LOCUS       NM_174918               1271 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens mast cell expressed membrane protein 1 (MCEMP1), mRNA.
ACCESSION   NM_174918
VERSION     NM_174918.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1271)
  AUTHORS   Perrot,C.Y., Karampitsakos,T., Unterman,A., Adams,T., Marlin,K.,
            Arsenault,A., Zhao,A., Kaminski,N., Katlaps,G., Patel,K.,
            Bandyopadhyay,D. and Herazo-Maya,J.D.
  TITLE     Mast-cell expressed membrane protein-1 is expressed in classical
            monocytes and alveolar macrophages in idiopathic pulmonary fibrosis
            and regulates cell chemotaxis, adhesion, and migration in a
            TGFbeta-dependent manner
  JOURNAL   Am J Physiol Cell Physiol 326 (3), C964-C977 (2024)
   PUBMED   38189137
  REMARK    GeneRIF: Mast-cell expressed membrane protein-1 is expressed in
            classical monocytes and alveolar macrophages in idiopathic
            pulmonary fibrosis and regulates cell chemotaxis, adhesion, and
            migration in a TGFbeta-dependent manner.
REFERENCE   2  (bases 1 to 1271)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1271)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1271)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 1271)
  AUTHORS   Raman,K., O'Donnell,M.J., Czlonkowska,A., Duarte,Y.C.,
            Lopez-Jaramillo,P., Penaherrera,E., Sharma,M., Shoamanesh,A.,
            Skowronska,M., Yusuf,S. and Pare,G.
  TITLE     Peripheral Blood MCEMP1 Gene Expression as a Biomarker for Stroke
            Prognosis
  JOURNAL   Stroke 47 (3), 652-658 (2016)
   PUBMED   26846866
  REMARK    GeneRIF: The expression of the gene MCEMP1 had the strongest
            association with stroke of 11,181 genes tested.
REFERENCE   6  (bases 1 to 1271)
  AUTHORS   Li,K., Wang,S.W., Li,Y., Martin,R.E., Li,L., Lu,M.,
            Lamhamedi-Cherradi,S.E., Hu,G., Demissie-Sanders,S., Zheng,J.,
            Chung,F., Oates,T. and Yao,Z.
  TITLE     Identification and expression of a new type II transmembrane
            protein in human mast cells
  JOURNAL   Genomics 86 (1), 68-75 (2005)
   PUBMED   15953541
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008763.9.
            
            On Mar 30, 2021 this sequence version replaced NM_174918.2.
            
            Summary: This gene encodes a single-pass transmembrane protein.
            Based on its expression pattern, it is speculated to be involved in
            regulating mast cell differentiation or immune responses. [provided
            by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF461155.1, BC035847.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA2142363
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333598.8/ ENSP00000329920.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC008763.9         107902-107987
            87-176              AC008763.9         108449-108538
            177-314             AC008763.9         108916-109053
            315-365             AC008763.9         109162-109212
            366-479             AC008763.9         109303-109416
            480-539             AC008763.9         109736-109795
            540-1271            AC008763.9         109910-110641
FEATURES             Location/Qualifiers
     source          1..1271
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1271
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /note="mast cell expressed membrane protein 1"
                     /db_xref="GeneID:199675"
                     /db_xref="HGNC:HGNC:27291"
                     /db_xref="MIM:609565"
     exon            1..86
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..556
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /note="epididymis secretory sperm binding protein"
                     /codon_start=1
                     /product="mast cell-expressed membrane protein 1"
                     /protein_id="NP_777578.3"
                     /db_xref="CCDS:CCDS12183.2"
                     /db_xref="GeneID:199675"
                     /db_xref="HGNC:HGNC:27291"
                     /db_xref="MIM:609565"
                     /translation="MQAPAFRDKKQGVSAKNQGAHDPDYENITLAFKNQDHAKGGHSR
                     PTSQVPAQCRPPSDSTQVPCWLYRAILSLYILLALAFVLCIILSAFIMVKNAEMSKEL
                     LGFKRELWNVSNSVQACEERQKRGWDSVQQSITMVRSKIDRLETTLAGIKNIDTKVQK
                     ILEVLQKMPQSSPQ"
     exon            87..176
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            177..314
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            315..365
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            366..479
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            480..539
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     exon            540..1271
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1251..1256
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /note="hexamer: AATAAA"
     polyA_site      1271
                     /gene="MCEMP1"
                     /gene_synonym="C19orf59"
                     /note="major polyA site"
ORIGIN      
        1 ggaggaaatc tacaagcacc aggaagtcaa gatgcaagca ccagccttca gggacaagaa
       61 acagggggtc tcagccaaga atcaaggtgc ccatgaccca gactatgaga atatcacctt
      121 ggccttcaaa aatcaggacc atgcaaaggg tggtcattca cgacccacga gccaagtccc
      181 agcccagtgc aggccgccct cagactccac ccaggtcccc tgctggttgt acagagccat
      241 cctgagcctg tacatcctcc tggccctggc ctttgtcctc tgcatcatcc tgtcagcctt
      301 catcatggtg aagaatgctg agatgtccaa ggagctgctg ggctttaaaa gggagctttg
      361 gaatgtctca aactccgtac aagcatgcga agagagacag aagagaggct gggattccgt
      421 tcagcagagc atcaccatgg tcaggagcaa gattgataga ttagagacga cattagcagg
      481 cataaaaaac attgacacaa aggtacagaa aatcttggag gtgctgcaga aaatgccaca
      541 gtcctcacct caataaatga gaggacattg tggcagccaa agccacaact tggaagatgg
      601 ggctgcacct gccaacgaag acgggaaatg accccccccc cccagcctag tgtgaacctg
      661 cccctcgtcc cacgtataga aaaacctcga gtcatggtga atgagtgtct cggagttgct
      721 cgtgtgtgtg tacacctgcg tgcgtgtgtg tgcgtgtgtg cgcgtgtgtt cgtgtatgtg
      781 cgtgtgtgcg tgcgcgtgtg tgtgcatttt gcaaagggtg gacatttcag tgtatctccc
      841 agaaaggtga tgaatgaata ggactgagag tcacagtgaa tgtggcatgc atgcctgtgt
      901 catgtgacat atgtgagtct cggcatgtca cggtgggtgg ctgtgtctga gcacctccag
      961 cagatgtcac tctgagtgtg ggtgttggtg acatgcattg cacgggcctg tctccctgtt
     1021 tgtgtaaaca tactagagta tactgcggcg tgttttctgt ctacccatgt catggtgggg
     1081 gagatttatc tccgtacatg tgggtgtcgc catgtgtgcc ctgtcactat ctgtggctgg
     1141 gtgaacggct gtgtcattat gagtgtgccg agttatgcca ccctgtgtgc tcagggcaca
     1201 tgcacacaga catttatctc tgcactcaca ttttgtgact tatgaagata aataaagtca
     1261 agggaaaaca g
//
