LOCUS       NM_001354969            2980 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens Mdm1 nuclear protein (MDM1), transcript variant 5,
            mRNA.
ACCESSION   NM_001354969 XM_005269026
VERSION     NM_001354969.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2980)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2980)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2980)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 2980)
  AUTHORS   Hensley,M.R., Chua,R.F., Leung,Y.F., Yang,J.Y. and Zhang,G.
  TITLE     Molecular Evolution of MDM1, a 'Duplication-Resistant' Gene in
            Vertebrates
  JOURNAL   PLoS One 11 (9), e0163229 (2016)
   PUBMED   27658201
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2980)
  AUTHORS   Van de Mark,D., Kong,D., Loncarek,J. and Stearns,T.
  TITLE     MDM1 is a microtubule-binding protein that negatively regulates
            centriole duplication
  JOURNAL   Mol Biol Cell 26 (21), 3788-3802 (2015)
   PUBMED   26337392
  REMARK    GeneRIF: Authorse propose that MDM1 is a negative regulator of
            centriole duplication and that its function is mediated through
            microtubule binding.
REFERENCE   6  (bases 1 to 2980)
  AUTHORS   Stangeland,B., Mughal,A.A., Grieg,Z., Sandberg,C.J., Joel,M.,
            Nygard,S., Meling,T., Murrell,W., Vik Mo,E.O. and Langmoen,I.A.
  TITLE     Combined expressional analysis, bioinformatics and targeted
            proteomics identify new potential therapeutic targets in
            glioblastoma stem cells
  JOURNAL   Oncotarget 6 (28), 26192-26215 (2015)
   PUBMED   26295306
REFERENCE   7  (bases 1 to 2980)
  AUTHORS   Greenwood,T.A., Akiskal,H.S., Akiskal,K.K. and Kelsoe,J.R.
  CONSRTM   Bipolar Genome Study
  TITLE     Genome-wide association study of temperament in bipolar disorder
            reveals significant associations with three novel Loci
  JOURNAL   Biol Psychiatry 72 (4), 303-310 (2012)
   PUBMED   22365631
REFERENCE   8  (bases 1 to 2980)
  AUTHORS   Chang,B., Mandal,M.N., Chavali,V.R., Hawes,N.L., Khan,N.W.,
            Hurd,R.E., Smith,R.S., Davisson,M.L., Kopplin,L., Klein,B.E.,
            Klein,R., Iyengar,S.K., Heckenlively,J.R. and Ayyagari,R.
  TITLE     Age-related retinal degeneration (arrd2) in a novel mouse model due
            to a nonsense mutation in the Mdm1 gene
  JOURNAL   Hum Mol Genet 17 (24), 3929-3941 (2008)
   PUBMED   18805803
  REMARK    GeneRIF: Not associated with age-related retinal degeneration.
REFERENCE   9  (bases 1 to 2980)
  AUTHORS   Snyder,L.C., Trusko,S.P., Freeman,N., Eshleman,J.R.,
            Fakharzadeh,S.S. and George,D.L.
  TITLE     A gene amplified in a transformed mouse cell line undergoes complex
            transcriptional processing and encodes a nuclear protein
  JOURNAL   J Biol Chem 263 (32), 17150-17158 (1988)
   PUBMED   3182840
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC022511.22 and AK026745.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001354969.1.
            
            Summary: This gene encodes a microtubule-binding nuclear protein
            that localizes to the centrioles of dividing cells and
            differentiating multiciliated cells and negatively regulates
            centriole duplication. The encoded protein is closely associated
            with the centriole barrel, and resides in the centriole lumen.
            Naturally-occurring mutations in the orthologous mouse gene are
            associated with age-related retinal degeneration. [provided by
            RefSeq, Feb 2019].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853563.7860.1,
                                           SRR14038195.1493172.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000682720.1/ ENSP00000507100.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-135               AC022511.22        85583-85717         c
            136-250             AC022511.22        84462-84576         c
            251-615             AC022511.22        80012-80376         c
            616-750             AC022511.22        78796-78930         c
            751-918             AC022511.22        76428-76595         c
            919-1022            AC022511.22        74880-74983         c
            1023-1122           AC022511.22        74702-74801         c
            1123-1152           AC022511.22        69936-69965         c
            1153-1328           AC022511.22        69433-69608         c
            1329-1646           AC022511.22        68303-68620         c
            1647-1756           AC022511.22        66999-67108         c
            1757-1866           AC022511.22        66798-66907         c
            1867-2119           AC022511.22        55975-56227         c
            2120-2179           AC022511.22        50278-50337         c
            2180-2979           AC022511.22        47922-48721         c
            2980-2980           AK026745.1         2026-2026
FEATURES             Location/Qualifiers
     source          1..2980
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q15"
     gene            1..2980
                     /gene="MDM1"
                     /note="Mdm1 nuclear protein"
                     /db_xref="GeneID:56890"
                     /db_xref="HGNC:HGNC:29917"
                     /db_xref="MIM:613813"
     exon            1..135
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..2292
                     /gene="MDM1"
                     /note="isoform 5 is encoded by transcript variant 5;
                     nuclear protein double minute 1; nuclear protein MDM1;
                     Mdm4, transformed 3T3 cell double minute 1, p53 binding
                     protein"
                     /codon_start=1
                     /product="nuclear protein MDM1 isoform 5"
                     /protein_id="NP_001341898.1"
                     /db_xref="CCDS:CCDS91723.1"
                     /db_xref="GeneID:56890"
                     /db_xref="HGNC:HGNC:29917"
                     /db_xref="MIM:613813"
                     /translation="MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQL
                     GITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPETPKSQEAEQKDV
                     TQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLS
                     ENVDNGLDRLLRKKAGLTVVPSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQ
                     FVPPFKGNSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLK
                     LEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPN
                     QGSLNAMWYAEVKELREKAEFYRKRVQGTHFSRDHLNQILSDSNCCWDVSSTTSSEGT
                     VSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRR
                     RLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEKLDVREKSKADKMK
                     EGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKMKPPAPEQRK
                     RMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLP
                     VSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNVGKARMNNLQLPQHE
                     AFNDEDEDRLSEISARSAASSLRAFQTLARAKKRKENFWGKT"
     exon            136..250
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            251..615
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..750
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            751..918
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1022
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1122
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1152
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1328
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1646
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1756
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1866
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2119
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2120..2179
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2180..2980
                     /gene="MDM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2960..2965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDM1"
                     /note="hexamer: AATAAA"
     polyA_site      2980
                     /gene="MDM1"
                     /note="major polyA site"
ORIGIN      
        1 gcgtagtcgg ggacgccggg ccgaggcttt gctagggaac actgttatcg ccccgccccc
       61 tcggagcttt ttctccagtt aactgtcgga gtagcggggg ctccggcgcc gggcgacatg
      121 ccggtgcgct tcaaggggct gagtgaatac cagaggaact tcctgtggaa aaagtcttat
      181 ttgtccgagt cttgtaattc ctccgtgggg cgaaagtacc catgggctgg acttagatca
      241 gatcaattag gcatcacgaa agagccaagt tttatttcaa aaagaagagt cccttaccat
      301 gacccacaga tttcaaaatc tctggagtgg aatggagcta tctcagagag caatgtggtt
      361 gcatcaccag aaccagaagc cccggaaaca ccaaaatcac aagaagcaga acaaaaggat
      421 gttactcaag aaagagttca ctcactagaa gcttccaggg ttcccaaaag aaccagatct
      481 cactctgcag actccagagc tgaaggggct tcagatgtgg aaaataatga gggtgtaaca
      541 aaccatacac cagttaatga aaatgtggaa ctggaacatt ctaccaaggt tctttcagaa
      601 aatgtagata atgggttgga tagacttctg cgtaagaaag ctggattgac tgttgttcct
      661 tcatataatg ccttgagaaa ttctgaatat caaaggcagt ttgtttggaa gacttctaaa
      721 gaaactgctc cagcttttgc agccaatcag gttttccaca ataaaagcca gtttgttcca
      781 ccattcaaag gtaactcagt catccatgaa actgaataca aaagaaattt caagggttta
      841 tctccagtga aagaaccaaa attaagaaat gatttgagag aaaacagaaa tcttgaaaca
      901 gtgtctcctg aaaggaagag taataaaata gacgatcgtt taaaattgga agcagagatg
      961 gaattaaaag acttacacca gcctaaaagg aagcttactc cttggaaaca tcaaaggctt
     1021 gggaaggtga attccgaata tagagcaaaa tttctgagcc cagctcagta tttatataaa
     1081 gctggggctt ggacacatgt aaagggaaac atgccaaatc agggttctct aaatgccatg
     1141 tggtatgctg aggttaaaga actccgagaa aaggctgagt tttataggaa gcgagttcag
     1201 gggacgcatt tttctcggga ccatctgaat cagattttat ctgatagcaa ctgctgttgg
     1261 gatgtctcct caaccacaag ctcagaagga accgttagta gcaacatcag agcattagat
     1321 cttgctggag atcctacaag ccataagact ttgcagaaat gtccttctac agaaccagaa
     1381 gaaaaaggaa atatcgtgga agaacagccc cagaaaaata ccacggagaa attgggtgtg
     1441 tcagctccca ccatacccgt tagaaggcgg ctggcttggg atacagagaa cacaagtgaa
     1501 gacgtacaga aacagcccgg ggagaaagag gaggaggacg acaatgaaga ggaaggggac
     1561 aggaaaacgg gcaagcaggc ttttatggga gagcaagaga agttggatgt acgtgagaaa
     1621 tctaaggcag ataagatgaa agaagggtca gattcttctg tatcctcaga aaaaggaggc
     1681 cggcttccta ctcccaagct gagagaactt ggtggaatcc agaggactca tcatgatctc
     1741 actactccag ctgttggtgg tgctgtttta gtgtctccat ctaagatgaa gcctccagcc
     1801 ccagaacaga ggaaaagaat gacctctcag gattgtttag aaacttcaaa gaatgatttt
     1861 actaagaaag aaagtcgtgc tgtatcccta ctgacttctc cagctgctgg tataaaaaca
     1921 gttgatcctc tgcctttgcg ggaagattct gaagacaata tccacaaatt tgctgaggca
     1981 actcttccag tttcaaaaat tccaaaatac ccaacaaatc cccctggaca gttgccttct
     2041 ccaccacatg ttccatccta ctggcatccc tctcgacgaa ttcagggctc tcttagagat
     2101 ccagagtttc agcacaatgt gggaaaagca aggatgaaca atttgcagtt acctcaacat
     2161 gaagccttta atgatgaaga tgaggacaga ttgtctgaga tttctgctcg ctctgcagct
     2221 tctagtctcc gggcttttca aactctggca cgagctaaga aaaggaagga gaatttctgg
     2281 ggtaaaacat aaacctagct gagttgcctt tatctaagga aacattggca taatttttct
     2341 ttattgctta ctgtgttaaa attttttgag tgaagttttt cctaacgttt tctactttga
     2401 aatatttaat ttccaataga acagtttact tggaaattgt taacataggc ttatacaaat
     2461 ttaactttta aagaattctt tttacatcta tcccagagta caaagaccta gattattgaa
     2521 ttcttcacat gtaactttcg taataggtgt catggataga ttttcaccta tccagagagt
     2581 attctaaaaa aataaacaaa gtgaagtaaa agttaagatc ccagtgtgaa gtatatattc
     2641 ccctaagatt tgatatatgt atctttataa ttgatgatgt tgtaaaatga atttgttgtt
     2701 cctttaacct ttgctgtagt gtttcttttt attttagttc cttctataca tgtttgcagt
     2761 gttaagataa ttgtactttg aaaacaccag ctgtatatat ttttcttatt tatgtaacaa
     2821 agtttgctga aagatatgta tatttttgat ctttgagtgt attctatttg tgtaaggact
     2881 ttggcttaca tttgaataat gtctagattt tgaaaaatta cctgtataat ggagaattaa
     2941 aactttgtag acattttgaa ataaaaatgg atcaagtgcg
//
