LOCUS       NM_014611              18485 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens midasin AAA ATPase 1 (MDN1), mRNA.
ACCESSION   NM_014611
VERSION     NM_014611.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 18485)
  AUTHORS   Raman,N., Weir,E. and Muller,S.
  TITLE     The AAA ATPase MDN1 Acts as a SUMO-Targeted Regulator in Mammalian
            Pre-ribosome Remodeling
  JOURNAL   Mol Cell 64 (3), 607-615 (2016)
   PUBMED   27814492
REFERENCE   2  (bases 1 to 18485)
  AUTHORS   Romes,E.M., Sobhany,M. and Stanley,R.E.
  TITLE     The Crystal Structure of the Ubiquitin-like Domain of Ribosome
            Assembly Factor Ytm1 and Characterization of Its Interaction with
            the AAA-ATPase Midasin
  JOURNAL   J Biol Chem 291 (2), 882-893 (2016)
   PUBMED   26601951
  REMARK    GeneRIF: the crystal structure of the UBL domain of the WDR12
            homologue from S. cerevisiae at 1.7 A resolution is reported and
            demonstrated that human midasin binds to WDR12 as well as Nle1
            through their respective UBL domains.
REFERENCE   3  (bases 1 to 18485)
  AUTHORS   Finkbeiner,E., Haindl,M. and Muller,S.
  TITLE     The SUMO system controls nucleolar partitioning of a novel
            mammalian ribosome biogenesis complex
  JOURNAL   EMBO J 30 (6), 1067-1078 (2011)
   PUBMED   21326211
REFERENCE   4  (bases 1 to 18485)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 18485)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   6  (bases 1 to 18485)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 18485)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   8  (bases 1 to 18485)
  AUTHORS   Garbarino,J.E. and Gibbons,I.R.
  TITLE     Expression and genomic analysis of midasin, a novel and highly
            conserved AAA protein distantly related to dynein
  JOURNAL   BMC Genomics 3, 18 (2002)
   PUBMED   12102729
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP360573.1, AF503925.1, AL096678.8, BC036888.1 and AK027048.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_014611.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503925.1, SRR14038193.867704.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369393.8/ ENSP00000358400.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                BP360573.1         1-71
            72-8037             AF503925.1         1-7966
            8038-8038           AL096678.8         101083-101083       c
            8039-10065          AF503925.1         7968-9994
            10066-10066         AL096678.8         86616-86616         c
            10067-17471         AF503925.1         9996-17400
            17472-18198         BC036888.1         1312-2038
            18199-18208         AK027048.1         1940-1949
            18209-18485         AL096678.8         35038-35314         c
FEATURES             Location/Qualifiers
     source          1..18485
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q15"
     gene            1..18485
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /note="midasin AAA ATPase 1"
                     /db_xref="GeneID:23195"
                     /db_xref="HGNC:HGNC:18302"
                     /db_xref="MIM:618200"
     exon            1..289
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..16978
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /note="MIDAS-containing protein; MDN1, midasin homolog;
                     dynein-related AAA-ATPase MDN1"
                     /codon_start=1
                     /product="midasin"
                     /protein_id="NP_055426.1"
                     /db_xref="CCDS:CCDS5024.1"
                     /db_xref="GeneID:23195"
                     /db_xref="HGNC:HGNC:18302"
                     /db_xref="MIM:618200"
                     /translation="MEHFLLEVAAAPLRLIAAKNEKSRSELGRFLAKQVWTPQDRQCV
                     LSTLAQLLLDKDCTVLVGRQLRPLLLDLLERNAEAIKAGGQINHDLHERLCVSMSKLI
                     GNHPDVLPFALRYFKDTSPVFQRLFLESSDANPVRYGRRRMKLRDLMEAAFKFLQQEQ
                     SVFRELWDWSVCVPLLRSHDTLVRWYTANCLALVTCMNEEHKLSFLKKIFNSDELIHF
                     RLRLLEEAQLQDLEKALVLANPEVSLWRKQKELQYLQGHLVSSDLSPRVTAVCGVVLP
                     GQLPAPGELGGNRSSSREQELALRSYVLVESVCKSLQTLAMAVASQNAVLLEGPIGCG
                     KTSLVEYLAAVTGRTKPPQLLKVQLGDQTDSKMLLGMYRCTDVPGEFVWQPGTLTQAA
                     TMGHWILLEDIDYAPLDVVSVLIPLLENGELLIPGRGDCLKVAPGFQFFATRRLLSCG
                     GNWYRPLNSHATLLDKYWTKIHLDNLDKRELNEVLQSRYPSLLAVVDHLLDIYIQLTG
                     EKHHSWSDSSVGCEQAPEEVSEARRENKRPTLEGRELSLRDLLNWCNRIAHSFDSSSL
                     SASLNIFQEALDCFTAMLSEHTSKLKMAEVIGSKLNISRKKAEFFCQLYKPEIVINEL
                     DLQVGRVRLLRKQSEAVHLQREKFTFAATRPSSVLIEQLAVCVSKGEPVLLVGETGTG
                     KTSTIQYLAHITGHRLRVVNMNQQSDTADLLGGYKPVDHKLIWLPLREAFEELFAQTF
                     SKKQNFTFLGHIQTCYRQKRWHDLLRLMQHVHKSAVNKDGKDSETGLLIKEKWEAFGL
                     RLNHAQQQMKMTENTLLFAFVEGTLAQAVKKGEWILLDEINLAAPEILECLSGLLEGS
                     SGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRNRFTELYVEELESKE
                     DLQVLIVDYLKGLSVNKNTVQGIINFYTALRKESGTKLVDGTGHRPHYSLRTLCRALR
                     FAASNPCGNIQRSLYEGFCLGFLTQLDRASHPIVQKLICQHIVPGNVKSLLKQPIPEP
                     KGGRLIQVEGYWIAVGDKEPTIDETYILTSSVKLNLRDIVRVVSAGTYPVLIQGETSV
                     GKTSLIQWLAAATGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGVLIDAMRKGY
                     WIILDELNLAPTDVLEALNRLLDDNRELLVTETQEVVKAHPRFMLFATQNPPGLYGGR
                     KVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVMLDLQSYRRSSSV
                     FAGKQGFITLRDLFRWAERYRLAEPTEKEYDWLQHLANDGYMLLAGRVRKQEEIDVIQ
                     EVLEKHFKKKLCPQSLFSKENVLKLLGKLSTQISTLECNFGHIVWTEGMRRLAMLVGR
                     ALEFGEPVLLVGDTGCGKTTICQVFAALANQKLYSVSCHLHMETSDFLGGLRPVRQKP
                     NDKEEIDTSRLFEWHDGPLVQAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLA
                     EKGSPEDKDSEIELLTAGKKFRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTSRE
                     DLIQIISHNLRPGLCLGRIDPKGSDIPEVMLDFIDWLTHQEFGRKCVVSIRDILSWVN
                     FMNKMGEEAALKRPEIISTVTSFVHAACLVYIDGIGSGVTSSGFGTALLARKECLKFL
                     IKRLAKIVRLTEYQKNELKIYDRMKAKEFTGIDNLWGIHPFFIPRGPVLHRNNIADYA
                     LSAGTTAMNAQRLLRATKLKKPILLEGSPGVGKTSLVGALAKASGNTLVRINLSEQTD
                     ITDLFGADLPVEGGKGGEFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDH
                     RGEIYVPELGMSFQVQHEKTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVID
                     MEFIASTLFPAIEKNIVKKMVAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWCQLM
                     LVDQSPGCYDPGQHVFLVYGERMRTEEDKKKVIAVFKDVFGSNSNPYMGTRLFRITPY
                     DVQLGYSVLSRGSCVPHPSRHPLLLLHQSFQPLESIMKCVQMSWMVILVGPASVGKTS
                     LVQLLAHLTGHTLKIMAMNSAMDTTELLGGFEQVDLIRPWRRLLEKVEGTVRALLRDS
                     LLISADDAEVVLRAWSHFLLTYKPKCLGEGGKAITMEIVNKLEAVLLLMQRLNNKINS
                     YCKAEFAKLVEEFRSFGVKLTQLASGHSHGTFEWVDSMLVQALKSGDWLLMDNVNFCN
                     PSVLDRLNALLEPGGVLTISERGMIDGSTPTITPNPNFRLFLSMDPVHGDISRAMRNR
                     GLEIYISGEGDASTPDNLDLKVLLHSLGLVGNSVCDILLALHTETRSTVVGSPTSSVS
                     TLIQTAILIVQYLQRGLSLDRAFSEACWEVYVCSQHSPANRKLVQALLEKHVSSLRAH
                     ETWGDSILGMGLWPDSVPSALFATEDSHLSTVRRDGQILVYCLNRMSMKTSSWTRSQP
                     FTLQDLEKIMQSPSPENLKFNAVEVNTYWIDEPDVLVMAVKLLIERATNQDWMLRVKW
                     LYHLAKNIPQGLESIQIHLEASAASLRNFYSHSLSGAVSNVFKILQPNTTDEFVIPLD
                     PRWNMQALDMIRNLMDFDPQTDQPDQLFALLESAANKTIIYLDREKRVFTEANLVSVG
                     SKKLRESVLRMSFEFHQDPESYHTLPHEIVVNLAAFFELCDALVLLWVQSSQGMVSDA
                     SANEILGSLRWRDRFWTVADTVKVDAPGLALLALHWHWVLKHLVHQIPRLLMNYEDKY
                     YKEVQTVSEHIQNCLGSQTGGFAGIKKLQKFLGRPFPFKDKLVVECFSQLKVLNKVLA
                     IREQMSALGESGWQEDINRLQVVASQWTLKKSLLQAWGLILRANILEDVSLDELKNFV
                     HAQCLELKAKGLSLGFLEKKHDEASSLSHPDLTSVIHLTRSVQLWPAMEYLAMLWRYK
                     VTADFMAQACLRRCSKNQQPQINEEISHLISFCLYHTPVTPQELRDLWSLLHHQKVSP
                     EEITSLWSELFNSMFMSFWSSTVTTNPEYWLMWNPLPGMQQREAPKSVLDSTLKGPGN
                     LNRPIFSKCCFEVLTSSWRASPWDVSGLPILSSSHVTLGEWVERTQQLQDISSMLWTN
                     MAISSVAEFRRTDSQLQGQVLFRHLAGLAELLPESRRQEYMQNCEQLLLGSSQAFQHV
                     GQTLGDMAGQEVLPKELLCQLLTSLHHFVGEGESKRSLPEPAQRGSLWVSLGLLQIQT
                     WLPQARFDPAVKREYKLNYVKEELHQLQCEWKTRNLSSQLQTGRDLEDEVVVSYSHPH
                     VRLLRQRMDRLDNLTCHLLKKQAFRPQLPAYESLVQEIHHYVTSIAKAPAVQDLLTRL
                     LQALHIDGPRSAQVAQSLLKEEASWQQSHHQFRKRLSEEYTFYPDAVSPLQASILQLQ
                     HGMRLVASELHTSLHSSMVGADRLGTLATALLAFPSVGPTFPTYYAHADTLCSVKSEE
                     VLRGLGKLILKRSGGKELEGKGQKACPTREQLLMNALLYLRSHVLCKGELDQRALQLF
                     RHVCQEIISEWDEQERIAQEKAEQESGLYRYRSRNSRTALSEEEEEEREFRKQFPLHE
                     KDFADILVQPTLEENKGTSDGQEEEAGTNPALLSQNSMQAVMLIHQQLCLNFARSLWY
                     QQTLPPHEAKHYLSLFLSCYQTGASLVTHFYPLMGVELNDRLLGSQLLACTLSHNTLF
                     GEAPSDLMVKPDGPYDFYQHPNVPEARQCQPVLQGFSEAVSHLLQDWPEHPALEQLLV
                     VMDRIRSFPLSSPISKFLNGLEILLAKAQDWEENASRALSLRKHLDLISQMIIRWRKL
                     ELNCWSMSLDNTMKRHTEKSTKHWFSIYQMLEKHMQEQTEEQEDDKQMTLMLLVSTLQ
                     AFIEGSSLGEFHVRLQMLLVFHCHVLLMPQVEGKDSLCSVLWNLYHYYKQFFDRVQAK
                     IVELRSPLEKELKEFVKISKWNDVSFWSIKQSVEKTHRTLFKFMKKFEAVLSEPCRSS
                     LVESDKEEQPDFLPRPTDGAASELSSIQNLNRALRETLLAQPAAGQATIPEWCQGAAP
                     SGLEGELLRRLPKLRKRMRKMCLTFMKESPLPRLVEGLDQFTGEVISSVSELQSLKVE
                     PSAEKEKQRSEAKHILMQKQRALSDLFKHLAKIGLSYRKGLAWARSKNPQEMLHLHPL
                     DLQSALSIVSSTQEADSRLLTEISSSWDGCQKYFYRSLARHARLNAALATPAKEMGMG
                     NVERCRGFSAHLMKMLVRQRRSLTTLSEQWIILRNLLSCVQEIHSRLMGPQAYPVAFP
                     PQDGVQQWTERLQHLAMQCQILLEQLSWLLQCCPSVGPAPGHGNVQVLGQPPGPCLEG
                     PELSKGQLCGVVLDLIPSNLSYPSPIPGSQLPSGCRMRKQDHLWQQSTTRLTEMLKTI
                     KTVKADVDKIRQQSCETLFHSWKDFEVCSSALSCLSQVSVHLQGLESLFILPGMEVEQ
                     RDSQMALVESLEYVRGEISKAMADFTTWKTHLLTSDSQGGNQMLDEGFVEDFSEQMEI
                     AIRAILCAIQNLEERKNEKAEENTDQASPQEDYAGFERLQSGHLTKLLEDDFWADVST
                     LHVQKIISAISELLERLKSYGEDGTAAKHLFFSQSCSLLVRLVPVLSSYSDLVLFFLT
                     MSLATHRSTAKLLSVLAQVFTELAQKGFCLPKEFMEDSAGEGATEFHDYEGGGIGEGE
                     GMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGEL
                     EEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGP
                     GMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDY
                     DENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPE
                     EAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEE
                     HSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHAS
                     CGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHT
                     RKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAF
                     EHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQ
                     LKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENEKPERSRESTIHT
                     AHQFLMDTIFQPFLKDVNELRQELERQLEMWQPRESGNPEEEKVAAEMWQSYLILTAP
                     LSQRLCEELRLILEPTQAAKLKGDYRTGKRLNIRKVIPYIASQFRKDKIWLRRTKPSK
                     RQYQICLAIDDSSSMVDNHTKQLAFESLAVIGNALTLLEVGQIAVCSFGESVKLLHPF
                     HEQFSDYSGSQILRLCKFQQKKTKIAQFLESVANMFAAAQQLSQNISSETAQLLLVVS
                     DGRGLFLEGKERVLAAVQAARNANIFVIFVVLDNPSSRDSILDIKVPIFKGPGEMPEI
                     RSYMEEFPFPYYIILRDVNALPETLSDALRQWFELVTASDHP"
     exon            290..516
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            517..741
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..849
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1042
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1285
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1417
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1521
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1636
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1830
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1831..1912
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..2008
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2121
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2122..2270
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2271..2331
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2543
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2544..2647
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2648..2792
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2793..2889
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            2890..3003
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3151
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3152..3262
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3263..3414
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3593
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3594..3802
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3803..3949
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            3950..4091
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4092..4226
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4227..4365
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4366..4504
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4505..4635
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4636..4780
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4781..4910
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            4911..5129
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            5130..5327
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            5328..5536
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            5537..5659
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            5660..5857
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            5858..5965
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            5966..6154
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            6155..6244
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            6245..6508
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            6509..6770
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            6771..6930
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            6931..7047
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            7048..7256
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            7257..7405
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            7406..7617
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            7618..7838
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            7839..7952
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            7953..8085
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            8086..8201
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            8202..8335
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            8336..8493
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            8494..8614
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            8615..8825
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            8826..9057
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            9058..9184
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            9185..9355
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            9356..9570
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            9571..9958
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            9959..10068
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            10069..10774
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            10775..10936
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            10937..11210
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            11211..11446
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            11447..11542
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            11543..11637
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            11638..11759
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            11760..11906
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            11907..12016
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12017..12090
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12091..12289
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12290..12452
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12453..12599
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12600..12726
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12727..12832
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12833..12948
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            12949..13434
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            13435..13661
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            13662..13817
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            13818..13981
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            13982..14143
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            14144..14281
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            14282..14423
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            14424..14599
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            14600..14752
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            14753..14900
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            14901..15208
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            15209..15370
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            15371..15472
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            15473..15677
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            15678..15848
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            15849..16012
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16013..16102
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16103..16218
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16219..16393
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16394..16467
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16468..16582
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16583..16646
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16647..16789
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     exon            16790..18485
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      18178..18183
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /note="hexamer: ATTAAA"
     polyA_site      18208
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /note="major polyA site"
     regulatory      18457..18462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDN1"
                     /gene_synonym="Rea1"
                     /note="hexamer: TATAAA"
     polyA_site      18485
                     /gene="MDN1"
                     /gene_synonym="Rea1"
ORIGIN      
        1 gatgacgtca aacgccgtgt gctcacccac gtgtggtgcc cctctcccgg tgtaggcgct
       61 ggagctgagg acgcctttcc tgcgggcgta gttgctggct gctcgggcac tgggacctcg
      121 gcggcttggg gacgctggcc gcgaagtagg gagcgcaggt ggccgctcgg ggtgagggcc
      181 ctgggtcatg gagcacttct tgctggaggt ggcagccgcg ccgctgcggt taatcgcagc
      241 caagaacgag aagagccgca gtgagttggg caggttcttg gccaagcagg tgtggacacc
      301 tcaagatcgc cagtgtgtcc tgagtacctt agcacagttg cttttggata aggactgtac
      361 tgtgctggtt ggtcgccagc ttcgccctct ccttttggat ttgctggaaa ggaatgccga
      421 agccattaaa gctggaggcc aaatcaacca tgatctgcat gaacggctat gtgtgtcgat
      481 gagcaaactc attggtaacc atcctgatgt cctcccgttt gccctgagat atttcaagga
      541 cacatcccca gtctttcaaa gacttttcct agagagttca gatgctaatc cagtacgcta
      601 tggacgtagg aggatgaagc tccgggacct aatggaagca gccttcaagt ttctgcagca
      661 ggagcagtct gtgttccggg agctctggga ctggagtgtg tgtgtccctc tcctcagaag
      721 ccatgacacc ttggttcgct ggtatacagc caattgtctt gctttggtta cctgtatgaa
      781 tgaagagcac aagttatcat ttcttaagaa gatatttaat agtgatgaat tgatccattt
      841 caggttgagg ttattagaag aggcccagtt gcaggacttg gagaaggcct tggttttggc
      901 caatccagaa gtctcccttt ggcgtaagca gaaggagctg cagtacttac agggacatct
      961 tgtttcgtct gacctctccc ctagggtgac agctgtttgt ggtgtggtgc tgcctgggca
     1021 gctgccagcc cctggagagc tgggtggtaa taggagttct tcacgtgaac aggagctggc
     1081 ccttaggtct tatgtgctgg ttgagtctgt ctgcaaaagt cttcagaccc tggctatggc
     1141 ggttgcttct cagaatgctg tgttgttgga aggaccaata ggatgtggca aaacttcctt
     1201 agttgaatat ttagctgcag tgacaggtag aacaaagcct cctcagcttc tcaaagtcca
     1261 gcttggagat cagactgaca gtaagatgct tttggggatg tatcgctgca cagatgttcc
     1321 tggagagttt gtgtggcagc ctggcaccct gacacaggca gccacaatgg gccactggat
     1381 ccttctggag gatattgact atgccccctt agacgtggtt tctgtgctga tccctctctt
     1441 ggagaatgga gagctcttga ttcctggccg aggtgactgt ctgaaagtgg cacctggatt
     1501 tcagtttttt gcaaccagga gactcttgag ctgtggagga aattggtatc gaccgctaaa
     1561 cagtcatgct actttgctag acaaatattg gaccaaaatt cacctggata acctggataa
     1621 gagagaactg aatgaggttc ttcagagcag atatcctagc ctattggcag tggttgatca
     1681 cctgcttgac atttatatcc aacttactgg agagaaacat cactcttgga gtgatagttc
     1741 tgttggatgt gaacaggcac ctgaagaagt ttcagaagcc agaagagaaa acaaaagacc
     1801 aacccttgag ggaagagaat tatctctaag ggatctgctg aattggtgta ataggattgc
     1861 ccatagcttt gacagttcat ctttatcagc atcattaaat atttttcaag aggctctaga
     1921 ctgtttcaca gcaatgcttt ctgagcatac aagcaaactg aaaatggcag aagttattgg
     1981 aagcaaattg aacatttcta gaaaaaaggc tgaattcttt tgtcaacttt ataaaccaga
     2041 aattgtgatc aatgagctag atttgcaagt gggtcgagtg cggcttctac ggaaacaaag
     2101 tgaggctgtt cacctacaga gggagaagtt cactttcgct gctacacggc cgtcctctgt
     2161 tctcatcgag cagcttgcag tgtgtgtcag caaaggggag cctgtgttgc tggtgggaga
     2221 gaccgggact ggcaaaacct ctaccatcca atacttggct cacattacag gccaccgttt
     2281 gagggttgtc aatatgaatc aacaaagtga tactgcagac ttgcttggag gttataaacc
     2341 ggtggaccat aagcttattt ggctaccctt acgggaggca tttgaggaac tctttgctca
     2401 gacattttcc aagaaacaaa actttacgtt cttggggcac attcagacct gttacagaca
     2461 gaaacggtgg catgatctcc tgagactaat gcagcatgta cacaagtctg ctgttaacaa
     2521 ggatggaaaa gacagtgaaa ctgggttact cataaaagag aaatgggaag catttggtct
     2581 tagactcaac catgcccaac aacagatgaa aatgactgaa aataccttat tgttcgcatt
     2641 tgtagagggt acattagctc aggctgtaaa gaaaggagag tggatcttgt tggatgagat
     2701 taacttggct gctccagaaa tactagaatg tctgagtggt ttgcttgaag gatcttctgg
     2761 atccctggtg ttgctggatc gaggagacac agagccactg gttcggcatc ctgacttccg
     2821 tttatttgcc tgtatgaatc cagcaactga tgtaggcaaa agaaatctcc caccaggaat
     2881 aagaaacagg ttcacagaac tttatgtaga agaattagaa agcaaagaag acttacaggt
     2941 tcttattgta gattatctga aaggattgag tgtgaacaag aatacagtgc aaggaatcat
     3001 aaacttctac acagctttgc ggaaagagtc tgggaccaaa ctggtggatg gcactggcca
     3061 tagacctcac tacagccttc ggactctgtg ccgggccctg cgatttgcag cctccaatcc
     3121 atgtggcaac attcagcgct cactctatga gggtttttgt ttgggtttct taacacagct
     3181 tgacagggca tcacacccaa tagttcagaa gctcatctgt caacacattg tccctggcaa
     3241 tgtcaagagt ctgctgaagc agcctattcc agagccaaaa ggaggtcggc ttatccaggt
     3301 tgaaggctac tggattgcgg tgggagacaa ggagcctaca atagatgaga cgtacattct
     3361 gacatcttct gtgaagctga acctgagaga tatagtccga gttgtctctg caggaaccta
     3421 tccagtgctg attcagggag agacatcagt tggtaaaaca agcctgatcc agtggctggc
     3481 tgcagctact ggcaaccact gtgtgcgtat taataatcac gaacacacgg atattcagga
     3541 gtacattggt tgttacacgt ctgactcctc agggaagctt gtctttaagg aaggtgttct
     3601 tattgatgcc atgagaaaag gctattggat tattttagat gaattaaatt tggcccctac
     3661 tgatgtgtta gaggcgctga ataggctgtt ggatgataac cgtgaattgc tagtaacaga
     3721 aacacaggaa gttgttaaag cacaccctcg gtttatgctt tttgccaccc aaaatccccc
     3781 aggactttat ggaggcagaa aggtcctttc tagagccttc aggaatcggt ttgtggaatt
     3841 gcactttgat gagttaccta gctccgagtt ggaaacaatc ttgcacaagc ggtgtagttt
     3901 gccaccctcc tattgcagca agttggttaa agtcatgctg gatcttcagt cctatcgcag
     3961 aagttcttca gtgtttgctg gaaagcaggg cttcatcacc cttcgtgatc tgttccgatg
     4021 ggctgaaaga tacagattgg ctgagccgac cgagaaggag tatgactggc tacagcattt
     4081 agccaatgat ggttatatgc ttctggcagg tcgagtcagg aagcaggagg aaattgatgt
     4141 gattcaagaa gtccttgaga aacatttcaa gaaaaaattg tgtcctcaat ctcttttctc
     4201 caaagaaaat gttctaaaat tgctgggtaa attgtctact cagatatcca cattggagtg
     4261 taactttggc catatcgtgt ggactgaggg catgcggaga ctcgcgatgc tagtgggaag
     4321 ggcattggaa tttggtgaac ctgtgctgct ggttggagac actgggtgtg ggaaaactac
     4381 tatctgtcag gtatttgcag ccttggcaaa tcagaaatta tactctgtca gctgccactt
     4441 acacatggag acatcagact tcctgggtgg cctgcggcca gtgagacaaa agccaaacga
     4501 caaggaagaa attgacacat caagactctt tgagtggcat gatgggcctc tggttcaggc
     4561 catgaaggag gacggctttt tcctcttgga tgagatctca ttggccgatg actctgtctt
     4621 ggaaagactc aacagtgtcc ttgaagtaga aaagtctctg gtattagctg aaaaaggcag
     4681 tccagaggac aaggatagtg aaatagagct gttgactgct gggaaaaaat ttcgtattct
     4741 agcaaccatg aaccctgggg gtgactttgg aaaaaaggag ctgtctcctg ccttaagaaa
     4801 ccggtttaca gaaatatggt gccctcaaag cacaagccgt gaagatttaa ttcagatcat
     4861 cagtcataat cttcgtccag gattgtgtct gggcagaata gatcctaaag ggtctgacat
     4921 acctgaagtg atgctggatt tcattgactg gctgacccac caagagtttg gcagaaagtg
     4981 tgtggtcagt atcagagata tcctgtcctg ggttaacttc atgaacaaaa tgggggagga
     5041 agctgctttg aaaaggccag agatcatctc cactgtgaca tcttttgtcc atgctgcatg
     5101 cctggtgtac atagatggaa taggttcagg ggtaacttcc tctgggtttg gtacagccct
     5161 tttggcacga aaagaatgtc tgaaatttct aatcaagagg cttgccaaga tagtacgact
     5221 tacagaatat cagaaaaatg agttgaagat ttatgacaga atgaaggcca aagaattcac
     5281 tggaatagat aacctttggg gaattcatcc attttttata ccaaggggac ctgtcctaca
     5341 caggaataat attgcagact atgcactcag tgcagggacc actgctatga atgcacagag
     5401 gctcttaaga gctaccaaac tgaagaagcc cattctcctg gagggttccc ctggtgttgg
     5461 caagacaagt ttggtgggag cattagcaaa ggcttcagga aatacccttg ttagaatcaa
     5521 cttatcagag caaacggaca tcacagacct gtttggagca gatctacctg ttgaaggtgg
     5581 caagggagga gagtttgcct ggcgtgatgg ccccttactg gcagctttga aggcaggcca
     5641 ttgggtggtg ttggatgagc ttaacctggc ttctcagtct gtattggaag gactcaatgc
     5701 ttgttttgac caccgaggag aaatctatgt gcctgagtta ggaatgagct ttcaagtgca
     5761 gcatgaaaag acgaagattt ttgggtgtca gaatcccttt agacaaggag gtgggaggaa
     5821 aggcttgccc aggtctttcc ttaacagatt cactcaggtc ttcgttgatc cccttacagt
     5881 aattgacatg gagttcattg ccagtacttt gtttccagcc attgagaaaa atattgttaa
     5941 gaaaatggtt gctttcaata accaaattga tcatgaagtg actgttgaga agaaatgggg
     6001 gcaaaaagga ggaccctggg aattcaacct ccgggacctt ttccgctggt gtcagttgat
     6061 gctggttgac cagtcccctg ggtgttatga tcctggtcag catgtgtttt tggtctatgg
     6121 tgaaagaatg agaaccgaag aggacaaaaa aaaggtcatt gctgtattca aggatgtgtt
     6181 tggttcaaat tccaacccat acatgggaac cagactattt cgtatcactc cctatgatgt
     6241 tcagttgggc tactcagtcc tttcccgtgg gagctgtgtt cctcacccgt cccgccatcc
     6301 cctgttgctc ctgcaccagt cattccaacc cctggagtca atcatgaagt gtgtgcagat
     6361 gagctggatg gtcatcctgg tcgggccagc ctctgtgggc aagaccagcc tggtccagct
     6421 tctggcacac cttactggcc acacattaaa gatcatggct atgaacagtg caatggatac
     6481 tactgagctg ctgggtggat ttgagcaggt tgatcttata cgaccttgga ggaggctgct
     6541 agagaaggtg gagggaactg taagggcact gttaagggat agcctcctta tcagtgctga
     6601 tgatgcagaa gtagtgctgc gagcctggag tcattttctt ctgacatata agcctaagtg
     6661 tcttggagaa ggtggtaaag ctatcacgat ggagattgtc aacaaactag aagcagtgtt
     6721 attgcttatg cagcgactca acaataaaat caactcatac tgcaaggcag agtttgccaa
     6781 acttgttgaa gagttccgaa gctttggtgt gaagcttacg cagttggcca gtggccatag
     6841 ccatggcaca tttgaatggg ttgacagcat gttggttcag gccctgaagt ctggagactg
     6901 gcttctgatg gacaatgtta acttctgcaa cccatcagtg ttggatcgtt tgaatgcttt
     6961 gcttgaaccc ggaggtgtcc tcactattag tgagagagga atgatagatg gatccactcc
     7021 cacgataaca ccaaatccca atttcagact tttcctctcg atggatcctg ttcatggaga
     7081 tatatcccga gctatgagga atcgtggact tgaaatctac atttcagggg aaggggatgc
     7141 aagcacccca gacaacctgg atttgaaagt tctgctgcac agccttggat tggtggggaa
     7201 cagtgtatgt gacatcctct tggctttaca cacagagacc cggagcactg ttgtaggttc
     7261 tccaacatct tctgtatcaa ctctaatcca gacagccata ctaattgtcc agtacctgca
     7321 gcgagggctg agtttagaca gagccttttc tgaagcatgc tgggaagtat atgtctgttc
     7381 ccagcattca ccagcaaacc ggaagcttgt acaggcttta ctggagaaac atgtttcttc
     7441 tttgcgagca catgaaacct ggggagactc cattcttggc atgggactgt ggccagattc
     7501 tgtgccctca gctctctttg ctactgaaga ttcacacctg tctacagtcc gaagagatgg
     7561 acagatctta gtatattgtc tcaacaggat gagcatgaaa accagcagct ggacaaggag
     7621 tcagcctttt accttgcaag acttagagaa aattatgcag tcccccagcc ctgagaacct
     7681 gaaattcaat gcagtcgaag tgaatactta ctggatcgat gaaccagatg ttttggtcat
     7741 ggctgttaaa ttgctcatag aaagagcaac caatcaggat tggatgctca gagttaaatg
     7801 gctttatcat ttagccaaga atataccgca ggggcttgag tccatacaaa ttcatttgga
     7861 agccagtgct gcatctctca ggaattttta ctcacattcc ctctcaggtg cagtcagtaa
     7921 tgttttcaaa atattacaac caaatacaac agatgaattt gtgatccctc tggatccccg
     7981 atggaatatg caggctctgg acatgattag aaatttgatg gactttgacc cacaaacgga
     8041 ccagcctgac cagctctttg cccttttaga atcagctgca aacaagacaa tcatatatct
     8101 tgaccgggaa aaacgggttt ttactgaagc aaatttggtt tctgttggta gcaaaaagct
     8161 aagagagagt gttttgagaa tgtcctttga attccatcaa gatccagaaa gctatcacac
     8221 tctgccccat gaaattgtgg tcaatcttgc tgcttttttt gaactttgtg atgcactagt
     8281 cctgctctgg gtacagtcct cccagggaat ggtgtctgat gccagtgcca atgagatctt
     8341 aggttctctg cggtggcggg accggttctg gactgtggcc gacacagtaa aagtagatgc
     8401 cccaggtctg gcccttcttg ccctccattg gcactgggtt ttaaaacatc tggtccacca
     8461 gatcccccga cttctgatga attatgaaga caaatattac aaagaagttc agactgtctc
     8521 agaacatatt cagaattgtc tggggagcca gactggtggc ttcgctggta taaagaagtt
     8581 gcagaagttc ctgggacgac cgtttccttt taaggacaag ctggtggtgg agtgtttttc
     8641 acaactgaag gtccttaaca aagtccttgc catcagggag cagatgtctg cccttgggga
     8701 gagtggatgg caggaagaca ttaaccgtct ccaagtggtt gcttctcagt ggacattaaa
     8761 gaaaagtctc ctgcaagcct ggggactgat cctcagagca aatattttgg aagatgtcag
     8821 cctagatgaa ttgaagaatt ttgtgcatgc tcagtgttta gaactgaaag ccaaaggact
     8881 ctcacttggt tttctggaga aaaagcatga tgaagcttcc tccctgtccc atccagactt
     8941 gacctccgta atccacctca ccaggagtgt tcagttgtgg cctgcaatgg agtacctggc
     9001 tatgctttgg cggtacaaag tgacagctga ttttatggca caagcttgtc tcagaagatg
     9061 cagcaaaaat caacaacccc agataaatga ggagataagt cacctcatct cattttgtct
     9121 ttatcacaca cctgttacac ctcaagagct tcgagatctg tggtccttgc tgcatcatca
     9181 gaaggtgtct cctgaagaaa ttacatcttt gtggtccgag ttatttaatt ccatgtttat
     9241 gtctttctgg agcagtactg tgaccacaaa tccagagtac tggctaatgt ggaacccttt
     9301 gcctggtatg cagcagaggg aggcacccaa gtctgttttg gactccacat tgaagggccc
     9361 cggcaatctc aatagaccca tattctctaa gtgctgcttt gaagtcttaa ccagcagctg
     9421 gagagcaagt ccctgggatg tgagtggcct ccccattctt tcctcctctc acgtgaccct
     9481 aggagagtgg gttgagagaa ctcagcagct ccaggacatc agttcgatgc tttggactaa
     9541 catggctatc tcttcagtag cagaattcag acgcacggat tcccaactcc aggggcaggt
     9601 gctgttccgg cacctggcag gcctagcaga gctgctccca gagtcccggc ggcaggagta
     9661 catgcagaac tgtgagcagc tgctgcttgg gagcagccag gccttccagc atgtgggcca
     9721 gacacttggg gacatggctg gtcaggaggt gctgcccaag gaactgctct gccagttgct
     9781 cacctccctg caccactttg ttggtgaagg ggagagtaag aggagcctgc ctgagccagc
     9841 ccagcgtggg agcctctggg tgagcctcgg cttgctccag attcagacat ggcttcccca
     9901 ggcacgcttt gaccctgcgg tgaagaggga gtacaagctc aattacgtca aggaagagtt
     9961 acaccaactg cagtgtgaat ggaagacccg gaacctgtca tcccagctgc agactggaag
    10021 agacctggaa gatgaagtcg ttgtcagcta ctctcatcct cacgtcaggc tgcttcgcca
    10081 aaggatggat cggctggata atttaacctg tcacctgttg aagaaacagg cctttagacc
    10141 ccagctgcct gcctacgagt ccctggttca ggagatccac cactacgtca ccagcatcgc
    10201 caaggcccct gctgttcagg atctgctcac acggcttctg caggccctcc acatagatgg
    10261 gccacggtct gcccaagtag cccagagcct tctaaaggag gaggcctctt ggcagcagtc
    10321 acaccaccag ttccggaagc ggctgtcaga ggagtacacc ttctatccag atgccgtgag
    10381 cccactgcag gcatccatat tgcagttaca acatggcatg aggctggtgg cctctgagct
    10441 ccacacctca ctccacagca gtatggttgg tgcagacagg ctggggaccc tggccacagc
    10501 cttgctggct ttcccatcgg tgggccccac cttcccgact tactatgctc atgcagacac
    10561 tttgtgctcg gtgaagtctg aggaggttct acgaggcctt gggaagctaa tcctcaagcg
    10621 ctcaggagga aaggagctgg aaggcaaggg ccagaaagcc tgtcccactc gggagcagct
    10681 gctgatgaat gctctccttt acctgcgctc ccacgtgtta tgcaagggag agttggacca
    10741 gagggccctg cagctcttca gacatgtgtg tcaggaaatc atcagtgagt gggatgagca
    10801 ggaacgcata gcccaagaga aggctgagca ggaaagcggc ctgtatagat acaggagcag
    10861 gaactctagg acagccctga gtgaagagga ggaggaagaa cgggagttca gaaaacagtt
    10921 ccccctgcat gaaaaggact ttgcagatat tttggtgcag ccaacgttgg aggagaacaa
    10981 aggaacttca gatgggcaag aagaggaagc aggcacaaac ccagctctcc tctcccagaa
    11041 ttcaatgcag gcagtaatgc tgatacacca gcaattgtgt ctcaactttg ctcgatccct
    11101 ctggtatcaa cagactctgc cgccacatga agcaaagcat tacctcagcc tgtttctgtc
    11161 ttgctatcag actggggcat cgcttgtgac acacttctac cccctgatgg gagttgaact
    11221 gaatgaccga ctcttgggca gccaactttt ggcctgtacc ctctcccata acactctttt
    11281 tggggaggca ccctcagacc tgatggtgaa acctgatggg ccctatgact tctaccagca
    11341 tcccaatgtt ccagaagcac ggcagtgtca acctgtgctt caaggtttct cagaggctgt
    11401 cagtcacttg ctacaggact ggccagaaca cccagcgctt gaacagctcc tggttgtaat
    11461 ggacagaatt cgtagtttcc cactttccag tcccatctca aagttcctga atggcttaga
    11521 gatccttctg gcaaaggcac aggattggga ggaaaatgca agtcgagctt tgtctttgcg
    11581 gaaacatctt gatttgatca gtcagatgat cattcggtgg cgtaaactgg agctgaactg
    11641 ctggtccatg agtttggata atactatgaa gcgccacacc gagaaatcca ccaagcactg
    11701 gttctccatc tatcagatgc ttgagaagca catgcaggaa caaacagaag aacaggaaga
    11761 tgacaaacag atgaccttga tgttgctggt cagcacatta caagcattta ttgaaggatc
    11821 ctcgctggga gagttccatg tgcgacttca gatgttactg gttttccatt gtcatgtctt
    11881 gctgatgcca caggttgaag gaaaggattc actttgcagt gttctatgga atttgtacca
    11941 ttattacaag caattctttg accgggtcca ggccaaaatt gtggaacttc gttcccccct
    12001 agaaaaagaa cttaaagaat ttgttaagat ttccaagtgg aatgatgtca gcttctggtc
    12061 cattaagcaa tctgtagaaa agacacacag gacactcttt aaattcatga agaaatttga
    12121 agcagtcctg agtgaaccct gccggtcatc cctggtggag agtgacaagg aagaacagcc
    12181 tgactttttg cccaggccaa cagatggagc tgcaagtgaa ctgtcttcca ttcagaatct
    12241 gaacagggca ctgagggaga ccctgttagc ccaaccagca gctgggcagg ccacaattcc
    12301 agagtggtgt cagggcgctg ctccttccgg cttggaaggg gagcttctgc gtcgcttgcc
    12361 aaagctcagg aaacgcatga ggaagatgtg cctgacgttc atgaaggaga gccccctgcc
    12421 tcgccttgtg gagggccttg atcagttcac aggtgaagtg atttcctctg tgagtgagct
    12481 gcagagctta aaggtggaac cctctgcaga gaaggagaag cagcggtcag aagccaagca
    12541 cattctcatg caaaaacagc gagctttgtc agacctcttt aaacaccttg caaaaattgg
    12601 tttgtcgtat cgcaaaggtc ttgcttgggc ccgttcaaaa aaccctcaag agatgcttca
    12661 tcttcaccca ttagatctcc agagcgcatt gtccatcgtc agcagcactc aggaggctga
    12721 ttctaggctg cttacagaaa tctcgtcttc atgggatgga tgccagaagt atttttatcg
    12781 ctctcttgca cggcatgcca ggcttaacgc agcactagca actcctgcca aggaaatggg
    12841 catgggcaac gtggagaggt gcagagggtt ctcagcacat ttgatgaaga tgctcgtccg
    12901 acagcggcgc tccctgacca cgctcagtga gcagtggatc atcctcagga acctcctcag
    12961 ctgtgtgcaa gagattcaca gcaggctgat ggggccccag gcctaccccg tggccttccc
    13021 ccctcaggat ggcgtgcagc agtggacaga gcgcctgcag cacctggcca tgcagtgcca
    13081 gatcctgctt gagcagctct cctggctcct ccagtgctgc cccagtgtag ggccagctcc
    13141 aggccatggc aatgtccagg tactggggca gcctcctggc ccctgcctgg aaggaccaga
    13201 acttagcaag ggacaacttt gtggagtagt gctggaccta attccttcca atctgagcta
    13261 cccatctcca atacctggaa gtcagctgcc ctctggttgc cggatgcgga aacaggatca
    13321 cctttggcaa cagtcaacta cgagattaac agagatgcta aaaaccatta aaacagtgaa
    13381 agctgacgtc gacaaaatta gacagcagtc ttgtgagact ctctttcatt cttggaaaga
    13441 ttttgaagtt tgctcttctg cgctgagttg cttgtcccag gtgtcagttc atttgcaggg
    13501 cctagagtcc ttgttcattc ttccagggat ggaggttgag caaagagact cacaaatggc
    13561 actagttgaa agtctggaat atgtaagagg agaaattagt aaagccatgg ctgactttac
    13621 tacctggaag acccatctgc ttacttcaga tagccaagga ggaaatcaaa tgttggacga
    13681 aggatttgtg gaagattttt cagagcaaat ggaaattgcc atccgagcca tcctctgtgc
    13741 catccagaac ttagaagaaa gaaagaatga aaaagcagag gagaacactg accaagcaag
    13801 cccacaagaa gattatgcag gctttgagag actgcaatca ggacatctaa caaaactctt
    13861 agaggatgac ttctgggccg atgtgagcac tttgcacgtg cagaaaataa tttctgccat
    13921 ctccgagctg ttggagaggc tgaaatcgta cggtgaggat ggcacagcag caaagcacct
    13981 gttcttcagc caatcctgtt ccttgctggt gcgcctggtg ccggtcctct ccagctactc
    14041 agacctcgtc ctcttcttcc tgaccatgtc tttagcaact caccgtagta ctgcaaagct
    14101 gctctctgtg cttgcccagg tctttacaga gcttgcccag aagggatttt gcttgcccaa
    14161 agaatttatg gaagattcag ctggagaggg agcaactgag ttccatgact atgagggagg
    14221 tggaattgga gaaggcgagg gcatgaagga tgtgagtgac cagatcggaa atgaagaaca
    14281 ggtggaagat acatttcaga agggtcaaga aaaagacaaa gaggatcctg attcaaaatc
    14341 tgatattaag ggcgaggata atgccattga gatgtcggaa gattttgatg ggaaaatgca
    14401 tgatggggag cttgaagaac aagaagagga tgatgagaaa tcagatagtg agggcggaga
    14461 cctggataaa cacatgggcg atctcaatgg tgaggaagct gacaaactag atgagaggct
    14521 ttggggtgat gatgatgagg aggaagatga ggaggaagaa gacaataaaa ctgaagaaac
    14581 aggaccagga atggatgagg aagattctga acttgttgct aaagatgaca acttggatag
    14641 tggcaattca aacaaagata aaagccagca agataagaag gaagaaaagg aagaagcaga
    14701 agctgatgat ggtggacaag gtgaagacaa aattaatgaa caaatagatg agagggacta
    14761 tgatgaaaat gaggtggacc cttaccatgg caatcaggaa aaggtgccag aacccgaggc
    14821 tttggacctt ccagatgact tgaacctcga cagtgaagac aagaatggtg gtgaggacac
    14881 cgacaatgaa gaaggagaag aagagaatcc tttggagata aaagaaaaac cagaagaagc
    14941 aggtcatgaa gctgaggaaa gaggagagac cgagaccgac cagaacgaaa gtcagagtcc
    15001 acaggagcct gaggaaggcc ccagtgaaga tgacaaggca gaaggggaag aggaaatgga
    15061 cacaggagct gatgaccaag atggagatgc tgctcagcat cctgaagaac actctgagga
    15121 gcagcagcag tctgtggagg aaaaagacaa ggaagccgat gaagaaggtg gagagaatgg
    15181 ccctgctgac caaggtttcc agccccagga ggaagaagaa cgggaggact ctgatacaga
    15241 ggagcaggtg ccagaggctt tggagaggaa ggagcatgcc tcctgtgggc agactggtgt
    15301 ggagaacatg cagaacacac aggccatgga gctggctggg gccgcacctg agaaggagca
    15361 ggggaaagag gaacacggaa gtggagctgc agatgcaaac caggcagaag gccatgaatc
    15421 gaatttcatt gcccagttgg cctcccagaa gcacaccagg aaaaacacac agagttttaa
    15481 gaggaaacct gggcaggctg acaatgaacg ttccatgggt gatcacaatg agcgtgtgca
    15541 caagaggctg aggactgtgg atacggacag ccatgccgag caggggccag ctcagcagcc
    15601 ccaggcccag gtggaggatg cagatgcatt cgagcacatt aaacaaggca gtgacgcata
    15661 cgatgcacag acctatgatg tggccagcaa agaacagcaa cagtctgcaa aagactctgg
    15721 caaagatcag gaagaggagg agatagagga cacccttatg gacacagagg agcaggagga
    15781 gttcaaagca gcagacgtgg agcagctgaa gccagaggaa atcaagtcgg gcaccacagc
    15841 acccttgggc tttgatgaga tggaagtgga gatccaaact gttaaaacag aggaagacca
    15901 agaccccaga acagacaaag cccataagga gacagaaaat gagaaaccag aaagaagccg
    15961 agagtctacc attcatacag ctcatcaatt cctcatggac acgatcttcc agcccttttt
    16021 aaaagatgtc aatgagctaa gacaggagct ggagagacag ctggaaatgt ggcagccacg
    16081 tgaatctgga aacccagagg aggagaaggt tgcagctgag atgtggcaga gttacctgat
    16141 cttaacagcg cctctttcac aacggttatg tgaagagctt cgtctcatat tagagcctac
    16201 ccaggcagcc aagctgaaag gagactatcg aactgggaaa cgactaaaca tacggaaagt
    16261 cattccatac attgctagtc aatttcggaa agacaagatt tggcttcgaa ggaccaagcc
    16321 cagtaaacgc cagtatcaga tttgtttggc tatcgatgac tcttctagta tggtagacaa
    16381 tcataccaag cagcttgcat ttgaatcttt ggctgtgatt ggaaatgctc taaccctcct
    16441 ggaagtgggt cagattgcag tgtgtagttt tggagaatct gtaaagctgt tacacccatt
    16501 tcatgagcag ttcagtgatt actctgggtc ccagattcta cgtctctgca aattccaaca
    16561 aaagaaaacc aagattgctc agtttctaga gtctgttgcc aacatgtttg cagctgctca
    16621 gcagctctcg cagaacatca gttcagaaac tgcacaactc ctcctggtag tctctgatgg
    16681 gcgaggcctt ttccttgagg gcaaagaaag agtcctggca gcagttcagg ctgcccggaa
    16741 tgcaaatatc tttgtcatct ttgttgtatt ggacaatccc agttcacggg attctatctt
    16801 ggacattaaa gtaccgatat ttaaaggacc tggagagatg cctgaaatcc gatcctacat
    16861 ggaagagttc ccattcccat actatatcat tcttcgagat gtaaacgcac ttcctgagac
    16921 actcagcgat gccctcagac agtggtttga gttggtgaca gcctctgacc acccatagaa
    16981 cagaaagaag agtccaaagt gagacttaac tgtggtcaga aggtcacatt gcttacccag
    17041 gtgctccctt ttggacaact acaaaaaatt ttattgtaat atttttattt tacaacgtga
    17101 tcttacagcc tacagaatgc tctctggctc ccggctttgc ctgggctgag gtttttatac
    17161 caaacctgga agcagcagca ggtgcctgaa ctcgtaacta gagaagagtt atccttcttc
    17221 cctgccttgg aagccctggc ctgggaggag gtcatacccc accgttggag cccagctgcc
    17281 tgttttcttt tgcaggggat ctgggcacct gtgccttgag gagatgctgc caggagcatg
    17341 ggactctgac agtcctttgt ataaaggact aaagggagct gcccttttga ccctgttcta
    17401 agctctgcct tgccaagccc atagtgtgtg cccaaaagct gtcaagtggc caagacagct
    17461 cgtttctgga gagtatgagg gtgtgttttc ttattgtgaa aggaactacc ttctcttaga
    17521 gggtaggaag aatgtggtgt gtgtgtgttc tcataaagca actggacatt ataggtgccc
    17581 aggtcatcta taaaaacgat ccttgggctg tgtaaaaatg aagtggcttt tcagtatcct
    17641 ctttcacact tgctgcttcg ggagactatg caatgatggg aaggtgattg cccctttatt
    17701 tcattcagtg ccatggtccc tgttgttgta gtaatttatt tgtttagttc attttttttt
    17761 ttcttaacag tcaaggggaa gagtgattcc tcacactgct ttcaagctgg actgagccag
    17821 tctcattctg ggaaagaaac gctgtgtcca gaactcagca gctccatcta ttttttccag
    17881 tcgaaagaaa ctgatcttta ggcagttttt acttggccag aaagcagtgc tgaatacttg
    17941 aaactgtgtg ctctgttcta cttaatgttc tgtcagaatg ttcttttgta ggcagtatgt
    18001 catgatgtaa tcatctatct ccttgtctgt ttccaagtta cactgtgaag tctgcgaccc
    18061 ttttgaggtg gtcatcaaag acacagattc cttgtttaac caagtgtccc aaagcatgta
    18121 cctgaagtta tatcattttt tattctaaaa agctatgcag cttatattct gaaaactatt
    18181 aaaacatata ccactgttgt tgatgtaatt tgtgactctt cttaatggaa gatgacagga
    18241 ttgtaaaagg tatgctaggg gactgatctt ctctgctgga tcagtcagtc agctgttact
    18301 agttgatgct gtgctaacat gatcccctcc tacttccatg ttgctcttac tacaaaggtt
    18361 atcatttgca tttatgtcca tggtaggctg agctataata tgctggcttt gcagcagaat
    18421 gaaaaggatg agttggtgta gccttataag gaggcttata aaaattaatt atcctccata
    18481 aatga
//
