LOCUS       NM_006739               3458 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens minichromosome maintenance complex component 5 (MCM5),
            mRNA.
ACCESSION   NM_006739
VERSION     NM_006739.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3458)
  AUTHORS   Zhu,F., Ye,Y., Shao,Y. and Xue,C.
  TITLE     MEG3 shuttled by exosomes released from human bone marrow
            mesenchymal stem cells promotes TP53 stability to regulate MCM5
            transcription in keloid fibroblasts
  JOURNAL   J Gene Med 26 (5), e3688 (2024)
   PUBMED   38686583
  REMARK    GeneRIF: MEG3 shuttled by exosomes released from human bone marrow
            mesenchymal stem cells promotes TP53 stability to regulate MCM5
            transcription in keloid fibroblasts.
REFERENCE   2  (bases 1 to 3458)
  AUTHORS   Mao,J., Shen,J., Lu,X., Cai,Y., Tao,R., Deng,Y., Zhang,Y., Wu,Y.
            and Chen,W.
  TITLE     MCM5 is an oncogene of colon adenocarcinoma and promotes
            progression through cell cycle control
  JOURNAL   Acta Histochem 125 (6), 152072 (2023)
   PUBMED   37385108
  REMARK    GeneRIF: MCM5 is an oncogene of colon adenocarcinoma and promotes
            progression through cell cycle control.
REFERENCE   3  (bases 1 to 3458)
  AUTHORS   Yang,X., Bai,Q., Chen,W., Liang,J., Wang,F., Gu,W., Liu,L., Li,Q.,
            Chen,Z., Zhou,A., Long,J., Tian,H., Wu,J., Ding,X., Zhou,N., Li,M.,
            Yang,Y. and Cai,J.
  TITLE     m6 A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis Promotes
            Partial EMT and LUAD Metastasis
  JOURNAL   Adv Sci (Weinh) 10 (20), e2206744 (2023)
   PUBMED   37171793
  REMARK    GeneRIF: m[6] A-Dependent Modulation via IGF2BP3/MCM5/Notch Axis
            Promotes Partial EMT and LUAD Metastasis.
REFERENCE   4  (bases 1 to 3458)
  AUTHORS   Gao,H., Wei,H., Yang,Y., Li,H., Liang,J., Ye,J., Zhang,F., Wang,L.,
            Shi,H., Wang,J. and Han,A.
  TITLE     Phase separation of DDX21 promotes colorectal cancer metastasis via
            MCM5-dependent EMT pathway
  JOURNAL   Oncogene 42 (21), 1704-1715 (2023)
   PUBMED   37029300
  REMARK    GeneRIF: Phase separation of DDX21 promotes colorectal cancer
            metastasis via MCM5-dependent EMT pathway.
REFERENCE   5  (bases 1 to 3458)
  AUTHORS   Wang,J., Amin,A., Cheung,M.H., Shi,L. and Liang,C.
  TITLE     Targeted inhibition of the expression of both MCM5 and MCM7 by
            miRNA-214 impedes DNA replication and tumorigenesis in
            hepatocellular carcinoma cells
  JOURNAL   Cancer Lett 539, 215677 (2022)
   PUBMED   35490917
  REMARK    GeneRIF: Targeted inhibition of the expression of both MCM5 and
            MCM7 by miRNA-214 impedes DNA replication and tumorigenesis in
            hepatocellular carcinoma cells.
REFERENCE   6  (bases 1 to 3458)
  AUTHORS   Tsuruga,H., Yabuta,N., Hashizume,K., Ikeda,M., Endo,Y. and
            Nojima,H.
  TITLE     Expression, nuclear localization and interactions of human MCM/P1
            proteins
  JOURNAL   Biochem Biophys Res Commun 236 (1), 118-125 (1997)
   PUBMED   9223437
REFERENCE   7  (bases 1 to 3458)
  AUTHORS   Ishimi,Y., Ichinose,S., Omori,A., Sato,K. and Kimura,H.
  TITLE     Binding of human minichromosome maintenance proteins with histone
            H3
  JOURNAL   J Biol Chem 271 (39), 24115-24122 (1996)
   PUBMED   8798650
REFERENCE   8  (bases 1 to 3458)
  AUTHORS   Paul,R., Hu,B., Musahl,C., Hameister,H. and Knippers,R.
  TITLE     Coding sequence and chromosome mapping of the human gene (CDC46)
            for replication protein hCdc46/Mcm5
  JOURNAL   Cytogenet Cell Genet 73 (4), 317-321 (1996)
   PUBMED   8751386
REFERENCE   9  (bases 1 to 3458)
  AUTHORS   Burkhart,R., Schulte,D., Hu,D., Musahl,C., Gohring,F. and
            Knippers,R.
  TITLE     Interactions of human nuclear proteins P1Mcm3 and P1Cdc46
  JOURNAL   Eur J Biochem 228 (2), 431-438 (1995)
   PUBMED   7705359
REFERENCE   10 (bases 1 to 3458)
  AUTHORS   Hu,B., Burkhart,R., Schulte,D., Musahl,C. and Knippers,R.
  TITLE     The P1 family: a new class of nuclear mammalian proteins related to
            the yeast Mcm replication proteins
  JOURNAL   Nucleic Acids Res 21 (23), 5289-5293 (1993)
   PUBMED   8265339
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BM787690.1, X74795.2 and
            Z82244.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006739.3.
            
            Summary: The protein encoded by this gene is structurally very
            similar to the CDC46 protein from S. cerevisiae, a protein involved
            in the initiation of DNA replication. The encoded protein is a
            member of the MCM family of chromatin-binding proteins and can
            interact with at least two other members of this family. The
            encoded protein is upregulated in the transition from the G0 to
            G1/S phase of the cell cycle and may actively participate in cell
            cycle regulation. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.22654.1,
                                           SRR1803614.45180.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000216122.9/ ENSP00000216122.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BM787690.1         21-75
            56-2529             X74795.2           1-2474
            2530-3458           Z82244.1           81926-82854
FEATURES             Location/Qualifiers
     source          1..3458
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..3458
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /note="minichromosome maintenance complex component 5"
                     /db_xref="GeneID:4174"
                     /db_xref="HGNC:HGNC:6948"
                     /db_xref="MIM:602696"
     exon            1..69
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            70..244
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2282
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /EC_number="3.6.4.12"
                     /note="minichromosome maintenance deficient 5 (cell
                     division cycle 46); CDC46 homolog; MCM5 minichromosome
                     maintenance deficient 5, cell division cycle 46"
                     /codon_start=1
                     /product="DNA replication licensing factor MCM5"
                     /protein_id="NP_006730.2"
                     /db_xref="CCDS:CCDS13915.1"
                     /db_xref="GeneID:4174"
                     /db_xref="HGNC:HGNC:6948"
                     /db_xref="MIM:602696"
                     /translation="MSGFDDPGIFYSDSFGGDAQADEGQARKSQLQRRFKEFLRQYRV
                     GTDRTGFTFKYRDELKRHYNLGEYWIEVEMEDLASFDEDLADYLYKQPAEHLQLLEEA
                     AKEVADEVTRPRPSGEEVLQDIQVMLKSDASPSSIRSLKSDMMSHLVKIPGIIIAASA
                     VRAKATRISIQCRSCRNTLTNIAMRPGLEGYALPRKCNTDQAGRPKCPLDPYFIMPDK
                     CKCVDFQTLKLQELPDAVPHGEMPRHMQLYCDRYLCDKVVPGNRVTIMGIYSIKKFGL
                     TTSRGRDRVGVGIRSSYIRVLGIQVDTDGSGRSFAGAVSPQEEEEFRRLAALPNVYEV
                     ISKSIAPSIFGGTDMKKAIACLLFGGSRKRLPDGLTRRGDINLLMLGDPGTAKSQLLK
                     FVEKCSPIGVYTSGKGSSAAGLTASVMRDPSSRNFIMEGGAMVLADGGVVCIDEFDKM
                     REDDRVAIHEAMEQQTISIAKAGITTTLNSRCSVLAAANSVFGRWDETKGEDNIDFMP
                     TILSRFDMIFIVKDEHNEERDVMLAKHVITLHVSALTQTQAVEGEIDLAKLKKFIAYC
                     RVKCGPRLSAEAAEKLKNRYIIMRSGARQHERDSDRRSSIPITVRQLEAIVRIAEALS
                     KMKLQPFATEADVEEALRLFQVSTLDAALSGTLSGVEGFTSQEDQEMLSRIEKQLKRR
                     FAIGSQVSEHSIIKDFTKQKYPEHAIHKVLQLMLRRGEIQHRMQRKVLYRLK"
     exon            245..371
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            372..500
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            501..673
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            674..829
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            830..996
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1168
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1280
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1424
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1490
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1491..1667
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1780
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1909
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            1910..2052
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            2053..2180
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     exon            2181..3458
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2505..2510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /note="hexamer: AATAAA"
     polyA_site      2529
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /note="major polyA site"
     regulatory      3443..3448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
                     /note="hexamer: AAGAAA"
     polyA_site      3458
                     /gene="MCM5"
                     /gene_synonym="CDC46; MGORS8; P1-CDC46"
ORIGIN      
        1 ccgcgaaact cggcggctga gcgtggaggt tcttgtctcc cctggtttgt gaagtgcgga
       61 aaaccagagg cgcagtcatg tcgggattcg acgatcctgg cattttctac agcgacagct
      121 tcgggggcga cgcccaggcc gacgaggggc aggcccgcaa atcgcagctg cagaggcgct
      181 tcaaggagtt cctgcggcag taccgagtgg gcaccgaccg cacgggcttc accttcaaat
      241 acagggatga actcaagcgg cattacaacc tgggggagta ctggattgag gtggagatgg
      301 aggatctggc cagctttgat gaggacctgg ccgactactt gtacaagcag ccagccgagc
      361 acctgcagct gctggaggaa gctgccaagg aggtagctga tgaggtgacc cggccccggc
      421 cttctgggga ggaggtgctc caggacatcc aggtcatgct caagtcggac gccagccctt
      481 ccagcattcg tagcctgaag tcggacatga tgtcacacct ggtgaagatc cctggcatca
      541 tcatcgcggc ctctgcggtc cgtgccaagg ccacccgcat ctctatccag tgccgcagct
      601 gccgcaacac cctcaccaac attgccatgc gccctggcct cgagggctat gccctgccca
      661 ggaagtgcaa cacagatcag gctgggcgcc ccaaatgccc attggacccg tacttcatca
      721 tgcccgacaa atgcaaatgc gtggacttcc agaccctgaa gctgcaggag ctgcctgatg
      781 cagtccccca cggggagatg cccagacaca tgcagctcta ctgcgacagg tacctgtgtg
      841 acaaggtcgt ccctgggaac agggttacca tcatgggcat ctactccatc aagaagtttg
      901 gcctgactac cagcaggggc cgtgacaggg tgggcgtggg catccgaagc tcctacatcc
      961 gtgtcctggg catccaggtg gacacagatg gctctggccg cagctttgct ggggccgtga
     1021 gcccccagga ggaggaggag ttccgtcgcc tggctgccct cccaaatgtc tatgaggtca
     1081 tctccaagag catcgccccc tccatctttg ggggcacaga catgaagaag gccattgcct
     1141 gcctgctctt tgggggctcc cgaaagaggc tccctgatgg acttactcgc cgaggagaca
     1201 tcaacctgct gatgctaggg gaccctggga cagccaagtc ccagcttctg aagtttgtgg
     1261 agaagtgttc tcccattggg gtatacacgt ctgggaaagg cagcagcgca gctggactga
     1321 cagcctcggt gatgagggac ccttcgtccc ggaatttcat catggagggc ggagccatgg
     1381 tcctggccga tggtggggtc gtctgtattg acgagtttga caagatgcga gaagatgacc
     1441 gtgtggcaat ccacgaagcc atggagcagc agaccatctc tatcgccaag gctgggatca
     1501 ccaccaccct gaactcccgc tgctccgtcc tggctgctgc caactcagtg ttcggccgct
     1561 gggatgagac gaagggggag gacaacattg acttcatgcc caccatcttg tcgcgcttcg
     1621 acatgatctt catcgtcaag gatgagcaca atgaggagag ggatgtgatg ctggccaagc
     1681 atgtcatcac tctgcacgtg agcgcactga cacagacaca ggctgtggag ggcgagattg
     1741 acctggccaa gctgaagaag tttattgcct actgccgagt gaagtgtggc ccccggctgt
     1801 cagcagaggc tgcagagaaa ctgaagaacc gctacatcat catgcggagc ggggcccgtc
     1861 agcacgagag ggacagtgac cgccgctcca gcatccccat cactgtgcgg cagctggagg
     1921 ccattgtgcg catcgcggaa gccctcagca agatgaagct gcagcccttc gccacagagg
     1981 cagatgtgga ggaggccctg cggctcttcc aagtgtccac gttggatgct gccttgtccg
     2041 gtaccctgtc aggggtggag ggcttcacca gccaggagga ccaggagatg ctgagccgca
     2101 tcgagaagca gctcaagcgc cgctttgcca ttggctccca ggtgtctgag cacagcatca
     2161 tcaaggactt caccaagcag aaatacccgg agcacgccat ccacaaggtg ctgcagctca
     2221 tgctgcggcg cggcgagatc cagcatcgca tgcagcgcaa ggttctctac cgcctcaagt
     2281 gagtcgcgcc gcctcactgg actcatggac tcgcccacgc ctcgcccctc ctgccgctgc
     2341 ctgccattga caatgttgct gggacctctg cctccccact gcagccctcg aacttcccag
     2401 gcaccctcct ttctgcccca gaggaaggag ctgtagtgtc ctgctgcctc tgggcgcccg
     2461 cctctagcgc ggttctggga agtgtgcttt tggcatccgt taataataaa gccacggtgt
     2521 gttcaggtat ctgtgggttt gtgcactcgg tgacctgtca cctccatcgt gccctcatgg
     2581 cagggtaagt gtgagggaac agggtctgga ggcagactgg ccagggtttc tgacttggat
     2641 ctgccactca gacttctggg taagtcacgt gacttgagtg ctccggtttc ttcatctgtt
     2701 tagcggggct cataaagcca ctcccttgat gctgggaatc cagtgagacc agggagtggg
     2761 gaagcgcttc tcaaagtgtg tgattttgat ccgcctcacc tgttccccag taacttattg
     2821 gggggctgcg agccgtggtg cggcggtcag actgcctgga ttcatggacc ctctccatgc
     2881 cttagtttcc ttatctgtaa gcaggctgat actagaacct gcttcacagg gttgtgctta
     2941 gggtcagtga gcagctgtta gtgaggggaa tgtagtggcc accaggcagg aactaggact
     3001 ccagccagtt ctttcctggt gggccacgtg taactgtgtg gccttgggcg agacatttca
     3061 cttttctgtg cctgagttta tcagtaaact ggagatgggg ggattcctca ccctgagttg
     3121 tgaggattga atgacagaag gcactagtga cagtgatgct ggaggaagga gtgttgccaa
     3181 gtgcctcggt cactttgcct aatttcagaa agtcactctg agttggtatg ttttgtgttt
     3241 ttaaaaaagc taggattcat aaaattaaat agaaatcagt gaaataaaat atttgatatt
     3301 taaaatacat ttagaaatac aaagtgtcaa gcaaaacgtg aatttggaaa tctatggaac
     3361 attagataag gtatttaaaa gtaattgcca tgtaaaaatg acacgaactt gaagtaagat
     3421 tatttgattt ttctaaaaat acaagaaagc ttggtgca
//
