LOCUS       NM_001113498            5726 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens MAM domain containing glycosylphosphatidylinositol
            anchor 2 (MDGA2), transcript variant 1, mRNA.
ACCESSION   NM_001113498
VERSION     NM_001113498.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5726)
  AUTHORS   Wang,K., Liang,Q., Li,X., Tsoi,H., Zhang,J., Wang,H., Go,M.Y.,
            Chiu,P.W., Ng,E.K., Sung,J.J. and Yu,J.
  TITLE     MDGA2 is a novel tumour suppressor cooperating with DMAP1 in
            gastric cancer and is associated with disease outcome
  JOURNAL   Gut 65 (10), 1619-1631 (2016)
   PUBMED   26206665
  REMARK    GeneRIF: A novel tumour suppressor gene, MDGA2, which is frequently
            inactivated by promoter methylation in Gastric cancer was
            identified. Promoter hypermethylation of MDGA2 represents a
            prognostic biomarker in patients with early stage Gastric cancer.
REFERENCE   2  (bases 1 to 5726)
  AUTHORS   Noth,I., Zhang,Y., Ma,S.F., Flores,C., Barber,M., Huang,Y.,
            Broderick,S.M., Wade,M.S., Hysi,P., Scuirba,J., Richards,T.J.,
            Juan-Guardela,B.M., Vij,R., Han,M.K., Martinez,F.J., Kossen,K.,
            Seiwert,S.D., Christie,J.D., Nicolae,D., Kaminski,N. and
            Garcia,J.G.N.
  TITLE     Genetic variants associated with idiopathic pulmonary fibrosis
            susceptibility and mortality: a genome-wide association study
  JOURNAL   Lancet Respir Med 1 (4), 309-317 (2013)
   PUBMED   24429156
REFERENCE   3  (bases 1 to 5726)
  AUTHORS   Wang,J., Bansal,A.T., Martin,M., Germer,S., Benayed,R., Essioux,L.,
            Lee,J.S., Begovich,A., Hemmings,A., Kenwright,A., Taylor,K.E.,
            Upmanyu,R., Cutler,P., Harari,O., Marchini,J., Criswell,L.A. and
            Platt,A.
  TITLE     Genome-wide association analysis implicates the involvement of
            eight loci with response to tocilizumab for the treatment of
            rheumatoid arthritis
  JOURNAL   Pharmacogenomics J 13 (3), 235-241 (2013)
   PUBMED   22491018
REFERENCE   4  (bases 1 to 5726)
  AUTHORS   Pettem,K.L., Yokomaku,D., Takahashi,H., Ge,Y. and Craig,A.M.
  TITLE     Interaction between autism-linked MDGAs and neuroligins suppresses
            inhibitory synapse development
  JOURNAL   J Cell Biol 200 (3), 321-336 (2013)
   PUBMED   23358245
REFERENCE   5  (bases 1 to 5726)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   6  (bases 1 to 5726)
  AUTHORS   Hellquist,A., Zucchelli,M., Lindgren,C.M., Saarialho-Kere,U.,
            Jarvinen,T.M., Koskenmies,S., Julkunen,H., Onkamo,P., Skoog,T.,
            Panelius,J., Raisanen-Sokolowski,A., Hasan,T., Widen,E.,
            Gunnarson,I., Svenungsson,E., Padyukov,L., Assadi,G., Berglind,L.,
            Makela,V.V., Kivinen,K., Wong,A., Cunningham Graham,D.S.,
            Vyse,T.J., D'Amato,M. and Kere,J.
  TITLE     Identification of MAMDC1 as a candidate susceptibility gene for
            systemic lupus erythematosus (SLE)
  JOURNAL   PLoS One 4 (12), e8037 (2009)
   PUBMED   19997561
  REMARK    GeneRIF: A novel uncharacterized gene, MAMDC1 (MAM domain
            containing glycosylphosphatidylinositol anchor 2, also known as
            MDGA2, MIM 611128), represents a putative susceptibility gene for
            systemic lupus erythematosus.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5726)
  AUTHORS   Hettema,J.M., van den Oord,E.J., An,S.S., Kendler,K.S. and Chen,X.
  TITLE     Follow-up association study of novel neuroticism gene MAMDC1
  JOURNAL   Psychiatr Genet 19 (4), 213-214 (2009)
   PUBMED   19440164
  REMARK    GeneRIF: No association of rs7151262 with neuroticism was found
REFERENCE   8  (bases 1 to 5726)
  AUTHORS   van den Oord,E.J., Kuo,P.H., Hartmann,A.M., Webb,B.T., Moller,H.J.,
            Hettema,J.M., Giegling,I., Bukszar,J. and Rujescu,D.
  TITLE     Genomewide association analysis followed by a replication study
            implicates a novel candidate gene for neuroticism
  JOURNAL   Arch Gen Psychiatry 65 (9), 1062-1071 (2008)
   PUBMED   18762592
  REMARK    GeneRIF: MAMDC1 gene is implicated in neuroticism.
            GeneRIF: Genome-wide association study of gene-disease association.
            (HuGE Navigator)
REFERENCE   9  (bases 1 to 5726)
  AUTHORS   Yang,Q., Kathiresan,S., Lin,J.P., Tofler,G.H. and O'Donnell,C.J.
  TITLE     Genome-wide association and linkage analyses of hemostatic factors
            and hematological phenotypes in the Framingham Heart Study
  JOURNAL   BMC Med Genet 8 Suppl 1 (Suppl 1), S12 (2007)
   PUBMED   17903294
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 5726)
  AUTHORS   Litwack,E.D., Babey,R., Buser,R., Gesemann,M. and O'Leary,D.D.
  TITLE     Identification and characterization of two novel brain-derived
            immunoglobulin superfamily members with a unique structural
            organization
  JOURNAL   Mol Cell Neurosci 25 (2), 263-274 (2004)
   PUBMED   15019943
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL162551.4, AL358832.3, AL157792.3, AL359951.4 and AL591771.1.
            
            On Nov 10, 2020 this sequence version replaced NM_001113498.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY369208.1, AK309211.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154665 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000399232.8/ ENSP00000382178.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1089              AL162551.4         56213-57301         c
            1090-1229           AL358832.3         26771-26910         c
            1230-1404           AL157792.3         132669-132843       c
            1405-1601           AL157792.3         58726-58922         c
            1602-1734           AL157792.3         46362-46494         c
            1735-2004           AL157792.3         11502-11771         c
            2005-2334           AL359951.4         32187-32516
            2335-2628           AL359951.4         58461-58754
            2629-2898           AL359951.4         136122-136391
            2899-3047           AL359951.4         173605-173753
            3048-3225           AL591771.1         118319-118496       c
            3226-3246           AL591771.1         113764-113784       c
            3247-3402           AL591771.1         110320-110475       c
            3403-3561           AL591771.1         109708-109866       c
            3562-3692           AL591771.1         91299-91429         c
            3693-3798           AL591771.1         82041-82146         c
            3799-5726           AL591771.1         76367-78294         c
FEATURES             Location/Qualifiers
     source          1..5726
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.3"
     gene            1..5726
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /note="MAM domain containing glycosylphosphatidylinositol
                     anchor 2"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
     exon            1..1089
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             810..3887
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /note="isoform 1 is encoded by transcript variant 1; MAM
                     domain-containing glycosylphosphatidylinositol anchor
                     protein 2; MAM domain containing 1"
                     /codon_start=1
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 2 isoform 1"
                     /protein_id="NP_001106970.4"
                     /db_xref="CCDS:CCDS45098.4"
                     /db_xref="GeneID:161357"
                     /db_xref="HGNC:HGNC:19835"
                     /db_xref="MIM:611128"
                     /translation="MSVWSAGLLRSARRRRRGRTDGRRFLLRRAVPGHLGLARARVER
                     AWLAAGLLKVPLRTPWAGYVHVHVKMDLLYGLVWLLTVLLEGISGQGVYAPPTVRIVH
                     SGLACNIEEERYSERVYTIREGETLELTCLVTGHPRPQIRWTKTAGSASDRFQDSSVF
                     NETLRITNIQRHQGGRYYCKAENGLGSPAIKSIRVDVYYLDDPVVTVHQSIGEAKEQF
                     YYERTVFLRCVANSNPPVRYSWRRGQEVLLQGSDKGVEIYEPFFTQGETKILKLKNLR
                     PQDYANYSCIASVRNVCNIPDKMVSFRLSNKTASPSIKLLVDDPIVVNPGEAITLVCV
                     TTGGEPAPSLTWVRSFGTLPEKTVLNGGTLTIPAITSDDAGTYSCIANNNVGNPAKKS
                     TNIIVRALKKGRFWITPDPYHKDDNIQIGREVKISCQVEAVPSEELTFSWFKNGRPLR
                     SSERMVITQTDPDVSPGTTNLDIIDLKFTDFGTYTCVASLKGGGISDISIDVNISSST
                     VPPNLTVPQEKSPLVTREGDTIELQCQVTGKPKPIILWSRADKEVAMPDGSMQMESYD
                     GTLRIVNVSREMSGMYRCQTSQYNGFNVKPREALVQLIVQYPPAVEPAFLEIRQGQDR
                     SVTMSCRVLRAYPIRVLTYEWRLGNKLLRTGQFDSQEYTEYAVKSLSNENYGVYNCSI
                     INEAGAGRCSFLVTGKAYAPEFYYDTYNPVWQNRHRVYSYSLQWTQMNPDAVDRIVAY
                     RLGIRQAGQQRWWEQEIKINGNIQKGELITYNLTELIKPEAYEVRLTPLTKFGEGDST
                     IRVIKYSAPVNPHLREFHCGFEDGNICLFTQDDTDNFDWTKQSTATRNTKYTPNTGPN
                     ADRSGSKEGFYMYIETSRPRLEGEKARLLSPVFSIAPKNPYGPTNTAYCFSFFYHMYG
                     QHIGVLNVYLRLKGQTTIENPLWSSSGNKGQRWNEAHVNIYPITSFQLIFEGIRGPGI
                     EGDIAIDDVSIAEGECAKQDLATKNSVDGAVGILVHIWLFPIIVLISILSPRR"
     exon            1090..1229
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1230..1404
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1601
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1734
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..2004
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2005..2334
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2335..2628
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2629..2898
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2899..3047
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3048..3225
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3226..3246
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..3402
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3561
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3562..3692
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3798
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3799..5726
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5701..5706
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /note="hexamer: AATAAA"
     polyA_site      5726
                     /gene="MDGA2"
                     /gene_synonym="c14_5286; MAMDC1"
                     /note="major polyA site"
ORIGIN      
        1 attctccctc tcttgcaagt ggcggtgcct ggactctgct ttcggctccg ggaattggtg
       61 cggccggcca gagcacctct acgctggccg ggcgctaaag gctattttgg agagcggtgg
      121 cggtggcggc tgggctggtg tgcccaagcg agctccagac gcacactccg ctccctgttg
      181 gaccctttcc tcctccttct tccccctcct cccttccctc ttccccaccc ccgttcccct
      241 agccccactc ctcctcttcc tcctcctcct cttcctcctc ctcctcttcc tcctctcccc
      301 gttcggcgat gcgagtctgt atcgtgtaac aggattggcg ttgcaatggc aactgatgga
      361 atgggggaag gcaagacagc agggctgggg gcttcggact gcgggcgggc gggccgctgt
      421 cgccgcttga cgcccctccg gggaccttcg cgagttactt tgtaaaggcg aatccaggca
      481 agagagccct gctcggtgtc ctgggtcaga ggccacttcc tgctcctcgg ctgtccaagc
      541 caggctccta ccgcgcggca cccccggccc cctgcccgcg cccgccgccg gcccagcgcg
      601 ccgccgccgc cgccgcagct gcggagactc gagcccgctt ccctgaagaa cacttcgcct
      661 cgcagctccc cttcccatca ccgccccctg ctcctccccg gcgtctgcga ttttcccagg
      721 cacccggtgt gagtgcggcg tgcgtgtgag tgtgtgtcag ggtattgtgt tgtgggagag
      781 tgtgtgagtg tgtgtgagtg tgtgtgtgca tgagtgtgtg gagtgcgggg ctcctgcgct
      841 ccgctcgccg ccgccgccgg ggaaggacag acggacggcg cttcctcctt cggcgagcgg
      901 ttcccgggca cctcggcttg gcccgggcgc gagtggagcg cgcctggctg gccgccggcc
      961 tcctgaaggt cccgttgcgt accccctggg ctggatatgt tcatgttcac gtgaagatgg
     1021 atttactgta cggtctcgtg tggctgctga cagtcctcct ggaggggatc tctggccaag
     1081 gagtgtacgc tcctcccacg gttcgtattg tgcactcagg cttggcctgt aacattgaag
     1141 aggagcgcta ctccgaaagg gtctacacta tccgggaagg agaaaccctt gagttgactt
     1201 gtctagtcac aggacatcca cgtccacaga tcaggtggac caaaacagca ggaagtgcct
     1261 ctgacagatt ccaagactca agtgtcttca atgagacttt gaggattaca aatattcagc
     1321 gacaccaagg aggccggtat tactgtaaag cagagaatgg cttggggtct ccagcgataa
     1381 agtcaatcag agtggatgta tactatttgg atgatccagt agtaactgtt catcaaagta
     1441 taggtgaagc taaagaacaa ttttactatg agagaacagt gttcctccgg tgtgttgcca
     1501 attccaatcc tcctgttcgg tatagctgga gacgtggcca ggaggtcttg ctgcaaggat
     1561 ctgataaagg agttgagatt tatgaaccat tctttaccca gggtgaaaca aagatcttaa
     1621 aactaaagaa tcttcgacct caggactatg ctaattatag ctgcattgct tcagtgagga
     1681 atgtatgtaa tattcctgat aagatggtgt cgtttagact gtccaataaa acagcatcac
     1741 cgtcaattaa actcttggtg gatgatccta tagttgtaaa tcctggagag gccataacat
     1801 tagtatgtgt tacaacagga ggagagcctg caccttctct cacctgggtc aggtcctttg
     1861 ggactctgcc tgaaaagact gttttgaatg gaggaacttt gaccatacct gccatcacct
     1921 cagatgatgc tggtacttac agctgcattg ccaataataa tgtgggaaac cctgcaaaaa
     1981 agtccaccaa catcattgtg agagcattaa aaaaaggacg attttggatc acaccagatc
     2041 cttatcacaa agatgacaac atccagattg gccgtgaggt gaaaatatct tgccaagtag
     2101 aagctgttcc ttctgaggag ctaacattta gttggtttaa aaatggtcgt ccattaagaa
     2161 gttctgagcg gatggtcatt acacagactg atcctgatgt ctctccggga acaacaaact
     2221 tggacatcat tgatttaaaa ttcacggatt ttgggacgta cacatgtgta gcatctctga
     2281 agggaggagg aatatctgat atcagtatcg atgttaatat atccagcagc acagttccac
     2341 ccaatctgac tgttccacag gaaaaatcac cattggtcac cagagaagga gacacaatag
     2401 aactgcaatg tcaagtaact ggcaaaccta aaccaatcat cctttggtct agagcggata
     2461 aagaagttgc aatgcctgat ggatcaatgc aaatggagag ttatgatgga acactgagga
     2521 ttgtgaatgt atctagggaa atgtcaggaa tgtacagatg tcagaccagc caatacaatg
     2581 gatttaacgt gaaaccaagg gaagccttgg tgcagctcat cgttcagtat ccccctgcag
     2641 tggaaccagc attcttggaa atccggcaag gacaggatcg aagtgtcact atgagttgca
     2701 gagtactgag agcctatcca atacgggtgc tgacctatga gtggcgcttg ggcaataaat
     2761 tattacggac gggtcaattt gactctcagg aatacacaga gtacgctgtg aagagtcttt
     2821 ccaatgaaaa ctatggggtt tataactgta gcatcataaa tgaagctgga gctgggagat
     2881 gcagctttct tgttacagga aaggcctatg ctccagaatt ctattatgat acctacaatc
     2941 cagtatggca gaacagacac cgtgtttatt cttacagtct acagtggaca cagatgaatc
     3001 ctgatgcagt ggatcggatt gttgcatacc ggttgggcat caggcaggct ggacagcagc
     3061 gctggtggga gcaggagatt aaaataaatg ggaatattca aaagggagaa ttaattacat
     3121 ataacttgac agagctaatt aaaccagaag cttatgaagt ccgactgact cctctcacca
     3181 aatttggtga aggagattca acaattcgtg tgatcaaata tagtgctcct gtaaatcctc
     3241 atttgagaga atttcattgt ggatttgaag atggtaatat ttgtttgttc actcaagatg
     3301 atacagataa ttttgactgg acaaagcaaa gtacagcaac aagaaataca aaatatactc
     3361 ctaatacagg acctaatgct gaccgtagtg gctccaaaga aggtttttat atgtacattg
     3421 agacatcacg acccagattg gaaggcgaaa aggctcgact tctcagccct gttttcagca
     3481 tagctcccaa aaacccttat ggacccacaa acactgcata ttgtttcagc ttcttttatc
     3541 acatgtatgg acaacatata ggtgtcttaa atgtttatct acgtttgaaa gggcaaacaa
     3601 caatagagaa tccactgtgg tcttcaagtg ggaataaagg acaaagatgg aatgaggctc
     3661 atgttaatat atacccaatt acttcatttc agctcatttt tgaaggtatc cgaggtcctg
     3721 gaatagaagg tgacattgct attgatgatg tatcaattgc agaaggagaa tgtgcaaaac
     3781 aagacctagc aactaagaat tccgttgatg gtgctgttgg gattttggtt catatatggc
     3841 tttttcccat tatcgtcctc atctctatct taagtcctcg aaggtgacct tatcctggca
     3901 gaggctataa aagattcacc aggcactggc atgaagaaag agtctttgta aatggacatt
     3961 gaacaaacaa actaccaaag attcctccac tgactactga ctcaaaaata aaataataaa
     4021 aacaaatttt tttaagcact ggggataaaa agacatcatg gaagtataac ttattccaga
     4081 ctaaacataa aagataatct tgacctgagt agagaagaga ccttcaggtg cttttgtggc
     4141 taaaaagatt acagcgtcat ctggttgaac tctggaaaaa aaaaaaaaaa tgaaaaaaag
     4201 aaaaaaaaaa gagctataga aatccttgtc aaagcacaaa gtcatggctg gttttgtttc
     4261 aaatgaatag tttgcttgtt accatggaaa cctaatggcc tgccaacaaa aacctcactg
     4321 taaacagggt acgtgaagag ctggcattta ttttccttac gagaaggttt tcgtagagaa
     4381 ttaaataaat gtaggccctt ttacctttgg ctgttaccct tccttgaaaa taacccgaac
     4441 tcagaattat ttaaagcatt catgtttctc cccaccttat ccccatccca cctttattat
     4501 tattattttt ctcccatggc taagctagat aactgtatgc tgtctctttt tgcatgcact
     4561 actatccagg atggtaaacc tgggcttaca tgttacacag gcttatcgga gtttgcttgc
     4621 ggccacttga acacccaaac tacgtcatct gttccaatga agaaaccaaa ccaccatctt
     4681 ttataaattg ccatggaaac caagtgcctt caatgaaaca agcctgaata attttcaact
     4741 cagaagcttg cactgctaag agtggtttgt gtaaaactat tttataaaca aactacagag
     4801 cctaaatgtg caaattacag gcaagacaac aaagccgctt ctgaagaaga aaggaccgaa
     4861 gctgctgcgt aagcccatgc agacaagata tttgttgttt aacctcctag acagccatgg
     4921 cctttcggct tattgtccat tagaaaatca cttccattga gaccagacat ggagcaacac
     4981 tttttttctt ccaggttatt aaatgggtca accagagcaa aaggttatta agaatactta
     5041 gtgcagaagg tggtaaaaca caaaagtgat ttttttactc taacctccat ttgaaatgaa
     5101 attggcccta gctttagagg gaacaagaaa atgtttggga ttgcagtgca tactaactct
     5161 acagtggaac tgggcctgaa aaatctggct ttattctaaa ctctgagggt aatatgcctc
     5221 tgccctttag tcagactctg tgcaaattgt gaaatattat tttattattt taccaagatt
     5281 ataaaaacac ttttacaaaa aaacaaaaac ctgtaaaaat aattttgagc tacctgacga
     5341 caaatcatat ctttaaccag ccagttttcc aatgcattgt aaatttcact taaacctgtt
     5401 ggttatgaaa atttgaagat cattttcctt aaattatctc agcttttaac ttcatttaaa
     5461 aagacttttg tctaagaaga atattattat tatatgttct ttcaacaccc caggattaaa
     5521 aaaactgatt atgcaagcaa ttggaatata agtattaaat tatagcattt gcaaatatta
     5581 atataaaagc acaacaaaat gtagtggaaa atgacaaagc ttgtttttta aaacaattct
     5641 gtagaaatgt ttgtgcaaat tcagtaattc aacttaaaat ataattttac agctatgttc
     5701 aataaagcct ctttccaggt aaggta
//
