LOCUS       NM_014060               9577 bp    mRNA    linear   PRI 12-DEC-2024
DEFINITION  Homo sapiens MCTS1 re-initiation and release factor (MCTS1),
            transcript variant 1, mRNA.
ACCESSION   NM_014060 XM_001715103
VERSION     NM_014060.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9577)
  AUTHORS   Bohlen,J., Zhou,Q., Philippot,Q., Ogishi,M., Rinchai,D.,
            Nieminen,T., Seyedpour,S., Parvaneh,N., Rezaei,N., Yazdanpanah,N.,
            Momenilandi,M., Conil,C., Neehus,A.L., Schmidt,C.,
            Arango-Franco,C.A., Voyer,T.L., Khan,T., Yang,R., Puchan,J.,
            Erazo,L., Roiuk,M., Vatovec,T., Janda,Z., Bagaric,I., Materna,M.,
            Gervais,A., Li,H., Rosain,J., Peel,J.N., Seeleuthner,Y., Han,J.E.,
            L'Honneur,A.S., Moncada-Velez,M., Martin-Fernandez,M., Horesh,M.E.,
            Kochetkov,T., Schmidt,M., AlShehri,M.A., Salo,E., Saxen,H.,
            ElGhazali,G., Yatim,A., Soudee,C., Sallusto,F., Ensser,A., Marr,N.,
            Zhang,P., Bogunovic,D., Cobat,A., Shahrooei,M., Beziat,V., Abel,L.,
            Wang,X., Boisson-Dupuis,S., Teleman,A.A., Bustamante,J., Zhang,Q.
            and Casanova,J.L.
  TITLE     Human MCTS1-dependent translation of JAK2 is essential for
            IFN-gamma immunity to mycobacteria
  JOURNAL   Cell 186 (23), 5114-5134 (2023)
   PUBMED   37875108
  REMARK    GeneRIF: Human MCTS1-dependent translation of JAK2 is essential for
            IFN-gamma immunity to mycobacteria.
REFERENCE   2  (bases 1 to 9577)
  AUTHORS   Ma,B., Wei,X., Zhou,S. and Yang,M.
  TITLE     MCTS1 enhances the proliferation of laryngeal squamous cell
            carcinoma via promoting OTUD6B-1 mediated LIN28B deubiquitination
  JOURNAL   Biochem Biophys Res Commun 678, 128-134 (2023)
   PUBMED   37634410
  REMARK    GeneRIF: MCTS1 enhances the proliferation of laryngeal squamous
            cell carcinoma via promoting OTUD6B-1 mediated LIN28B
            deubiquitination.
REFERENCE   3  (bases 1 to 9577)
  AUTHORS   Yang,M., Ma,B. and Liu,X.
  TITLE     MCTS1 promotes laryngeal squamous cell carcinoma cell growth via
            enhancing LARP7 stability
  JOURNAL   Clin Exp Pharmacol Physiol 49 (6), 652-660 (2022)
   PUBMED   35274760
  REMARK    GeneRIF: MCTS1 promotes laryngeal squamous cell carcinoma cell
            growth via enhancing LARP7 stability.
REFERENCE   4  (bases 1 to 9577)
  AUTHORS   de Carvalho,P.A., Bonatelli,M., Cordeiro,M.D., Coelho,R.F.,
            Reis,S., Srougi,M., Nahas,W.C., Pinheiro,C. and Leite,K.R.M.
  TITLE     MCT1 expression is independently related to shorter cancer-specific
            survival in clear cell renal cell carcinoma
  JOURNAL   Carcinogenesis 42 (12), 1420-1427 (2021)
   PUBMED   34668521
  REMARK    GeneRIF: MCT1 expression is independently related to shorter
            cancer-specific survival in clear cell renal cell carcinoma.
REFERENCE   5  (bases 1 to 9577)
  AUTHORS   Zhu,J., Wang,X., Shao,Z., Sun,W. and Wu,T.
  TITLE     Prognostic value of malignant T cell-amplified sequence 1 in head
            and neck squamous cell carcinoma
  JOURNAL   Biomark Med 15 (17), 1623-1639 (2021)
   PUBMED   34704820
  REMARK    GeneRIF: Prognostic value of malignant T cell-amplified sequence 1
            in head and neck squamous cell carcinoma.
REFERENCE   6  (bases 1 to 9577)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   7  (bases 1 to 9577)
  AUTHORS   Shi,B., Levenson,V. and Gartenhaus,R.B.
  TITLE     Identification and characterization of a novel enhancer for the
            human MCT-1 oncogene promoter
  JOURNAL   J Cell Biochem 90 (1), 68-79 (2003)
   PUBMED   12938157
  REMARK    GeneRIF: demonstrated the presence of sequence-specific DNA-binding
            protein in nuclear extracts designated as LMBF; the 26-mer
            oligonucleotide containing the LMBF binding site is required for
            maximum transcriptional activity of the MCT-1 promoter
REFERENCE   8  (bases 1 to 9577)
  AUTHORS   Shi,B., Hsu,H.L., Evens,A.M., Gordon,L.I. and Gartenhaus,R.B.
  TITLE     Expression of the candidate MCT-1 oncogene in B- and T-cell
            lymphoid malignancies
  JOURNAL   Blood 102 (1), 297-302 (2003)
   PUBMED   12637315
  REMARK    GeneRIF: tumor cell lines overexpressing MCT-1 exhibited increased
            growth rates and displayed increased protection against apoptosis
            induced by serum starvation
REFERENCE   9  (bases 1 to 9577)
  AUTHORS   Herbert,G.B., Shi,B. and Gartenhaus,R.B.
  TITLE     Expression and stabilization of the MCT-1 protein by DNA damaging
            agents
  JOURNAL   Oncogene 20 (46), 6777-6783 (2001)
   PUBMED   11709712
REFERENCE   10 (bases 1 to 9577)
  AUTHORS   Prosniak,M., Dierov,J., Okami,K., Tilton,B., Jameson,B.,
            Sawaya,B.E. and Gartenhaus,R.B.
  TITLE     A novel candidate oncogene, MCT-1, is involved in cell cycle
            progression
  JOURNAL   Cancer Res 58 (19), 4233-4237 (1998)
   PUBMED   9766643
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP226595.1, BC001013.2, AC011890.4 and BM671542.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014060.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.32437.1,
                                           SRR1660803.73098.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371317.10/ ENSP00000360367.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-65                BP226595.1         213-277
            66-805              BC001013.2         1-740
            806-9128            AC011890.4         12556-20878
            9129-9577           BM671542.1         17-465              c
FEATURES             Location/Qualifiers
     source          1..9577
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq24"
     gene            1..9577
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="MCTS1 re-initiation and release factor"
                     /db_xref="GeneID:28985"
                     /db_xref="HGNC:HGNC:23357"
                     /db_xref="MIM:300587"
     exon            1..147
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..682
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     multiple copies T-cell malignancies; malignant T-cell
                     amplified sequence 1; multiple copies in T-cell
                     lymphoma-1"
                     /codon_start=1
                     /product="malignant T-cell-amplified sequence 1 isoform 1"
                     /protein_id="NP_054779.1"
                     /db_xref="CCDS:CCDS14601.1"
                     /db_xref="GeneID:28985"
                     /db_xref="HGNC:HGNC:23357"
                     /db_xref="MIM:300587"
                     /translation="MFKKFDEKENVSNCIQLKTSVIKGIKNQLIEQFPGIEPWLNQIM
                     PKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAI
                     KFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNK
                     GIGIENIHYLNDGLWHMKTYK"
     exon            148..300
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            301..398
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..532
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..600
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     exon            601..9577
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      783..788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="hexamer: AATAAA"
     polyA_site      805
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="major polyA site"
     regulatory      9554..9559
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="hexamer: AATAAA"
     regulatory      9559..9564
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
                     /note="hexamer: AATATA"
     polyA_site      9573
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
     polyA_site      9577
                     /gene="MCTS1"
                     /gene_synonym="IMD118; MCT-1; MCT1"
ORIGIN      
        1 gttttccgga taacgactac agctccgact gtcagtgccg gccttcctcg tgtgagggga
       61 tctgccggac ccctgcaaat tcaatttctt tcccattccg ggcccttccc tatcgtcgcc
      121 cccttcacct tggatcatgt tcaagaaatt tgatgaaaaa gaaaatgtgt ccaactgcat
      181 ccagttgaaa acttcagtta ttaagggtat taagaatcaa ttgatagagc aatttccagg
      241 tattgaacca tggcttaatc aaatcatgcc taagaaagat cctgtcaaaa tagtccgatg
      301 ccatgaacat atagaaatcc ttacagtaaa tggagaatta ctctttttta gacaaagaga
      361 agggcctttt tatccaaccc taagattact tcacaaatat ccttttatcc tgccacacca
      421 gcaggttgat aaaggagcca tcaaatttgt actcagtgga gcaaatatca tgtgtccagg
      481 cttaacttct cctggagcta agctttaccc tgctgcagta gataccattg ttgctatcat
      541 ggcagaagga aaacagcatg ctctatgtgt tggagtcatg aagatgtctg cagaagacat
      601 tgagaaagtc aacaaaggaa ttggcattga aaatatccat tatttaaatg atgggctgtg
      661 gcatatgaag acatataaat gagcctcaga aggaatgcac ttgggctaaa tatggatatt
      721 gtgctgtatc tgtgtttgtg tctgtgtgtg acagcatgaa gataatgcct gtggttatgc
      781 tgaataaatt caccagatgc taaaattctg ttagcttcag aaattatttt aagttttctt
      841 aaactcaagt taaaattggg tagcaaactt ggacattaaa aggtatctgg taagtaagca
      901 aactcataca actaatgtcc tttcttaggc taatgatata agagtgaaga gcaggacttg
      961 gtcaatggat tgccatttta tggtagacct ctagagaaac tgtctagtta aatggggcta
     1021 gaaactagac taggaatttt attctattac tccaggggac ccagcagtgc tcattctcgt
     1081 gtgtgtgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgtgt gtgtgtgtgt tttgttgatt
     1141 gtttttttaa aaaaaacttc aatggaaaat tctaaacata ttaagaagtc tggagaatag
     1201 tataatggac ctctccatat ccatcaccca gtttcagttt atggtcagtc ttatttcatc
     1261 tatacctcaa ttatttctcc ccacccccca attattttga agcaaatccc agacatccta
     1321 tcatttcatc cataactact ttattctttt tttttttttt ttgaaacagg gtcttgctct
     1381 gttgcccagg ctggagtgca gtggtacgat cttggctcac tgtaacctcc acctcccggg
     1441 ttcaagcgat tcttgtgcct cagcctcctg agtagctggg attacaggca cgtgccacca
     1501 tgcccggcta attttgtatt tttggtagag atggggtttc gctatgttgg ccagactggt
     1561 cttgaactct tggcctcaag tgatccgtcc ccctctgcct cccaaagtgc tgggattaca
     1621 ggcatgagcc accgtgccca gctaattttt atatatttta tagttggcca ggctggtctt
     1681 gaactcctgg cctcaagtga tcagcctccc aaagtgctgg gattataggc atgagtcacc
     1741 atgcctggcg tcataactac tttagtgtgt atctttaaaa attagaaaaa ccccacaata
     1801 ccattatcac acctaaaaag ttgaactgtt tcttaatatg atcaactgtc tagactgtta
     1861 attctcttta actgttggtt tgcttgaaat aggtaccaca caaggttcat acattgcatt
     1921 tggttgttat ttattgaagt ctgtttaatt tataagttac cttttctttt cccccttaaa
     1981 ttatttaaga aatctagttg ttttgtcttt aaagtttcca cacatattct ggattttgtt
     2041 gattgtatca ctgtgaagtc attaacttgt ttttatgcct cctgtatatc ctgtaaacaa
     2101 ataagattga tcagattcag gttcagtttt tttagtgcct tcttttgagt aaagtcatac
     2161 caaacagatg cccagaacat ctggatttgg gtccccacta gactccttaa ataatgtata
     2221 tcttctataa gtggaatatg agggacatgg acctgcttta gtaagaacag taatctgttt
     2281 ggggagttaa aagagcagtt gtggatttat ttattgataa agaccatttt tcttcctaat
     2341 aaccttgctg ttattctagt gtcttagcca tcttcatttg gttgtttacc aatatatgac
     2401 atgtgatttt atttttcaga tggatacaga catatacaag attgtggtga cctgtgttac
     2461 agttagaagt tggtgagaaa ggtgagggtg gatagcaaaa agagagagat catttggctg
     2521 gctgttccag ctgggtctcc caggatgtaa cataggtgga catagatcca gggtctgacc
     2581 ctcagcttga gaaaccattt cccactgatg aaacttgaga gacttggaga ttccccagtt
     2641 agaatataaa tgtattaatt catagtgata ggtctgccta tggtaaacaa ttaggaaaca
     2701 ggaagttact tggtaaacac aggtatgagc aaaggaagat tgataaattg gggtaatatt
     2761 tcagttgtgc tgaggtaaga cttggagaat ttttcctgct tcatcattaa ttagaatgct
     2821 tatctctgcc aaaatctcat ctctttccta gcccatagag gtgccctgat attttatttc
     2881 ctatatcctt ttcaagttcc atgtagtttt ccttatgtta tgacagtttt attctgcagc
     2941 ttaccatatt atttattcct ggtccacgaa agtataaata gtctcatcag gaactcattt
     3001 gtaagtcatc tcccaggggg gtttcttcaa cagatagttt aattttttgc tgacttactg
     3061 gcttcaaatt cagatgtctc cctatttggg ggaggaggca ccctatttga ggcctgtagc
     3121 tccttatgtt cttaaaaaga atatacaagt catttatgtc agaatcaaac tttgaacctt
     3181 tatttttgtt gctaagagaa tgttttttga ccaagactgc ctatggagta ttagcaatga
     3241 aaaacaaagc acacatatac atacattaga gaagtaaaaa cttttaatag cttggttttt
     3301 gaaataattc atctttgtgt ctaaccactg ttacagtggg tgtaaggaac actttttaaa
     3361 tattcaacat caacatctgt gcttgttttt ctactgtgct gaggtacact gtgttgcctt
     3421 ggtgatatgg actaaatatg tatgttctct gcttcccctg ggtctgaggc ctctgctcat
     3481 cactgttaat cagggatgtc actctacatg tgtgatcctt gtcattttct aaacattagg
     3541 tcatacatga aaggcaattc aaagagatta aactagcaga tgtgtcagca tctttagata
     3601 ctgtgcttaa tggaaactta gtttacctat attcgtgaga ataggaatac agggatagag
     3661 agcctgcttc tctcaggcag tgtgtcttta gttcattttt agtttcaaaa ttaagtttgt
     3721 gtcaaaccaa cctacaatct agtaacttgt gtattggact cacttttact cagacaaggt
     3781 cagttcagct caataggtat ttattgagta tctactaggt tctaagtgac gtggcatgaa
     3841 gatgaataat acagaagtag cccttgctct taaggagctt ccaatctagt gagtaaagaa
     3901 aatttacatt ttaaataatc tgggtaatgg tgacagccca atactaatat gtaaagccag
     3961 taggaatgta ctaatccttt tccaatttta gtcatcaaaa attgtaaatt acaaatgaac
     4021 taaatgtagt aatattccat agattgtatc caatgtgagg gtaaaaaaaa aatcccagat
     4081 gtcttggagt tgccgtgatt cagcatccca actcagatga ttgtcctgtt gtccggtgac
     4141 ataatggcct gatcagttct cttctagcag actgtctgtt atggtggttt ggtagtggtc
     4201 tgttgggaag ctgcattttt ccttttctgt ttttatgctc tggaccccaa acaaaaacag
     4261 ctggatttat cccatgggta gtcatgaaca tttccaattt gagggatttt atattcccca
     4321 aacagaaggt tatatggcat atatcaaata ataatgatat ccagccaggt tccctgtcgt
     4381 acccaaatca gtaactgaag atacgtattt ctaagtataa tacttcagag gaagagataa
     4441 gaattacaat tcactaaatt cgtggaggtg tttcattata ataaatatgt cacttattaa
     4501 taatgtagca attatatatt aatggaaata tgaatgtatg cccaagcaaa atgtcataaa
     4561 tattttaact ttgtttgtct aggttcctta attttgagac tataattatc aaggctcttc
     4621 aagaaactca aaatgattct aatttctaag tagtatgcat taaaactgat atataatgaa
     4681 agaaaaacag tgaaaatgta tgcatcagtt tctaaagaaa tcatacttgt cattgtagag
     4741 atgcatgtaa attaaatgta ttatacattt ttatacttgt atgtatttta tactttgtat
     4801 gaatactttt attacacttt ttaaggcagg taaaagaatg agtagatgtt atcaactata
     4861 acaacaattt gttgaatact gtgttaaaac caagtaaagg accacaactc cacgagatca
     4921 ggaatgaatg aagaaaattg agggccagtt tttaaatcat tgttgagact attaggttca
     4981 tctgtctgtt taagagtctg gccttaggga atataattta tgcatgtaaa aaaatacagg
     5041 agatgattca ctggaatgtc tcttaataat accatgttca ttaagaatag gtcattggga
     5101 ggaaaaataa ataaaaacat ctgaactcat tagtataatt aatacttgcc tcttagaatg
     5161 aaaattaaag aactccaaat tttagccttg aatactttga gaaataaaag atgaattagt
     5221 gaaataattt ctacttaaaa tcttagttgt tacagagaat gacatgcctc actattaatg
     5281 tccaattcta attaatggat tgttttagaa atgtatttgt gaaatatagc aaacatagct
     5341 agtaatacta acaggtgaaa actgatattt caaatgacta aatagactta agattagagg
     5401 aaggtaggaa aaggtgtgca actaacagaa gcagttaacc aaaaaatgag cttcaggcat
     5461 cagtcttatt tggaagactg taaatcaaca ggctaacgtt caaaatatgg cagacatctt
     5521 aatatcaata tatgctaaat tggtttatct ttaggcagaa acagaaagca aaaaattaaa
     5581 ctcatccaac tcatacattt gttgttgttg ttgttgttgt tgtttttgag atggagtctt
     5641 gcttcattgc ccaggctgga gtgcaatggc acgatctcgg ctcactgcaa cctctgtctt
     5701 ccgggttcaa gcgattctcc tgcctcagcc tcccgagtag ctgggatccc atgcgtgtgc
     5761 caccacacct agctaatttt tgtattttta gtagagacag ggtttcacca tgttggccag
     5821 gctggtctca aactcctgac ctcaggtgat gcacccgcct tggcctccca aagtgctggg
     5881 attacaggtg tgaaccacca cacccgaccc aactaataca tttttaaaat cccattttaa
     5941 aagtaaaacc acagttttca tataacaaat gttattgctc ttcatttcat tctccaattt
     6001 taaaatgctt tactttcagc caatatgtga atataggaga cttcaaaagc ataatcaatt
     6061 actcccttaa agttcattgt aagtgttctc agaactctac cacctagaat ttaaagacgg
     6121 gaagatttac tttataattt taatttctta tcacaagact cgattgtcaa taactgttaa
     6181 cgtccattta ataatctatg gtgaaatagg taatttcttc ttattttcac aagcgtgtga
     6241 gtaaaagact gggttttaag caataaatca tttgttctaa ctaagcacat gcttggaaaa
     6301 agtgctattt ttccaaacgt atgccttgaa aacaaataca attcaattgc ctttttggtt
     6361 catgggaagc catactgcgg tggcttccaa ggttggccaa cctgttttta ttcttaccac
     6421 ctctttcaaa aagggatgtt gtctttgtcc ccaaattctg gtgttgtcct atgctgatgc
     6481 ataatgaagc cctgaggctt ggaaacttgc aaaccaataa gatgatttaa tgatgaaacg
     6541 gcatgtcagt ttgacactgt ctattaatag tccttgagtg agcttaaatt tgagacactt
     6601 ttaaaagcgg catgtagttc cagttttgct tcccttatca gtggagcttg agatgtctgt
     6661 tcctgccgac tgatgtttta acaaattttt agtttctcat gatgtgaaag attttgtatg
     6721 cacgtcttag tctggatact gttttcatta gttctaatgc tgctgcatgc aaattttgtt
     6781 taaaaccaaa attgactctt cacatctgga ctagattgga catggtgagg aggctggaag
     6841 gaaagtcctt tttgctctgt aggctctgga cagctttctt agagttgact tatccaggat
     6901 taagaaaaag ttttcttttg cgtgactaaa ttctttccac agtttgcttg tgtaagcatt
     6961 ttagatttaa gcaagttcaa cttgaaatat atttgaatat gaagtagaaa cagcttcatt
     7021 taatgggata atagcaatct ctaacccatc aaattaatat ctactaaata gcttccaaaa
     7081 agcactgact ggaaaatatt tttcactatc atggctttat tcagtttcaa aaacagtagg
     7141 ggctaaaatg tttggacatt tatcctgcat ttattttgtg tttcacaagg ttaaaatttt
     7201 gtattttgta aagtgtctga aaaggagtcc acaaagtatt tctgctttct tgctcctgaa
     7261 tgcaaaggtc tgagagaagg cacatcctca ttagcttctg ggtgttgtca aacccaatcc
     7321 tctctcaagt accaaatgcc cagatacatt tattgggatg caggaatctc acttaagtag
     7381 cggtttttgc tgatataaag acaaacatct tgattaaagt gtagggagat agaaactata
     7441 ccaatttggg caattttggc tctaatgtct aatttgttgt gaaaggggaa gatgttctaa
     7501 gctaatgttc ttaaaagtaa cttatgaatt tcttaaaaat agtttttaaa aagctgtttc
     7561 aggaaaagct gttttattgc atggcacaga ttaaatgtac agatgttatc ttaaaacaat
     7621 gaaagagttc ccctaatttg aatattcaat accagctgtt attcacatca atattttaac
     7681 attttaccat caagatattt aatacaaagg attgatacat atttaactgt ttagaattct
     7741 agttaaactt gtccagatga gtaagaggga aggagaaata acattctcca agtacctacc
     7801 atgtgcacaa gctctactta tatatcttgc ttaatcttag caatgattcc atgaggtaga
     7861 ttttaactct cattttacaa acgaggagac taaggctcag agaggtcata caacttcagg
     7921 aaagttgtat gacctctctg aggtaataaa tggcagaact ggaatttgaa cctaagtctc
     7981 cttgtctgca aatcctgtgt tttgcagaaa actctcctct tgtatttcat aaaatgttaa
     8041 atcttggccc aaattcaaat caccatcttt atgggttatt ggagagaggt ataagttggc
     8101 aagactctgt tccacgatgg gaaaaaatgg gtaggatttg aatgagtaag agtgggatac
     8161 ttgcacagta tcatatttgt gtggctggag taatgttttt ctgtttccct cttagcaaag
     8221 tggagtggga gaatcttgaa attgaactca gtcctgaggt ctgattttcc tattattagt
     8281 cactttcaag ccaggtgatt tgtgaccatt taaatgttat gctatttcaa agtcttctac
     8341 atctttagaa aaggacatga gggagggtta gttaagtggg gcaatgagaa tgtagagtgt
     8401 aatgtgcaaa agcaggacta gcagttgctt tgaagatatc tggggaaggc cgggcacggt
     8461 ggttcacgcc tgtaatccca gtactttggg aggccaaggt gggcggatca cgaggtcagg
     8521 agatcgagac catcctggct aacgtgaaac cccgtctata ctaaaaatac aaaaaattaa
     8581 ccggacgcag tggtgggcgc ctgtagtccc agctactcgg gaggctgagg caggagagtg
     8641 gcatgaaccc gggaggcgga gcttgcagtg agctgagatc gcaccactgc attccagcct
     8701 ggacaacaga gcgaaactcc gtctcaaaaa ccaaccaaac aaaaaacaaa aattagctgg
     8761 gcatggtggc gcgtgcctgt aatcccagca ctttgggagc caaggtgggt ggatcatgag
     8821 gtcagaagat tgagaccacc ctggccaaca tggtgaaatc ctgtctctac taaaaataca
     8881 aaaaaaaaaa aaaaaaaaaa aattagccgg gcgtggtggc gcgtgcctgt aatcccagct
     8941 acacaggagg ctgaggcagg agatttgctt gaacctggga ggcggaggtt gcagtgagcc
     9001 gagattgtgc cactgcactc cagcctgggc gacagagcaa gactccgtct aaaaaaaaaa
     9061 aaaagatatt aaaattaatg acaggaagag tttgggttca gttataattt aagggaaaaa
     9121 acattgaggg gcctaatcta cattttgctc cggatccaat gatttaattt ttgggaagaa
     9181 aaatccagtg attaaagtca tgcaaggaga tggcctgggg cttgctaaaa gtcaggttgc
     9241 agtttccatt gcattcaaga aaatcagaaa aataaataca acttttagaa gaaactaagt
     9301 tttctcccat tcatgtttag ctattggggg gtctcatact tctggacttg cttagaccta
     9361 tgctatctaa tatggtagcc tctgcccatc catatgtggc cactgagaac ttgaaatgtg
     9421 actagtttga attaagatgt gctgtaacta aaatacaccc tggatttcaa agacttaata
     9481 aataatgtaa attatctatt ctttcctgtt gattatatat tgaaatgata atattttgga
     9541 tatgtttggg ttaaataaaa tatattacta aaagtaa
//
