LOCUS       NM_006500               3327 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens melanoma cell adhesion molecule (MCAM), mRNA.
ACCESSION   NM_006500
VERSION     NM_006500.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3327)
  AUTHORS   Chen,J.M., He,J., Qiu,J.M., Yang,G.G., Wang,D. and Shen,Z.
  TITLE     Netrin-1-CD146 and netrin-1-S100A9 are associated with early stage
            of lymph node metastasis in colorectal cancer
  JOURNAL   BMC Gastroenterol 24 (1), 308 (2024)
   PUBMED   39261771
  REMARK    GeneRIF: Netrin-1-CD146 and netrin-1-S100A9 are associated with
            early stage of lymph node metastasis in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3327)
  AUTHORS   Wei,N., Wu,X., Yu,Y., Zhou,H., Cui,K., Zhao,X. and Zhang,X.
  TITLE     CD146 Promotes EMT-Mediated Migration and Invasion of NSCLC via
            PI3K/Akt Signaling Pathway
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 140 (2024)
   PUBMED   38682195
  REMARK    GeneRIF: CD146 Promotes EMT-Mediated Migration and Invasion of
            NSCLC via PI3K/Akt Signaling Pathway.
REFERENCE   3  (bases 1 to 3327)
  AUTHORS   Boutin,L., Roger,E., Gayat,E., Depret,F., Blot-Chabaud,M. and
            Chadjichristos,C.E.
  TITLE     The role of CD146 in renal disease: from experimental nephropathy
            to clinics
  JOURNAL   J Mol Med (Berl) 102 (1), 11-21 (2024)
   PUBMED   37993561
  REMARK    GeneRIF: The role of CD146 in renal disease: from experimental
            nephropathy to clinics.
            Review article
REFERENCE   4  (bases 1 to 3327)
  AUTHORS   Chen,J., Xu,Q., Liu,D., Li,X., Guo,M., Chen,X., Liao,J., Lei,R.,
            Li,W., Huang,H., Saw,P.E., Song,E., Yan,X. and Nie,Y.
  TITLE     CD146 promotes malignant progression of breast phyllodes tumor
            through suppressing DCBLD2 degradation and activating the AKT
            pathway
  JOURNAL   Cancer Commun (Lond) 43 (11), 1244-1266 (2023)
   PUBMED   37856423
  REMARK    GeneRIF: CD146 promotes malignant progression of breast phyllodes
            tumor through suppressing DCBLD2 degradation and activating the AKT
            pathway.
REFERENCE   5  (bases 1 to 3327)
  AUTHORS   Li,Y., Chai,J.L., Shi,X., Feng,Y., Li,J.J., Zhou,L.N., Cao,C. and
            Li,K.R.
  TITLE     Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis
  JOURNAL   Theranostics 13 (7), 2319-2336 (2023)
   PUBMED   37153740
  REMARK    GeneRIF: Galphai1/3 mediate Netrin-1-CD146-activated signaling and
            angiogenesis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3327)
  AUTHORS   Bardin,N., Frances,V., Lesaule,G., Horschowski,N., George,F. and
            Sampol,J.
  TITLE     Identification of the S-Endo 1 endothelial-associated antigen
  JOURNAL   Biochem Biophys Res Commun 218 (1), 210-216 (1996)
   PUBMED   8573133
REFERENCE   7  (bases 1 to 3327)
  AUTHORS   Shih,I.M., Elder,D.E., Speicher,D., Johnson,J.P. and Herlyn,M.
  TITLE     Isolation and functional characterization of the A32
            melanoma-associated antigen
  JOURNAL   Cancer Res 54 (9), 2514-2520 (1994)
   PUBMED   8162602
REFERENCE   8  (bases 1 to 3327)
  AUTHORS   Johnson,J.P., Rothbacher,U. and Sers,C.
  TITLE     The progression associated antigen MUC18: a unique member of the
            immunoglobulin supergene family
  JOURNAL   Melanoma Res 3 (5), 337-340 (1993)
   PUBMED   8292890
  REMARK    Review article
REFERENCE   9  (bases 1 to 3327)
  AUTHORS   Sers,C., Kirsch,K., Rothbacher,U., Riethmuller,G. and Johnson,J.P.
  TITLE     Genomic organization of the melanoma-associated glycoprotein MUC18:
            implications for the evolution of the immunoglobulin domains
  JOURNAL   Proc Natl Acad Sci U S A 90 (18), 8514-8518 (1993)
   PUBMED   8378324
REFERENCE   10 (bases 1 to 3327)
  AUTHORS   Lehmann,J.M., Riethmuller,G. and Johnson,J.P.
  TITLE     MUC18, a marker of tumor progression in human melanoma, shows
            sequence similarity to the neural cell adhesion molecules of the
            immunoglobulin superfamily
  JOURNAL   Proc Natl Acad Sci U S A 86 (24), 9891-9895 (1989)
   PUBMED   2602381
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU076908.1, BC056418.1, AB209925.1 and AP002956.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006500.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF089868.1, SRR1803614.131276.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264036.6/ ENSP00000264036.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AU076908.1         1-10
            11-1828             BC056418.1         1-1818
            1829-1940           AB209925.1         1839-1950
            1941-2701           BC056418.1         1931-2691
            2702-3327           AP002956.1         177800-178425       c
FEATURES             Location/Qualifiers
     source          1..3327
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q23.3"
     gene            1..3327
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /note="melanoma cell adhesion molecule"
                     /db_xref="GeneID:4162"
                     /db_xref="HGNC:HGNC:6934"
                     /db_xref="MIM:155735"
     exon            1..96
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..1970
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /note="Gicerin; melanoma adhesion molecule; cell surface
                     glycoprotein MUC18; cell surface glycoprotein P1H12;
                     melanoma-associated antigen A32; melanoma-associated
                     antigen MUC18; S-endo 1 endothelial-associated antigen"
                     /codon_start=1
                     /product="cell surface glycoprotein MUC18 precursor"
                     /protein_id="NP_006491.2"
                     /db_xref="CCDS:CCDS31690.1"
                     /db_xref="GeneID:4162"
                     /db_xref="HGNC:HGNC:6934"
                     /db_xref="MIM:155735"
                     /translation="MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTA
                     LLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLA
                     LTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVAT
                     CVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKD
                     AQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADG
                     NPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSE
                     PQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVL
                     QLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNL
                     SCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKN
                     TSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVI
                     VCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVEVKSDKLPEEMGLL
                     QGSSGDKRAPGDQGEKYIDLRH"
     exon            97..221
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            222..429
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            430..500
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            501..588
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            589..768
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            769..890
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1053
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1172
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1314
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1436
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1578
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1674
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1822
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1940
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..3327
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3304..3309
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /note="hexamer: AATAAA"
     polyA_site      3327
                     /gene="MCAM"
                     /gene_synonym="CD146; HEMCAM; MelCAM; METCAM; MUC18"
                     /note="major polyA site"
ORIGIN      
        1 acttggctct cgccctccgg ccgggaagca tggggcttcc caggctggtc tgcgccttct
       61 tgctcgccgc ctgctgctgc tgtcctcgcg tcgcgggtgt gcccggagag gctgagcagc
      121 ctgcgcctga gctggtggag gtggaagtgg gcagcacagc ccttctgaag tgcggcctct
      181 cccagtccca aggcaacctc agccatgtcg actggttttc tgtccacaag gagaagcgga
      241 cgctcatctt ccgtgtgcgc cagggccagg gccagagcga acctggggag tacgagcagc
      301 ggctcagcct ccaggacaga ggggctactc tggccctgac tcaagtcacc ccccaagacg
      361 agcgcatctt cttgtgccag ggcaagcgcc ctcggtccca ggagtaccgc atccagctcc
      421 gcgtctacaa agctccggag gagccaaaca tccaggtcaa ccccctgggc atccctgtga
      481 acagtaagga gcctgaggag gtcgctacct gtgtagggag gaacgggtac cccattcctc
      541 aagtcatctg gtacaagaat ggccggcctc tgaaggagga gaagaaccgg gtccacattc
      601 agtcgtccca gactgtggag tcgagtggtt tgtacacctt gcagagtatt ctgaaggcac
      661 agctggttaa agaagacaaa gatgcccagt tttactgtga gctcaactac cggctgccca
      721 gtgggaacca catgaaggag tccagggaag tcaccgtccc tgttttctac ccgacagaaa
      781 aagtgtggct ggaagtggag cccgtgggaa tgctgaagga aggggaccgc gtggaaatca
      841 ggtgtttggc tgatggcaac cctccaccac acttcagcat cagcaagcag aaccccagca
      901 ccagggaggc agaggaagag acaaccaacg acaacggggt cctggtgctg gagcctgccc
      961 ggaaggaaca cagtgggcgc tatgaatgtc agggcctgga cttggacacc atgatatcgc
     1021 tgctgagtga accacaggaa ctactggtga actatgtgtc tgacgtccga gtgagtcccg
     1081 cagcccctga gagacaggaa ggcagcagcc tcaccctgac ctgtgaggca gagagtagcc
     1141 aggacctcga gttccagtgg ctgagagaag agacaggcca ggtgctggaa agggggcctg
     1201 tgcttcagtt gcatgacctg aaacgggagg caggaggcgg ctatcgctgc gtggcgtctg
     1261 tgcccagcat acccggcctg aaccgcacac agctggtcaa cgtggccatt tttggccccc
     1321 cttggatggc attcaaggag aggaaggtgt gggtgaaaga gaatatggtg ttgaatctgt
     1381 cttgtgaagc gtcagggcac ccccggccca ccatctcctg gaacgtcaac ggcacggcaa
     1441 gtgaacaaga ccaagatcca cagcgagtcc tgagcaccct gaatgtcctc gtgaccccgg
     1501 agctgttgga gacaggtgtt gaatgcacgg cctccaacga cctgggcaaa aacaccagca
     1561 tcctcttcct ggagctggtc aatttaacca ccctcacacc agactccaac acaaccactg
     1621 gcctcagcac ttccactgcc agtcctcata ccagagccaa cagcacctcc acagagagaa
     1681 agctgccgga gccggagagc cggggcgtgg tcatcgtggc tgtgattgtg tgcatcctgg
     1741 tcctggcggt gctgggcgct gtcctctatt tcctctataa gaagggcaag ctgccgtgca
     1801 ggcgctcagg gaagcaggag atcacgctac ccccgtctcg taagagcgaa cttgtagttg
     1861 aagttaagtc agataagctc ccagaagaga tgggcctcct gcagggcagc agcggtgaca
     1921 agagggctcc gggagaccag ggagagaaat acatcgatct gaggcattag ccccgaatca
     1981 cttcagctcc cttccctgcc tggaccattc ccagctccct gctcactctt ctctcagcca
     2041 aagcctccaa agggactaga gagaagcctc ctgctcccct cgcctgcaca ccccctttca
     2101 gagggccact gggttaggac ctgaggacct cacttggccc tgcaaggccc gcttttcagg
     2161 gaccagtcca ccaccatctc ctccacgttg agtgaagctc atcccaagca aggagcccca
     2221 gtctcccgag cgggtaggag agtttcttgc agaacgtgtt ttttctttac acacattatg
     2281 gctgtaaata cctggctcct gccagcagct gagctgggta gcctctctga gctggtttcc
     2341 tgccccaaag gctggcttcc accatccagg tgcaccactg aagtgaggac acaccggagc
     2401 caggcgcctg ctcatgttga agtgcgctgt tcacacccgc tccggagagc accccagcag
     2461 catccagaag cagctgcagt gttgctgcca ccaccctcct gtctgcctct tcaaagtctc
     2521 ctgtgacatt ttttctttgg tcagaagcca ggaactggtg tcattcctta aaagatacgt
     2581 gccggggcca ggtgtggtgg ctcacgcctg taatcccagc actttgggag gccgaggcgg
     2641 gcggatcaca aagtcaggac gagaccatcc tggctaacac ggtgaaaccc tgtctctact
     2701 aaaaatacaa aaaaaaatta gctaggcgta gtggttggca cctatagtcc cagctactcg
     2761 gaaggctgaa gcaggagaat ggtatgaatc caggaggtgg agcttgcagt gagccgagac
     2821 cgtgccactg cactccagcc tgggcaacac agcgagactc cgtctcgagg aaaaaaaaag
     2881 aaaagatacg tgcctgcggt gaggaagctg ggcgctgttt tcgagttcag gtgaattagc
     2941 ctcaatcccc cgtgttcact tggctcccat agccctcttg atggatcacg taaaactgaa
     3001 aggcagcggg gagcagacaa agatgaggtc tacactgtcc ttcatgggga ttaaagctat
     3061 ggttatatta gcaccaaact tctacaaacc aagctcaggg ccccaaccct agaagggccc
     3121 aaatgagaga atggtactta gggatggaaa acgggcctgg ctagagcttc gggtgtgtgt
     3181 gtctgtctgt gtgtatgcat acatatgtgt gtatatatgg ttttgtcagg tgtgtaaatt
     3241 tgcaaattgt ttcctttata tatgtatgta tatatatata tgaaaatata tatatatatg
     3301 aaaaataaag cttaattgtc ccagaaa
//
