LOCUS       NM_017696               5219 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens minichromosome maintenance 9 homologous recombination
            repair factor (MCM9), transcript variant 1, mRNA.
ACCESSION   NM_017696
VERSION     NM_017696.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5219)
  AUTHORS   Acharya,A., Bret,H., Huang,J.W., Mutze,M., Gose,M., Kissling,V.M.,
            Seidel,R., Ciccia,A., Guerois,R. and Cejka,P.
  TITLE     Mechanism of DNA unwinding by MCM8-9 in complex with HROB
  JOURNAL   Nat Commun 15 (1), 3584 (2024)
   PUBMED   38678026
  REMARK    GeneRIF: Mechanism of DNA unwinding by MCM8-9 in complex with HROB.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5219)
  AUTHORS   McKinzey,D.R., Li,C., Gao,Y. and Trakselis,M.A.
  TITLE     Activity, substrate preference and structure of the HsMCM8/9
            helicase
  JOURNAL   Nucleic Acids Res 51 (14), 7330-7341 (2023)
   PUBMED   37309874
  REMARK    GeneRIF: Activity, substrate preference and structure of the
            HsMCM8/9 helicase.
REFERENCE   3  (bases 1 to 5219)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 5219)
  AUTHORS   Li,J., Yu,D., Liu,L., Liang,H., Ouyang,Q. and Liu,Y.
  TITLE     Structural study of the N-terminal domain of human MCM8/9 complex
  JOURNAL   Structure 29 (10), 1171-1181 (2021)
   PUBMED   34043945
  REMARK    GeneRIF: Structural study of the N-terminal domain of human MCM8/9
            complex.
REFERENCE   5  (bases 1 to 5219)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 5219)
  AUTHORS   Liu,Y., Richards,T.A. and Aves,S.J.
  TITLE     Ancient diversification of eukaryotic MCM DNA replication proteins
  JOURNAL   BMC Evol Biol 9, 60 (2009)
   PUBMED   19292915
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 5219)
  AUTHORS   Lutzmann,M. and Mechali,M.
  TITLE     MCM9 binds Cdt1 and is required for the assembly of prereplication
            complexes
  JOURNAL   Mol Cell 31 (2), 190-200 (2008)
   PUBMED   18657502
  REMARK    GeneRIF: Cdt1, with its two opposing regulatory binding factors
            MCM9 and geminin, appears to be a major platform on the
            pre-replication complexes to integrate cell-cycle signals.
REFERENCE   8  (bases 1 to 5219)
  AUTHORS   Maiorano,D., Lutzmann,M. and Mechali,M.
  TITLE     MCM proteins and DNA replication
  JOURNAL   Curr Opin Cell Biol 18 (2), 130-136 (2006)
   PUBMED   16495042
  REMARK    Review article
REFERENCE   9  (bases 1 to 5219)
  AUTHORS   Lutzmann,M., Maiorano,D. and Mechali,M.
  TITLE     Identification of full genes and proteins of MCM9, a novel,
            vertebrate-specific member of the MCM2-8 protein family
  JOURNAL   Gene 362, 51-56 (2005)
   PUBMED   16226853
  REMARK    GeneRIF: We also show that the very recently reported human MCM9
            protein (HsMCM9), which resembles a truncated MCM-like protein
            missing a part of the MCM2-7 signature domain, is an incomplete
            form of the full length HsMCM9 described here.
REFERENCE   10 (bases 1 to 5219)
  AUTHORS   Yoshida,K.
  TITLE     Identification of a novel cell-cycle-induced MCM family protein
            MCM9
  JOURNAL   Biochem Biophys Res Commun 331 (2), 669-674 (2005)
   PUBMED   15850810
  REMARK    GeneRIF: Identified a novel MCM family gene, MCM9, by using
            bioinformatics; mouse MCM9 mRNA was upregulated by transcription
            factor E2E1 and serum stimulation in NIH3T3 cells.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL132874.31 and AL359634.20.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 10, 2020 this sequence version replaced NM_017696.2.
            
            Summary: The protein encoded by this gene is a member of the
            mini-chromosome maintenance (MCM) protein family that are essential
            for the initiation of eukaryotic genome replication. Binding of
            this protein to chromatin has been shown to be a pre-requisite for
            recruiting the MCM2-7 helicase to DNA replication origins. This
            protein also binds, and is a positive regulator of, the chromatin
            licensing and DNA replication factor 1, CDT1. [provided by RefSeq,
            Nov 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1). Variants 1, 3, and 4 all encode the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.1861033.1,
                                           SRR14038191.1676212.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            MANE Ensembl match               :: ENST00000619706.5/
                                                ENSP00000480469.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-269               AL132874.31        39577-39845         c
            270-403             AL132874.31        37293-37426         c
            404-722             AL132874.31        36106-36424         c
            723-1039            AL132874.31        28497-28813         c
            1040-1121           AL132874.31        26691-26772         c
            1122-1322           AL132874.31        22247-22447         c
            1323-1448           AL132874.31        17981-18106         c
            1449-1568           AL132874.31        16336-16455         c
            1569-1743           AL359634.20        166891-167065       c
            1744-1946           AL359634.20        139568-139770       c
            1947-2150           AL359634.20        138447-138650       c
            2151-2233           AL359634.20        137302-137384       c
            2234-2379           AL359634.20        136667-136812       c
            2380-5219           AL359634.20        123975-126814       c
FEATURES             Location/Qualifiers
     source          1..5219
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q22.31"
     gene            1..5219
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /note="minichromosome maintenance 9 homologous
                     recombination repair factor"
                     /db_xref="GeneID:254394"
                     /db_xref="HGNC:HGNC:21484"
                     /db_xref="MIM:610098"
     exon            1..269
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            270..403
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            404..722
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             419..3850
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1; DNA
                     helicase MCM9; DNA replication licensing factor MCM9;
                     mini-chromosome maintenance deficient domain-containing
                     protein 1; minichromosome maintenance complex component 9"
                     /codon_start=1
                     /product="DNA helicase MCM9 isoform 1"
                     /protein_id="NP_060166.2"
                     /db_xref="CCDS:CCDS56447.1"
                     /db_xref="GeneID:254394"
                     /db_xref="HGNC:HGNC:21484"
                     /db_xref="MIM:610098"
                     /translation="MNSDQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNA
                     MTLFETNMEIGEYFNMFPSEVLTIFDSALRRSALTILQSLSQPEAVSMKQNLHARISG
                     LPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFVIKADF
                     EQYYTFCRPSSCPSLESCDSSKFTCLSGLSSSPTRCRDYQEIKIQEQVQRLSVGSIPR
                     SMKVILEDDLVDSCKSGDDLTIYGIVMQRWKPFQQDVRCEVEIVLKANYIQVNNEQSS
                     GIIMDEEVQKEFEDFWEYYKSDPFAGRNVILASLCPQVFGMYLVKLAVAMVLAGGIQR
                     TDATGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKD
                     SGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTR
                     TTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTKNEDWDRIISSFILEN
                     KGYPSKSEKLWSMEKMKTYFCLIRNLQPTLSDVGNQVLLRYYQMQRQSDCRNAARTTI
                     RLLESLIRLAEAHARLMFRDTVTLEDAITVVSVMESSMQGGALLGGVNALHTSFPENP
                     GEQYQRQCELILEKLELQSLLSEELRRLERLQNQSVHQSQPRVLEVETTPGSLRNGPG
                     EESNFRTSSQQEINYSTHIFSPGGSPEGSPVLDPPPHLEPNRSTSRKHSAQHKNNRDD
                     SLDWFDFMATHQSEPKNTVVVSPHPKTSGENMASKISNSTSQGKEKSEPGQRSKVDIG
                     LLPSPGETGVPWRADNVESNKKKRLALDSEAAVSADKPDSVLTHHVPRNLQKLCKERA
                     QKLCRNSTRVPAQCTVPSHPQSTPVHSPDRMLDSPKRKRPKSLAQVEEPAIENVKPPG
                     SPVAKLAKFTFKQKSKLIHSFEDHSHVSPGATKIAVHSPKISQRRTRRDAALPVKRPG
                     KLTSTPGNQISSQPQGETKEVSQQPPEKHGPREKVMCAPEKRIIQPELELGNETGCAH
                     LTCEGDKKEEVSGSNKSGKVHACTLARLANFCFTPPSESKSKSPPPERKNRGERGPSS
                     PPTTTAPMRVSKRKSFQLRGSTEKLIVSKESLFTLPELGDEAFDCDWDEEMRKKS"
     exon            723..1039
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1121
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1322
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1448
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1449..1568
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1743
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1946
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1947..2150
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2151..2233
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2379
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2380..5219
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5194..5199
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /note="hexamer: AATAAA"
     polyA_site      5219
                     /gene="MCM9"
                     /gene_synonym="C6orf61; dJ329L24.1; dJ329L24.3; MCMDC1;
                     ODG4"
                     /note="major polyA site"
ORIGIN      
        1 atccggaaga gccgccgggg cagggaagtt gaggcggtgc gcggcccggc gtcggtcgag
       61 agcgcaggcc cggcagagcc gcaggcgcta ggccgcccga cacagcccgc gcgtccccgc
      121 ggccggtggc gcctcgagcg gccacgtgca cgcgcgcact ccgcctcacc agccttcttg
      181 cgccggagac gaacccgctg cctggctgga gctctctggg cccttcggcc tcgggagcaa
      241 cgcgttcccg gcgacttctg acacagccac tgtttctgca gaacccagta gatttcctac
      301 ggtaagaaag agaaagaagg aaacaaattc acttccaagt atgaatttct aaggacagtc
      361 tgttaattat tcatgtcaga actggctgtc agtctgatta atgttaccta gattcaagat
      421 gaatagcgat caagttacac tggttggtca agtgtttgag tcatatgttt cggaatacca
      481 taagaatgat attcttctaa tcttgaagga aagggatgaa gatgctcatt acccagttgt
      541 ggttaatgcc atgactctgt ttgagaccaa catggaaatc ggggaatatt tcaacatgtt
      601 ccccagtgaa gtgcttacaa tttttgatag tgcactgcga aggtcagcct tgacaattct
      661 ccagtccctt tctcagcctg aggctgtttc catgaaacag aatcttcatg ccaggatatc
      721 aggtttgcct gtctgtcctg agctggtgag ggaacacata cctaaaacca aggatgtggg
      781 acacttttta tctgtcactg ggacagtgat tcgaacaagt ctggtgaagg ttctggagtt
      841 tgagcgggat tacatgtgta acaaatgcaa gcatgtgttt gtgatcaagg ctgactttga
      901 gcagtattac accttttgcc ggccatcctc gtgtcccagc ttggagagct gtgattcctc
      961 taaattcact tgcctctcag gcttgtcttc gtctccaacc aggtgtagag attaccagga
     1021 aatcaaaatt caggaacagg ttcaaaggct atctgttgga agtattccac gatctatgaa
     1081 ggttattctg gaagatgact tagtggatag ttgcaaatct ggtgatgacc tcactattta
     1141 cgggattgta atgcaacggt ggaagccctt tcagcaagat gtgcgctgtg aagtggagat
     1201 agtcctgaaa gcaaattaca tccaagtaaa taatgagcag tcctcaggga tcatcatgga
     1261 tgaggaggtc caaaaggaat tcgaagattt ttgggaatac tataagagcg atccctttgc
     1321 aggaaggaat gtaatattgg ctagcttgtg ccctcaagtg tttggaatgt atctagtaaa
     1381 gcttgctgtg gccatggtgc tggctggtgg gattcaaagg actgatgcta caggaacacg
     1441 ggtcagagga gaatctcatc ttttattggt tggggatcct ggcacaggga aatctcagtt
     1501 cctcaaatat gcagcaaaga ttacaccaag atctgtgctg accacaggaa ttggatctac
     1561 tagtgcaggt ctgacggtaa ctgctgtaaa agactcagga gaatggaatt tggaggctgg
     1621 ggcattagtt cttgcagatg cgggcctttg ctgtattgat gagttcaata gcctcaaaga
     1681 gcatgatagg accagtatcc atgaagcaat ggagcaacaa accataagtg ttgctaaggc
     1741 tggcctcgtg tgcaagctga acacaaggac caccatcctg gcagcaacga accccaaagg
     1801 ccagtacgac ccccaggagt ccgtgtctgt gaacattgcc ctcggcagcc cactcttaag
     1861 tcgatttgac ctgatcctgg ttttgcttga taccaagaat gaagactggg atcgtatcat
     1921 ttcctccttt atcttagaaa ataaaggtta cccaagcaaa tcagagaagc tctggagcat
     1981 ggaaaagatg aaaacctatt tctgcctcat aaggaatctg cagcccacac tgtctgatgt
     2041 gggcaatcag gttcttctcc ggtactacca gatgcaaagg cagagtgatt gccggaacgc
     2101 tgcccggacc accattcggc tgttggaaag cttgatacga ttagcagaag ctcatgctcg
     2161 cctgatgttt cgtgatactg taactctgga agacgctatt acggtggtgt cagtcatgga
     2221 gtcctcaatg cagggaggtg cactgctagg aggtgtgaat gccctccaca cttcctttcc
     2281 tgaaaaccct ggagagcagt accagagaca gtgtgaactt attctggaaa agctagagct
     2341 gcagagcctc ttgagtgaag agcttagaag acttgaaagg ttacagaatc agagtgtgca
     2401 ccaatcccaa ccacgggtat tggaggtaga gactactcca ggatccttga gaaatggtcc
     2461 aggggaagaa tcaaacttca gaacttcatc acagcaggaa atcaactata gcacacatat
     2521 cttctctcct ggaggcagcc ccgagggaag cccagttcta gatcccccac cgcatctgga
     2581 gcctaataga tcaacaagta ggaaacattc agctcagcac aaaaataaca gagatgacag
     2641 tttagattgg tttgatttca tggcaactca tcagagtgaa cctaaaaaca ctgttgttgt
     2701 gtctcctcat cccaaaacat ctggagaaaa tatggcttcg aagatctcta acagcacatc
     2761 tcagggtaag gagaagagtg agccaggcca aaggagcaaa gtggacattg ggttgcttcc
     2821 atcaccagga gagacaggtg ttccatggag ggcagacaat gtggaaagta acaagaaaaa
     2881 aaggctagca ctagattctg aagcagcagt ctctgctgat aaaccagact cagtactgac
     2941 tcatcatgtc cccaggaacc tgcagaagct gtgcaaagag agggcccaga agttgtgcag
     3001 aaatagcacc agggtgcctg cacagtgcac agtcccttcc catcctcagt ccactcctgt
     3061 acatagccca gacagaatgc tggactcacc caaaagaaag agaccgaaat cccttgcgca
     3121 agtggaagag cctgcaattg aaaatgttaa gcctccaggt tcccctgtgg ccaaactggc
     3181 aaaatttact ttcaagcaga agtcaaaact gatccactcc tttgaagatc acagccatgt
     3241 gtcacctggt gcaactaaaa tagcagttca tagtcctaaa atttcccagc gtagaacaag
     3301 aagagacgca gccttgccgg tgaagcgtcc aggaaagtta acatctaccc caggaaacca
     3361 gatctccagt cagccacagg gtgagacaaa ggaggtgtcg cagcagccac cagagaaaca
     3421 cggaccaaga gagaaggtga tgtgtgcccc tgagaagagg attattcagc ctgaattaga
     3481 gcttgggaac gagactgggt gtgctcatct tacttgtgag ggagacaaaa aggaagaggt
     3541 ttcaggcagt aataaaagcg gcaaggttca tgcctgcaca ttagccagat tggcaaactt
     3601 ctgctttact cccccatcgg aatccaaatc aaaatcccct cctcctgaaa ggaagaaccg
     3661 aggtgagaga ggcccaagct cccctcctac aaccacagct ccaatgcgtg tcagtaaaag
     3721 gaaatctttt cagctccgtg ggtccaccga gaaactgatt gtttccaaag aatccctctt
     3781 cactttacca gaactaggtg atgaagcatt tgattgtgac tgggatgaag agatgagaaa
     3841 aaagtcatag ttgggaaaag ctttctggtc aaatctcacc ttcttcaact ccacagagga
     3901 ccttcaggat atcaatatgg tatttataaa tgtatagaac aattggccat attgaggatc
     3961 actctgaata ctggctcccc cttaaggctt tctaatttca ggttaatctt catgacttaa
     4021 aaagttgtat aatcagttga ggtcagtgtg ataccagcag ctgagctgaa ttaattatgt
     4081 tgtgcttaat tttacaaatg gagtacttgt attcctgttc ctgaagctgt ttctgttttt
     4141 tgttttgttt tgtttttaag ggggagaggt tcttccctag attaatttct tctttcattc
     4201 actcaggaac aaatgtcaag aaggtagcac tcataaatct aacaaggcag atgaactctt
     4261 ttctactttt tttttttttt tttgtatttt cacctggaat gggctaagta cagtgaatat
     4321 aatcacttgg atgatttgcc aaaatcagac tatttttcta gtattatttt tgtattgatt
     4381 tgtgtggatc aggttaaatg tgactaatgc ttttctttct ttgagaggta tccttacaat
     4441 tccatgatgt tcttagagat ctggccactg gtcaaacagt acctttctga agtactgacc
     4501 ttctgagttg tcctttcttt cttgagccaa cattttgtac ttcagattct tttttctctt
     4561 gggggcctac cttcaaccaa gtaaaatact gtgattagaa gaagagagag tatgagccag
     4621 gcacagtgac tcactcctgt agtcctagct actcggggag gctgaggcag gatgattgct
     4681 taagcccagg agttcggggt tacagtgagc tgtggtcaca ccactgtatt ccagcctggg
     4741 tgacagagtg agatcctgtc tctaaaaata aaataaatga agaagagaga ctatgtggta
     4801 gtctcaatca aacatcatgt ctcatctacc cagctggtta atatggaaat gtgattccta
     4861 ctaagttgtg attcacttgt ctttaaaacc aaggaaatta tatactgttt ttggtcagaa
     4921 tagataacct caagctttgt ctttctatgt gcttttaaaa tcacttattc ctttggattc
     4981 taataagggt tattaggatt cagtaattat ggactttctc ttctgaagtg tgaatttgta
     5041 aactgattgt ttaattgtca gagggacttt tggacataga atactcaaaa ctatatgtat
     5101 tttgtttaat tttcacttca ttcaattcac gcattgaaaa caaatttaga aaatccaatt
     5161 tttcttaagc atttaaacgt tctaaaattc actaataaaa ttttctgaaa aaatttaaa
//
