LOCUS       NM_138418                931 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens MAPK regulated corepressor interacting protein 2
            (MCRIP2), transcript variant 1, mRNA.
ACCESSION   NM_138418
VERSION     NM_138418.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 931)
  AUTHORS   Wang,Y., Chen,D., Zhang,Y., Wang,P., Zheng,C., Zhang,S., Yu,B.,
            Zhang,L., Zhao,G., Ma,B., Cai,Z., Xie,N., Huang,S., Liu,Z., Mo,X.,
            Guan,Y., Wang,X., Fu,Y., Ma,D., Wang,Y. and Kong,W.
  TITLE     Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
            Through Sphingosine-1-Phosphate Receptor 2
  JOURNAL   Circulation 138 (1), 48-63 (2018)
   PUBMED   29453251
  REMARK    GeneRIF: Novel adipokine, FAM19A5, was capable of inhibiting
            postinjury neointima formation via sphingosine-1-phosphate receptor
            2-G12/13-RhoA signaling.
REFERENCE   2  (bases 1 to 931)
  AUTHORS   Bish,R., Cuevas-Polo,N., Cheng,Z., Hambardzumyan,D., Munschauer,M.,
            Landthaler,M. and Vogel,C.
  TITLE     Comprehensive Protein Interactome Analysis of a Key RNA Helicase:
            Detection of Novel Stress Granule Proteins
  JOURNAL   Biomolecules 5 (3), 1441-1466 (2015)
   PUBMED   26184334
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 931)
  AUTHORS   Kim,J.M., Lee,K.H., Jeon,Y.J., Oh,J.H., Jeong,S.Y., Song,I.S.,
            Kim,J.M., Lee,D.S. and Kim,N.S.
  TITLE     Identification of genes related to Parkinson's disease using
            expressed sequence tags
  JOURNAL   DNA Res 13 (6), 275-286 (2006)
   PUBMED   17213182
REFERENCE   4  (bases 1 to 931)
  AUTHORS   Oh,J.H., Yang,J.O., Hahn,Y., Kim,M.R., Byun,S.S., Jeon,Y.J.,
            Kim,J.M., Song,K.S., Noh,S.M., Kim,S., Yoo,H.S., Kim,Y.S. and
            Kim,N.S.
  TITLE     Transcriptome analysis of human gastric cancer
  JOURNAL   Mamm Genome 16 (12), 942-954 (2005)
   PUBMED   16341674
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM761884.1 and BC001912.1.
            
            On Nov 22, 2018 this sequence version replaced NM_138418.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.472016.1,
                                           SRR1163657.200302.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307650.9/ ENSP00000305138.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                BM761884.1         25-45
            22-931              BC001912.1         1-910
FEATURES             Location/Qualifiers
     source          1..931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..931
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /note="MAPK regulated corepressor interacting protein 2"
                     /db_xref="GeneID:84331"
                     /db_xref="HGNC:HGNC:14142"
     exon            1..216
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..647
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM195A; family with sequence similarity 195,
                     member A; MAPK regulated co-repressor interacting protein
                     2"
                     /codon_start=1
                     /product="MAPK regulated corepressor interacting protein 2
                     isoform 1"
                     /protein_id="NP_612427.2"
                     /db_xref="CCDS:CCDS10415.1"
                     /db_xref="GeneID:84331"
                     /db_xref="HGNC:HGNC:14142"
                     /translation="MYTITKGPSKLVAQRRTGPTQQQVEGRLGELLKCRQPAPPTSQP
                     PRAQPFAQPPGPWPLSSPGPRLVFNRVNGRRAPSTSPSFEGTQETYTVAHEENVRFVS
                     EAWQQVQQQLDGGPAGEGGPRPVQYVERTPNPRLQNFVPIDLDEWWAQQFLARITSCS
                     "
     exon            217..346
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /inference="alignment:Splign:2.1.0"
     exon            347..474
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /inference="alignment:Splign:2.1.0"
     exon            475..576
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /inference="alignment:Splign:2.1.0"
     exon            577..931
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      912..917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /note="hexamer: AATAAA"
     polyA_site      931
                     /gene="MCRIP2"
                     /gene_synonym="C16orf14; c349E10.1; FAM195A"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgtgtc cggggtcagc ccgagcccgt gcgggccctt taagggccgg gggcgtgtag
       61 cgggcccgcc ccctccccgc ggcgcccgca gtccgttaag tgcgagcccc ggcgcagggg
      121 ccggatctgg ccgggggccg gcggcggtgt gggagcggcg cgtcatgtac accatcacca
      181 aggggcccag caagctggtc gcgcagcgcc gcacaggtcc cacgcagcag caggtggagg
      241 gccggctcgg cgagctcctg aaatgccggc agcccgcgcc gccgacctcg cagcccccgc
      301 gggcgcagcc ctttgcgcag ccgccgggac cctggcccct gtcgagtcca gggccaaggc
      361 ttgtgttcaa tcgtgtgaat ggccggcggg ccccctccac gtccccatcc ttcgagggga
      421 cccaggagac ctacacagtg gcccacgagg agaatgtccg ctttgtgtcc gaagcctggc
      481 agcaggtgca acagcagctg gatggtggcc cagccggtga gggcgggcca aggcctgtgc
      541 agtacgtgga gaggaccccc aatccccggc tgcagaactt tgtgcccatt gacctagacg
      601 agtggtgggc gcagcagttc ctggcgagaa tcaccagctg ttcctagtgg ctgctgggag
      661 ggggcgctgc tacacggccg acctgtcgcc aggagagaag catggcgccc tgcccaccca
      721 ctgcgcctgg ctgggtgccg gccacacctg aagtgccagc atttggactt ttgcaccttt
      781 ttttcccttg gcccggctgt cccaaccaag ctgccatggc caagggccga acccgtctga
      841 cctcagccct gctcactgtg cccagggacc agcgaccagc ccctggggct ggcagggagg
      901 agctccaggc taataaagtg gagaaactgt c
//
