LOCUS       NM_173467               2057 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens malonyl-CoA-acyl carrier protein transacylase (MCAT),
            transcript variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_173467
VERSION     NM_173467.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2057)
  AUTHORS   Harper,N.J., Burnside,C. and Klinge,S.
  TITLE     Principles of mitoribosomal small subunit assembly in eukaryotes
  JOURNAL   Nature 614 (7946), 175-181 (2023)
   PUBMED   36482135
REFERENCE   2  (bases 1 to 2057)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 2057)
  AUTHORS   Gerber,S., Orssaud,C., Kaplan,J., Johansson,C. and Rozet,J.M.
  TITLE     MCAT Mutations Cause Nuclear LHON-like Optic Neuropathy
  JOURNAL   Genes (Basel) 12 (4), 521 (2021)
   PUBMED   33918393
  REMARK    GeneRIF: MCAT Mutations Cause Nuclear LHON-like Optic Neuropathy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2057)
  AUTHORS   Li,H., Yuan,S., Minegishi,Y., Suga,A., Yoshitake,K., Sheng,X.,
            Ye,J., Smith,S., Bunkoczi,G., Yamamoto,M. and Iwata,T.
  TITLE     Novel mutations in malonyl-CoA-acyl carrier protein transacylase
            provoke autosomal recessive optic neuropathy
  JOURNAL   Hum Mol Genet 29 (3), 444-458 (2020)
   PUBMED   31915829
  REMARK    GeneRIF: Novel mutations in malonyl-CoA-acyl carrier protein
            transacylase provoke autosomal recessive optic neuropathy.
REFERENCE   5  (bases 1 to 2057)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   6  (bases 1 to 2057)
  AUTHORS   Ma,J., Dempsey,A.A., Stamatiou,D., Marshall,K.W. and Liew,C.C.
  TITLE     Identifying leukocyte gene expression patterns associated with
            plasma lipid levels in human subjects
  JOURNAL   Atherosclerosis 191 (1), 63-72 (2007)
   PUBMED   16806233
REFERENCE   7  (bases 1 to 2057)
  AUTHORS   Kuhl,J.E., Ruderman,N.B., Musi,N., Goodyear,L.J., Patti,M.E.,
            Crunkhorn,S., Dronamraju,D., Thorell,A., Nygren,J., Ljungkvist,O.,
            Degerblad,M., Stahle,A., Brismar,T.B., Andersen,K.L., Saha,A.K.,
            Efendic,S. and Bavenholm,P.N.
  TITLE     Exercise training decreases the concentration of malonyl-CoA and
            increases the expression and activity of malonyl-CoA decarboxylase
            in human muscle
  JOURNAL   Am J Physiol Endocrinol Metab 290 (6), E1296-E1303 (2006)
   PUBMED   16434556
REFERENCE   8  (bases 1 to 2057)
  AUTHORS   Zhang,L., Joshi,A.K. and Smith,S.
  TITLE     Cloning, expression, characterization, and interaction of two
            components of a human mitochondrial fatty acid synthase.
            Malonyltransferase and acyl carrier protein
  JOURNAL   J Biol Chem 278 (41), 40067-40074 (2003)
   PUBMED   12882974
REFERENCE   9  (bases 1 to 2057)
  AUTHORS   Collins,J.E., Goward,M.E., Cole,C.G., Smink,L.J., Huckle,E.J.,
            Knowles,S., Bye,J.M., Beare,D.M. and Dunham,I.
  TITLE     Reevaluating human gene annotation: a second-generation analysis of
            chromosome 22
  JOURNAL   Genome Res 13 (1), 27-36 (2003)
   PUBMED   12529303
REFERENCE   10 (bases 1 to 2057)
  AUTHORS   Dunham,I., Shimizu,N., Roe,B.A., Chissoe,S., Hunt,A.R.,
            Collins,J.E., Bruskiewich,R., Beare,D.M., Clamp,M., Smink,L.J.,
            Ainscough,R., Almeida,J.P., Babbage,A., Bagguley,C., Bailey,J.,
            Barlow,K., Bates,K.N., Beasley,O., Bird,C.P., Blakey,S.,
            Bridgeman,A.M., Buck,D., Burgess,J., Burrill,W.D., O'Brien,K.P. et
            al.
  TITLE     The DNA sequence of human chromosome 22
  JOURNAL   Nature 402 (6761), 489-495 (1999)
   PUBMED   10591208
  REMARK    Erratum:[Nature 2000 Apr 20;404(6780):904]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL022237.1, BI464466.1,
            AL359401.1, BX111669.1, DB306307.1 and AI811069.1.
            
            On May 17, 2019 this sequence version replaced NM_173467.4.
            
            Summary: The protein encoded by this gene is found exclusively in
            the mitochondrion, where it catalyzes the transfer of a malonyl
            group from malonyl-CoA to the mitochondrial acyl carrier protein.
            The encoded protein may be part of a fatty acid synthase complex
            that is more like the type II prokaryotic and plastid complexes
            rather than the type I human cytosolic complex. Alternative
            splicing results in multiple transcript variants encoding different
            isoforms. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.235399.1,
                                           SRR7346977.2161931.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000290429.11/
                                                  ENSP00000290429.5
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL022237.1         58577-58577         c
            2-34                BI464466.1         7-39
            35-1386             AL359401.1         1-1352
            1387-1647           BX111669.1         213-473
            1648-2020           DB306307.1         36-408              c
            2021-2032           AI811069.1         56-67               c
            2033-2055           DB306307.1         1-23                c
            2056-2057           AI811069.1         31-32               c
FEATURES             Location/Qualifiers
     source          1..2057
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q13.2"
     gene            1..2057
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /note="malonyl-CoA-acyl carrier protein transacylase"
                     /db_xref="GeneID:27349"
                     /db_xref="HGNC:HGNC:29622"
                     /db_xref="MIM:614479"
     exon            1..473
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..1223
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /EC_number="2.3.1.39"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; mitochondrial malonyltransferase;
                     malonyl-CoA-acyl carrier protein transacylase,
                     mitochondrial; [Acyl-carrier-protein] malonyltransferase;
                     mitochondrial malonyl CoA:ACP acyltransferase; malonyl
                     CoA:ACP acyltransferase (mitochondrial);
                     [acyl-carrier-protein] S-malonyltransferase"
                     /codon_start=1
                     /product="malonyl-CoA-acyl carrier protein transacylase,
                     mitochondrial isoform a precursor"
                     /protein_id="NP_775738.3"
                     /db_xref="CCDS:CCDS33660.1"
                     /db_xref="GeneID:27349"
                     /db_xref="HGNC:HGNC:29622"
                     /db_xref="MIM:614479"
                     /translation="MSVRVARVAWVRGLGASYRRGASSFPVPPPGAQGVAELLRDATG
                     AEEEAPWAATERRMPGQCSVLLFPGQGSQVVGMGRGLLNYPRVRELYAAARRVLGYDL
                     LELSLHGPQETLDRTVHCQPAIFVASLAAVEKLHHLQPSVIENCVAAAGFSVGEFAAL
                     VFAGAMEFAEGLYAVKIRAEAMQEASEAVPSGMLSVLGQPQSKFNFACLEAREHCKSL
                     GIENPVCEVSNYLFPDCRVISGHQEALRFLQKNSSKFHFRRTRMLPVSGAFHTRLMEP
                     AVEPLTQALKAVDIKKPLVSVYSNVHAHRYRHPGHIHKLLAQQLVSPVKWEQTMHAIY
                     ERKKGRGFPQTFEVGPGRQLGAILKSCNMQAWKSYSAVDVLQTLEHVDLDPQEPPR"
     exon            474..561
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /inference="alignment:Splign:2.1.0"
     exon            562..779
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /inference="alignment:Splign:2.1.0"
     exon            780..2057
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /note="hexamer: CATAAA"
     polyA_site      1383
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
                     /note="major polyA site"
     polyA_site      1696
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
     polyA_site      1794
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
     polyA_site      2057
                     /gene="MCAT"
                     /gene_synonym="fabD; FASN2C; MCT; MCT1; MT; NET62; OPA15"
ORIGIN      
        1 gcagtcgggc ctcggtcgcc acggtaacgc gcgcgggcag gtgtccgacc atgagcgtcc
       61 gggtcgcacg ggtagcgtgg gtcaggggct tgggcgccag ctaccgccgc ggcgcctcga
      121 gcttcccggt gcctccgccg ggcgcccagg gtgtagcgga gctgctgcga gatgcgaccg
      181 gggcggagga ggaggcgccc tgggcggcga cggagcggcg aatgccgggc cagtgctccg
      241 tgctgctctt cccgggccag ggcagccagg tggtgggcat gggccgcggt ctgctcaact
      301 acccgcgcgt ccgcgaactc tacgccgccg cccgccgcgt gctgggctac gacctgctgg
      361 aactgagcct gcacgggccg caggagaccc tggaccgcac cgtgcactgt cagcccgcga
      421 tcttcgtggc atcgctggcc gctgtcgaga aactacatca cctgcagccc tcggtgattg
      481 agaactgtgt tgctgctgct ggattcagtg tgggagagtt tgcagcccta gtgtttgccg
      541 gagccatgga atttgctgaa ggtttgtatg cagtgaaaat ccgagctgag gccatgcagg
      601 aagcttcaga agctgtcccc agtgggatgc tgtctgtcct cggccagcct cagtccaagt
      661 tcaacttcgc ctgtttggaa gcccgggaac actgcaagtc tttaggcata gagaaccccg
      721 tatgtgaagt gtccaactac ctctttccag attgcagggt gatttcagga caccaagagg
      781 ctctacggtt tctccagaag aattcctcta agtttcattt cagacgcacc aggatgttgc
      841 cggttagtgg cgcattccac acccgcctca tggagccagc cgtggagccc ctgacgcaag
      901 ctttaaaggc agtcgacatt aagaagcctc tggtttctgt ctactccaac gtccacgcgc
      961 atagatacag gcatcccggg cacatccaca agctgctggc ccagcagctg gtctccccag
     1021 tgaagtggga gcagacgatg catgccatat acgaaaggaa aaagggcagg gggttccccc
     1081 aaactttcga agtaggccct ggcaggcagc tgggagccat cctgaagagc tgtaacatgc
     1141 aggcctggaa gtcctacagc gccgtggatg tgctgcagac cctcgaacat gtggacctgg
     1201 accctcagga gcccccgaga tgactgcagg gggctcaaat gcgatgaccc cctctgtcct
     1261 cctgaggaga ggctgtaggc tgtgcctgtc gccccctacc ttcctaatgg ctcctcctct
     1321 gaggagtgaa agggatttgt ttgcaacgtg ctttgaaggc cacataaaaa gccctaaaaa
     1381 tgagtatttc tttacatgac ccagtccatt tctccccctt ggaaaaacgt ttggacgttg
     1441 ggaagaatga tgccacaggg ctggtgtgtg gggaagctag aatcctggcc ccgcctctgc
     1501 cagccctgca ccataggcag gtgtgccatc tcagcgggaa ggggaggact ggctgctgca
     1561 gcctgtcctg ctctgtgagt gctgagaaca tgctggtgtg gcctcaattt cagccagtgc
     1621 caggggagcc cctccaccac ccccagcctg ccccccaggg ctcctttgtc acaaatctga
     1681 aaggttttag aacccagttg gccttggcag ttttgttcac ctcctcactt gacagctggg
     1741 agacagaggc ccacatttat ggacataccc aagagatatg tattgcctgc tgtgtgctag
     1801 agagtgagtg cgctctgttc tggtagaaag gtccttgagt gaggtgcggg gtgtggggag
     1861 tgccaggtag ggagggcgac tgaggccctg gtcctagggg tggaaccatg gaggaacacc
     1921 ctggtcaccc actgggactg cgggtctgcg gggcgccaga gggagcacag cacatacctg
     1981 cctcggagct gacccctggc tccatgcccc gtcctcagag cagctcctgc gccaatatta
     2041 agtatgagac attccaa
//
