LOCUS       XM_017005943            4852 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens MCF.2 cell line derived transforming
            sequence-like 2 (MCF2L2), transcript variant X1, mRNA.
ACCESSION   XM_017005943
VERSION     XM_017005943.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000003.12) annotated using gene prediction method: Gnomon,
            supported by EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017005943.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4852
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
     gene            1..4852
                     /gene="MCF2L2"
                     /gene_synonym="ARHGEF22"
                     /note="MCF.2 cell line derived transforming sequence-like
                     2; Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 8 ESTs, 68 long SRA reads, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 3 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:23101"
                     /db_xref="HGNC:HGNC:30319"
                     /db_xref="MIM:619946"
     CDS             643..3591
                     /gene="MCF2L2"
                     /gene_synonym="ARHGEF22"
                     /codon_start=1
                     /product="probable guanine nucleotide exchange factor
                     MCF2L2 isoform X1"
                     /protein_id="XP_016861432.2"
                     /db_xref="GeneID:23101"
                     /db_xref="HGNC:HGNC:30319"
                     /db_xref="MIM:619946"
                     /translation="MLSCLKEEMPPQELTRRLATVITHVDEIMQQEVRPLMAVEIIEQ
                     LHRQFAILSGGRGEDGAPIITFPEFSGFKHIPDEDFLNVMTYLTSIPSVEAASIGFIV
                     VIDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTK
                     VPIIMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQWVNHRTAIENFALTLKTTAQMLQ
                     TFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQEPATKCP
                     NSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKL
                     ALDNLLEEQAEFTGIGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALVGDQLIQSHH
                     YAADAIRPRCVELRHLCDDFINGNKKKWDILGKSLEFHRQLDKVSQWCEAGIYLLASQ
                     AVDKCQSREGVDIALNDIATFLGTVKEYPLLSPKEFYNEFELLLTLDAKAKAQKVLQR
                     LDDVQEIFHKRQVSLMKLAAKQTRPVQPVAPHPESSPKWVSSKTSQPSTSVPLARPLR
                     TSEEPYTETELNSRGKEDDETKFEVKSEEIFESHHERGNPELEQQARLGDLSPRRRII
                     RDLLETEEIYIKEIKSIIDGYITPMDFIWLKHLIPDVLQNNKDFLFGNIRELYEFHNR
                     TFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNLPRARAIWQECQDCAYFGVCQR
                     QLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGELGGSAKDGPKRTKD
                     SAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLLLHGPFSVWTIHKDR
                     YKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMTLSIRQLG
                     RGSHRKFEIASRNGLEKYILQAASKEIRDCWFSEISKLLMEQQNNIKGIFGGKIHSEL
                     YQLSSDLPLR"
ORIGIN      
        1 agtcactgtc tccccgcccc acggttccga gtaaggaccg gagctccact ccgggggtgg
       61 agcgcgggct ccccgcaggg aaaggtgcgc agcgttcccg accccaaaac gagcggcgct
      121 tgggagcgtg cgtgcctccc cgagagcccc gggcgccacc cgtgggctgg acgaggtggg
      181 cgctggggcg tggggccggc ggcgcagaga agccacggcc acctgccgcc tcccctgcac
      241 ctggcggagc atccctcact ctacagtccc tggaggcggc gccggaaacc tggcggccgg
      301 gaccgcgatt ctggaagccc cggagctcgc ccggccggag gagccggggc gcggttccgg
      361 cgagattggc gacttgcttc cttttgcaga acggccgctc ctctctcggt ccagctgcga
      421 cgctgggaaa gcgccagact tggtctgtca cgggagcccc cgcggggcgt ggcgagggag
      481 agctggccta ggctgcgagg gactctcgtt tcttgcctgg agagccagga agagggcgag
      541 ggcagagcat ccttgggcgg agatgccttt aaaaaatcat ccaccgcagc ggtagaaaca
      601 gttttgtttg gctttattta tacggaatgg tttttcagtg aaatgctgtc ttgcttaaaa
      661 gaagagatgc ctccccagga gctcacccgg cgactggcca cagtgatcac tcatgtcgat
      721 gaaattatgc agcaggaagt cagacccctg atggcggtgg agataataga acaacttcac
      781 agacaatttg ccattctttc aggaggccga ggggaggatg gcgcccccat catcacgttc
      841 ccagagtttt cggggttcaa acacatccca gatgaagact tcctgaatgt catgacctac
      901 ctgactagca tccccagtgt ggaggctgcc agcattggat tcattgttgt tatcgacaga
      961 cgaagagaca agtggagctc cgtaaaggca tccttgacac gaatagctgt ggcatttcca
     1021 ggaaacttac agctcatatt catccttcgt ccatctcgct ttatccagag gacattcact
     1081 gacattggca ttaaatacta tcgaaatgag tttaaaacga aagtgccgat catcatggta
     1141 aactctgtct ctgaccttca cggctacatc gacaaaagcc aactgacccg ggaattaggg
     1201 gggactttgg aatatcgcca cggtcagtgg gtaaatcacc gcactgccat cgaaaacttt
     1261 gccttgacct tgaagaccac tgcccagatg ctgcagacgt ttgggtcctg cctggccaca
     1321 gcagagctgc ccagaagcat gctatccacg gaagaccttc tcatgtccca cacaaggcag
     1381 cgggacaagc tgcaggatga gctgaaatta cttggaaagc aggggaccac attgctgtca
     1441 tgcatccaag aaccagcaac caaatgtccc aacagcaaac tcaatctcaa ccaacttgag
     1501 aatgtaacta ccatggaaag gttattagtt caactggatg aaacagaaaa agcctttagt
     1561 cacttttggt ctgagcatca tctgaagctt aaccagtgcc tacaactaca gcattttgag
     1621 cacgattttt gtaaggctaa gcttgccctg gataatttgc tggaagagca agcagagttt
     1681 acaggcattg gagacagcgt gatgcacgtg gagcagattc ttaaggaaca caaaaaactg
     1741 gaggaaaaaa gccaggagcc cctggaaaag gcccagctgc tggcactggt tggggaccag
     1801 ctcatccaaa gccaccatta tgcagcagat gccatcaggc cccggtgtgt ggagctcagg
     1861 cacctctgtg acgatttcat caatggaaac aagaaaaaat gggacatttt aggaaagtcc
     1921 ttagagtttc atagacagct ggacaaggtc agccaatggt gtgaggcagg aatctacctc
     1981 ttggcttccc aagctgtaga caagtgccag tctcgagaag gggttgatat cgccttgaac
     2041 gacattgcga cattcctggg cacagtcaag gagtacccgt tgctcagccc caaggagttt
     2101 tacaacgagt ttgagttgct gctcaccctc gatgcaaagg ccaaagccca gaaagttttg
     2161 cagaggctgg atgatgtcca ggaaatattt cacaagaggc aagtgagtct gatgaaactg
     2221 gcagccaaac agactcgtcc agtgcaacct gtggccccac atcctgagtc ttcaccaaaa
     2281 tgggtgtcat caaaaaccag ccagccctcc acctcggtcc ctctagctcg tcctctgaga
     2341 acgtctgagg aaccttatac ggagacagag ttgaactccc ggggaaagga agatgatgag
     2401 actaaatttg aagtcaagag tgaagaaatc tttgaaagcc atcatgaaag ggggaaccct
     2461 gagctggagc agcaggccag gctcggagac ctttcccccc gcaggcgcat tatacgtgac
     2521 ttgcttgaga ctgaagagat ttacataaaa gagattaaaa gcataattga tggatatatc
     2581 actccaatgg attttatttg gctaaagcat ctaattccag atgttcttca gaataacaag
     2641 gactttctct ttgggaatat tagagaactt tacgaatttc acaacaggac ttttctaaaa
     2701 gagttggaaa agtgtgctga gaaccctgaa cttctggcac attgctttct caagagaaaa
     2761 gaagatcttc agatatattt taaataccat aagaatctgc cccgagctag ggcaatctgg
     2821 caagagtgtc aagactgcgc ctactttggg gtatgccagc gccaactgga tcacaatctc
     2881 cctcttttta agtatctcaa aggaccaagc cagagactta taaaatacca gatgctgttg
     2941 aagggtctgc tggatttcga gtctcctgaa gatatggaga tagacccagg tgaactagga
     3001 ggctcggcta aggatgggcc aaagagaacc aaagattcag cattctcaac tgaactacaa
     3061 caagctttgg cagtgataga ggatttgatc aagtcctgtg agttggctgt ggacctagca
     3121 gcagtgactg aatgtccgga cgatattgga aaactaggca agctgttgct gcacggccct
     3181 ttcagcgtct ggacaattca caaggatcgt tataaaatga aggatttgat tcgatttaaa
     3241 cccagccaga ggcaaatcta cctatttgaa aggggaatag tgttctgtaa gatacgaatg
     3301 gagcctgggg accagggatt atctcctcat tacagcttca agaagaccat gaagctgatg
     3361 acactttcaa ttcgccagct tggaaggggg agccatagaa agtttgagat tgccagtcga
     3421 aatggacttg agaaatacat cctgcaggca gcttcaaaag aaatcagaga ctgttggttt
     3481 tcagaaataa gtaaattatt gatggaacaa caaaataata tcaaagggat atttggtggg
     3541 aaaatccaca gcgagcttta tcaattgagt tctgaccttc ccctcaggta atgttactag
     3601 ggtgaagaaa tgccagtttc atgtggaaag tctatcttcc atcatttata ctggcagtgg
     3661 tttgcatttt gggtaagaaa aatcacataa aaatgaaaag ataacttttt tctttagaga
     3721 tagcaggaat gcaactggct cacacttttt ctaggtcttc tatgatcatc agctgctcag
     3781 gaacgtgcaa agctgggtgt gcatcataag ataagggaaa aggtaaacca agcagtgtaa
     3841 ctggaaagcc accacatcag ttttctgtca caaaaaccaa gcaacataag ttcttgattt
     3901 aaactgtagg taactgccag gaactagtaa caatattatg tcattgattt tactttgtat
     3961 acagataaga tgggaaaaaa actatggttt acttttgttt tacaactatt aatattatgt
     4021 taaatatatg tcatggtaat tgagtaggag tgtcctagag gcttaacaca gaatgatatg
     4081 gcaactctag tagaaaaagt cacttgttcc ctgcagaaac aacattctag tcacaagctt
     4141 gtttagaaat ccttactcac taggtcagtg tttctcaaag ggtggtttaa ggaccacctg
     4201 cattcaaatt atttgaaggg cttgctacaa atgcagattt ctaggttcca ccccagaact
     4261 atagaatagc tagggttagt cctggggaca tacattttag cttattaagg tttctaggta
     4321 gagacctttt actacaattt ttaaaactcc tttactgagg tataatgaca cgataaacca
     4381 cacatattta aagtgtacaa tctgataagt tttgacatct gtatacatct gtaaggcatc
     4441 accacagtaa ggataatgaa catgcctatc accgccaaag gtttgttcac actgctttgc
     4501 attccctttc tcctgcccct ccctcaccca ccccaggtga ccaccaatct cctttctgtc
     4561 actataggtt agtttgcatt ttctagaatt tcataagaga taatacacta tgtacttttt
     4621 tttttggtct ggcttctctc ctctgcataa ttattctgag attcatctat ttggattttg
     4681 taaacaatag tacatatttt ggttgttgct gagtagtatt tcattgtttg gctagacccc
     4741 gttttcttta tccatttact tgttaatgaa catccgattt gtttctgctt tggggctatt
     4801 ttgaataatg ctgctatgaa catgcaagta caagtctttg tgtggacatg tg
//
