LOCUS       XM_017020494            7343 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens MCF.2 cell line derived transforming
            sequence like (MCF2L), transcript variant X5, mRNA.
ACCESSION   XM_017020494
VERSION     XM_017020494.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000013.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017020494.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7343
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
     gene            1..7343
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /note="MCF.2 cell line derived transforming sequence like;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 2 mRNAs, 58 ESTs, 561 long SRA reads, 2
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 1 sample with
                     support for all annotated introns"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
     CDS             897..4460
                     /gene="MCF2L"
                     /gene_synonym="ARHGEF14; DBS; OST"
                     /codon_start=1
                     /product="guanine nucleotide exchange factor DBS isoform
                     X4"
                     /protein_id="XP_016875983.1"
                     /db_xref="GeneID:23263"
                     /db_xref="HGNC:HGNC:14576"
                     /db_xref="MIM:609499"
                     /translation="MGDGKAVRISVAEMKSYYLYSEWCSWLLSVAEDEIMHQDIVPLC
                     AADIQDQLKKRFAYLSGGRGQDGSPVITFPDYPAFSEIPDKEFQNVMTYLTSIPSLQD
                     AGIGFILVIDRRRDKWTSVKASVLRIAASFPANLQLVLVLRPTGFFQRTLSDIAFKFN
                     RDDFKMKVPVIMLSSVPDLHGYIDKSQLTEDLGGTLDYCHSRWLCQRTAIESFALMVK
                     QTAQMLQSFGTELAETELPNDVQSTSSVLCAHTEKKDKAKEDLRLALKEGHSVLESLR
                     ELQAEGSEPSVNQDQLDNQATVQRLLAQLNETEAAFDEFWAKHQQKLEQCLQLRHFEQ
                     GFREVKAILDAASQKIATFTDIGNSLAHVEHLLRDLASFEEKSGVAVERARALSLDGE
                     QLIGNKHYAVDSIRPKCQELRHLCDQFSAEIARRRGLLSKSLELHRRLETSMKWCDEG
                     IYLLASQPVDKCQSQDGAEAALQEIEKFLETGAENKIQELNAIYKEYESILNQDLMEH
                     VRKVFQKQASMEEVFHRRQASLKKLAARQTRPVQPVAPRPEALAKSPCPSPGIRRGSE
                     NSSSEGGALRRGPYRRAKSEMSESRQGRGSAGEEEESLAILRRHVMSELLDTERAYVE
                     ELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHFHNRIFLRELENYTDC
                     PELVGRCFLERMEDFQIYEKYCQNKPRSESLWRQCSDCPFFQECQRKLDHKLSLDSYL
                     LKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSSILGILKAVNDSMHLIAITGYDG
                     NLGDLGKLLMQGSFSVWTDHKRGHTKVKELARFKPMQRHLFLHEKAVLFCKKREENGE
                     GYEKAPSYSYKQSLNMAAVGITENVKGDAKKFEIWYNAREEVYIVQAPTPEIKAAWVN
                     EIRKVLTSQLQACREASQHRALEQSQSLPLPAPTSTSPSRGNSRNIKKLEERKTDPLS
                     LEGYVSSAPLTKPPEKGKDDTVTSSASESSALSRKRFTLQGFANLKGQKASPTSPDKK
                     AKRHEVKSDPTPFGVRGWSKTSHSLEAPEDDGGWSSAEEQINSSDAEEDGGLGPKKLV
                     PGKYTVVADHEKGGPDALRVRSGDVVELVQEGDEGLWYVRDPTTGKEGWVPASSLSVR
                     LGPSGSAQCLSSSESSPGSAVLSNSSSCSEGGQAPFSDLQG"
ORIGIN      
        1 ctcagcctcc caaagtgctg ggattacagg catgagccat tgcgcccggc ctagaaattc
       61 tcttcataaa acgtgtttga gattggcaca ggaagtttca aacagaatca ggattcacca
      121 taagaagcag ataaatacat ttgaggcacc cagggtgagt gatctcagcg gaattcccct
      181 ttaagcttcc tagtagcgcg tgcaaaaagg aaaacgtgtg gatctaagac tgtgcacaaa
      241 caaaagctgt tcttctggga ggaaccaatc cctcagcaat cacacttgac tccctcgaag
      301 gaaagctgga aggggagagg gcgtcaggat gcaggtcccg gtgtctctgt gcagctcatc
      361 ctccttcaga ggccgctctg cttctgtcca tccctccaat tgccagtggt gtcagcattt
      421 ggggccgtga tcagatggag gaagactggc aagcagtcac ccccgacagg actctctggc
      481 tcagcctccc caggaatatg ctgctcccca ggcacagcgg aagacctgct gcgtttcatc
      541 ttccggctgc ctgtttaaag caagggaggc catgccccca gcggggtccc ttgtgcctgg
      601 acccaaggca agaatagctc aggcttgttc ctttttcctc aagttcctct cgggcgggca
      661 cggtgtgtcg cctggacctg catgtaaaca tcagggcgga gcaggaatcg gcctccagga
      721 gggtaattgc ctggcgtact ctgtcccagg tagtgggtga aatgaaagta aaaagccagc
      781 tggtccctca tgcagatttt aggggacaaa gttcagcata gaaaggtcct gttacaagga
      841 gagggttgtg gcgagcccag ggcagcgcgc gtcctccccg gcagctgatc ctcgccatgg
      901 gggacggaaa ggctgtccgg atttccgtgg cggaaatgaa aagctactac ctgtattctg
      961 agtggtgctc ctggctgctg tccgtggctg aggatgaaat catgcaccag gacatcgtcc
     1021 cgctctgtgc tgccgacatc caggaccagc taaagaagcg ctttgcttac ctgtccggtg
     1081 ggcgggggca ggacggaagc ccggttatca ccttccctga ctacccggcc ttcagcgaga
     1141 ttccggacaa ggagttccag aatgtcatga cctacctcac cagcatcccc agcctgcagg
     1201 acgctggcat cggattcatc ctggtgatag accggcgacg ggacaaatgg acctccgtga
     1261 aggcgtccgt cctgcgcatc gcagcatctt tcccggcaaa cctgcagctc gtcctcgtgc
     1321 ttcgcccgac gggttttttc caaaggactc tctccgacat cgctttcaaa ttcaatagag
     1381 atgactttaa gatgaaggtg ccggtcataa tgctgagctc cgtaccagac ttacacggtt
     1441 acatcgataa gtcgcagctg accgaggacc tgggtgggac cctggactac tgccactccc
     1501 ggtggctgtg ccagcgcacg gccatcgaaa gtttcgccct catggtgaag cagacggctc
     1561 agatgctgca gtccttcggg accgagctgg ctgaaacaga gctgcccaat gacgtccagt
     1621 cgacaagctc agtgctgtgt gcgcacacag agaagaagga caaggcgaag gaggatttga
     1681 ggctggcact gaaagagggg cacagtgtcc tggagagcct cagggagctg caggctgagg
     1741 gctcagagcc cagtgtgaac caggaccagc ttgacaacca ggccaccgtg cagaggctcc
     1801 tggcccagct gaacgaaacc gaggctgcct tcgatgagtt ctgggcaaag catcagcaga
     1861 aactggagca gtgtctgcag ctccggcact ttgagcaggg cttccgggag gtcaaagcca
     1921 tcttggacgc agcgtcccag aagatagcaa ccttcacaga catcggcaac agcctggcgc
     1981 atgtggagca cctgctgagg gacctggcca gcttcgagga gaaatcaggc gtggccgtgg
     2041 agagggcccg ggccctgtct ctggacggcg agcagctcat tgggaacaag cactacgcgg
     2101 tagactccat ccgcccaaag tgccaggagc tccggcacct ctgtgaccag ttctctgcgg
     2161 agatcgcaag gaggaggggg ctgctcagca agtccctgga gctgcaccgc cgcctggaga
     2221 cgtccatgaa gtggtgtgat gaagggattt acctgctggc ctcacaacct gtggacaagt
     2281 gccagtccca ggacggcgcg gaggctgccc tccaggaaat cgagaagttt ttggagaccg
     2341 gtgcggaaaa taagatccag gagctcaacg cgatttacaa ggaatacgaa tccatcctca
     2401 accaagatct catggagcac gtgcgaaagg tcttccagaa gcaggcaagc atggaggagg
     2461 tgttccaccg caggcaggcc agcctgaaga agctggcggc caggcagacg cggcccgtgc
     2521 agccggtggc ccccagaccc gaggcactgg caaagtcgcc ctgcccctcc ccaggcattc
     2581 ggcgaggctc tgagaactcc agctccgagg gcggtgcgct ccggagaggg ccctaccgga
     2641 gggccaagag tgagatgagt gagagccggc agggccgcgg ctcagcgggg gaggaggagg
     2701 aaagcctggc catcctgcgc aggcacgtga tgagcgagct cctggacaca gaacgggcct
     2761 acgtggagga gctgctgtgc gtcctggagg gctacgccgc ggagatggat aacccactga
     2821 tggctcacct cctgtcaaca ggccttcaca acaagaagga tgttttgttt ggaaacatgg
     2881 aggaaatcta tcacttccac aacaggatat tcctcaggga gctggaaaac tacactgact
     2941 gcccagaact ggttggaaga tgctttctgg agaggatgga agatttccag atctatgaga
     3001 agtactgtca gaacaagccc cgctctgaga gcctgtggag acagtgctcc gactgcccgt
     3061 ttttccagga atgccagaga aagctggacc acaagctgag cctggactcc tacctgctga
     3121 agccagtgca gaggatcacc aagtaccagc tgctgctcaa ggaaatgctg aaatacagca
     3181 ggaactgcga gggggctgag gacctgcagg aggcgctgag ctccatcctg ggcatcctga
     3241 aggccgtgaa cgactccatg cacctcatcg ctatcaccgg ctatgacggg aatctcggcg
     3301 acctgggcaa gctgctgatg cagggctcgt tcagcgtctg gaccgaccac aagaggggcc
     3361 acaccaaggt gaaggagctg gccaggttca agcccatgca gcggcacctg ttcctgcacg
     3421 agaaggcagt gctcttctgc aagaagaggg aggagaatgg ggaggggtat gagaaagctc
     3481 cctcctacag ctacaagcag tccttaaaca tggctgccgt tggcattacg gagaacgtga
     3541 agggagatgc taagaagttc gagatctggt acaacgcgcg cgaggaggtc tacatcgtcc
     3601 aggcgccaac tcctgagatt aaagccgcgt gggtgaatga aattcggaaa gtgctgacca
     3661 gccagctgca ggcttgtaga gaagccagcc agcaccgggc gctggagcag tcacagagcc
     3721 tgcccctgcc ggccccgacc agcaccagtc cctcaagagg aaactcaagg aacatcaaga
     3781 agctggaaga aaggaaaaca gaccccctaa gcctggaggg atacgtcagc tcagcgccac
     3841 tgacaaagcc ccccgaaaag ggcaaagatg acacggtcac tagctctgcc tcagaaagct
     3901 ctgcgctttc cagaaagcgc tttaccctgc agggttttgc taacctcaaa ggtcagaaag
     3961 cttctcctac cagtcctgac aaaaaagcca agcggcatga agtaaagagc gacccgactc
     4021 cctttggtgt gcgaggttgg agcaaaacgt cccactcact ggaggcacct gaggacgacg
     4081 ggggctggtc aagtgcagag gagcagatta actcgtccga cgcagaggag gacggcgggt
     4141 tgggccccaa gaagctggtt ccaggtaaat acacggtcgt ggcggaccac gagaagggag
     4201 gccccgatgc gctgcgcgtg aggagcgggg acgtggtgga gctggtgcag gagggcgacg
     4261 agggcctctg gtacgtcagg gacccgacca ctggcaagga gggctgggtg ccggccagca
     4321 gcctgtccgt ccggctcggc ccgtccggct cggcccagtg cctgagcagc tcagagtcga
     4381 gcccggggtc ggccgtgctg agcaactcgt ccagctgcag cgagggcggc caggccccct
     4441 tctccgacct gcaggggtag cgcggcctcg gcgccggaga cccgcgcgct gtctggggct
     4501 gcggtggcgt ggggagggcg cggcccccgg acgccccgag gaaggggcac ctcaccgccc
     4561 ccacccagag cgcctggccg tgcgggctgc agaggacccc tccggggcag aggcaggttc
     4621 cacggaagac cccggcccgc tggggcttcc ccggagactc cagagcccac agaggagggg
     4681 ccgcagggaa cagccccggg cggcaggcgc cgggcagcgg catctcgtcc tggctccacc
     4741 gtgctgcttc tgcctctgga cggtgctttc aggggacgcg cggaccgtgg tggagctgct
     4801 tccggagaag tggaggatcc tctggccaac ggcctgagga gagcggggca cggggtctct
     4861 ttagctttta caagttttag gattttttca agcagggatc aatcccgtgg ccattttttg
     4921 tggtactttg gcctcaattc ttcaccagga atcactgtgt ttacatgaaa tgacaatttg
     4981 atactgtatt tgatagaaaa ctattttttt gttaccgggg tttacataga agcacgttgt
     5041 ttataccact aagtgacttt gggggggctc tcccatggaa acggatggca ctccctgaag
     5101 ctccctggtc acaggtggat gaaaacgtgt ccgtgggtga catcaggtgg tgtctccacc
     5161 accaaaagca gttagaagcc aaggagattc ctttatctac ctagggttca ttttcaaaag
     5221 aaaatttaaa ctataattta aacaattaac gttcttttct acaaaaaaaa tgcagggact
     5281 tgattttttt aaagagcttc actgaattag gatattttta ttgcttttaa agaaaataca
     5341 aagatgcagt ttctgcaggg tgtggcgtgg accagtgctg ccgaccatag ctcagagagc
     5401 cctgcccctg cctcactgca ctgcagcctc ctcggaggcc gcacctccac tccactcccc
     5461 acgcgccccc tgcctcccac ccaggtccac ctgccacctg gtgaccacct tgagtacaga
     5521 agtgaaagtg gggagagtat tttattcaag tcacagcaga actggaaaaa aactcttctg
     5581 ttttaccaac ttcttgtgtt tcagaaacat attctgttca aaacttttga agccctttcg
     5641 gtgtctagtc tgcagatgtt tttgtatgtg tgcacctctg accatgtgtg tacatatgtg
     5701 tcttgctgga aaggacatat tcgctgtccc cgtgctgctg ggagggccgc ctcacagcct
     5761 cacggttccc agccccagca cagtggaggc aggcgtggct gcattcccct cacgctaccc
     5821 tcccagcggc ttgtagccgt cactggccag acctccaggg tgcggaatca aataggaagc
     5881 atgcagagac tcggcagctt ttcctctgat gtgtaagtta tttggaacgc gtgctgtgtc
     5941 ccgcgatgtc cctgatgtac tgtgcaggcg cggtgcctcc gtctcgtcgc acagctgcgc
     6001 gcccttgtgt gaccctcccc ataaaggcac tttacagctt catgtttcat ccactgtcac
     6061 ttttttttaa ctgctgatgt aaatggaatt ttaaaagcag agttctttat tgtatggatg
     6121 acgtttgaat aaatatcagc aactcctgcc atctgccttt gtctgtcaag acacagaacg
     6181 tctcagcagt cggggtttcc agggccgcag tgcactgtgc ttgcacatgg taagtcattg
     6241 ttgggacgga aaagaagccg gcagtgggca gggcccagcg tgcggctcag gcaccgagca
     6301 accgctttgc tttcttctgt cagacggcga tgatgacaaa atagcaacaa ggttgtgcgt
     6361 gtcagaaacg caaaggcagc agaggaagcg tagtggaacc attacagaat cacaatgcag
     6421 ccgacactct ccagaccaga aaagggagca taaagaaagg gtattgatcc aatagaagaa
     6481 gggaagggtg gagaaagggg aaagcatggt taacaggaaa caacatgtaa cggaagagac
     6541 agcccagatg tgtctggctc acaacagacg tgatcatgtt atgctggcct ggaagagcat
     6601 cggatcagac gtgacaagtc actgcttaga gaccatcaag caaatttata tatagattgg
     6661 agatttaaaa taaaagaaga cagaacagac aaacaccata agaaagctgg tgtagcagta
     6721 tcgatgacct gaaatgggat tcaggacagt tcatagagta aagggggctg cgtggcaatc
     6781 aggaactcat aagccactga ctataaagct caaaacacag caaagttggc agtcggcaga
     6841 cagcaatgtt gactgtcatg aaaagtgatc cctgtttgcc cctaaacgta gagaaatctg
     6901 cgttattttc cagcacacat ggagcacaaa caaaatattt gcaaaacaat gggaagatca
     6961 ttgaaacact gtttggcaat ttaaaagctt gtttctaact cacgggatgc gggcagtctg
     7021 ctctctagaa ctggacagcg tgcacagagc cacgggaggg agcagccacg gccagctcag
     7081 attggtgtcg acagcttagt ggtgtctgat tttatacatg acaaaatgaa cgagttaacc
     7141 atttaagcca aaaaaataag actagcgtaa cccaaagaaa gtatttaaat acttctgtca
     7201 attaggacag ttgagaaaag agaataacaa aatcaaaagc aaaactcaaa ctttgtacct
     7261 gaaaaatcta ataaaactga ctaatttata gaaaacctaa gaaactccat atcaaataaa
     7321 aaattttaaa tatgagagaa cca
//
