LOCUS       NM_005915               3753 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens minichromosome maintenance complex component 6 (MCM6),
            mRNA.
ACCESSION   NM_005915
VERSION     NM_005915.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3753)
  AUTHORS   Jiang,Y., Xue,Y., Yuan,X., Ye,S., Liu,M., Shi,Y. and Zhou,H.
  TITLE     MCM6 Inhibits Decidualization via Cross-Talking with ERK Pathway in
            Human Endometrial Stromal Cells
  JOURNAL   Reprod Sci 31 (7), 1915-1923 (2024)
   PUBMED   38347378
  REMARK    GeneRIF: MCM6 Inhibits Decidualization via Cross-Talking with ERK
            Pathway in Human Endometrial Stromal Cells.
REFERENCE   2  (bases 1 to 3753)
  AUTHORS   Kamal,M.M., Mia,M.S., Faruque,M.O., Rabby,M.G., Islam,M.N.,
            Talukder,M.E.K., Wani,T.A., Rahman,M.A. and Hasan,M.M.
  TITLE     In silico functional, structural and pathogenicity analysis of
            missense single nucleotide polymorphisms in human MCM6 gene
  JOURNAL   Sci Rep 14 (1), 11607 (2024)
   PUBMED   38773180
  REMARK    GeneRIF: In silico functional, structural and pathogenicity
            analysis of missense single nucleotide polymorphisms in human MCM6
            gene.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3753)
  AUTHORS   Zhang,H., Lin,Y.D., Zhuang,M.X., Zhu,L., Yu,Y., Chen,X.G.,
            Wang,Q.S. and Lin,M.B.
  TITLE     High MCM6 expression promotes proliferation and correlates with
            poor prognosis in triple-negative breast cancer
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (7), 2906-2922 (2024)
   PUBMED   38639528
  REMARK    GeneRIF: High MCM6 expression promotes proliferation and correlates
            with poor prognosis in triple-negative breast cancer.
REFERENCE   4  (bases 1 to 3753)
  AUTHORS   Luo,Y., Yang,Y., Yang,C., Li,C., Hu,R., Geng,W., Kang,X. and Lin,H.
  TITLE     UBE3A and MCM6 synergistically regulate the proliferation and
            migration of lung adenocarcinoma cells
  JOURNAL   FEBS Open Bio 13 (9), 1756-1771 (2023)
   PUBMED   37454373
  REMARK    GeneRIF: UBE3A and MCM6 synergistically regulate the proliferation
            and migration of lung adenocarcinoma cells.
REFERENCE   5  (bases 1 to 3753)
  AUTHORS   Smits,D.J., Schot,R., Popescu,C.A., Dias,K.R., Ades,L.,
            Briere,L.C., Sweetser,D.A., Kushima,I., Aleksic,B., Khan,S.,
            Karageorgou,V., Ordonez,N., Sleutels,F.J.G.T., van der Kaay,D.C.M.,
            Van Mol,C., Van Esch,H., Bertoli-Avella,A.M., Roscioli,T. and
            Mancini,G.M.S.
  TITLE     De novo MCM6 variants in neurodevelopmental disorders: a
            recognizable phenotype related to zinc binding residues
  JOURNAL   Hum Genet 142 (7), 949-964 (2023)
   PUBMED   37198333
  REMARK    GeneRIF: De novo MCM6 variants in neurodevelopmental disorders: a
            recognizable phenotype related to zinc binding residues.
REFERENCE   6  (bases 1 to 3753)
  AUTHORS   Ishimi,Y.
  TITLE     A DNA helicase activity is associated with an MCM4, -6, and -7
            protein complex
  JOURNAL   J Biol Chem 272 (39), 24508-24513 (1997)
   PUBMED   9305914
  REMARK    Erratum:[J Biol Chem 1998 Sep 4;273(36):23616]
REFERENCE   7  (bases 1 to 3753)
  AUTHORS   Tsuruga,H., Yabuta,N., Hosoya,S., Tamura,K., Endo,Y. and Nojima,H.
  TITLE     HsMCM6: a new member of the human MCM/P1 family encodes a protein
            homologous to fission yeast Mis5
  JOURNAL   Genes Cells 2 (6), 381-399 (1997)
   PUBMED   9286856
REFERENCE   8  (bases 1 to 3753)
  AUTHORS   Harvey,C.B., Wang,Y., Darmoul,D., Phillips,A., Mantei,N. and
            Swallow,D.M.
  TITLE     Characterisation of a human homologue of a yeast cell division
            cycle gene, MCM6, located adjacent to the 5' end of the lactase
            gene on chromosome 2q21
  JOURNAL   FEBS Lett 398 (2-3), 135-140 (1996)
   PUBMED   8977093
REFERENCE   9  (bases 1 to 3753)
  AUTHORS   Holthoff,H.P., Hameister,H. and Knippers,R.
  TITLE     A novel human Mcm protein: homology to the yeast replication
            protein Mis5 and chromosomal location
  JOURNAL   Genomics 37 (1), 131-134 (1996)
   PUBMED   8921380
REFERENCE   10 (bases 1 to 3753)
  AUTHORS   Ishimi,Y., Ichinose,S., Omori,A., Sato,K. and Kimura,H.
  TITLE     Binding of human minichromosome maintenance proteins with histone
            H3
  JOURNAL   J Biol Chem 271 (39), 24115-24122 (1996)
   PUBMED   8798650
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA521248.1, BC020268.1,
            CN389677.1, BC032374.1 and AA577398.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005915.5.
            
            Summary: The protein encoded by this gene is one of the highly
            conserved mini-chromosome maintenance proteins (MCM) that are
            essential for the initiation of eukaryotic genome replication. The
            hexameric protein complex formed by the MCM proteins is a key
            component of the pre-replication complex (pre_RC) and may be
            involved in the formation of replication forks and in the
            recruitment of other DNA replication related proteins. The MCM
            complex consisting of this protein and MCM2, 4 and 7 proteins
            possesses DNA helicase activity, and may act as a DNA unwinding
            enzyme. The phosphorylation of the complex by CDC2 kinase reduces
            the helicase activity, suggesting a role in the regulation of DNA
            replication. Single nucleotide polymorphisms in the intron regions
            of this gene are associated with differential transcriptional
            activation of the promoter of the neighboring lactase gene and,
            thereby, influence lactose intolerance in early adulthood.
            [provided by RefSeq, May 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032374.1, D84557.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264156.3/ ENSP00000264156.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                DA521248.1         35-86
            53-2936             BC020268.1         15-2898
            2937-3330           CN389677.1         223-616
            3331-3750           BC032374.1         3304-3723
            3751-3753           AA577398.1         5-7                 c
FEATURES             Location/Qualifiers
     source          1..3753
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q21.3"
     gene            1..3753
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /note="minichromosome maintenance complex component 6"
                     /db_xref="GeneID:4175"
                     /db_xref="HGNC:HGNC:6949"
                     /db_xref="MIM:601806"
     exon            1..185
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..2544
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /EC_number="3.6.4.12"
                     /note="minichromosome maintenance deficient (mis5, S.
                     pombe) 6; MCM6 minichromosome maintenance deficient 6
                     (MIS5 homolog, S. pombe)"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM6"
                     /protein_id="NP_005906.2"
                     /db_xref="CCDS:CCDS2179.1"
                     /db_xref="GeneID:4175"
                     /db_xref="HGNC:HGNC:6949"
                     /db_xref="MIM:601806"
                     /translation="MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEI
                     KYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRK
                     EIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLD
                     CQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRG
                     SIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGY
                     ETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEW
                     EKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINV
                     CIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALM
                     LADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISG
                     HYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRV
                     YSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESM
                     IRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGG
                     INGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDE
                     SALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGS
                     TEGSESYEEDPYLVVNPNYLLED"
     exon            186..332
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            333..443
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            444..693
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            694..859
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            860..1005
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1156
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1298
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1440
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1441..1548
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1704
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1705..1833
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1995
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            1996..2131
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2132..2287
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2288..2427
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..3753
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2916..2921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /note="hexamer: AATAAA"
     polyA_site      2936
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /note="major polyA site"
     regulatory      3729..3734
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
                     /note="hexamer: AATAAA"
     polyA_site      3753
                     /gene="MCM6"
                     /gene_synonym="MCG40308; Mis5; P105MCM"
ORIGIN      
        1 gcaaagctgc agcgtctgga aaaaagcgac ttgtggcggt cgagcgtggc gcaggcgaat
       61 cctcggcact aagcaaatat ggacctcgcg gcggcagcgg agccgggcgc cggcagccag
      121 cacctggagg tccgcgacga ggtggccgag aagtgccaga aactgttcct ggacttcttg
      181 gaggagtttc agagcagcga tggagaaatt aaatacttgc aattagcaga ggaactgatt
      241 cgtcctgaga gaaacacatt ggttgtgagt tttgtggacc tggaacaatt taaccagcaa
      301 ctttccacca ccattcaaga ggagttctat agagtttacc cttacctgtg tcgggccttg
      361 aaaacattcg tcaaagaccg taaagagatc cctcttgcca aggattttta tgttgcattc
      421 caagacctgc ctaccagaca caagattcga gagctcacct catccagaat tggtttgctc
      481 actcgcatca gtgggcaggt ggtgcggact cacccagttc acccagagct tgtgagcgga
      541 acttttctgt gcttggactg tcagacagtg atcagggatg tagaacagca gttcaaatac
      601 acacagccaa acatctgccg aaatccagtt tgtgccaaca ggaggagatt cttactggat
      661 acaaataaat caagatttgt tgattttcaa aaggttcgta ttcaagagac ccaagctgag
      721 cttcctcgag ggagtatccc ccgcagttta gaagtaattt taagggctga agctgtggaa
      781 tcagctcaag ctggtgacaa gtgtgacttt acagggacac tgattgttgt gcctgacgtc
      841 tccaagctta gcacaccagg agcacgtgca gaaactaatt cccgtgtcag tggtgttgat
      901 ggatatgaga cagaaggcat tcgaggactc cgggcccttg gtgttaggga cctttcttat
      961 aggctggtct ttcttgcctg ctgtgttgcg ccaaccaacc caaggtttgg ggggaaagag
     1021 ctcagagatg aggaacagac agctgagagc attaagaacc aaatgactgt gaaagaatgg
     1081 gagaaagtgt ttgagatgag tcaagataaa aatctatacc acaatctttg taccagcctg
     1141 ttccctacta tacatggcaa tgatgaagta aaacggggtg tcctgctgat gctctttggt
     1201 ggcgttccaa agacaacagg agaagggacc tctcttcgag gggacataaa tgtttgcatt
     1261 gttggtgacc caagtacagc taagagccaa tttctcaagc acgtggagga gttcagcccc
     1321 agagctgtct acaccagtgg taaagcgtcc agtgctgctg gcttaacagc agctgttgtg
     1381 agagatgaag aatctcatga gtttgtcatt gaggctggag ctttgatgtt ggctgataat
     1441 ggtgtgtgtt gtattgatga atttgataag atggacgtgc gggatcaagt tgctattcat
     1501 gaagctatgg aacagcagac catatccatc actaaagcag gagtgaaggc tactctgaac
     1561 gcccggacgt ccattttggc agcagcaaac ccaatcagtg gacactatga cagatcaaaa
     1621 tcattgaaac agaatataaa tttgtcagct cccatcatgt cccgattcga tctcttcttt
     1681 atccttgtgg atgaatgtaa tgaggttaca gattatgcca ttgccaggcg catagtagat
     1741 ttgcattcaa gaattgagga atcaattgat cgtgtctatt ccctcgatga tatcagaaga
     1801 tatcttctct ttgcaagaca gtttaaaccc aagatttcca aagagtcaga ggacttcatt
     1861 gtggagcaat ataaacatct ccgccagaga gatggttctg gagtgaccaa gtcttcatgg
     1921 aggattacag tgcgacagct tgagagcatg attcgtctct ctgaagctat ggctcggatg
     1981 cactgctgtg atgaggtcca acctaaacat gtgaaggaag ctttccggtt actgaataaa
     2041 tcaatcatcc gtgtggaaac acctgatgtc aatctagatc aagaggaaga gatccagatg
     2101 gaggtagatg agggtgctgg tggcatcaat ggtcatgctg acagccctgc tcctgtgaac
     2161 gggatcaatg gctacaatga agacataaat caagagtctg ctcccaaagc ctccttaagg
     2221 ctgggcttct ctgagtactg ccgaatctct aaccttattg tgcttcacct cagaaaggtg
     2281 gaagaagaag aggacgagtc agcattaaag aggagcgagc ttgttaactg gtacttgaag
     2341 gaaatcgaat cagagataga ctctgaagaa gaacttataa ataaaaaaag aatcatagag
     2401 aaagttattc atcgactcac acactatgat catgttctaa ttgagctcac ccaggctgga
     2461 ttgaaaggct ccacagaggg aagtgagagc tatgaagaag atccctactt ggtagttaac
     2521 cctaactact tgctcgaaga ttgagatagt gaaagtaact gaccagagct gaggaactgt
     2581 ggcacagcac ctcgtggcct ggagcctggc tggagctctg ctagggacag aagtgtttct
     2641 ggaagtgatg cttccaggat ttgttttcag aaacaagaat tgagttgatg gtcctatgtg
     2701 tcacattcat cacaggtttc ataccaacac aggcttcagc acttcctttg gtgtgtttcc
     2761 tgtcccagtg aagttggaac caaataatgt gtagtctcta taaccaatac ctttgttttc
     2821 atgtgtaaga aaaggcccat tacttttaag gtatgtgctg tcctattgag caaataactt
     2881 tttttcaatt gccagctact gcttttattc atcaaaataa aataacttgt tctgaagttg
     2941 tctattggat ttctttctac tgtaccctga ttattacttc catctacttc tgaatgtgag
     3001 actttccctt tttgcttaac ctggagtgaa gaggtagaac tgtggtatta tggatgaggt
     3061 ttctatgaga aggagtcatt agagaactca tatgaaagct agaggcctta gagatgactt
     3121 tccaaggtta attccagttg tttttttttt tttttaagtt tataaaagtt tattatactt
     3181 ttttaaaatt actctttagt aatttatttt acttctgtgt cctaagggta atttctcagg
     3241 attgttttca aattgctttt ttaggggaaa taggtcattt gctatattac aagcaatccc
     3301 caaattttat ggtcttccag gaaaagttat taccgtttat gatactaaca gttcctgaga
     3361 cttagctatg atcagtatgt tcatgaggtg gagcagttcc tgtgttgcag cttttaacaa
     3421 cagatggcat tcattaaatc acaaagtatg ttaaaggtca caaaagcaaa ataactgtct
     3481 gaggctaagg cccacgtggg acagtctaat acccatgagt actcaacttg ccttgatgtc
     3541 tgagctttcc agtgcaatgt gaatttgagc agccagaaat ctattagtag aaagcaagac
     3601 agattaatat aggttaaaac aatgatttaa atatgtttct cccaataatt atctctttcc
     3661 ctggaatcaa cttgtatgaa accttgtcaa aatgtactcc acaagtatgt acaattaagt
     3721 attttaaaaa taaatggcaa acattaaaaa caa
//
