LOCUS       NM_005297               2115 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens melanin concentrating hormone receptor 1 (MCHR1),
            mRNA.
ACCESSION   NM_005297
VERSION     NM_005297.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2115)
  AUTHORS   Takamura,N., Renaud,L., da Silveira,W.A. and Feghali-Bostwick,C.
  TITLE     PDGF Promotes Dermal Fibroblast Activation via a Novel Mechanism
            Mediated by Signaling Through MCHR1
  JOURNAL   Front Immunol 12, 745308 (2021)
   PUBMED   34912333
  REMARK    GeneRIF: PDGF Promotes Dermal Fibroblast Activation via a Novel
            Mechanism Mediated by Signaling Through MCHR1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2115)
  AUTHORS   Vawter,M.P., Schulmann,A., Alhassen,L., Alhassen,W., Hamzeh,A.R.,
            Sakr,J., Pauluk,L., Yoshimura,R., Wang,X., Dai,Q., Sanathara,N.,
            Civelli,O. and Alachkar,A.
  TITLE     Melanin Concentrating Hormone Signaling Deficits in Schizophrenia:
            Association With Memory and Social Impairments and Abnormal
            Sensorimotor Gating
  JOURNAL   Int J Neuropsychopharmacol 23 (1), 53-65 (2020)
   PUBMED   31563948
  REMARK    GeneRIF: Melanin Concentrating Hormone Signaling Deficits in
            Schizophrenia: Association With Memory and Social Impairments and
            Abnormal Sensorimotor Gating.
REFERENCE   3  (bases 1 to 2115)
  AUTHORS   Badgandi,H.B., Hwang,S.H., Shimada,I.S., Loriot,E. and
            Mukhopadhyay,S.
  TITLE     Tubby family proteins are adapters for ciliary trafficking of
            integral membrane proteins
  JOURNAL   J Cell Biol 216 (3), 743-760 (2017)
   PUBMED   28154160
REFERENCE   4  (bases 1 to 2115)
  AUTHORS   Fontaine-Bisson,B., Thorburn,J., Gregory,A., Zhang,H. and Sun,G.
  TITLE     Melanin-concentrating hormone receptor 1 polymorphisms are
            associated with components of energy balance in the Complex
            Diseases in the Newfoundland Population: Environment and Genetics
            (CODING) study
  JOURNAL   Am J Clin Nutr 99 (2), 384-391 (2014)
   PUBMED   24305679
  REMARK    GeneRIF: Polymorphisms in the MCHR1 gene are associated with
            differences in body composition and interact with physiologic and
            energy-related lifestyle factors.
REFERENCE   5  (bases 1 to 2115)
  AUTHORS   Qu,C., Sun,X., Shi,Y., Gong,A., Liang,S., Zhao,M., Chen,Y. and
            Liang,F.
  TITLE     Microarray-based mutation detection of pediatric sporadic
            nonsyndromic hearing loss in China
  JOURNAL   Int J Pediatr Otorhinolaryngol 76 (2), 235-239 (2012)
   PUBMED   22154049
  REMARK    GeneRIF: SLC-1 protein human mutation demonstrated important
            genetic susceptibility of sporadic nonsyndromic hearing loss in
            China.
REFERENCE   6  (bases 1 to 2115)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
REFERENCE   7  (bases 1 to 2115)
  AUTHORS   Shimomura,Y., Mori,M., Sugo,T., Ishibashi,Y., Abe,M., Kurokawa,T.,
            Onda,H., Nishimura,O., Sumino,Y. and Fujino,M.
  TITLE     Isolation and identification of melanin-concentrating hormone as
            the endogenous ligand of the SLC-1 receptor
  JOURNAL   Biochem Biophys Res Commun 261 (3), 622-626 (1999)
   PUBMED   10441476
REFERENCE   8  (bases 1 to 2115)
  AUTHORS   Saito,Y., Nothacker,H.P., Wang,Z., Lin,S.H., Leslie,F. and
            Civelli,O.
  TITLE     Molecular characterization of the melanin-concentrating-hormone
            receptor
  JOURNAL   Nature 400 (6741), 265-269 (1999)
   PUBMED   10421368
REFERENCE   9  (bases 1 to 2115)
  AUTHORS   Chambers,J., Ames,R.S., Bergsma,D., Muir,A., Fitzgerald,L.R.,
            Hervieu,G., Dytko,G.M., Foley,J.J., Martin,J., Liu,W.S., Park,J.,
            Ellis,C., Ganguly,S., Konchar,S., Cluderay,J., Leslie,R., Wilson,S.
            and Sarau,H.M.
  TITLE     Melanin-concentrating hormone is the cognate ligand for the orphan
            G-protein-coupled receptor SLC-1
  JOURNAL   Nature 400 (6741), 261-265 (1999)
   PUBMED   10421367
REFERENCE   10 (bases 1 to 2115)
  AUTHORS   Kolakowski,L.F. Jr., Jung,B.P., Nguyen,T., Johnson,M.P.,
            Lynch,K.R., Cheng,R., Heng,H.H., George,S.R. and O'Dowd,B.F.
  TITLE     Characterization of a human gene related to genes encoding
            somatostatin receptors
  JOURNAL   FEBS Lett 398 (2-3), 253-258 (1996)
   PUBMED   8977118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from Z86090.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 26, 2020 this sequence version replaced NM_005297.3.
            
            Summary: The protein encoded by this gene, a member of the G
            protein-coupled receptor family 1, is an integral plasma membrane
            protein which binds melanin-concentrating hormone. The encoded
            protein can inhibit cAMP accumulation and stimulate intracellular
            calcium flux, and is probably involved in the neuronal regulation
            of food consumption. Although structurally similar to somatostatin
            receptors, this protein does not seem to bind somatostatin.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF490537.2, BC021146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000249016.5/ ENSP00000249016.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               Z86090.10          100158-100408
            252-2115            Z86090.10          101623-103486
FEATURES             Location/Qualifiers
     source          1..2115
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2115
                     /gene="MCHR1"
                     /gene_synonym="GPR24; MCH-1R; MCH1R; SLC-1; SLC1"
                     /note="melanin concentrating hormone receptor 1"
                     /db_xref="GeneID:2847"
                     /db_xref="HGNC:HGNC:4479"
                     /db_xref="MIM:601751"
     exon            1..251
                     /gene="MCHR1"
                     /gene_synonym="GPR24; MCH-1R; MCH1R; SLC-1; SLC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1231
                     /gene="MCHR1"
                     /gene_synonym="GPR24; MCH-1R; MCH1R; SLC-1; SLC1"
                     /note="G protein-coupled receptor 24; MCH receptor 1;
                     somatostatin receptor-like protein"
                     /codon_start=1
                     /product="melanin-concentrating hormone receptor 1"
                     /protein_id="NP_005288.4"
                     /db_xref="CCDS:CCDS14004.2"
                     /db_xref="GeneID:2847"
                     /db_xref="HGNC:HGNC:4479"
                     /db_xref="MIM:601751"
                     /translation="MDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMP
                     SVFGTICLLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQ
                     LMGNGVWHFGETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVA
                     TLVICLLWALSFISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFA
                     LPFVVITAAYVRILQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQ
                     LTQLSISRPTLTFVYLYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQL
                     RAVSNAQTADEERTESKGT"
     exon            252..2115
                     /gene="MCHR1"
                     /gene_synonym="GPR24; MCH-1R; MCH1R; SLC-1; SLC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2084..2089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCHR1"
                     /gene_synonym="GPR24; MCH-1R; MCH1R; SLC-1; SLC1"
                     /note="hexamer: AATAAA"
     polyA_site      2115
                     /gene="MCHR1"
                     /gene_synonym="GPR24; MCH-1R; MCH1R; SLC-1; SLC1"
                     /note="major polyA site"
ORIGIN      
        1 agttgggctt ggaggcggca gcggctgcca ggctacggag gaagaccccc ttcccaactg
       61 cggggcttgc gctccgggac aaggtggcag gcgctggagg ctgccgcagc ctgcgtgggt
      121 ggaggggagc tcagctcggt tgtgggagca ggcgaccggc actggctgga tggacctgga
      181 agcctcgctg ctgcccactg gtcccaacgc cagcaacacc tctgatggcc ccgataacct
      241 cacttcggca ggatcacctc ctcgcacggg gagcatctcc tacatcaaca tcatcatgcc
      301 ttcggtgttc ggcaccatct gcctcctggg catcatcggg aactccacgg tcatcttcgc
      361 ggtcgtgaag aagtccaagc tgcactggtg caacaacgtc cccgacatct tcatcatcaa
      421 cctctcggta gtagatctcc tctttctcct gggcatgccc ttcatgatcc accagctcat
      481 gggcaatggg gtgtggcact ttggggagac catgtgcacc ctcatcacgg ccatggatgc
      541 caatagtcag ttcaccagca cctacatcct gaccgccatg gccattgacc gctacctggc
      601 cactgtccac cccatctctt ccacgaagtt ccggaagccc tctgtggcca ccctggtgat
      661 ctgcctcctg tgggccctct ccttcatcag catcacccct gtgtggctgt atgccagact
      721 catccccttc ccaggaggtg cagtgggctg cggcatacgc ctgcccaacc cagacactga
      781 cctctactgg ttcaccctgt accagttttt cctggccttt gccctgcctt ttgtggtcat
      841 cacagccgca tacgtgagga tcctgcagcg catgacgtcc tcagtggccc ccgcctccca
      901 gcgcagcatc cggctgcgga caaagagggt gacccgcaca gccatcgcca tctgtctggt
      961 cttctttgtg tgctgggcac cctactatgt gctacagctg acccagttgt ccatcagccg
     1021 cccgaccctc acctttgtct acttatacaa tgcggccatc agcttgggct atgccaacag
     1081 ctgcctcaac ccctttgtgt acatcgtgct ctgtgagacg ttccgcaaac gcttggtcct
     1141 gtcggtgaag cctgcagccc aggggcagct tcgcgctgtc agcaacgctc agacggctga
     1201 cgaggagagg acagaaagca aaggcacctg atacttcccc tgccaccctg cacacctcca
     1261 agtcagggca ccacaacacg ccaccgggag agatgctgag aaaaacccaa gaccgctcgg
     1321 gaaatgcagg aaggccgggt tgtgaggggt tgttgcaatg aaataaatac attccatggg
     1381 gctcacacgt tgctggggag gcctggagtc aggtttgggg ttttcagata tcagaaatcc
     1441 ccttggggga gcaggatgag acctttggat agaacagaag ctgagcaaga gaacatgttg
     1501 gtttggataa ccggttgcac tatatctgtg agctctcaaa tgtcttcttc ccaaggcaag
     1561 aggtggaagg gtactgactg ggtttgttta aagtcaggca gggctggagt gagcagccag
     1621 ggccatgttg cacaaggcct gagagacggg aaagggcccg atcgctcttt cccgcctctc
     1681 actggtgcga tggaaggtgg cctttctccc aagctggtgg ataatgaaaa ataaagcatc
     1741 ccatctctcg gcgttccagc atcctgtcaa tttccctttt gctctagagg atgcatgttt
     1801 atttgagggg atgtggcact gagcccacag gagtaaaagc ccagtttgct aggaggtctg
     1861 cttactgaaa acaaggagac ctggggtggg tgtggttggg ggtcttaaaa ctaataaaag
     1921 ctggggtcgg ggggcttttg cagctctggt gacattctct ccacggggca catttgctca
     1981 gtcactaatc cagcttgagt gtccgtgtgt tctgcatgtg caggggtcat tctagtgccc
     2041 ggtgtgttgg catcatcttt ttgctctagc ccttcctctc caaaataaaa tcaaataaag
     2101 gaaaatctcc accca
//
