LOCUS       NM_153487              10629 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens MAM domain containing glycosylphosphatidylinositol
            anchor 1 (MDGA1), mRNA.
ACCESSION   NM_153487
VERSION     NM_153487.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10629)
  AUTHORS   Gangwar,S.P., Zhong,X., Seshadrinathan,S., Chen,H., Machius,M. and
            Rudenko,G.
  TITLE     Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin
            Trans-synaptic Bridges
  JOURNAL   Neuron 94 (6), 1132-1141 (2017)
   PUBMED   28641112
  REMARK    GeneRIF: MDGAs regulate the formation of neuroligin-neurexin
            trans-synaptic bridges by sterically blocking access of neurexins
            to neuroligins.
REFERENCE   2  (bases 1 to 10629)
  AUTHORS   Navarini,A.A., Simpson,M.A., Weale,M., Knight,J., Carlavan,I.,
            Reiniche,P., Burden,D.A., Layton,A., Bataille,V., Allen,M.,
            Pleass,R., Pink,A., Creamer,D., English,J., Munn,S., Walton,S.,
            Willis,C., Deret,S., Voegel,J.J., Spector,T., Smith,C.H.,
            Trembath,R.C. and Barker,J.N.
  CONSRTM   Acne Genetic Study Group
  TITLE     Genome-wide association study identifies three novel susceptibility
            loci for severe Acne vulgaris
  JOURNAL   Nat Commun 5, 4020 (2014)
   PUBMED   24927181
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10629)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   4  (bases 1 to 10629)
  AUTHORS   Li,J., Liu,J., Feng,G., Li,T., Zhao,Q., Li,Y., Hu,Z., Zheng,L.,
            Zeng,Z., He,L., Wang,T. and Shi,Y.
  TITLE     The MDGA1 gene confers risk to schizophrenia and bipolar disorder
  JOURNAL   Schizophr Res 125 (2-3), 194-200 (2011)
   PUBMED   21146959
  REMARK    GeneRIF: The MDGA1 gene may confer risk to schizophrenia and
            bipolar disorder in Chinese Han population.
REFERENCE   5  (bases 1 to 10629)
  AUTHORS   Kahler,A.K., Djurovic,S., Kulle,B., Jonsson,E.G., Agartz,I.,
            Hall,H., Opjordsmoen,S., Jakobsen,K.D., Hansen,T., Melle,I.,
            Werge,T., Steen,V.M. and Andreassen,O.A.
  TITLE     Association analysis of schizophrenia on 18 genes involved in
            neuronal migration: MDGA1 as a new susceptibility gene
  JOURNAL   Am J Med Genet B Neuropsychiatr Genet 147B (7), 1089-1100 (2008)
   PUBMED   18384059
  REMARK    GeneRIF: MDGA1 is a new schizophrenia susceptibility gene, and
            altered neuronal migration is involved in SZ pathology.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 10629)
  AUTHORS   Liu,T., Qian,W.J., Gritsenko,M.A., Camp,D.G. 2nd, Monroe,M.E.,
            Moore,R.J. and Smith,R.D.
  TITLE     Human plasma N-glycoproteome analysis by immunoaffinity
            subtraction, hydrazide chemistry, and mass spectrometry
  JOURNAL   J Proteome Res 4 (6), 2070-2080 (2005)
   PUBMED   16335952
REFERENCE   7  (bases 1 to 10629)
  AUTHORS   Diaz-Lopez,A., Rivas,C., Iniesta,P., Moran,A., Garcia-Aranda,C.,
            Megias,D., Sanchez-Pernaute,A., Torres,A., Diaz-Rubio,E., Benito,M.
            and De Juan,C.
  TITLE     Characterization of MDGA1, a novel human
            glycosylphosphatidylinositol-anchored protein localized in lipid
            rafts
  JOURNAL   Exp Cell Res 307 (1), 91-99 (2005)
   PUBMED   15922729
  REMARK    GeneRIF: MDGA1, a novel glycosylphosphatidylinositol-anchored
            protein, is localized in lipid rafts.
REFERENCE   8  (bases 1 to 10629)
  AUTHORS   Litwack,E.D., Babey,R., Buser,R., Gesemann,M. and O'Leary,D.D.
  TITLE     Identification and characterization of two novel brain-derived
            immunoglobulin superfamily members with a unique structural
            organization
  JOURNAL   Mol Cell Neurosci 25 (2), 263-274 (2004)
   PUBMED   15019943
REFERENCE   9  (bases 1 to 10629)
  AUTHORS   De Juan,C., Iniesta,P., Gonzalez-Quevedo,R., Moran,A.,
            Sanchez-Pernaute,A., Torres,A.J., Balibrea,J.L., Diaz-Rubio,E.,
            Cruces,J. and Benito,M.
  TITLE     Genomic organization of a novel glycosylphosphatidylinositol MAM
            gene expressed in human tissues and tumors
  JOURNAL   Oncogene 21 (19), 3089-3094 (2002)
   PUBMED   12082541
  REMARK    GeneRIF: A novel human gene mapped to chromosome 6p21, encodes a
            putative glycosylphosphatidylinositol (GPI) anchored protein
            containing a MAM (meprin, A5 antigen, protein tyrosine phosphatase
            mu) domain. (GPIM)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049553.20 and AF478693.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_153487.3.
            
            Summary: This gene encodes a glycosylphosphatidylinositol
            (GPI)-anchored cell surface glycoprotein that is expressed
            predominantly in the developing nervous system. In addition to
            possessing several cell adhesion molecule-like domains, the mature
            protein has six Ig-like domains, a single fibronectin type III
            domain, a MAM domain and a C-terminal GPI-anchoring site. Studies
            in other mammals suggest this protein plays a role in cell
            adhesion, migration, and axon guidance and, in the developing
            brain, neuronal migration. In humans, this gene is associated with
            bipolar disorder and schizophrenia. [provided by RefSeq, Oct 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF478693.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000434837.8/ ENSP00000402584.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1139              AL049553.20        120682-121820       c
            1140-1454           AF478693.1         1247-1561
            1455-1651           AL049553.20        79637-79833         c
            1652-8800           AF478693.1         1759-8907
            8801-10629          AL049553.20        54616-56444         c
FEATURES             Location/Qualifiers
     source          1..10629
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.2"
     gene            1..10629
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="MAM domain containing glycosylphosphatidylinositol
                     anchor 1"
                     /db_xref="GeneID:266727"
                     /db_xref="HGNC:HGNC:19267"
                     /db_xref="MIM:609626"
     exon            1..1139
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             1073..3940
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="GPI and MAM protein; MAM domain-containing protein
                     3; glycosylphosphatidylinositol-MAM"
                     /codon_start=1
                     /product="MAM domain-containing
                     glycosylphosphatidylinositol anchor protein 1
                     preproprotein"
                     /protein_id="NP_705691.1"
                     /db_xref="CCDS:CCDS47417.1"
                     /db_xref="GeneID:266727"
                     /db_xref="HGNC:HGNC:19267"
                     /db_xref="MIM:609626"
                     /translation="MEVTCLLLLALIPFHCRGQGVYAPAQAQIVHAGQACVVKEDNIS
                     ERVYTIREGDTLMLQCLVTGHPRPQVRWTKTAGSASDKFQETSVFNETLRIERIARTQ
                     GGRYYCKAENGVGVPAIKSIRVDVQYLDEPMLTVHQTVSDVRGNFYQEKTVFLRCTVN
                     SNPPARFIWKRGSDTLSHSQDNGVDIYEPLYTQGETKVLKLKNLRPQDYASYTCQVSV
                     RNVCGIPDKAITFRLTNTTAPPALKLSVNETLVVNPGENVTVQCLLTGGDPLPQLQWS
                     HGPGPLPLGALAQGGTLSIPSVQARDSGYYNCTATNNVGNPAKKTVNLLVRSMKNATF
                     QITPDVIKESENIQLGQDLKLSCHVDAVPQEKVTYQWFKNGKPARMSKRLLVTRNDPE
                     LPAVTSSLELIDLHFSDYGTYLCMASFPGAPVPDLSVEVNISSETVPPTISVPKGRAV
                     VTVREGSPAELQCEVRGKPRPPVLWSRVDKEAALLPSGLPLEETPDGKLRLERVSRDM
                     SGTYRCQTARYNGFNVRPREAQVQLNVQFPPEVEPSSQDVRQALGRPVLLRCSLLRGS
                     PQRIASAVWRFKGQLLPPPPVVPAAAEAPDHAELRLDAVTRDSSGSYECSVSNDVGSA
                     ACLFQVSAKAYSPEFYFDTPNPTRSHKLSKNYSYVLQWTQREPDAVDPVLNYRLSIRQ
                     LNQHNAVVKAIPVRRVEKGQLLEYILTDLRVPHSYEVRLTPYTTFGAGDMASRIIHYT
                     EPINSPNLSDNTCHFEDEKICGYTQDLTDNFDWTRQNALTQNPKRSPNTGPPTDISGT
                     PEGYYMFIETSRPRELGDRARLVSPLYNASAKFYCVSFFYHMYGKHIGSLNLLVRSRN
                     KGALDTHAWSLSGNKGNVWQQAHVPISPSGPFQIIFEGVRGPGYLGDIAIDDVTLKKG
                     ECPRKQTDPNKVVVMPGSGAPCQSSPQLWGPMAIFLLALQR"
     exon            1140..1279
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1454
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1651
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1652..1784
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..2054
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2384
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2681
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2682..2966
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2967..3118
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3119..3296
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3297..3320
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3321..3473
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3474..3608
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3739
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3740..3848
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3849..10629
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4182..4187
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="hexamer: ATTAAA"
     polyA_site      4205
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="major polyA site"
     regulatory      8770..8775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="hexamer: AATAAA"
     polyA_site      8791
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="major polyA site"
     regulatory      10611..10616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
                     /note="hexamer: AATAAA"
     polyA_site      10629
                     /gene="MDGA1"
                     /gene_synonym="GPIM; MAMDC3"
ORIGIN      
        1 acagcaaagc ccaagttgct gagcgagcgg agcgctcccg cggcccggag ccgagcggcc
       61 gccgcgcccc ggagcccggc ccggccccgc ccgctctggg cccccgcagg ccaaggccgc
      121 cgggcggggg cggggacgac caacttgggg cgcggcgtag ccccgctctc ccgagagctc
      181 ggagcccggg agggctacgg ccgcggccag acggcgggag aggagcgcgg cgagcggagg
      241 cggcgagcgg cgcccgcgcc gcagccccgg cctgggcgag agcgcgaata tttttcaaaa
      301 gactcaaact ttcctccttt ccccgttttc tggggccctt cttgcctgga attgctctcc
      361 agattcccgc ggggcgccgg gctgctattc ttcccccggg tttatcggcg gctcggctaa
      421 cttcacggac ccggggaccc gcggcgctcg tccctcggcc gaacccagcc cgcgctgctc
      481 cccggatcag gagggccggg cccggggctg cttcgccgcc gcgagtgctt tcagcccggc
      541 cccctggagt cgggccgctg agcccacggc agcggccgca ggactggaaa cagcagattg
      601 attaactcga gcggagcccc ggcctccccg actccgctcc gctgaggggc ggccccagtg
      661 cggggaaacg acaagtttgt cagtcgtccg tggcctgttg gatcgaagcg ccgcctccgc
      721 cgccgagagg tccccggcgc ctagcatccc gcgcggacgg ccctgggtac ccggggcggc
      781 tcggcggccg ggctcctcgg gtcggggcgc tggctgctgt gccgggcgcg ccgaggcacc
      841 cggggctggg ccagcgcccc ctgcgtcccc acgcgggcag cggccccgcc ggaggagaaa
      901 cacgggtcgc cgccacctcc gcctcttcag tctcctggtc ttcgtcgccg ctctctctct
      961 cacctctcag ggaaaggggg ggacataggg gcgtcgcggg gccccggcga atgcgccccc
     1021 cgccgcctct cgggctgcgc cgcctcgcgg ggatgaagca ccggccgtga agatggaggt
     1081 gacctgcctt ctacttctgg cgctgatccc cttccactgc cggggacaag gagtctacgc
     1141 tccagcccag gcgcagatcg tgcatgcggg ccaggcatgt gtggtgaaag aggacaatat
     1201 cagcgagcgt gtctacacca tccgggaggg ggacaccctc atgctgcagt gccttgtaac
     1261 agggcaccct cgaccccagg tacggtggac caagacggca ggtagcgcct cggacaagtt
     1321 ccaggagaca tcggtgttca acgagacgct gcgcatcgag cgtattgcac gcacgcaggg
     1381 cggccgctac tactgcaagg ctgagaacgg cgtgggggtg ccggccatca agtccatccg
     1441 cgtggacgtg cagtacctgg atgagccaat gctgacggtg caccagacgg tgagcgatgt
     1501 gcgaggcaac ttctaccagg agaagacggt gttcctgcgc tgtactgtca actccaaccc
     1561 gcctgcccgc ttcatctgga agcggggttc cgatacccta tcccacagcc aggacaatgg
     1621 ggttgacatc tatgagcccc tctacactca gggggagacc aaggtcctga agctgaagaa
     1681 cctgcggccc caggactatg ccagctacac ctgccaggtg tctgtgcgta acgtgtgcgg
     1741 catcccagac aaggccatca ccttccggct caccaacacc acggcaccac cagccctgaa
     1801 gctgtctgtg aacgaaactc tggtggtgaa ccctggggag aatgtgacgg tgcagtgtct
     1861 gctgacaggc ggtgatcccc tcccccagct gcagtggtcc catgggcctg gcccactgcc
     1921 cctgggtgct ctggcccagg gtggcaccct cagcatccct tcagtgcagg cccgggactc
     1981 tggctactac aactgcacag ccaccaacaa tgtgggcaac cctgccaaga agactgtcaa
     2041 cctgctggtg cgatccatga agaacgctac attccagatc actcctgacg tgatcaaaga
     2101 gagtgagaac atccagctgg gccaggacct gaagctatcg tgccacgtgg atgcagtgcc
     2161 ccaggagaag gtgacctacc agtggttcaa gaatggcaag ccggcacgca tgtccaagcg
     2221 gctgctggtg acccgcaatg atcctgagct gcccgcagtc accagcagcc tagagctcat
     2281 tgacctgcac ttcagtgact atggcaccta cctgtgcatg gcttctttcc caggggcacc
     2341 cgtgcccgac ctcagcgtcg aggtcaacat ctcctctgag acagtgccgc ccaccatcag
     2401 tgtgcccaag ggtagggccg tggtgaccgt gcgcgaggga tcgcctgccg agctgcaatg
     2461 cgaggtgcgg ggcaagccgc ggccgccagt gctctggtcc cgcgtggaca aggaggctgc
     2521 actgctgccc tcggggctgc ccctggagga gactccggac gggaagctgc ggctggagcg
     2581 agtgagccga gacatgagcg ggacctaccg ctgccagacg gcccgctata atggcttcaa
     2641 cgtgcgcccc cgtgaggccc aggtgcagct gaacgtgcag ttcccgccgg aggtggagcc
     2701 cagttcccag gacgtgcgcc aggcgctggg ccggcccgtg ctcctgcgct gctcgctgct
     2761 gcgaggcagc ccccagcgca tcgcctcggc tgtgtggcgt ttcaaagggc agctgctgcc
     2821 gccgccgcct gttgttcccg ccgccgccga ggcgccggat cacgcggagc tgcgcctcga
     2881 cgccgtaact cgcgacagca gcggcagcta cgagtgcagc gtctccaacg atgtgggctc
     2941 ggctgcctgc ctcttccagg tctccgccaa agcctacagc ccggagtttt acttcgacac
     3001 ccccaacccc acccgcagcc acaagctgtc caagaactac tcctacgtgc tgcagtggac
     3061 tcagagggag cccgacgctg tcgaccctgt gctcaactac agactcagca tccgccagtt
     3121 gaaccagcac aatgcggtgg tcaaggccat cccggtccgg cgtgtggaga aggggcagct
     3181 gctggagtac atcctgaccg atctccgtgt gccccacagc tatgaggtcc gcctcacacc
     3241 ctataccacc ttcggggctg gtgacatggc ctcccgcatc atccactaca cagagcccat
     3301 caactctccg aacctttcag acaacacctg ccactttgag gatgagaaga tctgtggcta
     3361 tacccaggac ctgacagaca actttgactg gacgcggcag aatgccctca cccagaaccc
     3421 caaacgctcc cccaacactg gtccccccac cgacataagt ggcacccctg agggctacta
     3481 catgttcatc gagacatcga ggcctcggga gctgggggac cgtgcaaggt tagtgagtcc
     3541 cctctacaat gccagcgcca agttctactg tgtctccttc ttctaccaca tgtacgggaa
     3601 acacatcggc tccctcaacc tcctggtgcg gtcccggaac aaaggggctc tggacacgca
     3661 cgcctggtct ctcagtggca ataagggcaa tgtgtggcag caggcccatg tgcccatcag
     3721 ccccagtggg cccttccaga ttatttttga gggggttcga ggcccgggct acctggggga
     3781 tattgccata gatgacgtca cactgaagaa gggggagtgt ccccggaagc agacggatcc
     3841 caataaagtg gtggtgatgc cgggcagtgg agccccctgc cagtccagcc cacagctgtg
     3901 ggggcccatg gccatcttcc tcttggcgtt gcagagatga tgagagctgt gtggccaccc
     3961 ccccaacctt gcccccggca caccaaagtg tccacattgt accaaagact gacccccgcc
     4021 agctggggtg cccaggggca gggccggccc gccagggagg gggcctgcat tggctgcaag
     4081 gatgagcaga gaacaaggac agaggccagg cactgaggcc ctggagacag ctgttccact
     4141 tgcacacacg cacacactca tgctcacaca cacagagata tattaaagca caagtttcta
     4201 tctgacctgc cagcaccttc tttactgcaa agacagggga cttgcctgaa tggcatccgc
     4261 caacccaggg acctcggcgc aacataggcc ttgtccttgc tgcactcgtg gtgtgcttct
     4321 gactttaccc tgtcccctaa gtcaaggccg aactccagcc tggtggcttt gccagaaggg
     4381 agccagaagt ggggcagaca tggagcccct cccttggtca gactctggga ctcctgagat
     4441 gggagaggca gggatcagag gacgaacagg tgggactttg cgagctctgt gactgtccca
     4501 cgtccaggag acaaggaagg tagggcacct gctgcacacg attctgtcca gagtgagcac
     4561 tggatggtgg agaccatagg tcaccccaga ttccttgacc tatttctggg acaccatatt
     4621 tccctcctca gtgtgcaccc tttgaaggga cccagcacag ggtcttgggc ctgggcagtc
     4681 tgaagactga taacttcccc actccaccct acaagcagtg ggactcctga gaacacggtt
     4741 ctctcctagc ctcagccccc agctgggtct cagaggagct gggggagcgg tggccagccc
     4801 attttctggg gtgaggcttg acttggagaa aggcagaaga gacgtcccgc ttctgtgatt
     4861 tggtgccccc atatcagaca atgaatttgg aagtggagag gggccttcat ttcttatcta
     4921 cttggcatga aagggtgccc tggataggag ggtgtgtaca gggcaaaatg ccaaaaagca
     4981 ctgtctagtt gaaagttccc ttctccaccc aggggcagtg aaggaggagg ggcttataga
     5041 gctgggattg gtggagggag caggtgccag tcccctcact ctctgggagc tgtgaaaggg
     5101 atccctgtcc ttgggtcctg ggttaggcac ctgagattga catgatggga tctagatctt
     5161 tcctccttga catcacctga gcccccacct agccatccat gggagagaga aggcccagcc
     5221 ccttctagaa tgactcttta ggcatgcgtg catatgtgtg tatgtgtttg tgcccgtctg
     5281 tgtctaggta ccaccgtggg tacattgttg ggcaggagtg tgtgcaaaca caggtctgtg
     5341 tgtgcaatct cacatatctg cctgtgagac tggattgaga cccattcgtt tctatgaatg
     5401 tccgtgtacg tcagcgtgtg tgtccacctt cctgagtgat gtgttcgctt gtagggtgct
     5461 ggctgaatag actctgtcca gccctgttct gtagtctcaa gctgcctgcg atggcctgaa
     5521 attccacctt tcatccccta tggatgacgg agagcttaca gatgacccta ttgaatgcaa
     5581 gcacctttgg tgaggagcat cacagggctc cttctggagc atttggtggg gacagctgca
     5641 gagaagaggc ctggaactcg ggcagcactg cagtgccagg aggcaggcgg ggaaccgagg
     5701 caaaggctgc ccatctcccc ctgccaggcc tgtgtgatca ttatcaccaa cagctggtgg
     5761 gtggccgggc caggatgcag cggggccttc tgatgcccaa tcagcacggc tgccttcctg
     5821 acccagtcaa ggcctctgtc tgaaatgagt cgctccaggt tctcagcata cacttccatc
     5881 gcgtctgtcg ggtattgttc cttaactgtc ccatctgtgc agagtccatt gccccaacta
     5941 gactgtgagc tcctcctctg agccttccaa gtcccccctc caccttcgcc acctcccgct
     6001 cgtgcccagc acaagtgagc ctggtgtgga aaccactcca ttgcccggtg gaatggattc
     6061 tgtaatcagt ggttcctggc cttgcctgca gaatagaacc accagagtcc tttaaaaagt
     6121 attgctgctt ggttcccacc tcagaggttc tgagttaatt ggactggagc gcagtcggac
     6181 atcaagaaat gttgaaaagc tccttgggtt ctcctgacag caggaaccac tggcctggca
     6241 ccacctgggt gcttcctctg tgccctcgct ggggtaggca ttggagcacc agagatgaat
     6301 agccccaagt gctccctctt tggggttccc aaggcaccct gtgcctgctt ccctcagagg
     6361 accttccaat ccatttgccc cgcaaccctg gctgctccga caggggagac ttgtctccct
     6421 tgttcccctc aggatccata gagtggacag taaaggtgct cagtacatgt tggctgagct
     6481 gaactgcata catgtggccc ccaggttcct ggtctttatg gacgaagggc acaaggtgga
     6541 ggggggatgg ggggatgctg ctggaggtct cagtgggtgc agacagccct gccttgagga
     6601 tggcttgacc tgggattgac aaaatgtgtc tgctgaaatg ctgaggtccc cacgtgtgaa
     6661 tgggtgaggc tgatgtggat gtctgtgtgt gccagcaggt gggtggggga tgtgggtgtc
     6721 agtgtatgcc agtgggcact gtaaatgtct aggcatgtgc tggtctctgt gtgtttgtgt
     6781 gttcctcagc aggaatgagt gtctttgtgt atcacctggt gacttgtcag tgtctgtgtc
     6841 tgtgtgtgcc tgtgagccag catctctgta tcagtgttgc tcatgctgtg tctttgtgcg
     6901 ccatggtgtg tcagtgtctg tgtgttgatg ggtggcccat gagtgacccc cgccagggga
     6961 gaccaggctg gctggatcca gcacatctcc ccagtggcag cctcgccctc tgggtcaggg
     7021 tgactgaggc attttgtggc cttaaaacgg ggtgttcagg gtcagccctc agggtgctgg
     7081 ggcccttcca tcccttgtcc ccttcaggtt ggtgaaaagg actccggggg ccaggtgctg
     7141 tatagcagct tatggaagtc tcagctgggc tatcctgccc ttgggagcac agacaggctc
     7201 ctagggtgct gagtgaagcc tgaagaccaa gccccctcct cctggaatgc tccttccacc
     7261 cctacctctc agagatgggc ctgacacctc tttctcattc attctccttt tccctgtgct
     7321 ctgggaaagc ccctggctca ggctgtcaga gtgaggatgg acctcaaaag tttgatcccc
     7381 tcgtgcagat gaagaagctg aagcccagag tggggaaggg gagtggccca aggtcacaca
     7441 gctagtttga gtagagccag tcttgggaga gccaagtact acagccctgg gggtgtcaca
     7501 ccgcttgtca ctgcccctga ggtctcctgc caaacaactg cagggagttt ggctaacagt
     7561 cctgtgtcca gggtgccggt ggggatgtta tagatgttgc tgggatcctg ccctcggctc
     7621 caaattctgg cctctcatcc caggctgcag acccttctgc cccatgacag gcctgggtgc
     7681 cacacagagg tggccaccct cccaccacag tgtctgcagc tgctgccctt ctcccaggcc
     7741 cccagacaga agagaccctg tttcccctcc tctcccctgt gacttcacaa gagcttgggc
     7801 taggagtgaa ggtcagcatg ttctcatgtg ctcatcctct tggtttcccc aaagaccggg
     7861 agggtcacgg atggggcgtg cagaatcctt gtgttttttc tcgctgggca gcttgagggg
     7921 ctggggagta ttcccagggt ctttgctctg gagagtccct gcagagccac tggctgaggt
     7981 tgggttcagg gttcagcgga gtcctccatg cttccaaagg ccgggaagca cccgcctctc
     8041 tatcgagtca gtgctgtgcg tgtgtgtctg agaatgtgtg tgatgtgtgg agtgtgcgtg
     8101 tgtttgtgtg tgtgtgtgtg tgtgttgggg cagaaggacc actctttcct ggggatccct
     8161 tgacccttat aactagaagg gaccttaggg agcatctaag ctggtgcccc cattgtacag
     8221 gcgaggtcca gagggatggc atctgcccac cccacccctt gccctcttgt tgcctgcact
     8281 catttcccag ggaccctcct aggataggac tgccctcctt cctggccccc tcccgccatc
     8341 ctcccagcca cccacataat caccatctca gcccaactct ggtggccctc taggtctcca
     8401 tgcattcttc ctgccctaga gtagccagct caccaaggcc tttatcccca gcccaggaga
     8461 agggtcaggg agggaagggg ctgcaccagc cctgagacct caaagacttg ggagaaaagc
     8521 caaaactcct catgcccagg cccacatgtc tgaccacccc agcccacccc gccaccaagg
     8581 taaaagcaca acaggagacc cccttattaa tgggtgaaat gattggggtt gtttttttag
     8641 tcacacagcc ccatcctcac ccctttgcct tgctgtctgt ctccacccca gcctctgttc
     8701 cccatttgcc tctctttcac ctccaagccc ccaaatgtaa cctctagttg cggacgcggt
     8761 tgttctatca ataaagctgc agtgttctag cgctcagcgt cagccgtgtg tgttggcagg
     8821 gcagagtggg ccagggtcgg ggccggggca ctggagggct cctctcagct ccctgggggc
     8881 agcctttctt ctctttggca cctgtcgaca gggatcctgc tctgtggcct ggacagtgag
     8941 gacctgcatc ctggtctgct cccagtgaac ttgtgtgcat ttgttcattc agcaaatacc
     9001 aaccaaacac tgcctttgtg gaagcccctg tttaatggga gagatggaca gtaagctaat
     9061 aatgacacca agacatatat aatgatgtgt acagtgaggg ctgggaaggg aaattggtgc
     9121 tatgaaagaa ggtatgaaga gggttcttat ttgggttggg gcttcgggga agacttctct
     9181 aagagacatt taggagagac agaatgattg gagttagcct gttgggattg ggagaggctt
     9241 ctgagcagag ggaacagaat atgcaaaggc caacagggcc caaaaactta gaaggctcaa
     9301 ggaaggggag taagggcaaa ggaggaggac taaagttggt atggtggttg aaatgccatt
     9361 ttcccttctc ggcacccaac cctaccatcc ctcctacacg cttggagtcc cttccctctt
     9421 aatctctatt ctggccctac agaccccacc ctgcacccta cttggggctg cctcccttat
     9481 tcaccaccag ctagctgcat ccttgcccta agatcaagtt atgccaacct ttccctttac
     9541 cccagacctc tcagaattct agaatttcag agctaggagg tccttaaagg tcacttattt
     9601 caaacatcta ctcatatatt gtaggtgaga tgggcttgcc aaggtcatgg ggataggcag
     9661 tgatgagcat ttgcaaagtg accccaaatc aagggtgtgg atgtcatgat atggactaca
     9721 tcatatcagg caaatgacag gaagtgtctt tcaggttact tggttacaat gattcaggta
     9781 ggtcgattgg gcagtttcac ttccatgttc cagatgggga aactgaagct cagattacaa
     9841 gaccaagggc tccctctccc taccacctaa gttttattgg ctctcatgtt gggtaacttc
     9901 ttgctggcac acctggcctt tcttttctaa tggaagagga agggtctaag ggactcacca
     9961 ctgctgtagg ttggctccct gagcacagga agagaaatcc gctcaagctc actcaagtac
    10021 aggtgcatta ttgtgaggac aaacacagtg agggggatgg gcactcagaa atccaaacag
    10081 gagttgcaac agggatggtt ttcctgaacc agatgggcat tttggattca aggtagctct
    10141 aggatcatca tctacagaag tttctggtgc ttctgtattc ttctggtgct tctgtattct
    10201 acctgtggta gaataaagat ggctgcaaat cccatgttat ccttcctgta gagaggcaga
    10261 gtctaattcc cttcctcttg aatctgggtt gctcttagtg ccttgtttgt gcaatagaat
    10321 gtgacatgct gagttgaaga tgccttggag cttcagctca ggcctcttgg aacgttctct
    10381 ctggaagccc tgaactgcca cctaggatgt cctctgagtt gctctgagac cgtcatgctg
    10441 gaggggctct ggctgaccat cccagctgag tccagccttc cagccatctc caccaaagca
    10501 ccagaagata tgggagtgca gctgcctcag accttccaga ccagcctaac tgccacctga
    10561 attgctcggc caagctctgt ccaaattcct gacccatcgt catgggatat aataaaatag
    10621 ttgttttaa
//
