LOCUS       NM_002393              10050 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 1,
            mRNA.
ACCESSION   NM_002393
VERSION     NM_002393.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10050)
  AUTHORS   Patrick,N. and Markey,M.
  TITLE     Long-Read MDM4 Sequencing Reveals Aberrant Isoform Landscape in
            Metastatic Melanomas
  JOURNAL   Int J Mol Sci 25 (17), 9415 (2024)
   PUBMED   39273363
  REMARK    GeneRIF: Long-Read MDM4 Sequencing Reveals Aberrant Isoform
            Landscape in Metastatic Melanomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10050)
  AUTHORS   Wei,J., Chen,Y., Feng,T., Wei,Y., Yang,C., Zhang,C., Li,W. and
            Liu,G.
  TITLE     miR-34c-5p inhibited fibroblast proliferation, differentiation and
            epithelial-mesenchymal transition in benign airway stenosis via
            MDMX/p53 pathway
  JOURNAL   Funct Integr Genomics 24 (2), 37 (2024)
   PUBMED   38374244
  REMARK    GeneRIF: miR-34c-5p inhibited fibroblast proliferation,
            differentiation and epithelial-mesenchymal transition in benign
            airway stenosis via MDMX/p53 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10050)
  AUTHORS   Liu,J., Yang,J., Pan,Q., Wang,X., Wang,X., Chen,H., Zheng,X. and
            Huang,Q.
  TITLE     MDM4 was associated with poor prognosis and tumor-immune
            infiltration of cancers
  JOURNAL   Eur J Med Res 29 (1), 79 (2024)
   PUBMED   38281029
  REMARK    GeneRIF: MDM4 was associated with poor prognosis and tumor-immune
            infiltration of cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10050)
  AUTHORS   Mao,Y., Hu,Z., Zeng,Y., Zhou,Y. and Shi,Z.
  TITLE     LINC01094 accelerates the metastasis of hepatocellular carcinoma
            via the miR-26b-3p/MDM4 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (6), 181-185 (2023)
   PUBMED   37605571
  REMARK    GeneRIF: LINC01094 accelerates the metastasis of hepatocellular
            carcinoma via the miR-26b-3p/MDM4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 10050)
  AUTHORS   Jeyaraj,S., O'Brien,D.M. and Chandler,D.S.
  TITLE     MDM2 and MDM4 splicing: an integral part of the cancer spliceome
  JOURNAL   Front Biosci (Landmark Ed) 14 (7), 2647-2656 (2009)
   PUBMED   19273224
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10050)
  AUTHORS   Bartel,F., Schulz,J., Bohnke,A., Blumke,K., Kappler,M., Bache,M.,
            Schmidt,H., Wurl,P., Taubert,H. and Hauptmann,S.
  TITLE     Significance of HDMX-S (or MDM4) mRNA splice variant overexpression
            and HDMX gene amplification on primary soft tissue sarcoma
            prognosis
  JOURNAL   Int J Cancer 117 (3), 469-475 (2005)
   PUBMED   15906355
  REMARK    GeneRIF: HDMX gene was amplified in 17% of soft tissue sarcoma
            patienets and gene amplification was associated with poor
            prognosis.
REFERENCE   7  (bases 1 to 10050)
  AUTHORS   Giglio,S., Mancini,F., Gentiletti,F., Sparaco,G., Felicioni,L.,
            Barassi,F., Martella,C., Prodosmo,A., Iacovelli,S., Buttitta,F.,
            Farsetti,A., Soddu,S., Marchetti,A., Sacchi,A., Pontecorvi,A. and
            Moretti,F.
  TITLE     Identification of an aberrantly spliced form of HDMX in human
            tumors: a new mechanism for HDM2 stabilization
  JOURNAL   Cancer Res 65 (21), 9687-9694 (2005)
   PUBMED   16266988
REFERENCE   8  (bases 1 to 10050)
  AUTHORS   Shvarts,A., Bazuine,M., Dekker,P., Ramos,Y.F., Steegenga,W.T.,
            Merckx,G., van Ham,R.C., van der Houven van Oordt,W., van der
            Eb,A.J. and Jochemsen,A.G.
  TITLE     Isolation and identification of the human homolog of a new
            p53-binding protein, Mdmx
  JOURNAL   Genomics 43 (1), 34-42 (1997)
   PUBMED   9226370
REFERENCE   9  (bases 1 to 10050)
  AUTHORS   Kussie,P.H., Gorina,S., Marechal,V., Elenbaas,B., Moreau,J.,
            Levine,A.J. and Pavletich,N.P.
  TITLE     Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor
            transactivation domain
  JOURNAL   Science 274 (5289), 948-953 (1996)
   PUBMED   8875929
REFERENCE   10 (bases 1 to 10050)
  AUTHORS   Shvarts,A., Steegenga,W.T., Riteco,N., van Laar,T., Dekker,P.,
            Bazuine,M., van Ham,R.C., van der Houven van Oordt,W., Hateboer,G.,
            van der Eb,A.J. and Jochemsen,A.G.
  TITLE     MDMX: a novel p53-binding protein with some functional properties
            of MDM2
  JOURNAL   EMBO J 15 (19), 5349-5357 (1996)
   PUBMED   8895579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP247507.1, BC067299.1,
            BP334671.1, AB209383.1, AL512306.16, AK097188.1 and BX108199.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002393.4.
            
            Summary: This gene encodes a nuclear protein that contains a p53
            binding domain at the N-terminus and a RING finger domain at the
            C-terminus, and shows structural similarity to p53-binding protein
            MDM2. Both proteins bind the p53 tumor suppressor protein and
            inhibit its activity, and have been shown to be overexpressed in a
            variety of human cancers. However, unlike MDM2 which degrades p53,
            this protein inhibits p53 by binding its transcriptional activation
            domain. This protein also interacts with MDM2 protein via the RING
            finger domain, and inhibits the latter's degradation. So this
            protein can reverse MDM2-targeted degradation of p53, while
            maintaining suppression of p53 transactivation and apoptotic
            functions. Alternatively spliced transcript variants encoding
            different isoforms have been noted for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1, also known as MDM4-FL or HDMX)
            represents the predominant transcript, and encodes the longest
            isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853560.2715.1,
                                           SRR1660807.191110.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367182.8/ ENSP00000356150.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-482               BP247507.1         28-509
            483-1643            BC067299.1         500-1660
            1644-1840           BP334671.1         392-588
            1841-3010           AB209383.1         3432-4601
            3011-4523           AL512306.16        94513-96025         c
            4524-6130           AK097188.1         574-2180
            6131-10009          AL512306.16        89027-92905         c
            10010-10050         BX108199.1         14-54               c
FEATURES             Location/Qualifiers
     source          1..10050
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..10050
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="MDM4 regulator of p53"
                     /db_xref="GeneID:4194"
                     /db_xref="HGNC:HGNC:6974"
                     /db_xref="MIM:602704"
     exon            1..104
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..217
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..1612
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     double minute 4, human homolog of; p53-binding protein;
                     MDM4-related protein 1; MDM4, p53 regulator; protein Mdmx;
                     mdm2-like p53-binding protein; Mdm4 p53 binding protein
                     homolog"
                     /codon_start=1
                     /product="protein Mdm4 isoform 1"
                     /protein_id="NP_002384.2"
                     /db_xref="CCDS:CCDS1447.1"
                     /db_xref="GeneID:4194"
                     /db_xref="HGNC:HGNC:6974"
                     /db_xref="MIM:602704"
                     /translation="MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQG
                     EMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
                     RKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPT
                     SEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGST
                     DLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVI
                     EVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDC
                     SKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSV
                     EFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNII
                     HGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA"
     exon            218..292
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..426
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..482
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..550
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..650
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            651..811
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            812..961
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1042
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..10050
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10028..10033
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="hexamer: ATTAAA"
     polyA_site      10050
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="major polyA site"
ORIGIN      
        1 attactcgcc atttcaaaat gctgccgagg ccctaggatc tgtgactgcc acccctcccc
       61 ccacccgggc tcggcggggg agcgactcat ggagctgccg taagttttac caacagactg
      121 cagtttcttc actaccaaaa tgacatcatt ttccacctct gctcagtgtt caacatctga
      181 cagtgcttgc aggatctctc ctggacaaat caatcaggta cgaccaaaac tgccgctttt
      241 gaagattttg catgcagcag gtgcgcaagg tgaaatgttc actgttaaag aggtcatgca
      301 ctatttaggt cagtacataa tggtgaagca actttatgat cagcaggagc agcatatggt
      361 atattgtggt ggagatcttt tgggagaact actgggacgt cagagcttct ccgtgaaaga
      421 cccaagccct ctctatgata tgctaagaaa gaatcttgtc actttagcca ctgctactac
      481 agatgctgct cagactctcg ctctcgcaca ggatcacagt atggatattc caagtcaaga
      541 ccaactgaag caaagtgcag aggaaagttc cacttccaga aaaagaacta cagaagacga
      601 tatccccaca ctgcctacct cagagcataa atgcatacat tctagagaag atgaagactt
      661 aattgaaaat ttagcccaag atgaaacatc taggctggac cttggatttg aggagtggga
      721 tgtagctggc ctgccttggt ggtttttagg aaacttgaga agcaactata cacctagaag
      781 taatggctca actgatttac agacaaatca ggatgtgggt actgccattg tttcagatac
      841 tacagatgac ttgtggtttt tgaatgagtc agtatcagag cagttaggtg ttggaataaa
      901 agttgaagct gctgatactg aacaaacaag tgaagaagta gggaaagtaa gtgacaaaaa
      961 ggtgattgaa gtgggaaaaa atgatgacct ggaggactct aagtccttaa gtgatgatac
     1021 cgatgtagag gttacctctg aggatgagtg gcagtgtact gaatgcaaga aatttaactc
     1081 tccaagcaag aggtactgtt ttcgttgttg ggccttgagg aaggattggt attcagattg
     1141 ttcaaagtta acccattctc tctccacgtc tgatatcact gccatacctg aaaaggaaaa
     1201 tgaaggaaat gatgtccctg attgtcgaag aaccatttcg gctcctgtcg ttagacctaa
     1261 agatgcgtat ataaagaaag aaaactccaa actttttgat ccctgcaact cagtggaatt
     1321 cttggatttg gctcacagtt ctgaaagcca agagaccatc tcaagcatgg gagaacagtt
     1381 agataacctt tctgaacaga gaacagatac agaaaacatg gaggattgcc agaatctctt
     1441 gaagccatgt agcttatgtg agaaaagacc acgagacggg aacattattc atggaaggac
     1501 gggccatctt gtcacttgtt ttcactgtgc cagaagacta aagaaggctg gggcttcatg
     1561 ccctatttgc aagaaagaga ttcagctggt tattaaggtt tttatagcat aatggtagta
     1621 cgaacataaa aatgcattta ttccgttcac ttaccacatt atttgaaaat caatccttta
     1681 tttaatttta tttccaacct gtcagagaat gttcttaggc atcaaaatcc aaggtagctg
     1741 taagaaaaat actggagcta acaatgaaga acagaagtaa tctgattagt caaattatta
     1801 agtgccatgg attactttat gcagcagtca ggtacatagt taggtgaacc caaaagaaaa
     1861 actcttgaaa acaagagatt tcttccatgc acatttacaa tattgaggta taattaacat
     1921 gataaagtgt ttccttctaa cgagttgtag aaatctgagt aaccacccaa aaaagcaata
     1981 gaatgtttct gtcaccccaa aacactccct tctgcccctc ttcagacagt ccttcagcta
     2041 tttcatggct ctcaccctag tttttttttt ttttgcactt ttttttttcc gggggtatag
     2101 gggaggtgtg gggcgacagg gtctgtcttg ttctgtctcc caggctgaag tgcagtgcag
     2161 tggtatgatc atggctcact gcagccttgg tttcctgggc ataagtggtc ttcccacttc
     2221 agcctcctga gtagctgaga ctatagacta gcataaccac actggctaat tttttgtgga
     2281 gatgaagtct cactatgttg cccaggctgg tctcgaactc ctgggctcaa acaatcctcc
     2341 cgcctcagcc ttccaaattg ctgggattat agtcatgagg cacctagtct ggcccttttg
     2401 caagacttta atctgaaatc taaattttta aaatttaagt acttacaaag gatatactat
     2461 ccaacatatt gcatattata tatgtgcttt aaagtttttt tttttttttg agagacggtc
     2521 tcactttgtc atccaagctg gagtgcagtg gtgcaaacac ggcccacctc ctgggctcaa
     2581 gtgatcctcc agcctcagct tccctcacag gcattcacta tcactcccag ctaattaaaa
     2641 taatttgtag acggtgtctc gttatgttgc ccaggctggt ctcgaactcc tgggtttaag
     2701 tgattccccc gcctcagcct cccaaagtgt tgggcttaca gccttgagcc actatgcttg
     2761 gctcaaagat atttttatga aagccctggg actatagatt tagctgatta aatttataga
     2821 aaaagtcctg tcatataaac tggcaaagtc tgttcttaat ttaattagcc aaatcagact
     2881 taacttccgt cagaacatgt cttggtttta attcagataa acacacaaac atacttctct
     2941 ggcacagcct tcagaagcat cagtttttgt tttgttttgt tttgtttttt gagacagggt
     3001 cttgctctgt cgcccaggct ggagtgcact ggcacaatca cagttcactg cagcctcgac
     3061 ctcccagatc caagcaatcc tcccacctaa gcctcccaag tagctgggtc tataggcgcg
     3121 tgccaccacc atgcccagct gaattttgta ttttttgtac agacagcatt ttgccatgtt
     3181 gcccaggctg gtcccaaact tctagcctca agcaaccctc ctgcctcagc ctctcaaagt
     3241 gctaggattg cagtcctgag ctactgcccc ctaccctctt tgcgtcttag gagtcattta
     3301 gatttttttt gatccttttg tttagtgcct ctggagctgc ttacaccaag gcaatacgcc
     3361 ttgatatact ggatggttga gaggcagcct cttttttttt tttttttttt tttttttttt
     3421 ggaggatagg gagtatggct gttgtgaaaa gggaggtaaa gagaaatggt agatctgaag
     3481 aggcctcatc agagcacata ttttaggaca acacatatgg aaattggaca tctttaagtt
     3541 ggtttccata gagctatgca tgtatcctta cccccatggg aaaatgttgg tgtgttctca
     3601 agggtatgca tgtgtcattt tgaagaccaa ggccctagaa ttgtcaaact taaggatcat
     3661 aaaaatcatg agggttgctt gttaaaaatg tccaaacgtg cagagactga tctttgagat
     3721 ctggaccagg aatttgcatt tgaacaagtg ttcctggaat ctctatgcaa gttttataca
     3781 gaacatactt ttggaatcct tgccctagac aggggtgtcc aatcttttgg cttccctggt
     3841 ccacaatgga agaagaattg tcttggacca cacataaaat acactaacac taacaatagc
     3901 tgatgagcta aaaaaaaaaa aaaaaaaaat cgtggaccgg gcgtagtggc tcacgcctgt
     3961 aatcccaaca ctttgggaga tcacctaggt cgggagtttg agaccagcct gaccgacatg
     4021 gagaaacccc atttttacta aaaatacaaa aaattagctg ggcatggtgg tgcatgcctg
     4081 tagtcccagc tactcaggag gctgaggcag gagaatcgct tgaacctgag agggggagat
     4141 tgcggtgagc tgagattgcg ccattgcacc ccagcctggg caacaatagc gaaactgtct
     4201 cagaaaaaag aaaaaaaaaa tcgcaaaaag aaaaatctca taatgtcgtt gttggttttt
     4261 tttttttttt ttgagacagt ctcactctgt tgcccaggct ggagtgcaat ggcatgatct
     4321 ctgctcaccg caacctctgc ctcccgggtt caggtgattc tcctgcctca gcctcccaga
     4381 tagctgggac tacaggcaca taccaccatg cctggctaat ttttgtattt ttagtagaga
     4441 tgggggtttc actgtgttgg ccaggctggt ctcgaactcc tgacctcatg atccacacac
     4501 ctcggcctcc caaagtcctg cgattacagg cgtgagctac cgcacccagc caagttgtaa
     4561 tttttaataa aacttaagaa gtaaacattt tacttatgtt tataggtatt tgatcctaaa
     4621 tttgacacat cattgcccat gaaagaatcc tcttaggctg ctcagcttca ctcttcctgc
     4681 ttgcccaccg gggtttttca ctgcttctgt tagcactaag tacttagacg atcctaagat
     4741 atgtgcttga gccgaatttc atctttactt gtaggaaact ttaaactatt tcttttcttt
     4801 tctttttttt ttttttttac ttgagatgga gttttgctct tgtcgcccag gctggagtgc
     4861 agtggagtga tctcggctca ctgcaacctc tgcctcccgg gttcaaatga ttctcctgcc
     4921 tcagcctccc aagtagctgg gattacaggt gtgcaccacc atgtctggct aattttgtat
     4981 ttttagtaga gatggtttca ccatgttggt caggctggtc tcgaactcct gacctcaggt
     5041 catccaccca cctcagcctc gcaaagtgct gagattacag gcatgagcca cagcgcccag
     5101 cttaaactat tttcttggtc tgtttttgat tttctttttt ccttgccact gcggtacaga
     5161 ttttttttac tcactgccac taaactaaag caaggcatag tttatatgtg aagtgttcag
     5221 agtttactgc tataaggaaa cttccaaata ctgacattta ccttttagct gtagttattg
     5281 ggaccatgtg ctctggtttt ctggagactg ccaaattgct cccatttttc tgcatcccac
     5341 ctggtttctt tctgcatgtc ccctttcact ttcaaacctc ttcatttgga tgttaaatta
     5401 tatggtcacc tagttatagg taagccttgt tcgagttgat atcttgattg tgaggaagga
     5461 tctgtgtcat tggagcttgt ttctgctgca acgtgctgta gactatgaat aatgaaatca
     5521 caccacatta ccatcagatt tcttgtttta gttgtcaaat taatatttat gattgttatc
     5581 ttgggcgaaa agttcagagc agagatgaca aatcattaga acaacgatga atttcagtat
     5641 tacggctaaa aagttcttct gtctgaatat taactcactc tccttccagt gtacttcaca
     5701 gtaattggta tgctttttta tttaatgctt aaatcaaact ttataaaaat cttagaccag
     5761 atctttaata tggtatgcca tttccccagt ctaccaatgg aatagtatgg gtttctaatc
     5821 ctaggcttgt acaatggatt ggagttgagc catgccagcc tccacactgc cactaacttc
     5881 tgtaatgtaa gattgagtca ctgccaagca tttgaaatat gcagttgtgt tttaattata
     5941 atttatgtat agttagatgt atgtagtgca ttgtgtggta ttatttggtt tgtaagaatt
     6001 tatttttaag ggtcaaggtc atttgtaaca ttttgtgtgt gtcaattcaa tgcaatgttg
     6061 gctgcctttt gaagtctttg atatattggt gaatattctt ctgatctata atacaaagct
     6121 atgtaatgtt acctcttgac tcgcttttga aaggaagaca attgttaact agatatttga
     6181 gttttttccc ctcagaatta tgtgaatttc tgatatatgg ctttagatac tgtgaatctg
     6241 ttttccattt agtcagttat ctgcttaaat tgttcagaac tatatcctaa cgagcaatta
     6301 gttctgatgg ttctcccagt catgagtgtg catgtgtgca agcatgtttt gatcctgatg
     6361 ctacctttgc taaaaatggc catagattag gaactagcta tgtttttaga atcaaagatg
     6421 aaccggtaag ctgtctcatg taccaaacgt gaaatttaca gtgtttacaa atgtctggaa
     6481 ttttgcactg ccatagggaa tgttaaggtt acttggctgg aatttatcag acttgtgagt
     6541 aaacaagttg aagtttagca gatgaggggg aatattgagg cccctaaggc taaacaaaat
     6601 aatcagtatc tgagatagtg gctaatgtgg ctccccaggc ctaatttggg aacagttttt
     6661 cctgattgct ttgagaagta ctttcttttg acagaaattt tcattctgct tgccattgct
     6721 atattctccc tttataggag ccattggatt tctttccttt tgtgggaaat gtcccattag
     6781 cattttcaga tcttttgatg tgcactaatg ccattattgg taatgccgtt attggtgaat
     6841 acagcatagt taaataaact gttacagtaa atctacactt ggatttgctg cacctctacc
     6901 aatagccttt tgaatgactg aaagtgttaa cagagaaaga ggcatgtctg cagaaagaga
     6961 tagctaatat tttttggtac tttatctgaa atccaagatg ctgcttcccc tgcaggttgt
     7021 tttccttctt acgatcctca ttgaatcccc tctgggagca caggacagtt agtagaactc
     7081 tccatttctt tttttttttt tttagacgga gtctctctct gtcgccccgg ctggagtgca
     7141 gtggcgcgat ctcggctcac tgcaacctcc gcctcccggg ttcaccccat tctcctgcct
     7201 cagcctccct agtagctggg actataggcg cccgccacca cgcctggcta atttttgtat
     7261 ttttattgga gacggggttt caccgtctta gccaggatgg tcttgatctc ctgacctcgt
     7321 gatctgccca cctcagcctc ccaaagtact gggattacag gcgtgagcca ccgcgcccgg
     7381 ccggaactct ccatttctta aggtaaagag ggtcaaggat acctaaaaag ggtcaaataa
     7441 tgctagaaga gcaattcctc tttcagagca gttgctgtaa tttggcaaat gctttatcga
     7501 agattgatat taggctaggg gcggtggctt acgcctgtaa tcccagcact ttgggaggcc
     7561 gaggtgggtg gattgcctga gctcaggagt tcgagaccag tctgaccagt atggtgaaac
     7621 cctgtctcta ctaaaaatac aaaaattagc cggtcgtggt ggcgtgcacc tgtagtccca
     7681 gctacttggc aggttgagac aggagaatcg cttgaacctg ggaggtggag gttgcagtga
     7741 gccgagactg caccactgcg ctcccacctg ggtgacagag actctgtctc aaaaaaaagg
     7801 acatttatca ttataacatc ttattagagc ccctaatttc ttatctgaag gcactgtttt
     7861 tttttttaaa cagttaagta ctgatgtcaa cagacaaata tttctgatca gatagtcccc
     7921 tgtcaacagt agcaaatgtg gtttcataaa gtgggaagaa aacagcattt taaagtaact
     7981 ttttgggaga ctgatttgag taataataaa actctggtct cccttaagaa aaaaaaaccc
     8041 ttccaccttt actgtgtcat ttatatcccc ttagttccaa agttaattat cttatttctg
     8101 gatattgctt ttataccaaa gacccttatc agcccttgta actacagtat ctttagataa
     8161 gattcctctt tccagtcagt cctgggaaat gtttctgttg cagagttagg cggtagatgg
     8221 gaagctgtga tggcagagct actatctaat aaagtaacaa ctcgtagttg aggcttcctt
     8281 tctgtgtgtg atgggggata gggagttagc tcccctgttg tctcagcact aagaaattga
     8341 ggtcaggcca ggcgcggtgg ttcactcctg ttattccagc actggggtgg ccaaagtggg
     8401 cagattgctt gcgctctgga gctcgagacc agcctgggca acatggtgaa accctgtctc
     8461 taccaaaaat acaaaaaaaa agctgggcat ggtgggtgca tgcttgtccc agctactgag
     8521 gaggctgagg tgggaggatc gcttgagcct gggaggtgga ggttgcagtg agctgagatg
     8581 gcaccactgc aatccaaggt gggtgacaga gacgctgtct caaagaaatt gaggtcaggc
     8641 ttccttctta cagaattatt tttttctctg tagtttgcct cattttttca ctttcttttc
     8701 aatgagaatc gaagtgtttc ttttgggttt ttttttcccc cttttaaaat caacaggaaa
     8761 tgtttcaaag gagggatgaa atgcttcttg gcttcctcag cacttggcaa ggtagacctc
     8821 atagcaacct tgaatatgac tttctttagt ctctagctat gcactattaa gtgcctcttg
     8881 ggtagaggta gagttaagta ttgagtgcca gtcttgacgt ccgtatgcct cagtttttct
     8941 catatataaa aagcagtata catacctacc cttttctacc tcatcatttg ttgtagggat
     9001 taaatccggg agagcaattc tgaagcctat aaatttcctt gaagagatct aagaacctat
     9061 tatgctcttg gtgtaccaag ctctggggta tatattcaga atacctcatg ttctggaagc
     9121 tgagcactag ctccccttta ttgcctgcct ggcagagcct gtttgattac tgcaggccct
     9181 tttacccatg cttctagttt aggtattctt tctttgatat gaggctcttg accagaaaag
     9241 agttctttct ctaggtgttc tgagagaagt ttgtaaattt ggatagtaca ttctatcctg
     9301 ataaaaccac cttgctgtgg tcttgatgta caaaaaaaaa tttttttttt gagacagagt
     9361 cttactctgt cacccaggct ggaatgcagt ggcgcaatct tggttcactg caacccccgc
     9421 ctcctgggtt caagcgatcc tcctgcctca acctctcaag tagctgggac tacaggcgtg
     9481 caccaccaca cctggctaat tttgtatttt tagtagagac agggtttcac catgttggcc
     9541 aggctggtct tgaactcctg acctcaggcg atctgcccgc cttggcctcc caaagtactg
     9601 ggattacagg cgtgagcaac tgctcctggc ccaaaacatc tctttctaca tacacttgag
     9661 taggtggcat aaaatgcact gtcaatatat agaaaacatg aaattttcca aatatttccg
     9721 atcagagaat cacaagagca gcaaatgtgg tttcatcaag tgggaagaaa gcagcaattt
     9781 aaaataactt tttgggagac tgaattgagt aataataaaa cttcagtctt tcgctaataa
     9841 taataataat aataataata acaacaactt attgaatgtg gccagctcac tagatgagga
     9901 aagaggaagg cattttctgc attcttgcct agttttcctt ataagcacca ctaagttaat
     9961 agctctgtct ttttggtgtt tgcactatgt aatgctttta atacttttta attgtgcttt
    10021 tttatgtatt aaatgttttt ccttttgcca
//
