LOCUS       NM_021960               3950 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens MCL1 apoptosis regulator, BCL2 family member (MCL1),
            transcript variant 1, mRNA.
ACCESSION   NM_021960
VERSION     NM_021960.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3950)
  AUTHORS   Guan,Z., Li,H., Zhang,C., Huang,Z., Ye,M., Zhang,Y., Li,S. and
            Peng,K.
  TITLE     RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis
            to activate pathogenic NLRP3 pyroptosis
  JOURNAL   PLoS Pathog 20 (8), e1012387 (2024)
   PUBMED   39213434
  REMARK    GeneRIF: RVFV virulence factor NSs triggers the mitochondrial
            MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3950)
  AUTHORS   Cai,Y., Li,Y., Xu,Y., Yang,W. and Huang,M.
  TITLE     TCEB3 initiates ovarian cancer apoptosis by mediating
            ubiquitination and degradation of MCL-1
  JOURNAL   FASEB J 38 (8), e23625 (2024)
   PUBMED   38661028
  REMARK    GeneRIF: TCEB3 initiates ovarian cancer apoptosis by mediating
            ubiquitination and degradation of MCL-1.
REFERENCE   3  (bases 1 to 3950)
  AUTHORS   Kim,J.H., Sim,S.H., Ha,H.J., Ko,J.J., Lee,K. and Bae,J.
  TITLE     MCL-1ES, a novel variant of MCL-1, associates with MCL-1L and
            induces mitochondrial cell death
  JOURNAL   FEBS Lett 583 (17), 2758-2764 (2009)
   PUBMED   19683529
  REMARK    GeneRIF: Data show that MCL-1ES interacts with MCL-1L and induces
            mitochondrial cell death, suggesting that alternative splicing of
            MCL-1 may control the fate of cells.
REFERENCE   4  (bases 1 to 3950)
  AUTHORS   Fujise,K., Zhang,D., Liu,J. and Yeh,E.T.
  TITLE     Regulation of apoptosis and cell cycle progression by MCL1.
            Differential role of proliferating cell nuclear antigen
  JOURNAL   J Biol Chem 275 (50), 39458-39465 (2000)
   PUBMED   10978339
REFERENCE   5  (bases 1 to 3950)
  AUTHORS   Bae,J., Leo,C.P., Hsu,S.Y. and Hsueh,A.J.
  TITLE     MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member
            MCL-1, encodes a proapoptotic protein possessing only the BH3
            domain
  JOURNAL   J Biol Chem 275 (33), 25255-25261 (2000)
   PUBMED   10837489
REFERENCE   6  (bases 1 to 3950)
  AUTHORS   Akgul,C., Turner,P.C., White,M.R. and Edwards,S.W.
  TITLE     Functional analysis of the human MCL-1 gene
  JOURNAL   Cell Mol Life Sci 57 (4), 684-691 (2000)
   PUBMED   11130466
REFERENCE   7  (bases 1 to 3950)
  AUTHORS   Umezawa,A., Maruyama,T., Inazawa,J., Imai,S., Takano,T. and Hata,J.
  TITLE     Induction of mcl1/EAT, Bcl-2 related gene, by retinoic acid or heat
            shock in the human embryonal carcinoma cells, NCR-G3
  JOURNAL   Cell Struct Funct 21 (2), 143-150 (1996)
   PUBMED   8790944
REFERENCE   8  (bases 1 to 3950)
  AUTHORS   Yang,T., Kozopas,K.M. and Craig,R.W.
  TITLE     The intracellular distribution and pattern of expression of Mcl-1
            overlap with, but are not identical to, those of Bcl-2
  JOURNAL   J Cell Biol 128 (6), 1173-1184 (1995)
   PUBMED   7896880
REFERENCE   9  (bases 1 to 3950)
  AUTHORS   Craig,R.W., Jabs,E.W., Zhou,P., Kozopas,K.M., Hawkins,A.L.,
            Rochelle,J.M., Seldin,M.F. and Griffin,C.A.
  TITLE     Human and mouse chromosomal mapping of the myeloid cell leukemia-1
            gene: MCL1 maps to human chromosome 1q21, a region that is
            frequently altered in preneoplastic and neoplastic disease
  JOURNAL   Genomics 23 (2), 457-463 (1994)
   PUBMED   7835896
REFERENCE   10 (bases 1 to 3950)
  AUTHORS   Kozopas,K.M., Yang,T., Buchan,H.L., Zhou,P. and Craig,R.W.
  TITLE     MCL1, a gene expressed in programmed myeloid cell differentiation,
            has sequence similarity to BCL2
  JOURNAL   Proc Natl Acad Sci U S A 90 (8), 3516-3520 (1993)
   PUBMED   7682708
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356356.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_021960.4.
            
            Summary: This gene encodes an anti-apoptotic protein, which is a
            member of the Bcl-2 family. Alternative splicing results in
            multiple transcript variants. The longest gene product (isoform 1)
            enhances cell survival by inhibiting apoptosis while the
            alternatively spliced shorter gene products (isoform 2 and isoform
            3) promote apoptosis and are death-inducing. [provided by RefSeq,
            Oct 2010].
            
            Transcript Variant: This variant (1), also known as MCL-1L (long),
            represents the longest transcript and encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017197.2, L08246.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000369026.3/
                                                  ENSP00000358022.2
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-768               AL356356.17        106105-106872       c
            769-1016            AL356356.17        105506-105753       c
            1017-3950           AL356356.17        101820-104753       c
FEATURES             Location/Qualifiers
     source          1..3950
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.2"
     gene            1..3950
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /note="MCL1 apoptosis regulator, BCL2 family member"
                     /db_xref="GeneID:4170"
                     /db_xref="HGNC:HGNC:6943"
                     /db_xref="MIM:159552"
     exon            1..768
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1133
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     induced myeloid leukemia cell differentiation protein
                     Mcl-1; myeloid cell leukemia ES; bcl-2-like protein 3;
                     myeloid cell leukemia 1; bcl-2-related protein EAT/mcl1;
                     myeloid cell leukemia sequence 1 (BCL2-related); BCL2
                     family apoptosis regulator; MCL1, BCL2 family apoptosis
                     regulator"
                     /codon_start=1
                     /product="induced myeloid leukemia cell differentiation
                     protein Mcl-1 isoform 1"
                     /protein_id="NP_068779.1"
                     /db_xref="CCDS:CCDS957.1"
                     /db_xref="GeneID:4170"
                     /db_xref="HGNC:HGNC:6943"
                     /db_xref="MIM:159552"
                     /translation="MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASA
                     RREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPT
                     RRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSL
                     PSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGD
                     GVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAK
                     HLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLA
                     FAGVAGVGAGLAYLIR"
     exon            769..1016
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..3950
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3932..3937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /note="hexamer: AATAAA"
     polyA_site      3950
                     /gene="MCL1"
                     /gene_synonym="bcl2-L-3; BCL2L3; EAT; Mcl-1; MCL1-ES;
                     mcl1/EAT; MCL1L; MCL1S; TM"
                     /note="major polyA site"
ORIGIN      
        1 acttctcact tccgcttcct tccagtaagg agtcggggtc ttccccagtt ttctcagcca
       61 ggcggcggcg gcgactggca atgtttggcc tcaaaagaaa cgcggtaatc ggactcaacc
      121 tctactgtgg gggggccggc ttgggggccg gcagcggcgg cgccacccgc ccgggagggc
      181 gacttttggc tacggagaag gaggcctcgg cccggcgaga gataggggga ggggaggccg
      241 gcgcggtgat tggcggaagc gccggcgcaa gccccccgtc caccctcacg ccagactccc
      301 ggagggtcgc gcggccgccg cccattggcg ccgaggtccc cgacgtcacc gcgacccccg
      361 cgaggctgct tttcttcgcg cccacccgcc gcgcggcgcc gcttgaggag atggaagccc
      421 cggccgctga cgccatcatg tcgcccgaag aggagctgga cgggtacgag ccggagcctc
      481 tcgggaagcg gccggctgtc ctgccgctgc tggagttggt cggggaatct ggtaataaca
      541 ccagtacgga cgggtcacta ccctcgacgc cgccgccagc agaggaggag gaggacgagt
      601 tgtaccggca gtcgctggag attatctctc ggtaccttcg ggagcaggcc accggcgcca
      661 aggacacaaa gccaatgggc aggtctgggg ccaccagcag gaaggcgctg gagaccttac
      721 gacgggttgg ggatggcgtg cagcgcaacc acgagacggc cttccaaggc atgcttcgga
      781 aactggacat caaaaacgaa gacgatgtga aatcgttgtc tcgagtgatg atccatgttt
      841 tcagcgacgg cgtaacaaac tggggcagga ttgtgactct catttctttt ggtgcctttg
      901 tggctaaaca cttgaagacc ataaaccaag aaagctgcat cgaaccatta gcagaaagta
      961 tcacagacgt tctcgtaagg acaaaacggg actggctagt taaacaaaga ggctgggatg
     1021 ggtttgtgga gttcttccat gtagaggacc tagaaggtgg catcaggaat gtgctgctgg
     1081 cttttgcagg tgttgctgga gtaggagctg gtttggcata tctaataaga tagccttact
     1141 gtaagtgcaa tagttgactt ttaaccaacc accaccacca ccaaaaccag tttatgcagt
     1201 tggactccaa gctgtaactt cctagagttg caccctagca acctagccag aaaagcaagt
     1261 ggcaagagga ttatggctaa caagaataaa tacatgggaa gagtgctccc cattgattga
     1321 agagtcactg tctgaaagaa gcaaagttca gtttcagcaa caaacaaact ttgtttggga
     1381 agctatggag gaggactttt agatttagtg aagatggtag ggtggaaaga cttaatttcc
     1441 ttgttgagaa caggaaagtg gccagtagcc aggcaagtca tagaattgat tacccgccga
     1501 attcattaat ttactgtagt gttaagagaa gcactaagaa tgccagtgac ctgtgtaaaa
     1561 gttacaagta atagaactat gactgtaagc ctcagtactg tacaagggaa gcttttcctc
     1621 tctctaatta gctttcccag tatacttctt agaaagtcca agtgttcagg acttttatac
     1681 ctgttatact ttggcttggt ttccatgatt cttactttat tagcctagtt tatcaccaat
     1741 aatacttgac ggaaggctca gtaattagtt atgaatatgg atatcctcaa ttcttaagac
     1801 agcttgtaaa tgtatttgta aaaattgtat atatttttac agaaagtcta tttctttgaa
     1861 acgaaggaag tatcgaattt acattagttt ttttcatacc cttttgaact ttgcaacttc
     1921 cgtaattagg aacctgtttc ttacagcttt tctatgctaa actttgttct gttcagttct
     1981 agagtgtata cagaacgaat tgatgtgtaa ctgtatgcag actggttgta gtggaacaaa
     2041 tctgataact atgcaggttt aaattttctt atctgatttt ggtaagtatt ccttaggttt
     2101 ttctttgaaa acctgggatt gagaggttga tgaatggaaa ttctttcact tcattatatg
     2161 caagttttca ataattaggt ctaagtggag ttttaaggtt actgatgact tacaaataat
     2221 gggctctgat tgggcaatac tcatttgagt tccttccatt tgacctaatt taactggtga
     2281 aatttaaagt gaattcatgg gctcatcttt aaagctttta ctaaaagatt ttcagctgaa
     2341 tggaactcat tagctgtgtg catataaaaa gatcacatca ggtggatgga gagacatttg
     2401 atcccttgtt tgcttaataa attataaaat gatggcttgg aaaagcaggc tagtctaacc
     2461 atggtgctat tattaggctt gcttgttaca cacacaggtc taagcctagt atgtcaataa
     2521 agcaaatact tactgttttg tttctattaa tgattcccaa accttgttgc aagtttttgc
     2581 attggcatct ttggatttca gtcttgatgt ttgttctatc agacttaacc ttttatttcc
     2641 tgtccttcct tgaaattgct gattgttctg ctccctctac agatatttat atcaattcct
     2701 acagctttcc cctgccatcc ctgaactctt tctagccctt ttagattttg gcactgtgaa
     2761 acccctgctg gaaacctgag tgaccctccc tccccaccaa gagtccacag acctttcatc
     2821 tttcacgaac ttgatcctgt tagcaggtgg taataccatg ggtgctgtga cactaacagt
     2881 cattgagagg tgggaggaag tcccttttcc ttggactggt atcttttcaa ctattgtttt
     2941 atcctgtctt tgggggcaat gtgtcaaaag tcccctcagg aattttcaga ggaaagaaca
     3001 ttttatgagg ctttctctaa agtttccttt gtataggagt atgctcactt aaatttacag
     3061 aaagaggtga gctgtgttaa acctcagagt ttaaaagcta ctgataaact gaagaaagtg
     3121 tctatattgg aactagggtc atttgaaagc ttcagtctcg gaacatgacc tttagtctgt
     3181 ggactccatt taaaaatagg tatgaataag atgactaaga atgtaatggg gaagaactgc
     3241 cctgcctgcc catctcagag ccataaggtc atctttgcta gagctatttt tacctatgta
     3301 tttatcgttc ttgatcataa gccgcttatt tatatcatgt atctctaagg acctaaaagc
     3361 actttatgta gtttttaatt aatcttaaga tctggttacg gtaactaaaa aagcctgtct
     3421 gccaaatcca gtggaaacaa gtgcatagat gtgaattggt ttttaggggc cccacttccc
     3481 aattcattag gtatgactgt ggaaatacag acaaggatct tagttgatat tttgggcttg
     3541 gggcagtgag ggcttaggac accccaagtg gtttgggaaa ggaggagggg agtggtgggt
     3601 ttataggggg aggaggaggc aggtggtcta agtgctgact ggctacgtag ttcgggcaaa
     3661 tcctccaaaa gggaaaggga ggatttgctt agaaggatgg cgctcccagt gactactttt
     3721 tgacttctgt ttgtcttacg cttctctcag ggaaaaacat gcagtcctct agtgtttcat
     3781 gtacattctg tggggggtga acaccttggt tctggttaaa cagctgtact tttgatagct
     3841 gtgccaggaa gggttaggac caactacaaa ttaatgttgg ttgtcaaatg tagtgtgttt
     3901 ccctaacttt ctgtttttcc tgagaaaaaa aaataaatct tttattcaaa
//
