LOCUS       NM_173518               5074 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens minichromosome maintenance domain containing 2
            (MCMDC2), transcript variant 1, mRNA.
ACCESSION   NM_173518
VERSION     NM_173518.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5074)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG722401.1, AK302672.1, AK303003.1, AC011031.12 and AL833526.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173518.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK302672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000422365.7/ ENSP00000413632.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-629               BG722401.1         28-656
            630-1816            AK302672.1         611-1797
            1817-2285           AK303003.1         1595-2063
            2286-5003           AC011031.12        165368-168085
            5004-5074           AL833526.1         3692-3762
FEATURES             Location/Qualifiers
     source          1..5074
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q13.1"
     gene            1..5074
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /note="minichromosome maintenance domain containing 2"
                     /db_xref="GeneID:157777"
                     /db_xref="HGNC:HGNC:26368"
                     /db_xref="MIM:617545"
     exon            1..61
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            62..243
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     CDS             150..2195
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /note="isoform a is encoded by transcript variant 1; MCM
                     domain-containing protein C8orf45; MCM domain-containing
                     protein 2; minichromosome maintenance domain-containing
                     protein 2"
                     /codon_start=1
                     /product="minichromosome maintenance domain-containing
                     protein 2 isoform a"
                     /protein_id="NP_775789.3"
                     /db_xref="CCDS:CCDS6197.2"
                     /db_xref="GeneID:157777"
                     /db_xref="HGNC:HGNC:26368"
                     /db_xref="MIM:617545"
                     /translation="MSNLKMKEAALIYLDRSGGLQKFIDDCKYYNDSKQSYAVYRFKI
                     LINPSDVVELDAELGNHILHQPLKAAEVFQSVCFIAVKTLSLIGQLQTETQINIVLKL
                     THLPPLPSYGLDLCEFPLDYTSQRFYMMQGIVIAMTTITKYTQGARFLCSDEACPLSK
                     GFQYIRVHVPGATESATIRNDFLCNLCASSLQEDRKFRVLGDKQIVEIIATKALRAFQ
                     GYSNNQPFRFQSLTIFLRDESVNKMNIGNEYKIIGIPTCVKTSQTAVCIEANSITFCN
                     SKVPSGISDNFRCLLSLTSSSCWKFTAILANIFASQITPPGTYNLLKLCLLMSLVQTT
                     DRNKELEDCLDILIITSDTLLIDRLLNFSINLVPRGIRHLVSTEIFPTLSRNKYGTGA
                     VSIQAGSALLAKGGICFIGDLASHKKDKLEQLQTVLESRSITVYIPGKKFGEDIDQQM
                     TFPVQCSFWSFVDVDSSSRRNAQKINTLIGQMDCSLIPANLVEAFGLLINCNESSPCH
                     PFLPTVQHTLNKAINPEGLFYAASRQFTTEDFEKLLAFAKNLNVEFSLEAERMTHGYY
                     LASRRIRTGSVCGSKLSASALKYLVFLSEAHARLNLRNKVLKEDVLIAALLFETSLTL
                     KYGATVFCVAPNAVFPFELYNEEYLEQRDLYLTQCQQQLEQFIATYGPGTTIFSSDE"
     exon            244..374
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            375..434
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            435..630
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            631..753
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            754..858
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            859..984
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1222
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1428
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1595
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1775
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1918
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2028
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     exon            2029..5074
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5053..5058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /note="hexamer: AGTAAA"
     polyA_site      5062
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /note="major polyA site"
     polyA_site      5074
                     /gene="MCMDC2"
                     /gene_synonym="C8orf45"
                     /note="major polyA site"
ORIGIN      
        1 aggactccgc tccgcctacg ctgcaggcgg agagcaaccg ccaagcttgg tgggagtcaa
       61 ggttttcaca tcctttctat gagtttcgcc atctatagct tttatcaaca attgtggttt
      121 aatcaattag aaatattaac caggagaaaa tgtcaaatct aaaaatgaaa gaggcggccc
      181 tcatctatct tgacagaagt ggaggcctcc aaaagtttat agatgattgc aagtactaca
      241 atgattcaaa acaaagctat gctgtctatc gattcaaaat tttaataaat ccctctgatg
      301 ttgttgaatt agatgctgag cttggaaatc acattttaca ccaaccttta aaagctgctg
      361 aagtctttca atcagtctgt tttattgctg ttaagactct ctcattaatt ggacaattgc
      421 agactgaaac gcaaattaat atagtgctga aattaacaca tttacctccc ctgccaagtt
      481 atggtcttga tctttgtgag tttccacttg attatacatc tcagagattt tatatgatgc
      541 aaggaattgt gattgcaatg acaactataa ccaagtatac acaaggggca agatttcttt
      601 gttcagatga agcatgccct ctttcaaaag gatttcagta tataagagtg catgtgcctg
      661 gtgctacaga atctgcaacg ataagaaatg actttttgtg taatctatgt gcatcttcac
      721 ttcaagaaga cagaaaattt agagtacttg gtgataaaca aatagttgaa ataattgcca
      781 caaaggcact tcgtgctttt caaggatatt ctaacaacca gccatttagg tttcaatcac
      841 ttacaatttt cctaagagat gaatcagtga ataaaatgaa tataggaaat gaatataaaa
      901 ttattggaat tccaacctgt gtaaaaacct cacaaactgc tgtctgtata gaagcaaata
      961 gcataacttt ttgtaattca aaagttcctt caggaattag tgacaacttc aggtgtctcc
     1021 tctccttaac ttccagctca tgctggaagt ttacagcaat acttgccaat atctttgcat
     1081 cacaaattac ccctcctggg acttacaatt tgctcaagct ctgtttgttg atgagtctag
     1141 tacagacaac tgaccgtaac aaggaactgg aagattgcct ggatatttta attataacaa
     1201 gtgatactct actcatagac aggcttctga attttagcat aaaccttgtc ccccgtggta
     1261 tacgtcatct agtctctact gaaatttttc ccactctatc caggaataag tatggaactg
     1321 gagcagttag cattcaggct ggcagtgctt tgctagctaa aggtggtatc tgctttatag
     1381 gagacttggc ttcacacaaa aaagataaac ttgaacagct tcaaacagtt ctggagagca
     1441 gaagcatcac agtgtacatc ccaggaaaga agtttgggga ggatattgat caacagatga
     1501 cttttccagt tcagtgcagt ttttggtctt ttgttgatgt ggattcatct tcaaggagaa
     1561 atgcacagaa aatcaacact ctaattggtc agatggattg cagtttgatt ccagctaacc
     1621 ttgtggaggc atttggttta ttgattaact gcaacgagtc atctccctgc cacccatttc
     1681 ttcctactgt gcaacacact ttgaacaaag ccattaatcc tgaagggctg ttttatgcgg
     1741 cttctagaca gttcacaact gaagattttg aaaagctatt ggcttttgca aagaatttga
     1801 atgtagaatt cagcttggaa gcagaaagaa tgacccatgg ctattatcta gcaagtcgca
     1861 gaatcagaac aggctctgta tgtggatcaa agctgtcagc atctgcatta aaatatctcg
     1921 ttttcctatc tgaagcccat gcacgactga acttaaggaa caaagtgctt aaagaagatg
     1981 tgctgattgc agccttacta tttgaaacat ccctcacatt gaaatatggg gccactgtat
     2041 tttgtgttgc tccgaatgca gtatttccat ttgaactgta taatgaagaa tacttagagc
     2101 aaagggatct ctatctgact cagtgccaac aacagctgga acaatttatt gccacatatg
     2161 gacctgggac aactattttc tctagtgatg aataagcaat ttgaggaatt tttgttcatt
     2221 cctacttaag cagtggagaa aaagtgtgac tattttgaga gtgactttga agtaatgctt
     2281 tgataatact ctgtacagga atatattaca atactgtttt taaaaatata aaatatagtc
     2341 ccctcaaaac taattgctaa tgggataaat actaatccaa acctctaaaa ccaacagaat
     2401 tttaaaactt agaacaatgt ggacaattta aagtgataaa gttgtcaagg agaatactat
     2461 aaagaaaaac ctggttagcc cagaatacca gtggtgaaca gataaaaatg taaatgttgc
     2521 aatttgagca gtgtgtaaaa tggcaacctt tatgtagttc actctactgt cacaagatgg
     2581 caataactct ttacctacaa attactctaa aacatttttc ttccacttgt gaacttgcta
     2641 aactgatgag taaatacttt atataacccg aagcttcaaa tgtaaggcct tttcatactt
     2701 tattactggc ctgtccatta catactactg ttttagaagc cctaaatatg gaatcgggaa
     2761 aagccttgga agttttccat acgtatacgc taggttaaat gaaaaaaata ctttacacgg
     2821 aaacaaggag ccaataactt ataaattggc tctctaaccc taactggtta caagaaaggc
     2881 tccaaaaggc aaagaaacca acttgcaaat ctagtcctca tttttggagg gaagatatct
     2941 gctctgaaaa gataggggca ccatgagaaa acaaatccat cttgtaaaat ttataaatcc
     3001 tttttagttc agtttccata actttaataa aagatcagtt ctattcacag aaaagcaaaa
     3061 tgtcattacc aaattgccac tttattaacc aagatgttac catgcatcaa ttctttcaaa
     3121 actggtccct taacagagat gcttaactgt acagctggac ctctcccact ctccacagga
     3181 cccggaggaa gttgttcact attactgaat acctactagt agcagggagt aaacagtatt
     3241 agttttcaga agccaaaggt agtgtttttg ttttttgttt ttttgagatg gggtctcgct
     3301 ctgtcatgca ggctggagtg cagtggtgtt atcttggcac tgcaacctcc acctcccggg
     3361 ttcaagtgat tctcctgctg ggattacagg tgcactccac catgactggc taatttttgt
     3421 atttttagta gagacagggt ttcaccatgt tggccaggct ggtcttgaac tcccgacctc
     3481 aggtgatctg cctgcctcag tctcccaaag tgctaagaca acaggtatga gccaacacga
     3541 ctggcgactg tagttttcaa caaaatactt acatattaca gttctataat gttaagacgt
     3601 ttattttgtg cttctcaaat actacatttc aaacatgtct ggctctctat ggggggaagg
     3661 caaaacacat tcctatttta taaaactagg atccttttac aattggaaag tttaaaaact
     3721 tttttttttg gagacagggg ctgtcaccgt ttggagggtt gtggcgccac ctcagctccc
     3781 tgcagccttg accttgcaag taattctccc accttaggcc tccgagtagc tgggactaca
     3841 gggacatgct accaccctgg gataacttct gcattttttg tagagatgga attttgccat
     3901 gtttcccagg ctggtctcaa gtcatcctcc catctcagta cctcagcttc ccagtgttgg
     3961 gattacagga gtgagccacc atgcatggca caaagatggc ttttatttac ttatctatat
     4021 ttatatatac atatttatat gtagctgtca cccaagctgt agtgtactga tgcaatcata
     4081 gctcactgcc accttaatct ccccagctca aaaaacccaa cctcagtctc aaagatggtt
     4141 acttcaccac aaaaaaatta aaatgtttaa gtttctcatt aaagagtaga agtgtacatt
     4201 cagaaacaat tatgggaggt aattcattaa tattaaatat gccaacggta ttttaaaggt
     4261 tattggagaa ttagaagggg gtggggtgca ggacgaaaaa ttaatgggtg caatgtacac
     4321 cattcaggta atggctgcac aaaaagctca gactccaaac tacttcatat acctatgcaa
     4381 cagaactgca cttatacccc ccaaatctat actgagggaa gtgactaaga tgttgctata
     4441 caggttttat accatttatc atataaaaat tataaccttg gtaaaaggaa tttataagct
     4501 agtactcaac aggagaaaag atttagctct aaaccttcac ccagatataa attcagcttt
     4561 agaattcttg ccaatttagt cctagacaga ctggtctgct cagtcatttc tcttaacata
     4621 gcatattgct tagttattac atgtactagt attaggatga cttttttgtt cacaaagatg
     4681 aaagcaaact gaataaaaaa ggtgaaacct ttatctgtaa gggggaattt gattgctatt
     4741 tggtattaaa gagttttaag attcaaccac ctggtacaac agcaggctct gaaggggaag
     4801 ccagacaggg aacctagagg tacaagcaat gtctccccag ctgtcagcct caatgagaat
     4861 caccacccat aaataagcta attattgaca agattataat ctttcgaata tgttcaaaac
     4921 aggtctgact agtgactatg agaatggagc tatttagagt tgatttaaaa gaaaacactt
     4981 tattgttcag caattaaaag ttagccaaat atgtattttt ctccataatt tattgtgatg
     5041 ttatcaacat caagtaaaat gctcattttc atca
//
