LOCUS       NM_006337               1938 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens microspherule protein 1 (MCRS1), transcript variant 1,
            mRNA.
ACCESSION   NM_006337
VERSION     NM_006337.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1938)
  AUTHORS   Huang,C.J., Lyu,X. and Kang,J.
  TITLE     The molecular characteristics and functional roles of microspherule
            protein 1 (MCRS1) in gene expression, cell proliferation, and
            organismic development
  JOURNAL   Cell Cycle 22 (6), 619-632 (2023)
   PUBMED   36384428
  REMARK    GeneRIF: The molecular characteristics and functional roles of
            microspherule protein 1 (MCRS1) in gene expression, cell
            proliferation, and organismic development.
            Review article
REFERENCE   2  (bases 1 to 1938)
  AUTHORS   Laguillo-Diego,A., Kiewisz,R., Marti-Gomez,C., Baum,D.,
            Muller-Reichert,T. and Vernos,I.
  TITLE     MCRS1 modulates the heterogeneity of microtubule minus-end
            morphologies in mitotic spindles
  JOURNAL   Mol Biol Cell 34 (1), ar1 (2023)
   PUBMED   36350698
  REMARK    GeneRIF: MCRS1 modulates the heterogeneity of microtubule minus-end
            morphologies in mitotic spindles.
REFERENCE   3  (bases 1 to 1938)
  AUTHORS   Viard,J., Loe-Mie,Y., Daudin,R., Khelfaoui,M., Plancon,C.,
            Boland,A., Tejedor,F., Huganir,R.L., Kim,E., Kinoshita,M., Liu,G.,
            Haucke,V., Moncion,T., Yu,E., Hindie,V., Blehaut,H., Mircher,C.,
            Herault,Y., Deleuze,J.F., Rain,J.C., Simonneau,M. and
            Lepagnol-Bestel,A.M.
  TITLE     Chr21 protein-protein interactions: enrichment in proteins involved
            in intellectual disability, autism, and late-onset Alzheimer's
            disease
  JOURNAL   Life Sci Alliance 5 (12), e202101205 (2022)
   PUBMED   35914814
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1938)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 1938)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 1938)
  AUTHORS   Song,H., Li,Y., Chen,G., Xing,Z., Zhao,J., Yokoyama,K.K., Li,T. and
            Zhao,M.
  TITLE     Human MCRS2, a cell-cycle-dependent protein, associates with
            LPTS/PinX1 and reduces the telomere length
  JOURNAL   Biochem Biophys Res Commun 316 (4), 1116-1123 (2004)
   PUBMED   15044100
REFERENCE   7  (bases 1 to 1938)
  AUTHORS   Lehner,B., Semple,J.I., Brown,S.E., Counsell,D., Campbell,R.D. and
            Sanderson,C.M.
  TITLE     Analysis of a high-throughput yeast two-hybrid system and its use
            to predict the function of intracellular proteins encoded within
            the human MHC class III region
  JOURNAL   Genomics 83 (1), 153-167 (2004)
   PUBMED   14667819
REFERENCE   8  (bases 1 to 1938)
  AUTHORS   Lin,D.Y. and Shih,H.M.
  TITLE     Essential role of the 58-kDa microspherule protein in the
            modulation of Daxx-dependent transcriptional repression as revealed
            by nucleolar sequestration
  JOURNAL   J Biol Chem 277 (28), 25446-25456 (2002)
   PUBMED   11948183
  REMARK    GeneRIF: role in the modulation of Daxx-dependent transcriptional
            repression
REFERENCE   9  (bases 1 to 1938)
  AUTHORS   Bruni,R. and Roizman,B.
  TITLE     Herpes simplex virus 1 regulatory protein ICP22 interacts with a
            new cell cycle-regulated factor and accumulates in a cell
            cycle-dependent fashion in infected cells
  JOURNAL   J Virol 72 (11), 8525-8531 (1998)
   PUBMED   9765390
REFERENCE   10 (bases 1 to 1938)
  AUTHORS   Ren,Y., Busch,R.K., Perlaky,L. and Busch,H.
  TITLE     The 58-kDa microspherule protein (MSP58), a nucleolar protein,
            interacts with nucleolar protein p120
  JOURNAL   Eur J Biochem 253 (3), 734-742 (1998)
   PUBMED   9654073
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY078747.1, BC011794.2 and R66413.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006337.4.
            
            Transcript Variant: This variant (1) has an alternate 5' coding
            sequence, compared to variant 2. The resulting isoform (1) is
            shorter and has a distinct N-terminus, compared to isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011794.2, SRR14038194.4502291.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000343810.9/ ENSP00000345358.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                HY078747.1         4-17
            15-1935             BC011794.2         1-1921
            1936-1938           R66413.1           21-23               c
FEATURES             Location/Qualifiers
     source          1..1938
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..1938
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /note="microspherule protein 1"
                     /db_xref="GeneID:10445"
                     /db_xref="HGNC:HGNC:6960"
                     /db_xref="MIM:609504"
     exon            1..95
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            96..215
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     CDS             206..1594
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /note="isoform 1 is encoded by transcript variant 1; INO80
                     complex subunit Q; cell cycle-regulated factor (78 kDa);
                     INO80 complex subunit J; 58 kDa microspherule protein;
                     cell cycle-regulated factor p78"
                     /codon_start=1
                     /product="microspherule protein 1 isoform 1"
                     /protein_id="NP_006328.2"
                     /db_xref="CCDS:CCDS8787.1"
                     /db_xref="GeneID:10445"
                     /db_xref="HGNC:HGNC:6960"
                     /db_xref="MIM:609504"
                     /translation="MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPK
                     RRSSSRFIKRKKFDDELVESSLAKSSTRAKGASGVEPGRCSGSEPSSSEKKKVSKAPS
                     TPVPPSPAPAPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGV
                     KFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLS
                     KVGSTSQPTLETFQDLLHRHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGD
                     QVLNFSDAEDLIDDSKLKDMRDEVLEHELMVADRRQKREIRQLEQELHKWQVLVDSIT
                     GMSSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQG
                     VIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIA
                     LIRAEAAKITPQ"
     exon            216..354
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            355..493
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            494..652
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            653..762
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            763..871
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1010
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1086
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1087..1115
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1208
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1291
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1379
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1507
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1938
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1913..1918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /note="hexamer: AATAAA"
     polyA_site      1938
                     /gene="MCRS1"
                     /gene_synonym="ICP22BP; INO80Q; MCRS2; MSP58; P78"
                     /note="major polyA site"
ORIGIN      
        1 aaccggaagt agacgtacct cacggaagcc ggctttggcc ctgcggctgc taccgtcgcc
       61 gcggagaaat tgttggatct ggcagtctag gaatgaatct cctctcagcc tttaagctca
      121 cctggtcaga atccttggat gagcctgtgg gaccgttcct cctagcccgg tggtttggaa
      181 ccagtggctt tgggactgta agaggatgga caaagattct caggggctgc tagattcatc
      241 cctgatggca tcaggcactg ccagccgctc agaggatgag gagtcactgg cagggcagaa
      301 gcgagcctcc tcccaggcct tgggcaccat ccctaaacgg agaagctcct ccaggttcat
      361 caagaggaag aagttcgatg atgagctggt ggagagcagc ctggcaaaat cttctacccg
      421 ggcaaagggg gccagtgggg tggaaccagg gcgctgttcg gggagtgaac cctcctccag
      481 tgagaagaag aaggtatcca aagcccccag cactcctgtg ccacccagcc cagccccagc
      541 ccctggactc accaagcgtg tgaagaagag taaacagcca cttcaggtga ccaaggatct
      601 gggccgctgg aagcctgcag atgacctcct gctcataaat gctgtgttgc agaccaacga
      661 cctgacctcc gtccacctgg gcgtgaaatt cagctgccgc ttcacccttc gggaggtcca
      721 ggagcgttgg tacgccctgc tctacgatcc tgtcatctcc aagttggcct gtcaggccat
      781 gaggcagctg cacccagagg ctattgcagc catccagagc aaggccctgt ttagcaaggc
      841 tgaggagcag ctgctgagca aagtgggatc gaccagccag cccaccttgg agaccttcca
      901 ggacctgctg cacagacacc ctgatgcctt ctacctggcc cgtaccgcga aggccctgca
      961 ggcccactgg cagctcatga agcagtatta cctgctggag gaccagacag tgcagccgct
     1021 gcccaaaggg gaccaagtgc tgaacttctc tgatgcagag gacctgattg atgacagtaa
     1081 gctcaaggac atgcgagatg aggtcctgga acatgagctg atggtggctg accggcgcca
     1141 gaagcgagag attcggcagc tggaacagga actgcataag tggcaggtgc tagtggacag
     1201 catcacaggc atgagctctc cggacttcga caaccagaca ctggcagtgc tgcggggccg
     1261 catggtgcgg tacctgatgc gctcgcgtga gatcaccctg ggcagagcaa ccaaggataa
     1321 ccagattgat gtggacctgt ctctggaggg tccggcctgg aagatatccc ggaaacaagg
     1381 tgtcatcaag ctgaagaaca acggtgattt cttcattgcc aatgagggtc gacggcccat
     1441 ctacatcgat ggacggccgg tgctctgtgg ctccaaatgg cgcctcagca acaactctgt
     1501 ggtggagatc gccagcctgc gattcgtctt ccttatcaac caggacctca ttgccctcat
     1561 cagggctgag gctgccaaga tcacaccaca gtgaggagtg gtggcaggac tcgtgggccc
     1621 tctccggcct gtttcccctg ccactccagc ccccttgagc tgggaactca ggctcctgga
     1681 aaaacctggg cagtgggagg ctcagctgcg ggccattgat ttgagccttt gagggaggat
     1741 agggctggcc tttgtgaagc cagcagaggc tgagaacctc aggcttccct agatccagag
     1801 cccctcccca tcttcctctc tctaaaaaca accctacccc ccattgccac cttcactcct
     1861 gtgtctccag ctgattagcc tcagactctt cttttattgt ttttcttttg taaataaaaa
     1921 gcaccaggtt ccaaagta
//
