LOCUS       NM_005916               2467 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens minichromosome maintenance complex component 7 (MCM7),
            transcript variant 1, mRNA.
ACCESSION   NM_005916
VERSION     NM_005916.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2467)
  AUTHORS   Sun,Q., Sui,Y., Li,S., Zhou,R., Fu,Z., Luo,J. and Zhao,W.
  TITLE     RNF8-mediated multi-ubiquitination of MCM7: Linking disassembly of
            the CMG helicase with DNA damage response in human cells
  JOURNAL   Life Sci 353, 122912 (2024)
   PUBMED   39004272
  REMARK    GeneRIF: RNF8-mediated multi-ubiquitination of MCM7: Linking
            disassembly of the CMG helicase with DNA damage response in human
            cells.
REFERENCE   2  (bases 1 to 2467)
  AUTHORS   Wang,J., Amin,A., Cheung,M.H., Shi,L. and Liang,C.
  TITLE     Targeted inhibition of the expression of both MCM5 and MCM7 by
            miRNA-214 impedes DNA replication and tumorigenesis in
            hepatocellular carcinoma cells
  JOURNAL   Cancer Lett 539, 215677 (2022)
   PUBMED   35490917
  REMARK    GeneRIF: Targeted inhibition of the expression of both MCM5 and
            MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in
            hepatocellular carcinoma cells.
REFERENCE   3  (bases 1 to 2467)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   4  (bases 1 to 2467)
  AUTHORS   Su,D.
  TITLE     MCM7 affects the cisplatin resistance of liver cancer cells and the
            development of liver cancer by regulating the PI3K/Akt signaling
            pathway
  JOURNAL   Immunopharmacol Immunotoxicol 44 (1), 17-27 (2022)
   PUBMED   34821526
  REMARK    GeneRIF: MCM7 affects the cisplatin resistance of liver cancer
            cells and the development of liver cancer by regulating the
            PI3K/Akt signaling pathway.
REFERENCE   5  (bases 1 to 2467)
  AUTHORS   Rubisz,P., Hirnle,L. and Kobierzycki,C.
  TITLE     The Immunohistochemical Expression of MCM-3, -5, and -7 Proteins in
            the Uterine Fibroids
  JOURNAL   Curr Issues Mol Biol 43 (2), 802-817 (2021)
   PUBMED   34449552
  REMARK    GeneRIF: The Immunohistochemical Expression of MCM-3, -5, and -7
            Proteins in the Uterine Fibroids.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2467)
  AUTHORS   Suzuki,S., Adachi,A., Hiraiwa,A., Ohashi,M., Ishibashi,M. and
            Kiyono,T.
  TITLE     Cloning and characterization of human MCM7 promoter
  JOURNAL   Gene 216 (1), 85-91 (1998)
   PUBMED   9714754
REFERENCE   7  (bases 1 to 2467)
  AUTHORS   Fujita,M., Kiyono,T., Hayashi,Y. and Ishibashi,M.
  TITLE     hCDC47, a human member of the MCM family. Dissociation of the
            nucleus-bound form during S phase
  JOURNAL   J Biol Chem 271 (8), 4349-4354 (1996)
   PUBMED   8626784
REFERENCE   8  (bases 1 to 2467)
  AUTHORS   Musahl,C., Schulte,D., Burkhart,R. and Knippers,R.
  TITLE     A human homologue of the yeast replication protein Cdc21.
            Interactions with other Mcm proteins
  JOURNAL   Eur J Biochem 230 (3), 1096-1101 (1995)
   PUBMED   7601140
REFERENCE   9  (bases 1 to 2467)
  AUTHORS   Nakatsuru,S., Sudo,K. and Nakamura,Y.
  TITLE     Isolation and mapping of a human gene (MCM2) encoding a product
            homologous to yeast proteins involved in DNA replication
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 226-230 (1995)
   PUBMED   7842741
REFERENCE   10 (bases 1 to 2467)
  AUTHORS   Hu,B., Burkhart,R., Schulte,D., Musahl,C. and Knippers,R.
  TITLE     The P1 family: a new class of nuclear mammalian proteins related to
            the yeast Mcm replication proteins
  JOURNAL   Nucleic Acids Res 21 (23), 5289-5293 (1993)
   PUBMED   8265339
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073842.5.
            
            On Jul 25, 2019 this sequence version replaced NM_005916.4.
            
            Summary: The protein encoded by this gene is one of the highly
            conserved mini-chromosome maintenance proteins (MCM) that are
            essential for the initiation of eukaryotic genome replication. The
            hexameric protein complex formed by the MCM proteins is a key
            component of the pre-replication complex (pre_RC) and may be
            involved in the formation of replication forks and in the
            recruitment of other DNA replication related proteins. The MCM
            complex consisting of this protein and MCM2, 4 and 6 proteins
            possesses DNA helicase activity, and may act as a DNA unwinding
            enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate
            with this protein, and may regulate the binding of this protein
            with the tumorsuppressor protein RB1/RB. Alternatively spliced
            transcript variants encoding distinct isoforms have been reported.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D55716.1, BC013375.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303887.10/ ENSP00000307288.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-134               AC073842.5         103297-103430
            135-214             AC073842.5         104601-104680
            215-379             AC073842.5         104941-105105
            380-504             AC073842.5         105291-105415
            505-685             AC073842.5         105491-105671
            686-823             AC073842.5         105979-106116
            824-973             AC073842.5         106404-106553
            974-1088            AC073842.5         106746-106860
            1089-1220           AC073842.5         106949-107080
            1221-1304           AC073842.5         107310-107393
            1305-1698           AC073842.5         108527-108920
            1699-1782           AC073842.5         109224-109307
            1783-1951           AC073842.5         110353-110521
            1952-2061           AC073842.5         111293-111402
            2062-2467           AC073842.5         111561-111966
FEATURES             Location/Qualifiers
     source          1..2467
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..2467
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /note="minichromosome maintenance complex component 7"
                     /db_xref="GeneID:4176"
                     /db_xref="HGNC:HGNC:6950"
                     /db_xref="MIM:600592"
     exon            1..134
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     CDS             104..2263
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /EC_number="3.6.4.12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     minichromosome maintenance deficient 7; DNA replication
                     licensing factor MCM7; homolog of S. cerevisiae Cdc47;
                     CDC47 homolog; protein phosphatase 1, regulatory subunit
                     104"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM7 isoform 1"
                     /protein_id="NP_005907.3"
                     /db_xref="CCDS:CCDS5683.1"
                     /db_xref="GeneID:4176"
                     /db_xref="HGNC:HGNC:6950"
                     /db_xref="MIM:600592"
                     /translation="MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHRE
                     QVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVY
                     IEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKL
                     VTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGG
                     RLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGI
                     FLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYE
                     KLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLS
                     YIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKM
                     AEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLP
                     AALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMC
                     REKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDV
                     VEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQ
                     RCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV"
     exon            135..214
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            215..379
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            380..504
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            505..685
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            686..823
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            824..973
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1088
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1220
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1304
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1698
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1782
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1951
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2061
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2467
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2392..2397
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /note="hexamer: AATAAA"
     polyA_site      2415
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /note="major polyA site"
     regulatory      2440..2445
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
                     /note="hexamer: ATTAAA"
     polyA_site      2467
                     /gene="MCM7"
                     /gene_synonym="CDC47; MCM2; P1.1-MCM3; P1CDC47; P85MCM;
                     PNAS146; PPP1R104"
ORIGIN      
        1 aatttcggtt ggccggccac agtccaccgc gcggagattc tcagcttccc caggagcaag
       61 acctctgagc ccgccaagcg cggccgcacg gccctcggca gcgatggcac tgaaggacta
      121 cgcgctagag aaggaaaagg ttaagaagtt cttacaagag ttctaccagg atgatgaact
      181 cgggaagaag cagttcaagt atgggaacca gttggttcgg ctggctcatc gggaacaggt
      241 ggctctgtat gtggacctgg acgacgtagc cgaggatgac cccgagttgg tggactcaat
      301 ttgtgagaat gccaggcgct acgcgaagct ctttgctgat gccgtacaag agctgctgcc
      361 tcagtacaag gagagggaag tggtaaataa agatgtcctg gacgtttaca ttgagcatcg
      421 gctaatgatg gagcagcgga gtcgggaccc tgggatggtc cgaagccccc agaaccagta
      481 ccctgctgaa ctcatgcgca gatttgagct gtattttcaa ggccctagca gcaacaagcc
      541 tcgtgtgatc cgggaagtgc gggctgactc tgtggggaag ttggtaactg tgcgtggaat
      601 cgtcactcgt gtctctgaag tcaaacccaa gatggtggtg gccacttaca cttgtgacca
      661 gtgtggggca gagacctacc agccgatcca gtctcccact ttcatgcctc tgatcatgtg
      721 cccaagccag gagtgccaaa ccaaccgctc aggagggcgg ctgtatctgc agacacgggg
      781 ctccagattc atcaaattcc aggagatgaa gatgcaagaa catagtgatc aggtgcctgt
      841 gggaaatatc cctcgtagta tcacggtgct ggtagaagga gagaacacaa ggattgccca
      901 gcctggagac cacgtcagcg tcactggtat tttcttgcca atcctgcgca ctgggttccg
      961 acaggtggta cagggtttac tctcagaaac ctacctggaa gcccatcgga ttgtgaagat
     1021 gaacaagagt gaggatgatg agtctggggc tggagagctc accagggagg agctgaggca
     1081 aattgcagag gaggatttct acgaaaagct ggcagcttca atcgccccag aaatatacgg
     1141 gcatgaagat gtgaagaagg cactgctgct cctgctagtc gggggtgtgg accagtctcc
     1201 tcgaggcatg aaaatccggg gcaacatcaa catctgtctg atgggggatc ctggtgtggc
     1261 caagtctcag ctcctgtcat acattgatcg actggcgcct cgcagccagt acacaacagg
     1321 ccggggctcc tcaggagtgg ggcttacggc agctgtgctg agagactccg tgagtggaga
     1381 actgacctta gagggtgggg ccctggtgct ggctgaccag ggtgtgtgct gcattgatga
     1441 gttcgacaag atggctgagg ccgaccgcac agccatccac gaggtcatgg agcagcagac
     1501 catctccatt gccaaggccg gcattctcac cacactcaat gcccgctgct ccatcctggc
     1561 tgccgccaac cctgcctacg ggcgctacaa ccctcgccgc agcctggagc agaacataca
     1621 gctacctgct gcactgctct cccggtttga cctcctctgg ctgattcagg accggcccga
     1681 ccgagacaat gacctacggt tggcccagca catcacctat gtgcaccagc acagccggca
     1741 gcccccctcc cagtttgaac ctctggacat gaagctcatg aggcgttaca tagccatgtg
     1801 ccgcgagaag cagcccatgg tgccagagtc tctggctgac tacatcacag cagcatacgt
     1861 ggagatgagg cgagaggctt gggctagtaa ggatgccacc tatacttctg cccggaccct
     1921 gctggctatc ctgcgccttt ccactgctct ggcacgtctg agaatggtgg atgtggtgga
     1981 gaaagaagat gtgaatgaag ccatcaggct aatggagatg tcaaaggact ctcttctagg
     2041 agacaagggg cagacagcta ggactcagag accagcagat gtgatatttg ccaccgtccg
     2101 tgaactggtc tcagggggcc gaagtgtccg gttctctgag gcagagcagc gctgtgtatc
     2161 tcgtggcttc acacccgccc agttccaggc ggctctggat gaatatgagg agctcaatgt
     2221 ctggcaggtc aatgcttccc ggacacggat cacttttgtc tgattccagc ctgcttgcaa
     2281 ccctggggtc ctcttgttcc ctgctggcct gccccttggg aaggggcagt gatgcctttg
     2341 aggggaagga ggagcccctc tttctcccat gctgcactta ctccttttgc taataaaagt
     2401 gtttgtagat tgtcatcttc tagcctgggc ctgacttcca ttaaaacagg gttttgtgcg
     2461 tttttta
//
