LOCUS       NM_001039845            2334 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens malate dehydrogenase 1B (MDH1B), transcript variant 1,
            mRNA.
ACCESSION   NM_001039845
VERSION     NM_001039845.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2334)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK292378.1, BF979825.1 and AI076012.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001039845.2.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.580052.1,
                                           SRR1803616.222585.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000374412.8/ ENSP00000363533.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1766              AK292378.1         220-1985
            1767-2263           BF979825.1         18-514              c
            2264-2334           AI076012.1         10-80               c
FEATURES             Location/Qualifiers
     source          1..2334
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.3"
     gene            1..2334
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="malate dehydrogenase 1B"
                     /db_xref="GeneID:130752"
                     /db_xref="HGNC:HGNC:17836"
     exon            1..79
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     CDS             58..1614
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /EC_number="1.1.1.-"
                     /note="isoform a is encoded by transcript variant 1;
                     putative malate dehydrogenase 1B; malate dehydrogenase 1B,
                     NAD (soluble)"
                     /codon_start=1
                     /product="putative malate dehydrogenase 1B isoform a"
                     /protein_id="NP_001034934.1"
                     /db_xref="CCDS:CCDS33365.1"
                     /db_xref="GeneID:130752"
                     /db_xref="HGNC:HGNC:17836"
                     /translation="MAKFVIAGRADCPYYAKTELVADYLQKNLPDFRIHKITQRPEVW
                     EDWLKDVCEKNKWSHKNSPIIWRELLDRGGKGLLLGGYNEFLEHAQLYYDVTSSMTTE
                     LMMVIAQENLGAHIEKEQEEEALKTCINPLQVWITSASAPACYNLIPILTSGEVFGMH
                     TEISITLFDNKQAEEHLKSLVVETQDLASPVLRSVSICTKVEEAFRQAHVIVVLDDST
                     NKEVFTLEDCLRSRVPLCRLYGYLIEKNAHESVRVIVGGRTFVNLKTVLLMRYAPRIA
                     HNIIAVALGVEGEAKAILARKLKTAPSYIKDVIIWGNISGNNYVDLRKTRVYRYESAI
                     WGPLHYSRPVLNLIFDSEWVKREFVAILKNLTTTGRQFGGILAAHSIATTLKYWYHGS
                     PPGEIVSLGILSEGQFGIPKGIVFSMPVKFENGTWVVLTDLKDVEISEQIMTRMTSDL
                     IQEKLVALGDKIHFQPYQSGHKDLVPDEEKNLAMSDAAEFPNQIPQTTFEKPQSLEFL
                     NEFEGKTVES"
     exon            80..192
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            193..327
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            328..470
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            471..967
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1109
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1273
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1413
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1465
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1466..1516
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1585
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..2334
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1655..1660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="hexamer: AATAAA"
     polyA_site      1675
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="major polyA site"
     regulatory      1824..1829
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="hexamer: AATAAT"
     polyA_site      1847
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="major polyA site"
     regulatory      1884..1889
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="hexamer: AATAGA"
     polyA_site      1900
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
     regulatory      2244..2249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="hexamer: AATAAA"
     polyA_site      2269
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
     regulatory      2316..2321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
                     /note="hexamer: AATGAA"
     polyA_site      2334
                     /gene="MDH1B"
                     /gene_synonym="RP11-95H11"
ORIGIN      
        1 gcgtggttgc caggaaaccg cgaagccgcg gtccctgcct ctgagtctct ctcgaccatg
       61 gccaaattcg tcatcgcggg tagagcagat tgtccatatt atgctaaaac agaacttgtg
      121 gcagactatt tacaaaagaa tcttcctgat tttcggatac ataaaatcac acaacgtcct
      181 gaggtttggg aggattggct aaaagatgtg tgtgaaaaga ataagtggag tcacaagaat
      241 tcccctatca tctggagaga gctgttggat cgtggaggaa agggtttgct tttgggagga
      301 tataatgagt tcctggagca tgctcagctt tactatgatg tcacctctag catgacgact
      361 gaactgatga tggtaattgc tcaagagaac ctgggggcac atatagaaaa agagcaggag
      421 gaagaagccc tgaaaacttg catcaacccc ttgcaggtct ggatcaccag tgcctctgct
      481 cctgcctgct acaacctaat tcccatattg acgagtggcg aagtgtttgg gatgcataca
      541 gaaattagca taactctatt tgacaacaag caggcggaag aacatctcaa aagccttgtg
      601 gtggagaccc aagacctggc atctcccgtc ctgcgcagtg tctccatctg cacgaaggtg
      661 gaggaggcct tccgccaggc ccacgtcatt gtggtgctgg atgacagcac caacaaggag
      721 gtgttcactc tggaggactg cctccgaagc agggtgcctc tctgcaggct ctatgggtac
      781 ctgatagaga aaaatgctca tgagtctgtc agagtcatcg tgggagggag aacctttgta
      841 aacctgaaga cagttttact catgagatat gccccacgca ttgcacacaa cattattgct
      901 gtggcgctgg gggtggaagg tgaagcgaaa gccatactgg ccagaaaact gaagacagct
      961 ccttcataca ttaaagacgt gatcatttgg ggtaatatca gtggaaataa ttacgttgat
     1021 ctgagaaaaa caagggtgta cagatatgag agtgccattt ggggacctct tcattattca
     1081 cgccctgttt taaacttgat ttttgacagt gagtgggtaa aaagagaatt tgtggcaatt
     1141 cttaaaaact tgaccaccac aggaagacaa tttggaggca ttttggctgc acacagtata
     1201 gccactacac tgaaatactg gtaccatggc tcaccacctg gggagattgt atctttagga
     1261 atattgagtg aaggccagtt tggtattccg aaagggatcg tcttttctat gcctgtgaaa
     1321 tttgagaatg gaacttgggt ggttcttaca gatctcaaag atgttgaaat aagtgaacaa
     1381 ataatgaccc gaatgacaag tgatctaatt caggagaaac ttgttgcact tggagacaag
     1441 atacattttc agccatacca atcaggacat aaagatctgg tccctgatga agaaaaaaat
     1501 ctagctatgt cagatgcagc agagtttcca aatcagattc ctcaaaccac ctttgaaaag
     1561 ccacagagtc ttgagttcct aaatgaattt gaaggcaaaa ccgtggaatc ctaacagatc
     1621 aaattggatg aaatatataa ttacttgata gcacaataaa catagaaaga atttatatga
     1681 atgtctatat ttaaggaaga ataatttgaa agatttatgt cagtcttaga taataccatg
     1741 caaggcaatt aaatcactgt gacagcacag aggtcagagt tccgtcattt tgcattactt
     1801 gtatccactc atgtttgttt cataataatt gcattttctt agaactattt tggtgtcaaa
     1861 tgctattttt tatattacat taaaatagag ttgtcagtca ttgcatctgc ccatacatct
     1921 tctgagagaa cctgcttcct tccatcagcc atacctaaga cctgcaccta agtggccatg
     1981 tttgctcaaa tgtcctcatc accttggcct caactaatta ggccaaacag atgtacttca
     2041 ctcaaggaga accaatcata ttttctctct gtctctcaaa aaaaaattga actgagacca
     2101 gtgagtaagt tggtgtctgg gtcaggttaa tggtggtgaa ctatgtgcct gtgagctctt
     2161 cagagctggt tgggttcacc accttcataa gacctgcctc tgtaccattt ttccttgagt
     2221 gtgctttgta taaaggtctg tacaataaat cacacttttt taaagcttag attgaatagg
     2281 tttctgctcc ttgacaagag atatggcctg aataaaatga attttgaaag aaaa
//
