LOCUS       NM_003906               6403 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens minichromosome maintenance complex component 3
            associated protein (MCM3AP), mRNA.
ACCESSION   NM_003906
VERSION     NM_003906.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6403)
  AUTHORS   Oishi,T., Pagano,J., Sellers,C. and Jerath,N.U.
  TITLE     Two Cases of Periodic Paralysis Associated With MCM3AP Variants
  JOURNAL   J Clin Neuromuscul Dis 25 (1), 36-41 (2023)
   PUBMED   37611268
  REMARK    GeneRIF: Two Cases of Periodic Paralysis Associated With MCM3AP
            Variants.
REFERENCE   2  (bases 1 to 6403)
  AUTHORS   Sakai,Y., Phimsen,S., Okada,S. and Kuwahara,K.
  TITLE     The critical role of germinal center-associated nuclear protein in
            cell biology, immunohematology, and hematolymphoid oncogenesis
  JOURNAL   Exp Hematol 90, 30-38 (2020)
   PUBMED   32827560
  REMARK    GeneRIF: The critical role of germinal center-associated nuclear
            protein in cell biology, immunohematology, and hematolymphoid
            oncogenesis.
            Review article
REFERENCE   3  (bases 1 to 6403)
  AUTHORS   Zhao,K., Tu,C., Liang,K., Li,Y. and Yu,Y.
  TITLE     Long noncoding RNA MCM3AP antisense RNA 1 is downregulated in
            chronic obstructive pulmonary disease and regulates human bronchial
            smooth muscle cell proliferation
  JOURNAL   J Int Med Res 48 (9), 300060520935215 (2020)
   PUBMED   32940099
  REMARK    GeneRIF: Long noncoding RNA MCM3AP antisense RNA 1 is downregulated
            in chronic obstructive pulmonary disease and regulates human
            bronchial smooth muscle cell proliferation.
REFERENCE   4  (bases 1 to 6403)
  AUTHORS   Woldegebriel,R., Kvist,J., Andersson,N., Ounap,K., Reinson,K.,
            Wojcik,M.H., Bijlsma,E.K., Hoffer,M.J.V., Ryan,M.M., Stark,Z.,
            Walsh,M., Cuppen,I., van den Boogaard,M.H., Bharucha-Goebel,D.,
            Donkervoort,S., Winchester,S., Zori,R., Bonnemann,C.G.,
            Maroofian,R., O'Connor,E., Houlden,H., Zhao,F., Carpen,O.,
            White,M., Sreedharan,J., Stewart,M., Ylikallio,E. and Tyynismaa,H.
  TITLE     Distinct effects on mRNA export factor GANP underlie neurological
            disease phenotypes and alter gene expression depending on intron
            content
  JOURNAL   Hum Mol Genet 29 (9), 1426-1439 (2020)
   PUBMED   32202298
  REMARK    GeneRIF: Distinct effects on mRNA export factor GANP underlie
            neurological disease phenotypes and alter gene expression depending
            on intron content.
REFERENCE   5  (bases 1 to 6403)
  AUTHORS   Dong,H.L., Wei,Q., Li,J.Q., Li,H.F., Bai,G., Ma,H. and Wu,Z.Y.
  TITLE     Genetic spectrum of MCM3AP and its relationship with phenotype of
            Charcot-Marie-Tooth disease
  JOURNAL   J Peripher Nerv Syst 25 (2), 107-111 (2020)
   PUBMED   32319184
  REMARK    GeneRIF: Genetic spectrum of MCM3AP and its relationship with
            phenotype of Charcot-Marie-Tooth disease.
REFERENCE   6  (bases 1 to 6403)
  AUTHORS   Kuwahara,K., Tomiyasu,S., Fujimura,S., Nomura,K., Xing,Y.,
            Nishiyama,N., Ogawa,M., Imajoh-Ohmi,S., Izuta,S. and Sakaguchi,N.
  TITLE     Germinal center-associated nuclear protein (GANP) has a
            phosphorylation-dependent DNA-primase activity that is up-regulated
            in germinal center regions
  JOURNAL   Proc Natl Acad Sci U S A 98 (18), 10279-10283 (2001)
   PUBMED   11526238
REFERENCE   7  (bases 1 to 6403)
  AUTHORS   Takei,Y., Swietlik,M., Tanoue,A., Tsujimoto,G., Kouzarides,T. and
            Laskey,R.
  TITLE     MCM3AP, a novel acetyltransferase that acetylates replication
            protein MCM3
  JOURNAL   EMBO Rep 2 (2), 119-123 (2001)
   PUBMED   11258703
REFERENCE   8  (bases 1 to 6403)
  AUTHORS   Abe,E., Kuwahara,K., Yoshida,M., Suzuki,M., Terasaki,H., Matsuo,Y.,
            Takahashi,E.I. and Sakaguchi,N.
  TITLE     Structure, expression, and chromosomal localization of the human
            gene encoding a germinal center-associated nuclear protein (GANP)
            that associates with MCM3 involved in the initiation of DNA
            replication
  JOURNAL   Gene 255 (2), 219-227 (2000)
   PUBMED   11024281
REFERENCE   9  (bases 1 to 6403)
  AUTHORS   Kuwahara,K., Yoshida,M., Kondo,E., Sakata,A., Watanabe,Y., Abe,E.,
            Kouno,Y., Tomiyasu,S., Fujimura,S., Tokuhisa,T., Kimura,H.,
            Ezaki,T. and Sakaguchi,N.
  TITLE     A novel nuclear phosphoprotein, GANP, is up-regulated in
            centrocytes of the germinal center and associated with MCM3, a
            protein essential for DNA replication
  JOURNAL   Blood 95 (7), 2321-2328 (2000)
   PUBMED   10733502
REFERENCE   10 (bases 1 to 6403)
  AUTHORS   Takei,Y. and Tsujimoto,G.
  TITLE     Identification of a novel MCM3-associated protein that facilitates
            MCM3 nuclear localization
  JOURNAL   J Biol Chem 273 (35), 22177-22180 (1998)
   PUBMED   9712829
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000471.2, AL079407.1,
            AJ010089.1, BC104958.1 and AA659734.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003906.4.
            
            Summary: The minichromosome maintenance protein 3 (MCM3) is one of
            the MCM proteins essential for the initiation of DNA replication.
            The protein encoded by this gene is a MCM3 binding protein. It was
            reported to have phosphorylation-dependent DNA-primase activity,
            which was up-regulated in antigen immunization induced germinal
            center. This protein was demonstrated to be an acetyltransferase
            that acetylates MCM3 and plays a role in DNA replication. The
            mutagenesis of a nuclear localization signal of MCM3 affects the
            binding of this protein with MCM3, suggesting that this protein may
            also facilitate MCM3 nuclear localization. This gene is expressed
            in the brain or in neuronal tissue. An allelic variant encoding
            amino acid Lys at 915, instead of conserved Glu, has been
            identified in patients with mild intellectual disability. [provided
            by RefSeq, Jan 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ010089.1, BC104958.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000291688.6/ ENSP00000291688.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AP000471.2         17527-17743         c
            218-289             AL079407.1         366-437
            290-3255            AJ010089.1         2-2967
            3256-6293           BC104958.1         3007-6044
            6294-6403           AA659734.1         13-122              c
FEATURES             Location/Qualifiers
     source          1..6403
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..6403
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /note="minichromosome maintenance complex component 3
                     associated protein"
                     /db_xref="GeneID:8888"
                     /db_xref="HGNC:HGNC:6946"
                     /db_xref="MIM:603294"
     exon            1..1544
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     CDS             326..6268
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /EC_number="2.3.1.48"
                     /note="MCM3 minichromosome maintenance deficient 3
                     associated protein; germinal center-associated nuclear
                     protein; MCM3 import protein; 80 kDa MCM3-associated
                     protein; germinal-centre associated nuclear protein; MCM3
                     acetyltransferase; MCM3 acetylating protein"
                     /codon_start=1
                     /product="germinal-center associated nuclear protein"
                     /protein_id="NP_003897.2"
                     /db_xref="CCDS:CCDS13734.1"
                     /db_xref="GeneID:8888"
                     /db_xref="HGNC:HGNC:6946"
                     /db_xref="MIM:603294"
                     /translation="MNPTNPFSGQQPSAFSASSSNVGTLPSKPPFRFGQPSLFGQNST
                     LSGKSSGFSQVSSFPASSGVSHSSSVQTLGFTQTSSVGPFSGLEHTSTFVATSGPSSS
                     SVLGNTGFSFKSPTSVGAFPSTSAFGQEAGEIVNSGFGKTEFSFKPLENAVFKPILGA
                     ESEPEKTQSQIASGFFTFSHPISSAPGGLAPFSFPQVTSSSATTSNFTFSKPVSSNNS
                     LSAFTPALSNQNVEEEKRGPKSIFGSSNNSFSSFPVSSAVLGEPFQASKAGVRQGCEE
                     AVSQVEPLPSLMKGLKRKEDQDRSPRRHGHEPAEDSDPLSRGDHPPDKRPVRLNRPRG
                     GTLFGRTIQDVFKSNKEVGRLGNKEAKKETGFVESAESDHMAIPGGNQSVLAPSRIPG
                     VNKEEETESREKKEDSLRGTPARQSNRSESTDSLGGLSPSEVTAIQCKNIPDYLNDRT
                     ILENHFGKIAKVQRIFTRRSKKLAVVHFFDHASAALARKKGKSLHKDMAIFWHRKKIS
                     PNKKPFSLKEKKPGDGEVSPSTEDAPFQHSPLGKAAGRTGASSLLNKSSPVKKPSLLK
                     AHQFEGDSFDSASEGSEGLGPCVLSLSTLIGTVAETSKEKYRLLDQRDRIMRQARVKR
                     TDLDKARTFVGTCLDMCPEKERYMRETRSQLSVFEVVPGTDQVDHAAAVKEYSRSSAD
                     QEEPLPHELRPLPVLSRTMDYLVTQIMDQKEGSLRDWYDFVWNRTRGIRKDITQQHLC
                     DPLTVSLIEKCTRFHIHCAHFMCEEPMSSFDAKINNENMTKCLQSLKEMYQDLRNKGV
                     FCASEAEFQGYNVLLSLNKGDILREVQQFHPAVRNSSEVKFAVQAFAALNSNNFVRFF
                     KLVQSASYLNACLLHCYFSQIRKDALRALNFAYTVSTQRSTIFPLDGVVRMLLFRDCE
                     EATDFLTCHGLTVSDGCVELNRSAFLEPEGLSKTRKSVFITRKLTVSVGEIVNGGPLP
                     PVPRHTPVCSFNSQNKYIGESLAAELPVSTQRPGSDTVGGGRGEECGVEPDAPLSSLP
                     QSLPAPAPSPVPLPPVLALTPSVAPSLFQLSVQPEPPPPEPVPMYSDEDLAQVVDELI
                     QEALQRDCEEVGSAGAAYAAAALGVSNAAMEDLLTAATTGILRHIAAEEVSKERERRE
                     QERQRAEEERLKQERELVLSELSQGLAVELMERVMMEFVRETCSQELKNAVETDQRVR
                     VARCCEDVCAHLVDLFLVEEIFQTAKETLQELQCFCKYLQRWREAVTARKKLRRQMRA
                     FPAAPCCVDVSDRLRALAPSAECPIAEENLARGLLDLGHAGRLGISCTRLRRLRNKTA
                     HQMKVQHFYQQLLSDVAWASLDLPSLVAEHLPGRQEHVFWKLVLVLPDVEEQSPESCG
                     RILANWLKVKFMGDEGSVDDTSSDAGGIQTLSLFNSLSSKGDQMISVNVCIKVAHGAL
                     SDGAIDAVETQKDLLGASGLMLLLPPKMKSEDMAEEDVYWLSALLQLKQLLQAKPFQP
                     ALPLVVLVPSPGGDAVEKEVEDGLMLQDLVSAKLISDYTVTEIPDTINDLQGSTKVLQ
                     AVQWLVSHCPHSLDLCCQTLIQYVEDGIGHEFSGRFFHDRRERRLGGLASQEPGAIIE
                     LFNSVLQFLASVVSSEQLCDLSWPVTEFAEAGGSRLLPHLHWNAPEHLAWLKQAVLGF
                     QLPQMDLPPLGAPWLPVCSMVVQYASQIPSSRQTQPVLQSQVENLLHRTYCRWKSKSP
                     SPVHGAGPSVMEIPWDDLIALCINHKLRDWTPPRLPVTSEALSEDGQICVYFFKNDLK
                     KYDVPLSWEQARLQTQKELQLREGRLAIKPFHPSANNFPIPLLHMHRNWKRSTECAQE
                     GRIPSTEDLMRGASAEELLAQCLSSSLLLEKEENKRFEDQLQQWLSEDSGAFTDLTSL
                     PLYLPQTLVSLSHTIEPVMKTSVTTSPQSDMMREQLQLSEATGTCLGERLKHLERLIR
                     SSREEEVASELHLSALLDMVDI"
     exon            1545..1768
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1769..1847
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..1992
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2183
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2184..2323
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2521
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2522..2790
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2791..2953
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            2954..3114
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3115..3356
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3559
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3560..3660
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3661..3792
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3793..3906
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            3907..4059
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4060..4257
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4258..4326
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..4461
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4462..4615
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4616..4874
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4875..4972
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            4973..5363
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            5364..5621
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            5622..5751
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            5752..5958
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            5959..6109
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     exon            6110..6403
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6384..6389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /note="hexamer: GATAAA"
     polyA_site      6403
                     /gene="MCM3AP"
                     /gene_synonym="GANP; MAP80; PNRIID; SAC3"
                     /note="major polyA site"
ORIGIN      
        1 atcttaaagg atcacgcttt aaacctctgt aacaaagtaa ttatttgtac cactctctac
       61 cccaccctcc aacaaaataa cctatcggct ctcagaaaat aataaccctt tgcctgcctt
      121 tgaaatagtt atccttttag tatgacagtg ttcaaaaatt cttttcttag acttgtagca
      181 gaacatagct atgatgatct gaatttttct ctttcagctt gttctaaaga cgaaggggaa
      241 ctccctagtg ctacaggctg tttcaggaag ccaattaatt ttgtacacat aatacttaat
      301 taccttctaa taattggagc agaagatgaa cccaactaat cctttcagtg ggcagcagcc
      361 tagtgctttt tcggcgtctt ctagtaatgt aggaacactt ccatctaagc cgccatttcg
      421 atttggtcaa ccttctcttt ttggacaaaa cagtacctta tctgggaaga gctcgggatt
      481 ttcacaggta tccagctttc cagcgtcttc tggagtaagt cattcctctt cagtgcaaac
      541 attagggttc acccaaacct caagtgttgg acccttttct ggacttgagc acacttccac
      601 ctttgtggct acctctgggc cttcaagttc atctgtgctg ggaaacacag gatttagttt
      661 taaatcaccc accagtgttg gggctttccc aagcacttct gcttttggac aagaagctgg
      721 agaaatagtg aactctggtt ttgggaaaac agaattcagc tttaaacctc tggaaaatgc
      781 agtgttcaaa ccaatactgg gggctgaatc tgagccagag aaaacccaga gccaaattgc
      841 ttctgggttt tttacatttt cccacccaat tagtagtgca cctggaggcc tggccccttt
      901 ctcttttcct caagtaacaa gtagttcagc taccacttca aattttacct tttcaaaacc
      961 tgttagtagt aataattcat tatctgcctt tacccctgct ttgtcaaacc aaaatgtaga
     1021 ggaagagaag agaggaccta agtcaatatt tggaagttct aataatagct tcagtagctt
     1081 ccctgtatca tctgcggttt tgggcgaacc tttccaggct agcaaagcag gtgtcaggca
     1141 ggggtgtgaa gaagctgttt cccaggtgga accacttccc agcctaatga aaggactgaa
     1201 aaggaaggag gaccaggatc gctccccaag gagacatggc cacgagccag cagaagattc
     1261 ggatcctctg tcccggggcg atcatcctcc agacaaacga cctgtccgcc tgaatcgacc
     1321 ccggggaggt actttatttg gtcggacgat acaggatgtt ttcaaaagca ataaggaagt
     1381 aggtcgtctg ggcaacaagg aggccaaaaa ggaaactggc tttgttgagt ctgcagaaag
     1441 tgaccacatg gctatcccag gagggaatca gtctgtcctg gcaccttccc ggattccagg
     1501 tgtgaataaa gaggaagaaa ctgaaagtag agagaagaaa gaagattctc taagaggaac
     1561 tccggcgcgt cagagtaaca gaagcgagag cacagacagt cttgggggct tgtctccctc
     1621 tgaagtcaca gccatccagt gcaagaacat ccctgactac ctcaacgaca ggaccattct
     1681 ggagaaccat tttggcaaaa ttgctaaagt gcagcgcatc tttaccaggc gcagcaaaaa
     1741 gcttgcagtg gtacatttct ttgatcatgc atctgcagcc ctggctagaa agaaggggaa
     1801 aagtttgcat aaagacatgg ctatcttttg gcacaggaag aaaataagcc ccaataagaa
     1861 acccttttcc ctgaaggaga agaaaccagg tgacggtgaa gtcagcccga gcacagagga
     1921 tgcacccttt cagcactctc ctcttggcaa ggccgcaggg aggactggtg ctagcagcct
     1981 cctgaataaa agctctccag tgaagaagcc aagtcttcta aaggcccacc aattcgaggg
     2041 agactctttt gactcagcct ccgagggctc cgagggcctc gggccatgtg tgctctccct
     2101 cagtaccctg ataggcactg tggctgagac atccaaggag aagtaccgcc tgcttgacca
     2161 gagagacagg atcatgcggc aagctcgggt gaagagaacc gatctggaca aagcgaggac
     2221 ttttgttggc acctgcctgg atatgtgtcc tgagaaggag aggtacatgc gggagacccg
     2281 tagccagctg agcgtgttcg aagtggtccc agggactgac caggtggacc acgcagcagc
     2341 tgtgaaagag tacagtcggt cctcggcgga tcaggaggag cccctgcccc acgagctgcg
     2401 gcccttgcca gtgctcagca ggaccatgga ctacctggtg acccagatca tggaccagaa
     2461 ggagggcagc ctgcgggatt ggtatgactt cgtgtggaac cgcacgcgtg gcatacggaa
     2521 ggatatcacg cagcagcacc tctgtgaccc cctgacggtg tccctgattg agaagtgcac
     2581 ccggtttcac atccactgtg cccacttcat gtgtgaggag cccatgtcct cctttgatgc
     2641 caagatcaat aatgagaaca tgaccaagtg cctgcagagc ctgaaggaga tgtaccagga
     2701 cctgagaaac aagggtgtct tctgtgccag cgaagcggag ttccagggct acaatgttct
     2761 gctcagtctc aacaagggag acatcctaag agaagtacaa cagttccatc ctgctgttag
     2821 aaactcatct gaggtgaaat ttgctgttca ggcttttgct gcattgaaca gtaataattt
     2881 tgtgagattt ttcaaactgg tccagtcagc ttcttacctg aacgcttgtc ttttacactg
     2941 ttacttcagt cagatccgca aggatgctct ccgggcgctc aactttgcgt acacggtgag
     3001 cacacagcga tctaccatct ttcccctgga tggtgtggtg cgcatgctgc tgttcagaga
     3061 ctgtgaagag gccaccgact tcctcacctg ccacggcctc accgtttccg acggctgtgt
     3121 ggagctgaac cggtctgcat tcctggaacc agagggatta tccaagacca ggaagtcggt
     3181 gtttattact aggaagctga cggtgtcagt cggggaaatt gtgaacggag ggccattgcc
     3241 ccccgtccct cgtcataccc ctgtgtgcag cttcaactcc cagaacaagt acatcgggga
     3301 gagcctggcc gcggagctgc ccgtcagcac ccagagaccc ggctccgaca cagtgggcgg
     3361 agggagagga gaggagtgtg gtgtagagcc ggatgcaccc ctgtccagtc tcccacagtc
     3421 tctaccagcc cctgcgccct caccagtgcc tctgcctcct gtcctggcac tgaccccgtc
     3481 tgtggcgccc agcctcttcc agctgtctgt gcagcctgaa ccaccgcctc cagagcccgt
     3541 gcccatgtac tctgacgagg acctggcgca ggtggtggac gagctcatcc aggaggccct
     3601 gcagagggac tgtgaggaag ttggctctgc gggtgctgcc tacgcagctg ccgccctggg
     3661 tgtttctaat gctgctatgg aggatttgtt aacagctgca accacgggca ttttgaggca
     3721 cattgcagct gaagaagtgt ctaaggaaag agagcgaagg gagcaggaga ggcagcgggc
     3781 tgaagaggaa aggttgaaac aagagagaga gctggtgtta agtgagctga gccagggcct
     3841 ggccgtggag ctgatggaac gcgtgatgat ggagtttgtg agggaaacct gctcccagga
     3901 gttgaagaat gcagtagaga cagaccagag ggtccgtgtg gcccgttgct gtgaggatgt
     3961 ctgtgcccac ttagtggact tgtttctcgt ggaggaaatc ttccagactg caaaggagac
     4021 cctccaggag cttcagtgct tctgcaagta tctacagcgg tggagggaag ctgtcacagc
     4081 ccgcaagaaa ctgaggcgcc aaatgcgggc tttccctgct gcgccctgct gcgtggacgt
     4141 gagcgaccgg ctgagggcgc tggcgcccag cgcagagtgc cccattgctg aagagaacct
     4201 ggccaggggc ctcctggacc tgggccatgc agggagattg ggcatctcct gcaccaggtt
     4261 aaggcggctc agaaacaaga cagctcacca gatgaaggtt cagcacttct accagcagct
     4321 gctgagtgat gtggcatggg cgtctctgga cctgccatcc ctcgtggctg agcacctccc
     4381 tgggaggcag gagcatgtgt tttggaagct ggtgctggtg ttgccggatg tagaggagca
     4441 gtccccagag agttgtggca gaattctagc aaattggtta aaagtcaagt tcatgggaga
     4501 tgaaggctca gtggatgaca catccagcga tgctggtggg attcagacgc tttcgctttt
     4561 caactcactt agcagcaaag gggatcagat gatttctgtt aacgtgtgta taaaggtggc
     4621 ccatggcgcc ctcagtgatg gtgccattga tgctgtggag acacagaagg acctcctggg
     4681 agccagtggg ctcatgctgc tgcttccccc caaaatgaag agtgaggaca tggcagagga
     4741 ggacgtgtac tggctgtcgg ccttgctgca gctcaagcag ctcctgcagg ctaagccctt
     4801 ccagcctgcg cttcctctgg tggttcttgt gcctagccca ggaggggacg ccgttgagaa
     4861 ggaagtagaa gatggtctga tgctacagga cttggtttca gctaagctga tttcagatta
     4921 cactgttacc gagatccctg ataccattaa tgatctacaa ggttcaacta aggttttgca
     4981 agcagtgcag tggctggttt cccactgccc ccattccctt gacctctgct gccagactct
     5041 cattcagtac gtcgaagacg ggattggcca tgagtttagt ggccgctttt tccatgacag
     5101 aagagagagg cgtctgggcg gtcttgcttc tcaggagcct ggcgccatca ttgagctgtt
     5161 taacagtgtg ctgcagttcc tggcttctgt ggtgtcctct gaacagctgt gtgacctgtc
     5221 ctggcctgtc actgagtttg ctgaggcagg gggcagccgg ctgcttcctc acctgcactg
     5281 gaatgcccca gagcacctgg cctggctgaa gcaggctgtg ctcgggttcc agcttccgca
     5341 gatggacctt ccacccctgg gggccccctg gctccccgtg tgctccatgg ttgtccagta
     5401 cgcctcccag atccccagct cacgccagac acagcctgtc ctccagtccc aggtggagaa
     5461 cctgctccac agaacctact gtaggtggaa gagcaagagt ccctccccag tccatggggc
     5521 aggcccctcg gtcatggaga tcccatggga tgatcttatc gccttgtgta tcaaccacaa
     5581 gctgagagac tggacgcccc cccggcttcc tgttacatca gaggcgctga gtgaagatgg
     5641 tcagatatgt gtgtattttt ttaaaaacga tttgaaaaaa tatgatgttc ctttgtcgtg
     5701 ggaacaagcc aggttgcaga cgcagaagga gctacagctg agagagggac gtttggcaat
     5761 aaagcctttt catccttctg caaacaattt tcccatacca ttgcttcaca tgcaccgtaa
     5821 ctggaagagg agcacagagt gtgctcaaga ggggaggatt cccagcacag aggatctgat
     5881 gcgaggagct tctgctgagg agctcttggc gcagtgtttg tcgagcagtc tgctgctgga
     5941 gaaagaagag aacaagaggt ttgaagatca gcttcagcaa tggttgtctg aagactcagg
     6001 agcatttacg gatttaactt cccttcccct ctatcttcct cagactctag tgtctctttc
     6061 tcacactatt gaacctgtga tgaaaacatc tgtaactact agcccacaga gtgacatgat
     6121 gagggagcaa ctgcagctgt cagaggcgac aggaacgtgt ctaggcgaac gactaaagca
     6181 cctggaaagg ctgatccgga gttcaaggga agaggaagtt gcctctgagc tccatctctc
     6241 tgcgctgcta gacatggtgg acatttgagc agcctgacct gtggggaggg ggtctctccc
     6301 gaagagtttc tgtttttact caaaataatg ttattctcag atgcttgatg cactgttgga
     6361 aatgtgatta atttaatcat gcagataaac catttaaatg tca
//
