LOCUS       XM_047419580            7170 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens mediator of DNA damage checkpoint 1 (MDC1),
            transcript variant X1, mRNA.
ACCESSION   XM_047419580
VERSION     XM_047419580.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000006.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7170
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
     gene            1..7170
                     /gene="MDC1"
                     /gene_synonym="NFBD1"
                     /note="mediator of DNA damage checkpoint 1; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 54 ESTs, 740 long SRA reads, 3 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments"
                     /db_xref="GeneID:9656"
                     /db_xref="HGNC:HGNC:21163"
                     /db_xref="MIM:607593"
     CDS             180..6512
                     /gene="MDC1"
                     /gene_synonym="NFBD1"
                     /codon_start=1
                     /product="mediator of DNA damage checkpoint protein 1
                     isoform X1"
                     /protein_id="XP_047275536.1"
                     /db_xref="GeneID:9656"
                     /db_xref="HGNC:HGNC:21163"
                     /db_xref="MIM:607593"
                     /translation="MGHPTFPTCQQFPSRVAYFQIMEDTQAIDWDVEEEEETEQSSES
                     LRCNVEPVGRLHIFSGAHGPEKDFPLHLGKNVVGRMPDCSVALPFPSISKQHAEIEIL
                     AWDKAPILRDCGSLNGTQILRPPKVLSPGVSHRLRDQELILFADLLCQYHRLDVSLPF
                     VSRGPLTVEETPRVQGETQPQRLLLAEDSEEEVDFLSERRMVKKSRTTSSSVIVPESD
                     EEGHSPVLGGLGPPFAFNLNSDTDVEEGQQPATEEASSAARRGATVEAKQSEAEVVTE
                     IQLEKDQPLVKERDNDTKVKRGAGNGVVPAGVILERSQPPGEDSDTDVDDDSRPPGRP
                     AEVHLERAQPFGFIDSDTDAEEERIPATPVVIPMKKRKIFHGVGTRGPGAPGLAHLQE
                     SQAGSDTDVEEGKAPQAVPLEKSQASMVINSDTDDEEEVSAALTLAHLKESQPAIWNR
                     DAEEDMPQRVVLLQRSQTTTERDSDTDVEEEELPVENREAVLKDHTKIRALVRAHSEK
                     DQPPFGDSDDSVEADKSSPGIHLERSQASTTVDINTQVEKEVPPGSAIIHIKKHQVSV
                     EGTNQTDVKAVGGPAKLLVVSLEEAWPLHGDCETDAEEGTSLTASVVADVRKSQLPAE
                     GDAGAEWAAAVLKQERAHEVGAQGGPPVAQVEQDLPISRENLTDLVVDTDTLGESTQP
                     QREGAQVPTGREREQHVGGTKDSEDNYGDSEDLDLQATQCFLENQGLEAVQSMEDEPT
                     QAFMLTPPQELGPSHCSFQTTGTLDEPWEVLATQPFCLRESEDSETQPFDTHLEAYGP
                     CLSPPRAIPGDQHPESPVHTEPMGIQGRGRQTVDKVMGIPKETAERVGPERGPLERET
                     EKLLPERQTDVTGEEELTKGKQDREQKQLLARDTQRQESDKNGESASPERDRESLKVE
                     IETSEEIQEKQVQKQTLPSKAFEREVERPVANRECDPAELEEKVPKVILERDTQRGEP
                     EGGSQDQKGQASSPTPEPGVGAGDLPGPTSAPVPSGSQSGGRGSPVSPRRHQKGLLNC
                     KMPPAEKASRIRAAEKVSRGDQESPDACLPPTVPEAPAPPQKPLNSQSQKHLAPPPLL
                     SPLLPSIKPTVRKTRQDGSQEAPEAPLSSELEPFHPKPKIRTRKSSRMTPFPATSAAP
                     EPHPSTSTAQPVTPKPTSQATRSRTNRSSVKTPEPVVPTAPELQPSTSTDQPVTSEPT
                     SQVTRGRKSRSSVKTPETVVPTALELQPSTSTDRPVTSEPTSQATRGRKNRSSVKTPE
                     PVVPTAPELQPSTSTDQPVTSEPTYQATRGRKNRSSVKTPEPVVPTAPELRPSTSTDR
                     PVTPKPTSRTTRSRTNMSSVKTPETVVPTAPELQISTSTDQPVTPKPTSRTTRSRTNM
                     SSVKNPESTVPIAPELPPSTSTEQPVTPEPTSRATRGRKNRSSGKTPETLVPTAPKLE
                     PSTSTDQPVTPEPTSQATRGRTNRSSVKTPETVVPTAPELQPSTSTDQPVTPEPTSQA
                     TRGRTDRSSVKTPETVVPTAPELQASASTDQPVTSEPTSRTTRGRKNRSSVKTPETVV
                     PAAPELQPSTSTDQPVTPEPTSRATRGRTNRSSVKTPESIVPIAPELQPSTSRNQLVT
                     PEPTSRATRCRTNRSSVKTPEPVVPTAPEPHPTTSTDQPVTPKLTSRATRRKTNRSSV
                     KTPKPVEPAASDLEPFTPTDQSVTPEAIAQGGQSKTLRSSTVRAMPVPTTPEFQSPVT
                     TDQPISPEPITQPSCIKRQRAAGNPGSLAAPIDHKPCSAPLEPKSQASRNQRWGAVRA
                     AESLTAIPEPASPQLLETPIHASQIQKVEPAGRSRFTPELQPKASQSRKRSLATMDSP
                     PHQKQPQRGEVSQKTVIIKEEEEDTAEKPGKEEDVVTPKPGKRKRDQAEEEPNRIPSR
                     SLRRTKLNQESTAPKVLFTGVVDARGERAVLALGGSLAGSAAEASHLVTDRIRRTVKF
                     LCALGRGIPILSLDWLHQSRKAGFFLPPDEYVVTDPEQEKNFGFSLQDALSRARERRL
                     LEGYEIYVTPGVQPPPPQMGEIISCCGGTYLPSMPRSYKPQRVVITCPQDFPHCSIPL
                     RVGLPLLSPEFLLTGVLKQEAKPEAFVLSPLEMSST"
ORIGIN      
        1 gaccgttact ggtggcgcgc gcggggactt aaagtaggta tgaagacaca gggagacgtc
       61 gggccacaag ggaacccact gaggtgggga ccaaagatgg tggctctttg aattggagcc
      121 aagcgtggtg ggcacccgct gagttggcct gtcataaaga cggagttgac actttatcca
      181 tggggcatcc tactttccct acctgtcaac agtttccctc tagagtggca tattttcaga
      241 tcatggagga cacccaggct attgactggg atgttgaaga agaggaggag acagagcaat
      301 ccagtgaatc cttgaggtgt aacgtggagc cagtagggcg gctacatatc tttagtggtg
      361 cccatggacc agaaaaagat ttcccactac acctcgggaa gaatgtggta ggccgaatgc
      421 ctgactgctc tgtggccctg ccctttccat ctatctccaa acaacatgca gagattgaaa
      481 tcttagcctg ggacaaggca cctatcctcc gagactgtgg gagccttaat ggtactcaaa
      541 tcctgagacc tcctaaggtt ttgagccctg gggtgagtca ccgtctgagg gaccaggaat
      601 tgattctctt tgctgacttg ctctgccagt accatcgcct ggatgtctct ctgccctttg
      661 tctcccgggg ccctctgaca gtagaagaga cacccagagt acagggagaa actcaacccc
      721 agaggcttct gttggctgag gactcggagg aggaagtaga ttttctttct gaaaggcgta
      781 tggtaaaaaa atcaaggacc acatcttcct ctgtgatagt tccagagagt gatgaagagg
      841 ggcattcccc ggtcctgggc ggccttgggc cgccttttgc cttcaatttg aacagtgaca
      901 cagatgtgga agaaggtcag caaccagcca cagaggaggc ctcctcagct gccagaagag
      961 gtgccactgt agaggcaaag cagtctgaag ctgaagttgt aactgaaatc cagcttgaaa
     1021 aggatcagcc tttagtgaag gagagggaca atgatacaaa agtcaagagg ggtgcaggga
     1081 atggggtggt tccagctggg gtgattctgg agaggagcca acctcctgga gaggacagtg
     1141 acacagatgt ggatgatgac agcaggcctc ctggaaggcc agctgaggtc catttggaaa
     1201 gggctcagcc ttttggcttc atcgacagcg acactgatgc ggaagaagag aggatcccag
     1261 caaccccagt tgtcattcct atgaagaaga ggaagatctt ccatggagta ggtacaaggg
     1321 gtcctggagc accaggcctg gcccatctgc aggagagcca ggctggtagt gatacagatg
     1381 tggaagaagg caaggcccca caggctgtcc ctctggagaa aagccaagct tccatggtta
     1441 tcaacagcga tacagatgac gaggaagaag tctcagcagc gctgactttg gcacatctga
     1501 aagagagcca gcctgctata tggaacagag atgcagaaga ggacatgccc caacgtgtgg
     1561 tccttctgca gcgaagccaa accaccactg agagagacag tgacacagac gtggaggagg
     1621 aagagctccc agtggaaaat agagaagctg tcctcaagga tcacacaaag attagagccc
     1681 ttgttagagc acattcagaa aaggaccaac ctccttttgg ggacagtgat gacagtgtgg
     1741 aagcagataa gagctcacct gggatccacc tggagagaag ccaagcctcc accacagtgg
     1801 acatcaacac acaagtggag aaggaagtcc cgccagggtc agccattata catataaaga
     1861 agcatcaggt gtctgtggag gggacaaatc aaacagatgt gaaagcagtt gggggaccag
     1921 caaagctgct tgtggtatct ctagaggaag cctggcctct gcatggggac tgtgaaacag
     1981 atgcagagga gggcacctcc ctaacagcct cagtagttgc agatgtaaga aagagccagc
     2041 ttccagcaga aggggatgct ggggcagagt gggctgcagc tgttcttaag caggagagag
     2101 ctcatgaggt gggggcccag ggtgggccac ctgtggcaca agtggagcag gacctcccta
     2161 tctcaagaga gaacctcaca gatctggtgg tggacacaga cactctaggg gaatccaccc
     2221 agccacagag agagggagcc caggtcccca caggaaggga gagagaacaa catgtgggtg
     2281 ggaccaagga ctctgaagac aactatggtg attctgaaga tctggaccta caagctaccc
     2341 agtgctttct ggagaatcag ggcctggaag cagtccagag catggaggat gaacctaccc
     2401 aggccttcat gttgactcca ccccaagagc ttggcccttc ccattgcagc ttccagacaa
     2461 caggtaccct agatgaacca tgggaggtcc tggctacaca gccattctgt ctgagagagt
     2521 ctgaggactc tgagacccag ccttttgaca cgcaccttga ggcctatgga ccttgcctgt
     2581 ctccacctag ggcaatacca ggagaccaac atccagagag cccagttcac acagagccaa
     2641 tggggattca aggcagaggg aggcagactg tggataaagt catgggtata ccaaaagaaa
     2701 cagcagagag ggtgggccct gagagagggc cattggagag agaaactgag aaactgctac
     2761 cagaaagaca gacagatgtg acaggagagg aagaattaac caaggggaaa caggacagag
     2821 aacaaaaaca gttgttagct agagacaccc agagacaaga atctgacaaa aatggggaaa
     2881 gtgcaagtcc tgaaagagat agggagagtt tgaaggtaga aattgagaca tctgaggaaa
     2941 tacaagagaa acaagtacag aagcagaccc ttccaagcaa agcatttgag agagaagtag
     3001 agagaccagt agcaaacaga gagtgcgatc cagccgagtt agaagagaag gtgcccaaag
     3061 tgatcctgga gagagataca cagagagggg agccagaggg agggagccag gaccagaaag
     3121 ggcaggcctc cagcccaaca ccagagcctg gggtgggggc gggggacctt ccgggaccta
     3181 cctcagcccc cgtaccttct gggagccagt caggtggaag gggatcccca gtgagcccca
     3241 ggaggcatca gaaaggcctc ctgaattgca agatgccacc tgctgagaag gcttccagga
     3301 tcagagctgc tgagaaggtt tccaggggcg atcaggaatc tccagatgct tgtctgcctc
     3361 ctacagtacc tgaagcccca gccccacccc aaaagcccct taactctcag agccagaaac
     3421 atcttgcacc tccgcccctt ctttctcccc ttttaccttc tatcaagcca accgttcgta
     3481 agaccaggca agatgggagt caggaagctc cagaggctcc cttgtcctca gagctggagc
     3541 ctttccaccc aaagcctaaa attagaactc ggaagtcctc cagaatgaca ccctttccag
     3601 ctacctctgc tgcccctgag ccccaccctt ccacctccac agcccagcca gtcactccca
     3661 agcccacatc tcaggccact aggagcagga caaataggtc ctctgtcaag acccctgaac
     3721 cagttgtccc cacagcccct gagctccagc cttccacctc cacagaccag cctgtcacct
     3781 ctgagcccac atctcaggtt actaggggaa gaaaaagtag atcctctgtc aagacccctg
     3841 aaacagttgt gcccacagcc cttgagctcc agccttccac ctccaccgac cgacctgtca
     3901 cctctgaacc cacctctcag gctactaggg gaagaaaaaa tagatcctct gtcaagaccc
     3961 ctgaaccagt tgtccccaca gcccctgagc tccagccttc cacctccaca gaccagcctg
     4021 tcacttctga gcccacatat caggctacta ggggaagaaa aaatagatcc tctgtcaaga
     4081 cccctgaacc agttgtgccc acagcccctg agctccggcc ttccacctcc acagaccgac
     4141 ctgtcacccc caagcccaca tctcggacca ctaggagcag gacaaatatg tcctctgtca
     4201 agacccctga aacagttgtc cccacagccc ctgagctcca gatttccacc tccacagacc
     4261 aacctgtcac ccctaagccc acatctcgga ccactaggag caggacaaat atgtcctctg
     4321 tgaagaaccc tgaatcaact gtccctatag cccctgagct cccaccttcc acctccacag
     4381 agcagcctgt cacccctgag cccacatctc gggctactag gggaagaaaa aatagatcct
     4441 ctggcaagac ccctgaaaca cttgtcccca cagcccctaa gctcgagcct tccacttcca
     4501 cagaccaacc tgtcactcct gagcccacat ctcaggccac caggggcagg acaaataggt
     4561 cctctgtgaa gacccctgaa acagttgtcc ccacagcccc tgagctccag ccttccacct
     4621 ccacagacca gcctgttacc cctgagccta cgtctcaggc tactagggga agaacagata
     4681 gatcctctgt caagactcct gaaacagttg tccccacagc ccctgagcta caggcttccg
     4741 cctccacaga ccagcctgtc acctctgagc ccacatctcg gaccactagg ggaagaaaaa
     4801 atcggtcctc tgtcaagacc cctgaaacag ttgtgcccgc agcccctgag ctccagcctt
     4861 ccacctccac agaccaacct gtcacccctg agcccacatc tcgggccact aggggcagga
     4921 caaataggtc ctctgtcaag acccctgaat caattgtccc tatagcccct gagcttcagc
     4981 cttccacctc cagaaaccag cttgtcaccc ctgagcccac atctcgggcc actaggtgca
     5041 ggacaaatag gtcctctgtc aagacccctg agccagttgt ccccacagcc cctgagcccc
     5101 atcctaccac ctccacagac cagcctgtca cccccaagct cacatctagg gccactagga
     5161 gaaagacaaa taggtcctct gtcaagactc ccaaaccagt tgaaccagca gcctctgatc
     5221 ttgagccttt tacccccaca gaccagtccg tcacccctga ggccatagct cagggtggtc
     5281 agagcaaaac actgaggtct tccacagtaa gagctatgcc ggttcctacc acccctgaat
     5341 tccaatctcc tgtcaccaca gaccagccta tttcccctga gcctattact caacccagtt
     5401 gcatcaagag gcagagagcc gctgggaacc ctggctccct cgcagctccc attgaccata
     5461 agccttgctc tgcacccttg gaacctaaat cccaggcctc aaggaaccaa agatggggag
     5521 cagtgagagc agctgaatcc cttacagcca ttcctgagcc tgcctctccc cagcttcttg
     5581 agacaccaat tcatgcctcc cagatccaaa aggtggaacc agcaggtaga tctaggttca
     5641 ccccggagct ccagcctaag gcctctcaaa gccgcaagag gtctttagct accatggatt
     5701 caccaccaca tcaaaaacag ccccaaagag gggaagtctc ccagaagaca gtgattatca
     5761 aggaagagga agaagatact gcagagaagc cagggaagga agaggatgtc gtgactccaa
     5821 aaccaggcaa gagaaagaga gaccaggcag aggaggagcc caacagaata ccaagccgca
     5881 gcctccgacg gaccaaactt aaccaagaat caacagcccc caaagtgctc ttcacaggag
     5941 tggtggatgc tcggggagag cgggctgtgc tggcactggg gggaagtctg gctggttcag
     6001 cggcagaggc ttcccacctg gtcactgatc gcatccgccg gacagtcaag ttcctgtgtg
     6061 ccctggggcg gggaatcccc attctgtccc tggactggct gcatcagtcc cgcaaggctg
     6121 gtttcttctt acccccggat gaatatgtgg tgaccgaccc tgagcaagag aagaactttg
     6181 gctttagcct tcaagacgca ctgagcaggg ctcgggagcg aaggctgcta gagggctatg
     6241 agatctatgt gacccctgga gtccagccac caccacctca gatgggagag attattagct
     6301 gctgtggagg cacataccta cccagcatgc ctcggtccta taagcctcag agagttgtga
     6361 tcacatgccc tcaggacttc cctcattgct ccattccact acgggttggg ctgcccctcc
     6421 tctcgcctga gttcctgctg actggagtgc tgaagcagga agccaagcca gaggcctttg
     6481 tcctctcccc tttggagatg tcatccacct gagaactcca ctaccctttt ccctcccaga
     6541 ccacgaatta gaagatatgt ggaagaaaga actcagggcg ttagaaagga ttggggtata
     6601 ttgatacaac ttgtcctgga acatgggtgg gaccagaaat ctttatgaat aaatgaaaag
     6661 ataagggatt tggaagccac aggttgtttt ttgtttgttt gtttgttttt ttaatggcca
     6721 ttttatttta tttgtattta tagtttttta tttgtataga tttaggggat acaagatttc
     6781 ttacatgcat gtattaaatg gccattttaa aattagctag tttcatgctc agatgtcata
     6841 agtggcagct atctttagcc agactgttgc agttattgct cgatgccact catggtgtcc
     6901 tacctcctat ttggaaacca tctctatttt tttcttactg agattcttac tttggggtca
     6961 ggaacttgaa gggatgcttg gagtgagtag atttgagggt ccagttatgg agtgctacta
     7021 aaacattttc ttctctcctg gcctctggaa gcatctttag ctttgacttt gggcaagtct
     7081 ctgtactttt ctggccagct tttccaggat ttataaaatt agagcttcgg cttgacctct
     7141 gtgataaata aatattcact ctgtgcctta
//
