LOCUS       NM_001385001            7724 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens multiple C2 and transmembrane domain containing 2
            (MCTP2), transcript variant 4, mRNA.
ACCESSION   NM_001385001 XM_005254955
VERSION     NM_001385001.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7724)
  AUTHORS   Sun,Y., Men,W., Kennerknecht,I., Fang,W., Zheng,H.F., Zhang,W. and
            Rao,Y.
  TITLE     Human genetics of face recognition: discovery of MCTP2 mutations in
            humans with face blindness (congenital prosopagnosia)
  JOURNAL   Genetics 227 (2) (2024)
   PUBMED   38547502
  REMARK    GeneRIF: Human genetics of face recognition: discovery of MCTP2
            mutations in humans with face blindness (congenital prosopagnosia).
REFERENCE   2  (bases 1 to 7724)
  AUTHORS   Liu,Y., Zhang,K. and Yang,X.
  TITLE     CircMCTP2 enhances the progression of bladder cancer by regulating
            the miR-99a-5p/FZD8 axis
  JOURNAL   J Egypt Natl Canc Inst 36 (1), 8 (2024)
   PUBMED   38494582
  REMARK    GeneRIF: CircMCTP2 enhances the progression of bladder cancer by
            regulating the miR-99a-5p/FZD8 axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7724)
  AUTHORS   Joshi,A.S., Ragusa,J.V., Prinz,W.A. and Cohen,S.
  TITLE     Multiple C2 domain-containing transmembrane proteins promote lipid
            droplet biogenesis and growth at specialized endoplasmic reticulum
            subdomains
  JOURNAL   Mol Biol Cell 32 (12), 1147-1157 (2021)
   PUBMED   33826368
  REMARK    GeneRIF: Multiple C2 domain-containing transmembrane proteins
            promote lipid droplet biogenesis and growth at specialized
            endoplasmic reticulum subdomains.
REFERENCE   4  (bases 1 to 7724)
  AUTHORS   Sun,G., Li,Z., He,Z., Wang,W., Wang,S., Zhang,X., Cao,J., Xu,P.,
            Wang,H., Huang,X., Xia,Y., Lv,J., Xuan,Z., Jiang,T., Fang,L.,
            Yang,J., Zhang,D., Xu,H. and Xu,Z.
  TITLE     Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer
            by miR-99a-5p-mediated induction of MTMR3 expression
  JOURNAL   J Exp Clin Cancer Res 39 (1), 246 (2020)
   PUBMED   33198772
  REMARK    GeneRIF: Circular RNA MCTP2 inhibits cisplatin resistance in
            gastric cancer by miR-99a-5p-mediated induction of MTMR3
            expression.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7724)
  AUTHORS   Lee,J.H., Cho,M.H., Hersh,C.P., McDonald,M.L., Crapo,J.D.,
            Bakke,P.S., Gulsvik,A., Comellas,A.P., Wendt,C.H., Lomas,D.A.,
            Kim,V. and Silverman,E.K.
  CONSRTM   COPDGene and ECLIPSE Investigators
  TITLE     Genetic susceptibility for chronic bronchitis in chronic
            obstructive pulmonary disease
  JOURNAL   Respir Res 15 (1), 113 (2014)
   PUBMED   25241909
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7724)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 7724)
  AUTHORS   Djurovic,S., Le Hellard,S., Kahler,A.K., Jonsson,E.G., Agartz,I.,
            Steen,V.M., Hall,H., Wang,A.G., Rasmussen,H.B., Melle,I., Werge,T.
            and Andreassen,O.A.
  TITLE     Association of MCTP2 gene variants with schizophrenia in three
            independent samples of Scandinavian origin (SCOPE)
  JOURNAL   Psychiatry Res 168 (3), 256-258 (2009)
   PUBMED   19223264
  REMARK    GeneRIF: The present study suggested that MCPT2 gene as aputative
            susceptibility gene for schizophrenia of Scandinavian origin.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 7724)
  AUTHORS   Daly,A.K., Donaldson,P.T., Bhatnagar,P., Shen,Y., Pe'er,I.,
            Floratos,A., Daly,M.J., Goldstein,D.B., John,S., Nelson,M.R.,
            Graham,J., Park,B.K., Dillon,J.F., Bernal,W., Cordell,H.J.,
            Pirmohamed,M., Aithal,G.P. and Day,C.P.
  CONSRTM   DILIGEN Study; International SAE Consortium
  TITLE     HLA-B*5701 genotype is a major determinant of drug-induced liver
            injury due to flucloxacillin
  JOURNAL   Nat Genet 41 (7), 816-819 (2009)
   PUBMED   19483685
REFERENCE   9  (bases 1 to 7724)
  AUTHORS   Verma,R., Holmans,P., Knowles,J.A., Grover,D., Evgrafov,O.V.,
            Crowe,R.R., Scheftner,W.A., Weissman,M.M., DePaulo,J.R. Jr.,
            Potash,J.B. and Levinson,D.F.
  TITLE     Linkage disequilibrium mapping of a chromosome 15q25-26 major
            depression linkage region and sequencing of NTRK3
  JOURNAL   Biol Psychiatry 63 (12), 1185-1189 (2008)
   PUBMED   18367154
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 7724)
  AUTHORS   Shin,O.H., Han,W., Wang,Y. and Sudhof,T.C.
  TITLE     Evolutionarily conserved multiple C2 domain proteins with two
            transmembrane regions (MCTPs) and unusual Ca2+ binding properties
  JOURNAL   J Biol Chem 280 (2), 1641-1651 (2005)
   PUBMED   15528213
  REMARK    GeneRIF: MCTPs are evolutionarily conserved C2 domain proteins that
            are unusual in that the C2 domains are anchored in the membrane by
            two closely spaced transmembrane regions and represent
            Ca(2+)-binding but not phospholipid-binding modules
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110027.5, AC135626.4 and AC103749.2.
            
            On Jul 2, 2020 this sequence version replaced XM_005254955.4.
            
            Transcript Variant: This variant (4), as well as variants 1, 5, and
            6, encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074969.7410.1,
                                           SRR14038191.195947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357742.10/ ENSP00000350377.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC110027.5         129-232             c
            105-634             AC135626.4         49694-50223         c
            635-697             AC135626.4         34080-34142         c
            698-806             AC135626.4         32787-32895         c
            807-949             AC135626.4         8992-9134           c
            950-1026            AC135626.4         8149-8225           c
            1027-1138           AC135626.4         7500-7611           c
            1139-1174           AC135626.4         3260-3295           c
            1175-1339           AC103749.2         136236-136400       c
            1340-1470           AC103749.2         133925-134055       c
            1471-1657           AC103749.2         124746-124932       c
            1658-1751           AC103749.2         122357-122450       c
            1752-1854           AC103749.2         108413-108515       c
            1855-1957           AC103749.2         107012-107114       c
            1958-2059           AC103749.2         93475-93576         c
            2060-2134           AC103749.2         92542-92616         c
            2135-2254           AC103749.2         90518-90637         c
            2255-2377           AC103749.2         52239-52361         c
            2378-2419           AC103749.2         49577-49618         c
            2420-2529           AC103749.2         34291-34400         c
            2530-2639           AC103749.2         22095-22204         c
            2640-2737           AC103749.2         15744-15841         c
            2738-7724           AC103749.2         8585-13571          c
FEATURES             Location/Qualifiers
     source          1..7724
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.2"
     gene            1..7724
                     /gene="MCTP2"
                     /note="multiple C2 and transmembrane domain containing 2"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
     exon            1..104
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            105..634
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..2806
                     /gene="MCTP2"
                     /note="isoform 1 is encoded by transcript variant 4;
                     multiple C2 and transmembrane domain-containing protein 2;
                     multiple C2-domains with two transmembrane regions 2 1;
                     multiple C2 domains, transmembrane 2"
                     /codon_start=1
                     /product="multiple C2 and transmembrane domain-containing
                     protein 2 isoform 1"
                     /protein_id="NP_001371930.1"
                     /db_xref="CCDS:CCDS32338.1"
                     /db_xref="GeneID:55784"
                     /db_xref="HGNC:HGNC:25636"
                     /db_xref="MIM:616297"
                     /translation="MDLDKPSVWGSLKQRTRPLLINLSKKKVKKNPSKPPDLRARHHL
                     DRRLSLSVPDLLEAEALAPEGRPYSGPQSSYTSVPSSLSTAGIFPKSSSSSLKQSEEE
                     LDWSQEEASHLHVVETDSEEAYASPAERRRVSSNGIFDLQKTSLGGDAPEEPEKLCGS
                     SDLNASMTSQHFEEQSVPGEASDGLSNLPSPFAYLLTIHLKEGRNLVVRDRCGTSDPY
                     VKFKLNGKTLYKSKVIYKNLNPVWDEIVVLPIQSLDQKLRVKVYDRDLTTSDFMGSAF
                     VILSDLELNRTTEHILKLEDPNSLEDDMGVIVLNLNLVVKQGDFKRHRWSNRKRLSAS
                     KSSLIRNLRLSESLKKNQLWNGIISITLLEGKNVSGGSMTEMFVQLKLGDQRYKSKTL
                     CKSANPQWQEQFDFHYFSDRMGILDIEVWGKDNKKHEERLGTCKVDISALPLKQANCL
                     ELPLDSCLGALLMLVTLTPCAGVSVSDLCVCPLADLSERKQITQRYCLQNSLKDVKDV
                     GILQVKVLKAADLLAADFSGKSDPFCLLELGNDRLQTHTVYKNLNPEWNKVFTFPIKD
                     IHDVLEVTVFDEDGDKPPDFLGKVAIPLLSIRDGQPNCYVLKNKDLEQAFKGVIYLEM
                     DLIYNPVKASIRTFTPREKRFVEDSRKLSKKILSRDVDRVKRITMAIWNTMQFLKSCF
                     QWESTLRSTIAFAVFLITVWNFELYMIPLALLLIFVYNFIRPVKGKVSSIQDSQESTD
                     IDDEEDEDDKESEKKGLIERIYMVQDIVSTVQNVLEEIASFGERIKNTFNWTVPFLSS
                     LACLILAAATIILYFIPLRYIILIWGINKFTKKLRNPYSIDNNELLDFLSRVPSDVQK
                     VQYAELKLCSSHSPLRKKRSAL"
     exon            635..697
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            698..806
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..949
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            950..1026
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1138
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1174
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1339
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1470
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1657
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1658..1751
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1854
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1957
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2059
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2134
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2254
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2255..2377
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2419
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2420..2529
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2639
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2640..2737
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2738..7724
                     /gene="MCTP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4136..4141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTP2"
                     /note="hexamer: AACAAA"
     polyA_site      4176
                     /gene="MCTP2"
                     /note="major polyA site"
     regulatory      5805..5810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTP2"
                     /note="hexamer: AATATA"
     polyA_site      5833
                     /gene="MCTP2"
                     /note="major polyA site"
     regulatory      5947..5952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTP2"
                     /note="hexamer: ATTAAA"
     polyA_site      5969
                     /gene="MCTP2"
     regulatory      7702..7707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCTP2"
                     /note="hexamer: AATAAA"
     polyA_site      7724
                     /gene="MCTP2"
                     /note="major polyA site"
ORIGIN      
        1 agggttgctc cctgcgcttc cgagtggcga ctgcagcggg tccggtgcag gtgaggggcg
       61 cgcgcctgcc cagctttgca gcccccgaac gcggcctcgc acaggagtca ttgcagtttt
      121 cagtagaggt gtacttctga gaagtggctt cttgggtctt catgcagcca tggatctgga
      181 taaaccatct gtttggggct cattaaaaca gcggaccagg ccattgttga tcaacttgag
      241 caagaagaag gtgaaaaaga acccaagtaa gcccccagat ctacgggcaa ggcatcactt
      301 ggaccgccgt ctcagcctct ctgtgcctga tctcctggag gctgaggcct tggccccaga
      361 gggccggcct tactccgggc cacagtcttc ctacacctcg gtgcccagca gtctgtccac
      421 tgcagggatc tttcccaaga gcagcagtag ctccttgaaa cagtctgaag aagaattgga
      481 ttggagccag gaagaagcca gtcacctcca tgtggtggaa acagactcag aggaggccta
      541 tgcctctcct gctgagcgga gacgggtgtc cagcaacggc atctttgatc ttcagaaaac
      601 ttcccttgga ggggatgcac cagaagagcc agagaagcta tgtggaagca gtgacctgaa
      661 tgcttctatg acatctcaac attttgaaga acaatctgta ccgggggaag ccagtgatgg
      721 cttgagtaac ctccccagcc cttttgcgta cctcctcacc atacacctga aggaaggccg
      781 gaacctggtt gtccgagatc gctgtggcac aagtgatcct tatgtgaaat ttaagctgaa
      841 tgggaagacg ctgtacaaaa gtaaagtcat atataagaac ttgaacccag tatgggatga
      901 gatagttgta ttgccaatcc aaagccttga tcaaaagcta cgtgtgaagg tatatgatcg
      961 agatttaacc acatctgatt tcatgggttc tgcatttgtc attctcagtg atcttgagct
     1021 taacagaaca actgaacata ttttaaaact ggaagatcca aacagtttag aagatgacat
     1081 gggagtgatc gtgttaaatt tgaacctagt ggtaaaacag ggtgatttca agagacaccg
     1141 ttggtcaaat cggaagcgat taagtgccag caagtcctct ttgatacgca acctacggct
     1201 ctctgagtcc ttgaaaaaga accaactctg gaacgggatt ataagtataa ctttgttgga
     1261 agggaagaat gtctcaggag gaagcatgac agagatgttt gtccagttaa aactgggaga
     1321 tcagaggtat aaaagtaaga cactgtgtaa gagtgcaaat ccgcagtggc aggaacagtt
     1381 tgactttcac tacttctctg acaggatggg cattttggac attgaagtgt ggggaaagga
     1441 caacaaaaag catgaggaac gtctgggcac gtgtaaagtg gatatctcgg cactccctct
     1501 gaagcaagcc aactgcctgg agctgccact ggacagctgt ctgggggctc tccttatgtt
     1561 ggtcacactt acaccctgtg cgggggtctc cgtctctgat ctgtgtgtct gccccttagc
     1621 agacctcagc gaaagaaagc agattaccca gcgatattgc ttacagaact ccctgaaaga
     1681 tgtgaaagac gtcggcattc tacaagtgaa ggttttaaag gcagcagatc tcttagcggc
     1741 agatttctca gggaagagtg acccattttg cttgttggag ttaggcaatg accgacttca
     1801 gacgcatacc gtctacaaaa acctcaaccc tgaatggaac aaagttttta catttcccat
     1861 taaagatatc catgatgttt tggaagtgac agtgtttgat gaagatggag ataaaccccc
     1921 agattttctt ggaaaagttg ccattccctt gctgtccatt agagatggac aaccgaattg
     1981 ttatgtacta aagaataaag atttagaaca agcttttaaa ggagttattt acttagagat
     2041 ggaccttata tataatccgg tgaaagcaag tattaggact tttactcccc gggaaaagcg
     2101 ctttgttgaa gacagccgca agctgtccaa aaagatctta tcaagagatg tggaccgtgt
     2161 gaaaagaatc actatggcaa tatggaatac aatgcagttc cttaaaagct gcttccagtg
     2221 ggaatccaca ttaagaagta caatagcatt cgcggtattt ttgatcactg tctggaattt
     2281 tgaactatat atgatcccct tggcattgtt gctgatcttt gtctacaatt tcatcagacc
     2341 tgtgaaaggc aaggtcagca gcatccagga cagccaggag agcacagaca tagatgacga
     2401 ggaggatgaa gatgacaagg aatctgagaa aaaggggttg attgaaagaa tctatatggt
     2461 acaggatatt gtttcaactg ttcaaaacgt cttggaggaa atagcttctt ttggagaaag
     2521 gattaagaac acatttaact ggacggtccc cttcctttca tctctggcct gtttgattct
     2581 ggcagcagcc accatcattt tgtatttcat tccactgcgg tacatcattt taatctgggg
     2641 cataaataaa tttactaaga agcttcgaaa tccctattcc atcgacaata atgagctact
     2701 agacttcctc tctagggtac cgtctgatgt tcaaaaggtg cagtatgcag aattgaaact
     2761 ctgcagcagc cacagccccc tgcggaagaa gcgcagcgct ctctagggca cacaccgact
     2821 ttggacagca gcacccaata ttgtgtttgg ttgagtagac caatgttatg gctgtttcag
     2881 tggtacccaa ggtgtccttc tgaaatgcat gccctgtggc accctctgta tacttcctcc
     2941 tccttcacgt gcacagacat acacacatgt gcacacaccc tcatgcatgg gtgtcctagt
     3001 tgcgtagagg gtcagcccag cgaaaagcaa caaccccaag actgtgaaag actaacatcc
     3061 attctgaaat aggagataac aaggctgcca tggatctgaa caccaccttc cttgagaaca
     3121 gccaggagcc cacttggatt caagagtgac tttgaacttg ttttcacacc tccaacagac
     3181 tctcattaag attcagttat ttccgctccc cagccccaca ctcctttcag attatcgttc
     3241 atgggcgtaa gtctcttctc agagttaaca agtctttggt agtcatcctc tgtccaaata
     3301 ttgtatatta ttaaaaggca tttttaataa ttaccagaat tagctcaaac ctttagggat
     3361 ctttcagcca tgattattaa ggatatgtat gtgaattttt gggaaacctc tcggtgctgg
     3421 atgccagcct acagcagggt ccattgctgg caatggatgg cccaggaagg tccctagaga
     3481 tcactcactt gaaaaatgag ggtcccatga aagtatttgg ttgccttctg atgccacttc
     3541 ttctcacttt actttttgct tattttcaaa atattataaa atgtcaacat ataatttcag
     3601 aaaggcaggt gggggtaggg gagaaatgaa tgaataaatt ctctaggtat ttagaaagat
     3661 aagaaactga agaccgagag actaataagg ctgcttacct aattattata atcatttcat
     3721 ttgcctgaat gttttaagca ggaagtagaa atactttggc tgcccaaatg tatcttttgt
     3781 tcctcttaga agtaaaataa gctacataca ataaaaattt atttcagaac cccatttcta
     3841 gaaaatacca ccccagagtc ctcatttgat agcatctgtc tcctgcagac ctcatcattc
     3901 cacagtattt ccctgccatg taaaaatcct gactttgtgc gtatataaaa tgtatgcaat
     3961 taagtctgtt taaatgatat ttaagtttta aagactgtat tttgttgaca catactttgt
     4021 gcagttttta tgtatgtatg tattataaaa aaagttaagg ttaaaaagat ctcatttaat
     4081 agtgagttca ctattttttt ttttttgtct ctgggttgta atttaataat cttcaaacaa
     4141 aatgtttacg aaaaatgcca aagattctaa atcttatcat cccgtgtctg tttttcttca
     4201 tgttgtatct cactgggttg ctttctggct gagccagaat tctgcatgat ttgatttact
     4261 tcaagttaat gaagctggct ggaaaagagc cttgcagaaa ttataaaagc tccagtaaat
     4321 ctcgtagttg tacatacaat agatacccaa gaacctcttt tgttaaacca gttactcaat
     4381 cttctgtgta aacaatgcct cattgtcttg cttctaacta tcatctagtt tatcatagtc
     4441 tgtcattttg taacgaccta agtcagacat ttttaaacag acatgtgaga tctgatcagt
     4501 catttgaatg aaaactttca gcagcaaaat aaccccttat ttatttaaaa gtggaaccaa
     4561 tactttattg ttgttctttt gctatagaat ttcaaaatga aattatttgc ccgacaagaa
     4621 ggcatcatta gttagacttg tttcctctgt agcccgattg aaattctcag tgttaagttt
     4681 aggacccaaa caccagctgg gacgtaagag caggaccgaa tcaaccttga ataaactgta
     4741 tatagaaaac aattgttagt tgattaagta gacattggat gtttgttaga aaggaatgtt
     4801 agttgtaagt gacatgttaa gatttataca attgtcaaaa acttttagga aagattccag
     4861 aatgcttttg ataaaattta tcgattgtgg attcacagtg tgataattaa gtagggatgt
     4921 tgaagtcttg ccaagttttc ctggttccct tctcaaactt tatcttccca tttctagccc
     4981 tgtctctcta tcttacaggc atctacacct cagcaagtca gaaactaaac atcatctgtc
     5041 tctccctgtc ttcagaaccc caaccctcat aatctccttc cagcttcctt atttccctta
     5101 ccaggactgg cattttctgg gcttggaatt tctcggtcat cctctttttt tttgttcctc
     5161 gtgctgttgt cctcgtctcc caacccctaa agcctagtag gtccagtgtc aatgcattaa
     5221 ccacttctgt tctgatttcc accacccaag tggaggcctt cataacctct cagacgtcac
     5281 ggccatgatg ccagttacat tatgcctagt taatcttcat tcagactgga aggacctgcc
     5341 cccagttgtt tctttctgaa tagattctac tctccttcaa cacttccaaa gtctcctgcc
     5401 ccaaagaggc ttagttagtc ctgtggctgg atgtgactcc aacttccttt tttgtaccat
     5461 cacatctttc atatctttct ggcatctgcc atacatcata agaggctttg accactgtcc
     5521 tccactgaat agcccattac agctagcacc taatagttac tcaggaaata aatacatgtt
     5581 taacaggcca ggtcgtagag attatttttc tttctctgcc ttttcatgtg ctgctttcag
     5641 aacagagggc tggattggat agattagtat gatctatcct ggagattcat ttcttgcatt
     5701 aagagcttat tttgtgtgat attatttata atccctgact atgtcaatta taaactttta
     5761 aattatgtct tatatttgaa gttcttacct acatatcaga ggaaaatata atgtttattt
     5821 ctaggtggta aaacaatctt ctggattctt ttttctttac ttgtaaatta tcatttaaca
     5881 agtctatatt gaatgccgat aattttctgg aacaaaacag actacattcc cttggtaaag
     5941 ccagacatta aacagatact ttcaagcaac agcatgccat gctcagattt aagtttgaaa
     6001 aatattctag ctgcaatgga tagcctagca attttcaaag tttagagaag ttattaatat
     6061 tagccctttg tagtactcct gataaatgaa taacaccctg gactttcaaa tagtggcact
     6121 gggaaaaaag taagtagaat tgagagatgg tgaagagata aagtgagcag gacttaacaa
     6181 ttgctggact atgggatgag ggagcgtaga gtcaaggatg gctctcagtc cctaggtctc
     6241 caggtctagg aagatggtgt tacctttcac taagggagag aactgtaaga actgctgtga
     6301 gaggaccaca ggagtccagt tttagcgctg aatctcaggt gactgaaaag catccaaata
     6361 ggaatgtcag caaggtaatg gaatatatag ttctcagaga agtaacacac tgtacttgag
     6421 atgtacacaa gttaaaggca aacattgtat atgaaaagtg atcaaaacta catgcttcaa
     6481 gaaattaaac cttgaagaac tcaacagtta atgtcatata tagaaaggca agtcagttaa
     6541 gagtgtaaat agaaacgggt aaatacagag gagaaaaaca gtaagcatgg actgtcctag
     6601 aattcagtgg cagagcatac tgcaagaaag ctgatgtggt caataatatc aaatgccgct
     6661 gagatcacat aagtacagaa tcatgacctt aatggtttga cagtttggaa gcaccctggc
     6721 aacaagccat ttcagtggaa tggtagaaat ggaaaccacg ctgggttgag aagtgagtgg
     6781 atgtgaaaat atggggcctc tgaatggagg taacccttga aaaattccac tgtggagaag
     6841 aaaggagaga gagagggctg gaatttggaa tgaaaggaga tatttgggat tattttagta
     6901 agaaaacaga ggtgtcatga cctcagtgta accctattag ctgcaaaaaa ttcttcatgg
     6961 gcttgagatg gagttagcca tattcattat tgaaaactat gttctgcact tatacattgt
     7021 tggttggagt gtaaattagt tcaaccgctg tggaagacag ggtgggtgtt tcctcaaaaa
     7081 cctaaagaca gaaataccat ttgacccagc aatcccataa ctgggtatgt acccaaagga
     7141 atataaattg ttctactata aaaacacatg cacacacatg ttcactgcaa cactatttac
     7201 aatagcaaag acactggatc agtctaaatg cccatcattg atagaatgga taaagaaaat
     7261 gtggtagagg tacaccatgg aatactatgc agccataaaa aagaatgaga tcatgtcctt
     7321 ttgcaggaac ttggatacag ctggaggcca ttatccttag caaactaatg cagcaacaga
     7381 aaaccaaata ccacatgttc tcatttatag gtaggagtta aatgatgaga acacatggac
     7441 atgtagaagg gaacaaaata cactgggggc tattggaggg tgaagggtga aaggaggaag
     7501 aggatcagga aaaataatga gtaccaggct taatacatgg gcgatgaaat aatctgtatg
     7561 acaagcctct ctgacacagt ttacctatgt aacaaacctg cacagttacc cctgaacttt
     7621 aaaaaaaact atgttctatc aaaacctgcc tctcatttat gtattaggaa tcttgtgaca
     7681 acggaacagt tgaaaaatta aaataaaaat tgcctgaaaa tgca
//
