LOCUS       NM_001040179            3759 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens melanin concentrating hormone receptor 2 (MCHR2),
            transcript variant 1, mRNA.
ACCESSION   NM_001040179
VERSION     NM_001040179.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3759)
  AUTHORS   Geets,E., Aerts,E., Verrijken,A., Van Hoorenbeeck,K., Verhulst,S.,
            Van Gaal,L. and Van Hul,W.
  TITLE     DNA sequencing and copy number variation analysis of MCHR2 in a
            cohort of Prader Willi like (PWL) patients
  JOURNAL   Obes Res Clin Pract 12 (2), 158-166 (2018)
   PUBMED   29066024
  REMARK    GeneRIF: results are in line with some previously performed studies
            suggesting that MCHR2 is not a major contributor to human obesity
            and the Prader Willi Syndrome phenotype
REFERENCE   2  (bases 1 to 3759)
  AUTHORS   Fischer,J., Degenhardt,F., Hofmann,A., Redler,S., Basmanav,F.B.,
            Heilmann-Heimbach,S., Hanneken,S., Giehl,K.A., Wolff,H., Moebus,S.,
            Kruse,R., Lutz,G., Blaumeiser,B., Bohm,M., Garcia Bartels,N.,
            Blume-Peytavi,U., Petukhova,L., Christiano,A.M., Nothen,M.M. and
            Betz,R.C.
  TITLE     Genomewide analysis of copy number variants in alopecia areata in a
            Central European cohort reveals association with MCHR2
  JOURNAL   Exp Dermatol 26 (6), 536-541 (2017)
   PUBMED   27306922
  REMARK    GeneRIF: evidence for the involvement of duplications in MCHR2 in
            alopecia areata pathogenesis in a Central European cohort
REFERENCE   3  (bases 1 to 3759)
  AUTHORS   Delacretaz,A., Preisig,M., Vandenberghe,F., Saigi Morgui,N.,
            Quteineh,L., Choong,E., Gholam-Rezaee,M., Kutalik,Z.,
            Magistretti,P., Aubry,J.M., von Gunten,A., Castelao,E.,
            Vollenweider,P., Waeber,G., Conus,P. and Eap,C.B.
  TITLE     Influence of MCHR2 and MCHR2-AS1 Genetic Polymorphisms on Body Mass
            Index in Psychiatric Patients and In Population-Based Subjects with
            Present or Past Atypical Depression
  JOURNAL   PLoS One 10 (10), e0139155 (2015)
   PUBMED   26461262
  REMARK    GeneRIF: This study provides new insights on the possible influence
            of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on
            the pathophysiology of atypical depression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3759)
  AUTHORS   Perry,J.R., Day,F., Elks,C.E., Sulem,P., Thompson,D.J.,
            Ferreira,T., He,C., Chasman,D.I., Esko,T., Thorleifsson,G.,
            Albrecht,E., Ang,W.Q., Corre,T., Cousminer,D.L., Feenstra,B.,
            Franceschini,N., Ganna,A., Johnson,A.D., Kjellqvist,S.,
            Lunetta,K.L., McMahon,G., Nolte,I.M., Paternoster,L., Porcu,E.,
            Smith,A.V., Stolk,L., Teumer,A., Tsernikova,N., Tikkanen,E.,
            Ulivi,S., Wagner,E.K., Amin,N., Bierut,L.J., Byrne,E.M.,
            Hottenga,J.J., Koller,D.L., Mangino,M., Pers,T.H.,
            Yerges-Armstrong,L.M., Zhao,J.H., Andrulis,I.L., Anton-Culver,H.,
            Atsma,F., Bandinelli,S., Beckmann,M.W., Benitez,J., Blomqvist,C.,
            Bojesen,S.E., Bolla,M.K., Bonanni,B., Brauch,H., Brenner,H.,
            Buring,J.E., Chang-Claude,J., Chanock,S., Chen,J.,
            Chenevix-Trench,G., Collee,J.M., Couch,F.J., Couper,D.,
            Coveillo,A.D., Cox,A., Czene,K., D'adamo,A.P., Smith,G.D., De
            Vivo,I., Demerath,E.W., Dennis,J., Devilee,P., Dieffenbach,A.K.,
            Dunning,A.M., Eiriksdottir,G., Eriksson,J.G., Fasching,P.A.,
            Ferrucci,L., Flesch-Janys,D., Flyger,H., Foroud,T., Franke,L.,
            Garcia,M.E., Garcia-Closas,M., Geller,F., de Geus,E.E., Giles,G.G.,
            Gudbjartsson,D.F., Gudnason,V., Guenel,P., Guo,S., Hall,P.,
            Hamann,U., Haring,R., Hartman,C.A., Heath,A.C., Hofman,A.,
            Hooning,M.J., Hopper,J.L., Hu,F.B., Hunter,D.J., Karasik,D.,
            Kiel,D.P., Knight,J.A., Kosma,V.M., Kutalik,Z., Lai,S.,
            Lambrechts,D., Lindblom,A., Magi,R., Magnusson,P.K., Mannermaa,A.,
            Martin,N.G., Masson,G., McArdle,P.F., McArdle,W.L., Melbye,M.,
            Michailidou,K., Mihailov,E., Milani,L., Milne,R.L., Nevanlinna,H.,
            Neven,P., Nohr,E.A., Oldehinkel,A.J., Oostra,B.A., Palotie,A.,
            Peacock,M., Pedersen,N.L., Peterlongo,P., Peto,J., Pharoah,P.D.,
            Postma,D.S., Pouta,A., Pylkas,K., Radice,P., Ring,S.,
            Rivadeneira,F., Robino,A., Rose,L.M., Rudolph,A., Salomaa,V.,
            Sanna,S., Schlessinger,D., Schmidt,M.K., Southey,M.C., Sovio,U.,
            Stampfer,M.J., Stockl,D., Storniolo,A.M., Timpson,N.J., Tyrer,J.,
            Visser,J.A., Vollenweider,P., Volzke,H., Waeber,G.,
            Waldenberger,M., Wallaschofski,H., Wang,Q., Willemsen,G.,
            Winqvist,R., Wolffenbuttel,B.H., Wright,M.J., Boomsma,D.I.,
            Econs,M.J., Khaw,K.T., Loos,R.J., McCarthy,M.I., Montgomery,G.W.,
            Rice,J.P., Streeten,E.A., Thorsteinsdottir,U., van Duijn,C.M.,
            Alizadeh,B.Z., Bergmann,S., Boerwinkle,E., Boyd,H.A., Crisponi,L.,
            Gasparini,P., Gieger,C., Harris,T.B., Ingelsson,E., Jarvelin,M.R.,
            Kraft,P., Lawlor,D., Metspalu,A., Pennell,C.E., Ridker,P.M.,
            Snieder,H., Sorensen,T.I., Spector,T.D., Strachan,D.P.,
            Uitterlinden,A.G., Wareham,N.J., Widen,E., Zygmunt,M., Murray,A.,
            Easton,D.F., Stefansson,K., Murabito,J.M. and Ong,K.K.
  CONSRTM   Australian Ovarian Cancer Study; GENICA Network; kConFab; LifeLines
            Cohort Study; InterAct Consortium; Early Growth Genetics (EGG)
            Consortium
  TITLE     Parent-of-origin-specific allelic associations among 106 genomic
            loci for age at menarche
  JOURNAL   Nature 514 (7520), 92-97 (2014)
   PUBMED   25231870
REFERENCE   5  (bases 1 to 3759)
  AUTHORS   Chen,X., Mihalic,J., Fan,P., Liang,L., Lindstrom,M., Wong,S.,
            Ye,Q., Fu,Y., Jaen,J., Chen,J.L., Dai,K. and Li,L.
  TITLE     Discovery and characterization of a potent and selective antagonist
            of melanin-concentrating hormone receptor 2
  JOURNAL   Bioorg Med Chem Lett 22 (1), 363-366 (2012)
   PUBMED   22123324
  REMARK    GeneRIF: Discovery and characterization of a potent and selective
            antagonist of melanin-concentrating hormone receptor 2
REFERENCE   6  (bases 1 to 3759)
  AUTHORS   Wang,S., Behan,J., O'Neill,K., Weig,B., Fried,S., Laz,T., Bayne,M.,
            Gustafson,E. and Hawes,B.E.
  TITLE     Identification and pharmacological characterization of a novel
            human melanin-concentrating hormone receptor, mch-r2
  JOURNAL   J Biol Chem 276 (37), 34664-34670 (2001)
   PUBMED   11459838
REFERENCE   7  (bases 1 to 3759)
  AUTHORS   An,S., Cutler,G., Zhao,J.J., Huang,S.G., Tian,H., Li,W., Liang,L.,
            Rich,M., Bakleh,A., Du,J., Chen,J.L. and Dai,K.
  TITLE     Identification and characterization of a melanin-concentrating
            hormone receptor
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7576-7581 (2001)
   PUBMED   11416225
REFERENCE   8  (bases 1 to 3759)
  AUTHORS   Sailer,A.W., Sano,H., Zeng,Z., McDonald,T.P., Pan,J., Pong,S.S.,
            Feighner,S.D., Tan,C.P., Fukami,T., Iwaasa,H., Hreniuk,D.L.,
            Morin,N.R., Sadowski,S.J., Ito,M., Ito,M., Bansal,A., Ky,B.,
            Figueroa,D.J., Jiang,Q., Austin,C.P., MacNeil,D.J., Ishihara,A.,
            Ihara,M., Kanatani,A., Van der Ploeg,L.H., Howard,A.D. and Liu,Q.
  TITLE     Identification and characterization of a second
            melanin-concentrating hormone receptor, MCH-2R
  JOURNAL   Proc Natl Acad Sci U S A 98 (13), 7564-7569 (2001)
   PUBMED   11404457
REFERENCE   9  (bases 1 to 3759)
  AUTHORS   Hill,J., Duckworth,M., Murdock,P., Rennie,G., Sabido-David,C.,
            Ames,R.S., Szekeres,P., Wilson,S., Bergsma,D.J., Gloger,I.S.,
            Levy,D.S., Chambers,J.K. and Muir,A.I.
  TITLE     Molecular cloning and functional characterization of MCH2, a novel
            human MCH receptor
  JOURNAL   J Biol Chem 276 (23), 20125-20129 (2001)
   PUBMED   11274220
REFERENCE   10 (bases 1 to 3759)
  AUTHORS   Mori,M., Harada,M., Terao,Y., Sugo,T., Watanabe,T., Shimomura,Y.,
            Abe,M., Shintani,Y., Onda,H., Nishimura,O. and Fujino,M.
  TITLE     Cloning of a novel G protein-coupled receptor, SLT, a subtype of
            the melanin-concentrating hormone receptor
  JOURNAL   Biochem Biophys Res Commun 283 (5), 1013-1018 (2001)
   PUBMED   11355873
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK123634.1 and AL590725.5.
            
            On Jul 12, 2019 this sequence version replaced NM_001040179.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123634.1, SRR1803611.134518.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000281806.7/ ENSP00000281806.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1394              AK123634.1         1-1394
            1395-3759           AL590725.5         91890-94254
FEATURES             Location/Qualifiers
     source          1..3759
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q16.2"
     gene            1..3759
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /note="melanin concentrating hormone receptor 2"
                     /db_xref="GeneID:84539"
                     /db_xref="HGNC:HGNC:20867"
                     /db_xref="MIM:606111"
     exon            1..288
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /inference="alignment:Splign:2.1.0"
     exon            289..497
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /inference="alignment:Splign:2.1.0"
     CDS             316..1338
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /note="melanin-concentrating hormone 2; G protein-coupled
                     receptor slt; MCH receptor 2; G-protein coupled receptor
                     145"
                     /codon_start=1
                     /product="melanin-concentrating hormone receptor 2"
                     /protein_id="NP_001035269.1"
                     /db_xref="CCDS:CCDS5044.1"
                     /db_xref="GeneID:84539"
                     /db_xref="HGNC:HGNC:20867"
                     /db_xref="MIM:606111"
                     /translation="MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGII
                     CSTGLVGNILIVFTIIRSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFG
                     GPLCTIITSLDTCNQFACSAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAA
                     SFILALPVWVYSKVIKFKDGVESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYI
                     LILCYTWEMYQQNKDARCCNPSVPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQ
                     MEQPTLAFYVGYYLSICLSYASSSINPFLYILLSGNFQKRLPQIQRRATEKEINNMGN
                     TLKSHF"
     exon            498..707
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /inference="alignment:Splign:2.1.0"
     exon            708..902
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /inference="alignment:Splign:2.1.0"
     exon            903..1022
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..3759
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3738..3743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /note="hexamer: AATAAA"
     polyA_site      3759
                     /gene="MCHR2"
                     /gene_synonym="GPR145; GPRv17; MCH-2R; MCH-R2; MCH2;
                     MCH2R; MCHR-2; SLT"
                     /note="major polyA site"
ORIGIN      
        1 agaaaagagc acgacgcacc cgatgctcgg attggatgaa gtggcaaagg taaccccgct
       61 ggttcgggcg tttggctgtt cctgtgcctg gacccccgct ttggaaatgg aggtggggct
      121 ggctcccaac ctgtctcaga gaccctcgca ctcctccccc accttccgtc agctgggacc
      181 cgctgagagc cgtttttggt cacgcgcgct tagcggatag acctgcagtc ccgcagagag
      241 gaagggcgcc cgggctgtcc gccgcgcggg gaggacgcga gcacccagct ttaatccctg
      301 gaaagtccac gaacaatgaa tccatttcat gcatcttgtt ggaacacctc tgccgaactt
      361 ttaaacaaat cctggaataa agagtttgct tatcaaactg ccagtgtggt agatacagtc
      421 atcctccctt ccatgattgg gattatctgt tcaacagggc tggttggcaa catcctcatt
      481 gtattcacta taataagatc caggaaaaaa acagtccctg acatctatat ctgcaacctg
      541 gctgtggctg atttggtcca catagttgga atgccttttc ttattcacca atgggcccga
      601 gggggagagt gggtgtttgg ggggcctctc tgcaccatca tcacatccct ggatacttgt
      661 aaccaatttg cctgtagtgc catcatgact gtaatgagtg tggacaggta ctttgccctc
      721 gtccaaccat ttcgactgac acgttggaga acaaggtaca agaccatccg gatcaatttg
      781 ggcctttggg cagcttcctt tatcctggca ttgcctgtct gggtctactc gaaggtcatc
      841 aaatttaaag acggtgttga gagttgtgct tttgatttga catcccctga cgatgtactc
      901 tggtatacac tttatttgac gataacaact ttttttttcc ctctaccctt gattttggtg
      961 tgctatattt taattttatg ctatacttgg gagatgtatc aacagaataa ggatgccaga
     1021 tgctgcaatc ccagtgtacc aaaacagaga gtgatgaagt tgacaaagat ggtgctggtg
     1081 ctggtggtag tctttatcct gagtgctgcc ccttatcatg tgatacaact ggtgaactta
     1141 cagatggaac agcccacact ggccttctat gtgggttatt acctctccat ctgtctcagc
     1201 tatgccagca gcagcattaa cccttttctc tacatcctgc tgagtggaaa tttccagaaa
     1261 cgtctgcctc aaatccaaag aagagcgact gagaaggaaa tcaacaatat gggaaacact
     1321 ctgaaatcac acttttagga aagtacatgg atcaccatga gtctagacat gattgtctat
     1381 cttactggta ttatcagaaa gggcaggtgt accgatatgt ttatgcccat tcttcttgtg
     1441 tacttgtgac tcttagcagc atggaagaga agtgtaacca tgcaaataca atgagcttaa
     1501 tatgctaact ttagcaagat gtaaaatgtt gatctatatt gtgggtaggg aatgggatag
     1561 tctgagatac ccaggcttca tgatggtgta tattatttca gcatattata aactagtcac
     1621 taatgaaaat ggccatccat gaccattgac tcaaaactca ccaaggaacc tgaccttgcc
     1681 ctccacactg tggcctcact gtaacagttt cctcaaggtt cctaggaggg tatcacctta
     1741 gagtgaagtc taaaatttgg ctatttttta tctataaaaa atgtcagttt tatatggtcc
     1801 aatactaata ccctcaacaa ctaagcccca ccttttagaa taagttacca tttattgcac
     1861 acatgcaatg tgtaagatta catgtaacaa acctgtgaaa taagtattat tacctttgtt
     1921 tgctaaggct cagaaaggag aaatgatagg cctaatgctg caacagctat ctaagagctg
     1981 agctaacatt cagctctgcc tgtttctttt ctactgcacg accttgacaa cctttactta
     2041 tcatactgga gaacccagta acttggagtt tcttttgctt tctcctgtag ccctacaaga
     2101 ggagaactaa agtctgatag aaatgagttg atgttttaag catcattttg gattatcttt
     2161 gttctcacac ctgctaactg tagaaactgg catctgcact ttaataataa tactttactt
     2221 ctggacttta agcataatta ggaaacattc ctggccgggt gcagtggctc atgcctgtaa
     2281 tcccagcact ttgggaggtg gaggcaggtg gatcacaaag tcagaagttc aagaccagtc
     2341 tggccaacat agtgagaccc tgtctactaa aaataaaaaa agattagccg agcatggtgg
     2401 tgtgtgcctg tagtcccagc tactcaggag gctgaggcag gagaattgct tgaacccagg
     2461 aggtggaggt tacagtgagc cgagatcacg ccactgcact ccagcttggg caatagagtg
     2521 agacgtcatc tcaaaaaaaa aaacaaaaca aacaaaaaaa aaaacaagaa acattccctt
     2581 ttggttacag tatacatgtt tgttctaagg tacaaaaagt aattagccct taaattttca
     2641 taggtattca ttatatctat ctttcctctt tagacttata tatagttagg aaaggaaaca
     2701 atgcatttaa tgcctgtgtt ctacactaag acaaatattg ttatttttgc ttgtggataa
     2761 agtctgtaaa cccaccttct tcatctaaat acattaaatt tgttttctcc gtaaacatct
     2821 gaaaccaatt ttcaaccagc cccttctaga aaaagagtta accattttta tatctgatct
     2881 ccatttttat atttcaattg tgtttggata aacttgtatt tgaatcaacc cagacgtgat
     2941 ttttaaccct atttatttta ctctagaatt tttaggcacc atttcagaac tggatagtat
     3001 ctaaatgcat atctggatga atggttctgt aaaccacatg agaactacac actgagacag
     3061 gtagcatctg aaacatttta tttccatagc tgaggtctag agacctacat atgcagctgg
     3121 atgctcctat aaaacgtcaa taagaagctg tgtcatggcc acagtttcag gggtcttcat
     3181 tctcactttt ctaagatgca acagtccggg ctcagtgaat aatattgact tctgaagacc
     3241 cagcacaatg ggtcagaaac atcttattat gtgataattg aagagcaatt gcttactttc
     3301 attgtttttt taatacagaa aaatattatg attttaaaga cttagcttta aaccacagac
     3361 ctttttctag tagcagtccc aatagtcctc aaataattgg ccagtgaatt attttaaatt
     3421 atatttacta agagttgtaa ggagctttat ttagcattta atcaaagtag aaaataaaaa
     3481 gggtgattaa taaatttatt tttgtccctt tatatagcgt ttctatgcat aagcatattt
     3541 atatgcagat ttacagaggt gatttgatag agattctttg tgtgttttct atgtttggcc
     3601 atgatatgta tacatgttta ctttcaaatg aagttaataa tgatacttgg gtatttgtca
     3661 ctcagtcaaa taataatcgt atccttattc tattcttatt caattctagg tgcctcattt
     3721 aaactttgat ctcaattaat aaaaatgaat gagtaaaaa
//
