LOCUS       NM_005913               1723 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens melanocortin 5 receptor (MC5R), mRNA.
ACCESSION   NM_005913
VERSION     NM_005913.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1723)
  AUTHORS   Orenay,O.M., Sarifakioglu,E. and Gulekon,A.
  TITLE     Evaluation of perilipin 2 and melanocortin 5 receptor serum levels
            with sebogenesis in acne vulgaris patients
  JOURNAL   Acta Dermatovenerol Alp Pannonica Adriat 30 (1), 7-9 (2021)
   PUBMED   33765750
  REMARK    GeneRIF: Evaluation of perilipin 2 and melanocortin 5 receptor
            serum levels with sebogenesis in acne vulgaris patients.
REFERENCE   2  (bases 1 to 1723)
  AUTHORS   Maisto,R., Oltra,M., Vidal-Gil,L., Martinez-Gil,N.,
            Sancho-Pelluz,J., Filippo,C.D., Rossi,S., D Amico,M., Barcia,J.M.
            and Romero,F.J.
  TITLE     ARPE-19-derived VEGF-containing exosomes promote neovascularization
            in HUVEC: the role of the melanocortin receptor 5
  JOURNAL   Cell Cycle 18 (4), 413-424 (2019)
   PUBMED   30739530
  REMARK    GeneRIF: MCR5 is a modulator of the responses stimulated by glucose
            in ARPE-19 cells, which might possibly be translated into a
            modulation of the retinal pigment epithelium response to diabetes
            in vivo.
REFERENCE   3  (bases 1 to 1723)
  AUTHORS   Rodrigues,A.R., Sousa,D., Almeida,H. and Gouveia,A.M.
  TITLE     Cell surface targeting of the Melanocortin 5 Receptor (MC5R)
            requires serine-rich terminal motifs
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1864 (7), 1217-1226 (2017)
   PUBMED   28396017
  REMARK    GeneRIF: Mutations in residues S4/S5 and S17/E18 retained MC5R at
            the ER/Golgi complex and did not affect MC5R homodimerization.
REFERENCE   4  (bases 1 to 1723)
  AUTHORS   Lantang,A.M., Innes,B.A., Gan,E.H., Pearce,S.H. and Lash,G.E.
  TITLE     Expression of melanocortin receptors in human endometrium
  JOURNAL   Hum Reprod 30 (10), 2404-2410 (2015)
   PUBMED   26223677
  REMARK    GeneRIF: melanocortin receptors MC2R, MC3R and MC5R are most
            abundantly expressed in glandular epithelium of the endometrium
REFERENCE   5  (bases 1 to 1723)
  AUTHORS   Frandberg,P.A., Xu,X. and Chhajlani,V.
  TITLE     Glutamine235 and arginine272 in human melanocortin 5 receptor
            determines its low affinity to MSH
  JOURNAL   Biochem Biophys Res Commun 236 (2), 489-492 (1997)
   PUBMED   9240466
REFERENCE   6  (bases 1 to 1723)
  AUTHORS   Yang,Y.K., Ollmann,M.M., Wilson,B.D., Dickinson,C., Yamada,T.,
            Barsh,G.S. and Gantz,I.
  TITLE     Effects of recombinant agouti-signaling protein on melanocortin
            action
  JOURNAL   Mol Endocrinol 11 (3), 274-280 (1997)
   PUBMED   9058374
REFERENCE   7  (bases 1 to 1723)
  AUTHORS   Chhajlani,V.
  TITLE     Distribution of cDNA for melanocortin receptor subtypes in human
            tissues
  JOURNAL   Biochem Mol Biol Int 38 (1), 73-80 (1996)
   PUBMED   8932521
REFERENCE   8  (bases 1 to 1723)
  AUTHORS   Fathi,Z., Iben,L.G. and Parker,E.M.
  TITLE     Cloning, expression, and tissue distribution of a fifth
            melanocortin receptor subtype
  JOURNAL   Neurochem Res 20 (1), 107-113 (1995)
   PUBMED   7739752
REFERENCE   9  (bases 1 to 1723)
  AUTHORS   Chowdhary,B.P., Gustavsson,I., Wikberg,J.E. and Chhajlani,V.
  TITLE     Localization of the human melanocortin-5 receptor gene (MC5R) to
            chromosome band 18p11.2 by fluorescence in situ hybridization
  JOURNAL   Cytogenet Cell Genet 68 (1-2), 79-81 (1995)
   PUBMED   7956366
REFERENCE   10 (bases 1 to 1723)
  AUTHORS   Chhajlani,V., Muceniece,R. and Wikberg,J.E.
  TITLE     Molecular cloning of a novel human melanocortin receptor
  JOURNAL   Biochem Biophys Res Commun 195 (2), 866-873 (1993)
   PUBMED   8396929
  REMARK    Erratum:[Biochem Biophys Res Commun. 1996 Jan 17;218(2):638. doi:
            10.1006/bbrc.1996.0113.. PMID: 8561809]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AP001525.6, DR002771.1 and BC069153.1.
            
            On May 30, 2019 this sequence version replaced NM_005913.2.
            
            Summary: This gene encodes a member of the seven-pass transmembrane
            G protein-coupled melanocortin receptor protein family that
            stimulate cAMP signal transduction. The encoded protein is a
            receptor for melanocyte-stimulating hormone and adrenocorticotropic
            hormone and is suggested to play a role in sebum generation.
            [provided by RefSeq, Jun 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.65151.1, DR002771.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2157437, SAMEA2158800
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000589410.2/ ENSP00000468086.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AP001525.6         161880-161885
            7-667               DR002771.1         7-667
            668-1143            BC069153.1         504-979
            1144-1723           AP001525.6         164475-165054
FEATURES             Location/Qualifiers
     source          1..1723
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18p11.21"
     gene            1..1723
                     /gene="MC5R"
                     /gene_synonym="MC2"
                     /note="melanocortin 5 receptor"
                     /db_xref="GeneID:4161"
                     /db_xref="HGNC:HGNC:6933"
                     /db_xref="MIM:600042"
     exon            1..126
                     /gene="MC5R"
                     /gene_synonym="MC2"
                     /inference="alignment:Splign:2.1.0"
     exon            127..1723
                     /gene="MC5R"
                     /gene_synonym="MC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1143
                     /gene="MC5R"
                     /gene_synonym="MC2"
                     /codon_start=1
                     /product="melanocortin receptor 5"
                     /protein_id="NP_005904.1"
                     /db_xref="CCDS:CCDS11868.1"
                     /db_xref="GeneID:4161"
                     /db_xref="HGNC:HGNC:6933"
                     /db_xref="MIM:600042"
                     /translation="MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFL
                     TLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNK
                     HLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSG
                     AIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKR
                     IAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSH
                     FNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD"
ORIGIN      
        1 agagccgcag ccgcctagct gggggagagg cccgtccggg gctggctctg agcgccgcac
       61 ggccgtcgga tcccggggac gccgggggcc cgggctgagc gccgcggccc gcgaggagga
      121 gcaccgtaaa tttgctgcca agacaagagg tgtatttctc cagcaatgaa ttcctcattt
      181 cacctgcatt tcttggatct caacctgaat gccacagagg gcaacctttc aggacccaat
      241 gtcaaaaaca agtcttcacc atgtgaagac atgggcattg ctgtggaggt gtttctcact
      301 ctgggtgtca tcagcctctt ggagaacatc ttggtcatag gggccatagt gaagaacaaa
      361 aacctgcact cccccatgta cttcttcgtg tgcagcctgg cagtggcgga catgctggtg
      421 agcatgtcca gtgcctggga gaccatcacc atctacctac tcaacaacaa gcacctagtg
      481 atagcagacg cctttgtgcg ccacattgac aatgtgtttg actccatgat ctgcatttcc
      541 gtggtggcat ccatgtgcag cttactggcc attgcagtgg ataggtacgt caccatcttc
      601 tacgccctgc gctaccacca catcatgacg gcgaggcgct caggggccat catcgccggc
      661 atctgggctt tctgcacggg ctgcggcatt gtcttcatcc tgtactcaga atccacctac
      721 gtcatcctgt gcctcatctc catgttcttc gctatgctgt tcctcctggt gtctctgtac
      781 atacacatgt tcctcctggc gcggactcac gtcaagcgga tcgcggctct gcccggggcc
      841 agctctgcgc ggcagaggac cagcatgcag ggcgcggtca ccgtcaccat gctgctgggc
      901 gtgtttaccg tgtgctgggc cccgttcttc cttcatctca ctttaatgct ttcttgccct
      961 cagaacctct actgctctcg cttcatgtct cacttcaata tgtacctcat actcatcatg
     1021 tgtaattccg tgatggaccc tctcatatat gccttccgca gccaagagat gcggaagacc
     1081 tttaaggaga ttatttgctg ccgtggtttc aggatcgcct gcagctttcc cagaagggat
     1141 taagcacaaa gtgctcctct ctgtggctct gttctccttt gtttgctcac ctatgacaaa
     1201 gcgacagcca aggggtaggc gggagtgcta gcatcccatt tttctcttta ccagctcaga
     1261 catgggccta agaggctctc tctgttcagt tcctggtgat tatgtccaac atgcaagggt
     1321 tgcttatcca ctctggggac agtcatgaca atttcttact gtccttttgt gtcctatggt
     1381 ttctactgct cccacccatt tctgggggcc ccatccaccc tccacctagc aggcatgtgc
     1441 tcggggaatg cacagcaccc tcagtgcaag ccagacatga tgaaacacgt attgtgacgc
     1501 gaagaaaacc gtgatatcga cgccaggtgg gattgcttct tctccccaga agcaggtcca
     1561 cactctgctg gctgcactct gagctatgca tgcttttcag ggaagaaaag agtggccaga
     1621 ttctttccat cagaagcaat ctgttcattt gttctgaaat gtcttctttg ctccccttgc
     1681 ctgaactttt gattcatggc ttttgttcat aattgtctga ata
//
