LOCUS       XM_017017761            3209 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens melanoma cell adhesion molecule (MCAM),
            transcript variant X3, mRNA.
ACCESSION   XM_017017761
VERSION     XM_017017761.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000011.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017017761.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
     gene            1..3209
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /note="melanoma cell adhesion molecule; Derived by
                     automated computational analysis using gene prediction
                     method: Gnomon. Supporting evidence includes similarity
                     to: 1 mRNA, 219 ESTs, 994 long SRA reads, 2 Proteins, and
                     96% coverage of the annotated genomic feature by RNAseq
                     alignments, including 116 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:4162"
                     /db_xref="HGNC:HGNC:6934"
                     /db_xref="MIM:155735"
     CDS             30..1844
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /codon_start=1
                     /product="cell surface glycoprotein MUC18 isoform X3"
                     /protein_id="XP_016873250.1"
                     /db_xref="GeneID:4162"
                     /db_xref="HGNC:HGNC:6934"
                     /db_xref="MIM:155735"
                     /translation="MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTA
                     LLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLA
                     LTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVAT
                     CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKD
                     AQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADG
                     NPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSE
                     PQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVL
                     QLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNL
                     SCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKN
                     TSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVI
                     VCILVLAVLGAVLYFLYKKGKLPCRRSGKQEMERNTSI"
ORIGIN      
        1 acttggctct cgccctccgg ccgggaagca tggggcttcc caggctggtc tgcgccttct
       61 tgctcgccgc ctgctgctgc tgtcctcgcg tcgcgggtgt gcccggagag gctgagcagc
      121 ctgcgcctga gctggtggag gtggaagtgg gcagcacagc ccttctgaag tgcggcctct
      181 cccagtccca aggcaacctc agccatgtcg actggttttc tgtccacaag gagaagcgga
      241 cgctcatctt ccgtgtgcgc cagggccagg gccagagcga acctggggag tacgagcagc
      301 ggctcagcct ccaggacaga ggggctactc tggccctgac tcaagtcacc ccccaagacg
      361 agcgcatctt cttgtgccag ggcaagcgcc ctcggtccca ggagtaccgc atccagctcc
      421 gcgtctacaa agctccggag gagccaaaca tccaggtcaa ccccctgggc atccctgtga
      481 acagtaagga gcctgaggag gtcgctacct gtgtagggag gaacgggtac cccattcctc
      541 aagtcatctg gtacaagaat ggccggcctc tgaaggagga gaagaaccgg gtccacattc
      601 agtcgtccca gactgtggag tcgagtggtt tgtacacctt gcagagtatt ctgaaggcac
      661 agctggttaa agaagacaaa gatgcccagt tttactgtga gctcaactac cggctgccca
      721 gtgggaacca catgaaggag tccagggaag tcaccgtccc tgttttctac ccgacagaaa
      781 aagtgtggct ggaagtggag cccgtgggaa tgctgaagga aggggaccgc gtggaaatca
      841 ggtgtttggc tgatggcaac cctccaccac acttcagcat cagcaagcag aaccccagca
      901 ccagggaggc agaggaagag acaaccaacg acaacggggt cctggtgctg gagcctgccc
      961 ggaaggaaca cagtgggcgc tatgaatgtc agggcctgga cttggacacc atgatatcgc
     1021 tgctgagtga accacaggaa ctactggtga actatgtgtc tgacgtccga gtgagtcccg
     1081 cagcccctga gagacaggaa ggcagcagcc tcaccctgac ctgtgaggca gagagtagcc
     1141 aggacctcga gttccagtgg ctgagagaag agacaggcca ggtgctggaa agggggcctg
     1201 tgcttcagtt gcatgacctg aaacgggagg caggaggcgg ctatcgctgc gtggcgtctg
     1261 tgcccagcat acccggcctg aaccgcacac agctggtcaa cgtggccatt tttggccccc
     1321 cttggatggc attcaaggag aggaaggtgt gggtgaaaga gaatatggtg ttgaatctgt
     1381 cttgtgaagc gtcagggcac ccccggccca ccatctcctg gaacgtcaac ggcacggcaa
     1441 gtgaacaaga ccaagatcca cagcgagtcc tgagcaccct gaatgtcctc gtgaccccgg
     1501 agctgttgga gacaggtgtt gaatgcacgg cctccaacga cctgggcaaa aacaccagca
     1561 tcctcttcct ggagctggtc aatttaacca ccctcacacc agactccaac acaaccactg
     1621 gcctcagcac ttccactgcc agtcctcata ccagagccaa cagcacctcc acagagagaa
     1681 agctgccgga gccggagagc cggggcgtgg tcatcgtggc tgtgattgtg tgcatcctgg
     1741 tcctggcggt gctgggcgct gtcctctatt tcctctataa gaagggcaag ctgccgtgca
     1801 ggcgctcagg gaagcaggag atggagagaa atacatcgat ctgaggcatt agccccgaat
     1861 cacttcagct cccttccctg cctggaccat tcccagctcc ctgctcactc ttctctcagc
     1921 caaagcctcc aaagggacta gagagaagcc tcctgctccc ctcgcctgca cacccccttt
     1981 cagagggcca ctgggttagg acctgaggac ctcacttggc cctgcaaggc ccgcttttca
     2041 gggaccagtc caccaccatc tcctccacgt tgagtgaagc tcatcccaag caaggagccc
     2101 cagtctcccg agcgggtagg agagtttctt gcagaacgtg ttttttcttt acacacatta
     2161 tggctgtaaa tacctggctc ctgccagcag ctgagctggg tagcctctct gagctggttt
     2221 cctgccccaa aggctggctt ccaccatcca ggtgcaccac tgaagtgagg acacaccgga
     2281 gccaggcgcc tgctcatgtt gaagtgcgct gttcacaccc gctccggaga gcaccccagc
     2341 agcatccaga agcagctgca gtgttgctgc caccaccctc ctgtctgcct cttcaaagtc
     2401 tcctgtgaca ttttttcttt ggtcagaagc caggaactgg tgtcattcct taaaagatac
     2461 gtgccggggc caggtgtggt ggctcacgcc tgtaatccca gcactttggg aggccgaggc
     2521 gggcggatca caaagtcagg acgagaccat cctggctaac acggtgaaac cctgtctcta
     2581 ctaaaaatac aaaaaaaaat tagctaggcg tagtggttgg cacctatagt cccagctact
     2641 cggaaggctg aagcaggaga atggtatgaa tccaggaggt ggagcttgca gtgagccgag
     2701 accgtgccac tgcactccag cctgggcaac acagcgagac tccgtctcga ggaaaaaaaa
     2761 agaaaagata cgtgcctgcg gtgaggaagc tgggcgctgt tttcgagttc aggtgaatta
     2821 gcctcaatcc cccgtgttca cttggctccc atagccctct tgatggatca cgtaaaactg
     2881 aaaggcagcg gggagcagac aaagatgagg tctacactgt ccttcatggg gattaaagct
     2941 atggttatat tagcaccaaa cttctacaaa ccaagctcag ggccccaacc ctagaagggc
     3001 ccaaatgaga gaatggtact tagggatgga aaacgggcct ggctagagct tcgggtgtgt
     3061 gtgtctgtct gtgtgtatgc atacatatgt gtgtatatat ggttttgtca ggtgtgtaaa
     3121 tttgcaaatt gtttccttta tatatgtatg tatatatata tatgaaaata tatatatata
     3181 tgaaaaataa agcttaattg tcccagaaa
//
