LOCUS       NM_001278516            9982 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 4,
            mRNA.
ACCESSION   NM_001278516 NR_024171
VERSION     NM_001278516.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9982)
  AUTHORS   Patrick,N. and Markey,M.
  TITLE     Long-Read MDM4 Sequencing Reveals Aberrant Isoform Landscape in
            Metastatic Melanomas
  JOURNAL   Int J Mol Sci 25 (17), 9415 (2024)
   PUBMED   39273363
  REMARK    GeneRIF: Long-Read MDM4 Sequencing Reveals Aberrant Isoform
            Landscape in Metastatic Melanomas.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 9982)
  AUTHORS   Wei,J., Chen,Y., Feng,T., Wei,Y., Yang,C., Zhang,C., Li,W. and
            Liu,G.
  TITLE     miR-34c-5p inhibited fibroblast proliferation, differentiation and
            epithelial-mesenchymal transition in benign airway stenosis via
            MDMX/p53 pathway
  JOURNAL   Funct Integr Genomics 24 (2), 37 (2024)
   PUBMED   38374244
  REMARK    GeneRIF: miR-34c-5p inhibited fibroblast proliferation,
            differentiation and epithelial-mesenchymal transition in benign
            airway stenosis via MDMX/p53 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 9982)
  AUTHORS   Liu,J., Yang,J., Pan,Q., Wang,X., Wang,X., Chen,H., Zheng,X. and
            Huang,Q.
  TITLE     MDM4 was associated with poor prognosis and tumor-immune
            infiltration of cancers
  JOURNAL   Eur J Med Res 29 (1), 79 (2024)
   PUBMED   38281029
  REMARK    GeneRIF: MDM4 was associated with poor prognosis and tumor-immune
            infiltration of cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9982)
  AUTHORS   Mao,Y., Hu,Z., Zeng,Y., Zhou,Y. and Shi,Z.
  TITLE     LINC01094 accelerates the metastasis of hepatocellular carcinoma
            via the miR-26b-3p/MDM4 axis
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (6), 181-185 (2023)
   PUBMED   37605571
  REMARK    GeneRIF: LINC01094 accelerates the metastasis of hepatocellular
            carcinoma via the miR-26b-3p/MDM4 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9982)
  AUTHORS   Jeyaraj,S., O'Brien,D.M. and Chandler,D.S.
  TITLE     MDM2 and MDM4 splicing: an integral part of the cancer spliceome
  JOURNAL   Front Biosci (Landmark Ed) 14 (7), 2647-2656 (2009)
   PUBMED   19273224
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 9982)
  AUTHORS   Bartel,F., Schulz,J., Bohnke,A., Blumke,K., Kappler,M., Bache,M.,
            Schmidt,H., Wurl,P., Taubert,H. and Hauptmann,S.
  TITLE     Significance of HDMX-S (or MDM4) mRNA splice variant overexpression
            and HDMX gene amplification on primary soft tissue sarcoma
            prognosis
  JOURNAL   Int J Cancer 117 (3), 469-475 (2005)
   PUBMED   15906355
  REMARK    GeneRIF: HDMX gene was amplified in 17% of soft tissue sarcoma
            patienets and gene amplification was associated with poor
            prognosis.
REFERENCE   7  (bases 1 to 9982)
  AUTHORS   Giglio,S., Mancini,F., Gentiletti,F., Sparaco,G., Felicioni,L.,
            Barassi,F., Martella,C., Prodosmo,A., Iacovelli,S., Buttitta,F.,
            Farsetti,A., Soddu,S., Marchetti,A., Sacchi,A., Pontecorvi,A. and
            Moretti,F.
  TITLE     Identification of an aberrantly spliced form of HDMX in human
            tumors: a new mechanism for HDM2 stabilization
  JOURNAL   Cancer Res 65 (21), 9687-9694 (2005)
   PUBMED   16266988
REFERENCE   8  (bases 1 to 9982)
  AUTHORS   Shvarts,A., Bazuine,M., Dekker,P., Ramos,Y.F., Steegenga,W.T.,
            Merckx,G., van Ham,R.C., van der Houven van Oordt,W., van der
            Eb,A.J. and Jochemsen,A.G.
  TITLE     Isolation and identification of the human homolog of a new
            p53-binding protein, Mdmx
  JOURNAL   Genomics 43 (1), 34-42 (1997)
   PUBMED   9226370
REFERENCE   9  (bases 1 to 9982)
  AUTHORS   Kussie,P.H., Gorina,S., Marechal,V., Elenbaas,B., Moreau,J.,
            Levine,A.J. and Pavletich,N.P.
  TITLE     Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor
            transactivation domain
  JOURNAL   Science 274 (5289), 948-953 (1996)
   PUBMED   8875929
REFERENCE   10 (bases 1 to 9982)
  AUTHORS   Shvarts,A., Steegenga,W.T., Riteco,N., van Laar,T., Dekker,P.,
            Bazuine,M., van Ham,R.C., van der Houven van Oordt,W., Hateboer,G.,
            van der Eb,A.J. and Jochemsen,A.G.
  TITLE     MDMX: a novel p53-binding protein with some functional properties
            of MDM2
  JOURNAL   EMBO J 15 (19), 5349-5357 (1996)
   PUBMED   8895579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK310903.1, BC067299.1,
            AL512306.16 and BX108199.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001278516.1.
            
            Summary: This gene encodes a nuclear protein that contains a p53
            binding domain at the N-terminus and a RING finger domain at the
            C-terminus, and shows structural similarity to p53-binding protein
            MDM2. Both proteins bind the p53 tumor suppressor protein and
            inhibit its activity, and have been shown to be overexpressed in a
            variety of human cancers. However, unlike MDM2 which degrades p53,
            this protein inhibits p53 by binding its transcriptional activation
            domain. This protein also interacts with MDM2 protein via the RING
            finger domain, and inhibits the latter's degradation. So this
            protein can reverse MDM2-targeted degradation of p53, while
            maintaining suppression of p53 transactivation and apoptotic
            functions. Alternatively spliced transcript variants encoding
            different isoforms have been noted for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (4, also known as MDM4-S, HDMX-S,
            or HDMX-E) lacks an internal coding exon compared to variant 1. The
            resulting isoform (4) has a much shorter and alternate C-terminus
            compared to isoform 1. Annotation of this protein causes this
            transcript to be a candidate for nonsense-mediated mRNA decay
            (NMD); however, this protein was shown in PMID: 10075736 to be
            biologically valid.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK310903.1, BC143431.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate :: PMID: 15906355
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-726               AK310903.1         1-726
            727-1575            BC067299.1         812-1660
            1576-9794           AL512306.16        89174-97392         c
            9795-9982           BX108199.1         14-201              c
FEATURES             Location/Qualifiers
     source          1..9982
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..9982
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="MDM4 regulator of p53"
                     /db_xref="GeneID:4194"
                     /db_xref="HGNC:HGNC:6974"
                     /db_xref="MIM:602704"
     exon            1..104
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            105..217
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             140..562
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="isoform 4 is encoded by transcript variant 4;
                     double minute 4, human homolog of; p53-binding protein;
                     MDM4-related protein 1; MDM4, p53 regulator; protein Mdmx;
                     mdm2-like p53-binding protein; Mdm4 p53 binding protein
                     homolog"
                     /codon_start=1
                     /product="protein Mdm4 isoform 4"
                     /protein_id="NP_001265445.1"
                     /db_xref="CCDS:CCDS60396.1"
                     /db_xref="GeneID:4194"
                     /db_xref="HGNC:HGNC:6974"
                     /db_xref="MIM:602704"
                     /translation="MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQG
                     EMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDML
                     RKNLVTLATATTAKCRGKFHFQKKNYRRRYPHTAYLRA"
     exon            218..292
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            293..426
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            427..482
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..582
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            583..743
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            744..893
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..974
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     exon            975..9982
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9960..9965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="hexamer: ATTAAA"
     polyA_site      9982
                     /gene="MDM4"
                     /gene_synonym="BMFS6; HDMX; MDMX; MRP1"
                     /note="major polyA site"
ORIGIN      
        1 attactcgcc atttcaaaat gctgccgagg ccctaggatc tgtgactgcc acccctcccc
       61 ccacccgggc tcggcggggg agcgactcat ggagctgccg taagttttac caacagactg
      121 cagtttcttc actaccaaaa tgacatcatt ttccacctct gctcagtgtt caacatctga
      181 cagtgcttgc aggatctctc ctggacaaat caatcaggta cgaccaaaac tgccgctttt
      241 gaagattttg catgcagcag gtgcgcaagg tgaaatgttc actgttaaag aggtcatgca
      301 ctatttaggt cagtacataa tggtgaagca actttatgat cagcaggagc agcatatggt
      361 atattgtggt ggagatcttt tgggagaact actgggacgt cagagcttct ccgtgaaaga
      421 cccaagccct ctctatgata tgctaagaaa gaatcttgtc actttagcca ctgctactac
      481 agcaaagtgc agaggaaagt tccacttcca gaaaaagaac tacagaagac gatatcccca
      541 cactgcctac ctcagagcat aaatgcatac attctagaga agatgaagac ttaattgaaa
      601 atttagccca agatgaaaca tctaggctgg accttggatt tgaggagtgg gatgtagctg
      661 gcctgccttg gtggttttta ggaaacttga gaagcaacta tacacctaga agtaatggct
      721 caactgattt acagacaaat caggatgtgg gtactgccat tgtttcagat actacagatg
      781 acttgtggtt tttgaatgag tcagtatcag agcagttagg tgttggaata aaagttgaag
      841 ctgctgatac tgaacaaaca agtgaagaag tagggaaagt aagtgacaaa aaggtgattg
      901 aagtgggaaa aaatgatgac ctggaggact ctaagtcctt aagtgatgat accgatgtag
      961 aggttacctc tgaggatgag tggcagtgta ctgaatgcaa gaaatttaac tctccaagca
     1021 agaggtactg ttttcgttgt tgggccttga ggaaggattg gtattcagat tgttcaaagt
     1081 taacccattc tctctccacg tctgatatca ctgccatacc tgaaaaggaa aatgaaggaa
     1141 atgatgtccc tgattgtcga agaaccattt cggctcctgt cgttagacct aaagatgcgt
     1201 atataaagaa agaaaactcc aaactttttg atccctgcaa ctcagtggaa ttcttggatt
     1261 tggctcacag ttctgaaagc caagagacca tctcaagcat gggagaacag ttagataacc
     1321 tttctgaaca gagaacagat acagaaaaca tggaggattg ccagaatctc ttgaagccat
     1381 gtagcttatg tgagaaaaga ccacgagacg ggaacattat tcatggaagg acgggccatc
     1441 ttgtcacttg ttttcactgt gccagaagac taaagaaggc tggggcttca tgccctattt
     1501 gcaagaaaga gattcagctg gttattaagg tttttatagc ataatggtag tacgaacata
     1561 aaaatgcatt tattccgttc acttaccaca ttatttgaaa atcaatcctt tatttaattt
     1621 tatttccaac ctgtcagaga atgttcttag gcatcaaaat ccaaggtagc tgtaagaaaa
     1681 atactggagc taacaatgaa gaacagaagt aatctgatta gtcaaattat taagtgccat
     1741 ggattacttt atgcagcagt caggtacata gttaggtgaa cccaaaagaa aaactcttga
     1801 aaacaagaga tttcttccat gcacatttac aatattgagg tataattaac atgataaagt
     1861 gtttccttct aacgagttgt agaaatctga gtaaccaccc aaaaaagcaa tagaatgttt
     1921 ctgtcacccc aaaacactcc cttctgcccc tcttcagaca gtccttcagc tatttcatgg
     1981 ctctcaccct agtttttttt ttttttgcac tttttttttt ccgggggtat aggggaggtg
     2041 tggggcgaca gggtctgtct tgttctgtct cccaggctga agtgcagtgc agtggtatga
     2101 tcatggctca ctgcagcctt ggtttcctgg gcataagtgg tcttcccact tcagcctcct
     2161 gagtagctga gactatagac tagcataacc acactggcta attttttgtg gagatgaagt
     2221 ctcactatgt tgcccaggct ggtctcgaac tcctgggctc aaacaatcct cccgcctcag
     2281 ccttccaaat tgctgggatt atagtcatga ggcacctagt ctggcccttt tgcaagactt
     2341 taatctgaaa tctaaatttt taaaatttaa gtacttacaa aggatatact atccaacata
     2401 ttgcatatta tatatgtgct ttaaagtttt tttttttttt tgagagacgg tctcactttg
     2461 tcatccaagc tggagtgcag tggtgcaaac acggcccacc tcctgggctc aagtgatcct
     2521 ccagcctcag cttccctcac aggcattcac tatcactccc agctaattaa aataatttgt
     2581 agacggtgtc tcgttatgtt gcccaggctg gtctcgaact cctgggttta agtgattccc
     2641 ccgcctcagc ctcccaaagt gttgggctta cagccttgag ccactatgct tggctcaaag
     2701 atatttttat gaaagccctg ggactataga tttagctgat taaatttata gaaaaagtcc
     2761 tgtcatataa actggcaaag tctgttctta atttaattag ccaaatcaga cttaacttcc
     2821 gtcagaacat gtcttggttt taattcagat aaacacacaa acatacttct ctggcacagc
     2881 cttcagaagc atcagttttt gttttgtttt gttttgtttt ttgagacagg gtcttgctct
     2941 gtcgcccagg ctggagtgca ctggcacaat cacagttcac tgcagcctcg acctcccaga
     3001 tccaagcaat cctcccacct aagcctccca agtagctggg tctataggcg cgtgccacca
     3061 ccatgcccag ctgaattttg tattttttgt acagacagca ttttgccatg ttgcccaggc
     3121 tggtcccaaa cttctagcct caagcaaccc tcctgcctca gcctctcaaa gtgctaggat
     3181 tgcagtcctg agctactgcc ccctaccctc tttgcgtctt aggagtcatt tagatttttt
     3241 ttgatccttt tgtttagtgc ctctggagct gcttacacca aggcaatacg ccttgatata
     3301 ctggatggtt gagaggcagc ctcttttttt tttttttttt tttttttttt ttggaggata
     3361 gggagtatgg ctgttgtgaa aagggaggta aagagaaatg gtagatctga agaggcctca
     3421 tcagagcaca tattttagga caacacatat ggaaattgga catctttaag ttggtttcca
     3481 tagagctatg catgtatcct tacccccatg ggaaaatgtt ggtgtgttct caagggtatg
     3541 catgtgtcat tttgaagacc aaggccctag aattgtcaaa cttaaggatc ataaaaatca
     3601 tgagggttgc ttgttaaaaa tgtccaaacg tgcagagact gatctttgag atctggacca
     3661 ggaatttgca tttgaacaag tgttcctgga atctctatgc aagttttata cagaacatac
     3721 ttttggaatc cttgccctag acaggggtgt ccaatctttt ggcttccctg gtccacaatg
     3781 gaagaagaat tgtcttggac cacacataaa atacactaac actaacaata gctgatgagc
     3841 taaaaaaaaa aaaaaaaaaa atcgtggacc gggcgtagtg gctcacgcct gtaatcccaa
     3901 cactttggga gatcacctag gtcgggagtt tgagaccagc ctgaccgaca tggagaaacc
     3961 ccatttttac taaaaataca aaaaattagc tgggcatggt ggtgcatgcc tgtagtccca
     4021 gctactcagg aggctgaggc aggagaatcg cttgaacctg agagggggag attgcggtga
     4081 gctgagattg cgccattgca ccccagcctg ggcaacaata gcgaaactgt ctcagaaaaa
     4141 agaaaaaaaa aatcgcaaaa agaaaaatct cataatgtcg ttgttggttt tttttttttt
     4201 ttttgagaca gtctcactct gttgcccagg ctggagtgca atggcatgat ctctgctcac
     4261 cgcaacctct gcctcccggg ttcaggtgat tctcctgcct cagcctccca gatagctggg
     4321 actacaggca cataccacca tgcctggcta atttttgtat ttttagtaga gatgggggtt
     4381 tcactgtgtt ggccaggctg gtctcgaact cctgacctca tgatccacac acctcggcct
     4441 cccaaagtcc tgcgattaca ggcgtgagct accgcaccca gccaagttgt aatttttaat
     4501 aaaacttaag aagtaaacat tttacttatg tttataggta tttgatccta aatttgacac
     4561 atcattgccc atgaaagaat cctcttaggc tgctcagctt cactcttcct gcttgcccac
     4621 cggggttttt cactgcttct gttagcacta agtacttaga cgatcctaag atatgtgctt
     4681 gagccgaatt tcatctttac ttgtaggaaa ctttaaacta tttcttttct tttctttttt
     4741 tttttttttt acttgagatg gagttttgct cttgtcgccc aggctggagt gcagtggagt
     4801 gatctcggct cactgcaacc tctgcctccc gggttcaaat gattctcctg cctcagcctc
     4861 ccaagtagct gggattacag gtgtgcacca ccatgtctgg ctaattttgt atttttagta
     4921 gagatggttt caccatgttg gtcaggctgg tctcgaactc ctgacctcag gtcatccacc
     4981 cacctcagcc tcgcaaagtg ctgagattac aggcatgagc cacagcgccc agcttaaact
     5041 attttcttgg tctgtttttg attttctttt ttccttgcca ctgcggtaca gatttttttt
     5101 actcactgcc actaaactaa agcaaggcat agtttatatg tgaagtgttc agagtttact
     5161 gctataagga aacttccaaa tactgacatt taccttttag ctgtagttat tgggaccatg
     5221 tgctctggtt ttctggagac tgccaaattg ctcccatttt tctgcatccc acctggtttc
     5281 tttctgcatg tcccctttca ctttcaaacc tcttcatttg gatgttaaat tatatggtca
     5341 cctagttata ggtaagcctt gttcgagttg atatcttgat tgtgaggaag gatctgtgtc
     5401 attggagctt gtttctgctg caacgtgctg tagactatga ataatgaaat cacaccacat
     5461 taccatcaga tttcttgttt tagttgtcaa attaatattt atgattgtta tcttgggcga
     5521 aaagttcaga gcagagatga caaatcatta gaacaacgat gaatttcagt attacggcta
     5581 aaaagttctt ctgtctgaat attaactcac tctccttcca gtgtacttca cagtaattgg
     5641 tatgcttttt tatttaatgc ttaaatcaaa ctttataaaa atcttagacc agatctttaa
     5701 tatggtatgc catttcccca gtctaccaat ggaatagtat gggtttctaa tcctaggctt
     5761 gtacaatgga ttggagttga gccatgccag cctccacact gccactaact tctgtaatgt
     5821 aagattgagt cactgccaag catttgaaat atgcagttgt gttttaatta taatttatgt
     5881 atagttagat gtatgtagtg cattgtgtgg tattatttgg tttgtaagaa tttattttta
     5941 agggtcaagg tcatttgtaa cattttgtgt gtgtcaattc aatgcaatgt tggctgcctt
     6001 ttgaagtctt tgatatattg gtgaatattc ttctgatcta taatacaaag ctatgtaatg
     6061 ttacctcttg actcgctttt gaaaggaaga caattgttaa ctagatattt gagttttttc
     6121 ccctcagaat tatgtgaatt tctgatatat ggctttagat actgtgaatc tgttttccat
     6181 ttagtcagtt atctgcttaa attgttcaga actatatcct aacgagcaat tagttctgat
     6241 ggttctccca gtcatgagtg tgcatgtgtg caagcatgtt ttgatcctga tgctaccttt
     6301 gctaaaaatg gccatagatt aggaactagc tatgttttta gaatcaaaga tgaaccggta
     6361 agctgtctca tgtaccaaac gtgaaattta cagtgtttac aaatgtctgg aattttgcac
     6421 tgccataggg aatgttaagg ttacttggct ggaatttatc agacttgtga gtaaacaagt
     6481 tgaagtttag cagatgaggg ggaatattga ggcccctaag gctaaacaaa ataatcagta
     6541 tctgagatag tggctaatgt ggctccccag gcctaatttg ggaacagttt ttcctgattg
     6601 ctttgagaag tactttcttt tgacagaaat tttcattctg cttgccattg ctatattctc
     6661 cctttatagg agccattgga tttctttcct tttgtgggaa atgtcccatt agcattttca
     6721 gatcttttga tgtgcactaa tgccattatt ggtaatgccg ttattggtga atacagcata
     6781 gttaaataaa ctgttacagt aaatctacac ttggatttgc tgcacctcta ccaatagcct
     6841 tttgaatgac tgaaagtgtt aacagagaaa gaggcatgtc tgcagaaaga gatagctaat
     6901 attttttggt actttatctg aaatccaaga tgctgcttcc cctgcaggtt gttttccttc
     6961 ttacgatcct cattgaatcc cctctgggag cacaggacag ttagtagaac tctccatttc
     7021 tttttttttt tttttagacg gagtctctct ctgtcgcccc ggctggagtg cagtggcgcg
     7081 atctcggctc actgcaacct ccgcctcccg ggttcacccc attctcctgc ctcagcctcc
     7141 ctagtagctg ggactatagg cgcccgccac cacgcctggc taatttttgt atttttattg
     7201 gagacggggt ttcaccgtct tagccaggat ggtcttgatc tcctgacctc gtgatctgcc
     7261 cacctcagcc tcccaaagta ctgggattac aggcgtgagc caccgcgccc ggccggaact
     7321 ctccatttct taaggtaaag agggtcaagg atacctaaaa agggtcaaat aatgctagaa
     7381 gagcaattcc tctttcagag cagttgctgt aatttggcaa atgctttatc gaagattgat
     7441 attaggctag gggcggtggc ttacgcctgt aatcccagca ctttgggagg ccgaggtggg
     7501 tggattgcct gagctcagga gttcgagacc agtctgacca gtatggtgaa accctgtctc
     7561 tactaaaaat acaaaaatta gccggtcgtg gtggcgtgca cctgtagtcc cagctacttg
     7621 gcaggttgag acaggagaat cgcttgaacc tgggaggtgg aggttgcagt gagccgagac
     7681 tgcaccactg cgctcccacc tgggtgacag agactctgtc tcaaaaaaaa ggacatttat
     7741 cattataaca tcttattaga gcccctaatt tcttatctga aggcactgtt ttttttttta
     7801 aacagttaag tactgatgtc aacagacaaa tatttctgat cagatagtcc cctgtcaaca
     7861 gtagcaaatg tggtttcata aagtgggaag aaaacagcat tttaaagtaa ctttttggga
     7921 gactgatttg agtaataata aaactctggt ctcccttaag aaaaaaaaac ccttccacct
     7981 ttactgtgtc atttatatcc ccttagttcc aaagttaatt atcttatttc tggatattgc
     8041 ttttatacca aagaccctta tcagcccttg taactacagt atctttagat aagattcctc
     8101 tttccagtca gtcctgggaa atgtttctgt tgcagagtta ggcggtagat gggaagctgt
     8161 gatggcagag ctactatcta ataaagtaac aactcgtagt tgaggcttcc tttctgtgtg
     8221 tgatggggga tagggagtta gctcccctgt tgtctcagca ctaagaaatt gaggtcaggc
     8281 caggcgcggt ggttcactcc tgttattcca gcactggggt ggccaaagtg ggcagattgc
     8341 ttgcgctctg gagctcgaga ccagcctggg caacatggtg aaaccctgtc tctaccaaaa
     8401 atacaaaaaa aaagctgggc atggtgggtg catgcttgtc ccagctactg aggaggctga
     8461 ggtgggagga tcgcttgagc ctgggaggtg gaggttgcag tgagctgaga tggcaccact
     8521 gcaatccaag gtgggtgaca gagacgctgt ctcaaagaaa ttgaggtcag gcttccttct
     8581 tacagaatta tttttttctc tgtagtttgc ctcatttttt cactttcttt tcaatgagaa
     8641 tcgaagtgtt tcttttgggt ttttttttcc cccttttaaa atcaacagga aatgtttcaa
     8701 aggagggatg aaatgcttct tggcttcctc agcacttggc aaggtagacc tcatagcaac
     8761 cttgaatatg actttcttta gtctctagct atgcactatt aagtgcctct tgggtagagg
     8821 tagagttaag tattgagtgc cagtcttgac gtccgtatgc ctcagttttt ctcatatata
     8881 aaaagcagta tacataccta cccttttcta cctcatcatt tgttgtaggg attaaatccg
     8941 ggagagcaat tctgaagcct ataaatttcc ttgaagagat ctaagaacct attatgctct
     9001 tggtgtacca agctctgggg tatatattca gaatacctca tgttctggaa gctgagcact
     9061 agctcccctt tattgcctgc ctggcagagc ctgtttgatt actgcaggcc cttttaccca
     9121 tgcttctagt ttaggtattc tttctttgat atgaggctct tgaccagaaa agagttcttt
     9181 ctctaggtgt tctgagagaa gtttgtaaat ttggatagta cattctatcc tgataaaacc
     9241 accttgctgt ggtcttgatg tacaaaaaaa aatttttttt ttgagacaga gtcttactct
     9301 gtcacccagg ctggaatgca gtggcgcaat cttggttcac tgcaaccccc gcctcctggg
     9361 ttcaagcgat cctcctgcct caacctctca agtagctggg actacaggcg tgcaccacca
     9421 cacctggcta attttgtatt tttagtagag acagggtttc accatgttgg ccaggctggt
     9481 cttgaactcc tgacctcagg cgatctgccc gccttggcct cccaaagtac tgggattaca
     9541 ggcgtgagca actgctcctg gcccaaaaca tctctttcta catacacttg agtaggtggc
     9601 ataaaatgca ctgtcaatat atagaaaaca tgaaattttc caaatatttc cgatcagaga
     9661 atcacaagag cagcaaatgt ggtttcatca agtgggaaga aagcagcaat ttaaaataac
     9721 tttttgggag actgaattga gtaataataa aacttcagtc tttcgctaat aataataata
     9781 ataataataa taacaacaac ttattgaatg tggccagctc actagatgag gaaagaggaa
     9841 ggcattttct gcattcttgc ctagttttcc ttataagcac cactaagtta atagctctgt
     9901 ctttttggtg tttgcactat gtaatgcttt taatactttt taattgtgct tttttatgta
     9961 ttaaatgttt ttccttttgc ca
//
