     QTGPLRSSLEESPFEA"
     exon            149..209
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            210..320
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            321..428
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            429..514
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /inference="alignment:Splign:2.1.0"
     exon            515..723
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      688..693
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /note="hexamer: ATTAAA"
     polyA_site      723
                     /gene="MDP1"
                     /gene_synonym="FN6PASE; MDP-1"
                     /note="major polyA site"
ORIGIN      
        1 gccatttgtc tatggcaggc agggtggctg ccttagctgc cggaggttcc gcactctcta
       61 aggccccggg tgaagcccca cctctgctgc gcgcagcctg cggtgcgggt catggcgcgg
      121 ctaccgaagc tggcagtctt tgatttggat tacactctct ggcctttctg ggtcgacacg
      181 cacgtagacc ctccgttcca taagagcagt gatggaactg tacgagatag gcggggccaa
      241 gacgtccgac tgtacccaga ggtgcctgag gtcctaaaac gattgcagag ccttggggtg
      301 cccggtgcgg ctgcttcaag gacaagtgag atagaagggg ccaaccagct actggagctc
      361 tttgacctct tcaggtactt tgttcatcgg gaaatctatc caggcagcaa gatcacacac
      421 tttgagaggt tgcagcagaa gactggaatt cctttctccc agatgatctt ctttgatgat
      481 gagaggcgga atattgtaga cgtcagcaaa ctgggtgtta cctgcattca catccagaat
      541 ggaatgaatc ttcaaactct aagtcaaggg ttagagacat ttgcgaaggc ccaaactggg
      601 cctttgaggt ccagccttga ggagagccca tttgaggcct aaactgaaag gaaatcaaga
      661 aggcattttc aggtgcattt gtaatttatt aaagttcatc tgtgtgtgac agaagagatt
      721 tta
//
