LOCUS       NM_001025101            2738 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens myelin basic protein (MBP), transcript variant 7,
            mRNA.
ACCESSION   NM_001025101 XM_005266698
VERSION     NM_001025101.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2738)
  AUTHORS   Martin Monreal,M.T., Hansen,B.E., Iversen,P.F., Enevold,C.,
            Odum,N., Sellebjerg,F., Hojrup,P., Rode von Essen,M. and
            Nielsen,C.H.
  TITLE     Citrullination of myelin basic protein induces a Th17-cell response
            in healthy individuals and enhances the presentation of MBP85-99 in
            patients with multiple sclerosis
  JOURNAL   J Autoimmun 139, 103092 (2023)
   PUBMED   37506490
  REMARK    GeneRIF: Citrullination of myelin basic protein induces a Th17-cell
            response in healthy individuals and enhances the presentation of
            MBP85-99 in patients with multiple sclerosis.
REFERENCE   2  (bases 1 to 2738)
  AUTHORS   Zhang,F., Zeng,J., Zhang,X., Gu,J., Han,Y., Zhang,P., Li,W. and
            Gu,R.
  TITLE     Investigation of the relationship between MBP gene polymorphisms
            and delayed encephalopathy after acute carbon monoxide poisoning
  JOURNAL   Neurotoxicology 94, 217-222 (2023)
   PUBMED   36481359
  REMARK    GeneRIF: Investigation of the relationship between MBP gene
            polymorphisms and delayed encephalopathy after acute carbon
            monoxide poisoning.
REFERENCE   3  (bases 1 to 2738)
  AUTHORS   Mancino,D.N.J., Lima,A., Roig,P., Garcia Segura,L.M., De
            Nicola,A.F. and Garay,L.I.
  TITLE     Tibolone restrains neuroinflammation in mouse experimental
            autoimmune encephalomyelitis
  JOURNAL   J Neuroendocrinol 34 (1), e13078 (2022)
   PUBMED   34961984
REFERENCE   4  (bases 1 to 2738)
  AUTHORS   Martinsen,V. and Kursula,P.
  TITLE     Multiple sclerosis and myelin basic protein: insights into protein
            disorder and disease
  JOURNAL   Amino Acids 54 (1), 99-109 (2022)
   PUBMED   34889995
  REMARK    GeneRIF: Multiple sclerosis and myelin basic protein: insights into
            protein disorder and disease.
            Review article
REFERENCE   5  (bases 1 to 2738)
  AUTHORS   Nevinsky,G.A., Baranova,S.V., Buneva,V.N. and Dmitrenok,P.S.
  TITLE     Multiple Sclerosis: Enzymatic Cross Site-Specific Hydrolysis of H1
            Histone by IgGs against H1, H2A, H2B, H3, H4 Histones, and Myelin
            Basic Protein
  JOURNAL   Biomolecules 11 (8), 1140 (2021)
   PUBMED   34439806
  REMARK    GeneRIF: Multiple Sclerosis: Enzymatic Cross Site-Specific
            Hydrolysis of H1 Histone by IgGs against H1, H2A, H2B, H3, H4
            Histones, and Myelin Basic Protein.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2738)
  AUTHORS   Tienari,P.J., Wikstrom,J., Sajantila,A., Palo,J. and Peltonen,L.
  TITLE     Genetic susceptibility to multiple sclerosis linked to myelin basic
            protein gene
  JOURNAL   Lancet 340 (8826), 987-991 (1992)
   PUBMED   1383661
REFERENCE   7  (bases 1 to 2738)
  AUTHORS   Boylan,K.B., Ayres,T.M., Popko,B., Takahashi,N., Hood,L.E. and
            Prusiner,S.B.
  TITLE     Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a
            new form of oligonucleotide repetitive sequence showing length
            polymorphism
  JOURNAL   Genomics 6 (1), 16-22 (1990)
   PUBMED   1689270
REFERENCE   8  (bases 1 to 2738)
  AUTHORS   Kamholz,J., de Ferra,F., Puckett,C. and Lazzarini,R.
  TITLE     Identification of three forms of human myelin basic protein by cDNA
            cloning
  JOURNAL   Proc Natl Acad Sci U S A 83 (13), 4962-4966 (1986)
   PUBMED   2425357
REFERENCE   9  (bases 1 to 2738)
  AUTHORS   Kishimoto,A., Nishiyama,K., Nakanishi,H., Uratsuji,Y., Nomura,H.,
            Takeyama,Y. and Nishizuka,Y.
  TITLE     Studies on the phosphorylation of myelin basic protein by protein
            kinase C and adenosine 3':5'-monophosphate-dependent protein kinase
  JOURNAL   J Biol Chem 260 (23), 12492-12499 (1985)
   PUBMED   2413024
REFERENCE   10 (bases 1 to 2738)
  AUTHORS   Saxe,D.F., Takahashi,N., Hood,L. and Simon,M.I.
  TITLE     Localization of the human myelin basic protein gene (MBP) to region
            18q22----qter by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 39 (4), 246-249 (1985)
   PUBMED   2414074
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018529.12, AB208986.1,
            AK128770.1, AK098402.1 and BC080654.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001025101.1.
            
            Summary: The protein encoded by the classic MBP gene is a major
            constituent of the myelin sheath of oligodendrocytes and Schwann
            cells in the nervous system. However, MBP-related transcripts are
            also present in the bone marrow and the immune system. These mRNAs
            arise from the long MBP gene (otherwise called 'Golli-MBP') that
            contains 3 additional exons located upstream of the classic MBP
            exons. Alternative splicing from the Golli and the MBP
            transcription start sites gives rise to 2 sets of MBP-related
            transcripts and gene products. The Golli mRNAs contain 3 exons
            unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They
            encode hybrid proteins that have N-terminal Golli aa sequence
            linked to MBP aa sequence. The second family of transcripts contain
            only MBP exons and produce the well characterized myelin basic
            proteins. This complex gene structure is conserved among species
            suggesting that the MBP transcription unit is an integral part of
            the Golli transcription unit and that this arrangement is important
            for the function and/or regulation of these genes. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (7) contains 3 exons unique to
            Golli-MBP and exons 1 and 3-7 of the classic MBP. It encodes the
            longer of the Golli-mbp isoforms (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3210695.1,
                                           SRR14038193.2233904.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000355994.7/ ENSP00000348273.2
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-14                AC018529.12        113275-113288       c
            15-805              AB208986.1         1-791
            806-2074            AK128770.1         228-1496
            2075-2731           AK098402.1         1494-2150
            2732-2738           BC080654.1         2109-2115
FEATURES             Location/Qualifiers
     source          1..2738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q23"
     gene            1..2738
                     /gene="MBP"
                     /note="myelin basic protein"
                     /db_xref="GeneID:4155"
                     /db_xref="HGNC:HGNC:6925"
                     /db_xref="MIM:159430"
     exon            1..204
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            205..280
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             230..1144
                     /gene="MBP"
                     /note="isoform 1 is encoded by transcript variant 7;
                     Golli-MBP; myelin A1 protein; myelin membrane
                     encephalitogenic protein"
                     /codon_start=1
                     /product="Golli-MBP isoform 1"
                     /protein_id="NP_001020272.1"
                     /db_xref="GeneID:4155"
                     /db_xref="HGNC:HGNC:6925"
                     /db_xref="MIM:159430"
                     /translation="MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNE
                     VFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGR
                     EDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARH
                     GFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDEN
                     PVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFK
                     GVDAQGTLSKIFKLGGRDSRSGSPMARR"
     exon            281..368
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            369..805
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            806..910
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            911..946
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            947..979
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1099
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..2738
                     /gene="MBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2713..2718
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBP"
                     /note="hexamer: AATAAA"
     polyA_site      2738
                     /gene="MBP"
                     /note="major polyA site"
ORIGIN      
        1 agtcaccgcc gccgcgcgcc agagagaagc agcctccggc cccggcggcc cctgtctccc
       61 gaccccggaa ggcgaagcag gctgcccggg gaccccgcgc gtgggcgctt gaagccgaga
      121 ccagcctgcc cgggcctggg caggcggagc agggccttgg accccgcggc gcccctcggc
      181 ctcggagcaa cgagcgcagc gccgcctctg aagagccaat ccattcagga tgggaaacca
      241 cgcaggcaaa cgagaattaa atgccgagaa ggccagtacg aatagtgaaa ctaacagagg
      301 agaatctgaa aaaaagagaa acctgggtga actttcacgg acaacctcag aggacaacga
      361 agtgttcgga gaggcagatg cgaaccagaa caatgggacc tcctctcagg acacagcggt
      421 gactgactcc aagcgcacag cggacccgaa gaatgcctgg caggatgccc acccagctga
      481 cccagggagc cgcccccact tgatccgcct cttttcccga gatgccccgg ggagggagga
      541 caacaccttc aaagacaggc cctctgagtc cgacgagctc cagaccatcc aagaagacag
      601 tgcagccacc tccgagagcc tggatgtgat ggcgtcacag aagagaccct cccagaggca
      661 cggatccaag tacctggcca cagcaagtac catggaccat gccaggcatg gcttcctccc
      721 aaggcacaga gacacgggca tccttgactc catcgggcgc ttctttggcg gtgacagggg
      781 tgcgcccaag cggggctctg gcaaggactc acaccacccg gcaagaactg ctcactacgg
      841 ctccctgccc cagaagtcac acggccggac ccaagatgaa aaccccgtag tccacttctt
      901 caagaacatt gtgacgcctc gcacaccacc cccgtcgcag ggaaagggga gaggactgtc
      961 cctgagcaga tttagctggg gggccgaagg ccagagacca ggatttggct acggaggcag
     1021 agcgtccgac tataaatcgg ctcacaaggg attcaaggga gtcgatgccc agggcacgct
     1081 ttccaaaatt tttaagctgg gaggaagaga tagtcgctct ggatcaccca tggctagacg
     1141 ctgaaaaccc acctggttcc ggaatcctgt cctcagcttc ttaatataac tgccttaaaa
     1201 ctttaatccc acttgcccct gttacctaat tagagcagat gacccctccc ctaatgcctg
     1261 cggagttgtg cacgtagtag ggtcaggcca cggcagccta ccggcaattt ccggccaaca
     1321 gttaaatgag aacatgaaaa cagaaaacgg ttaaaactgt ccctttctgt gtgaagatca
     1381 cgttccttcc cccgcaatgt gcccccagac gcacgtgggt cttcaggggg ccaggtgcac
     1441 agacgtccct ccacgttcac ccctccaccc ttggactttc ttttcgccgt ggctgcggca
     1501 cccttgcgct tttgctggtc actgccatgg aggcacacag ctgcagagac agagaggacg
     1561 tgggcggcag agaggactgt tgacatccaa gcttcctttg tttttttttc ctgtccttct
     1621 ctcacctcct aaagtagact tcatttttcc taacaggatt agacagtcaa ggagtggctt
     1681 actacatgtg ggagcttttg gtatgtgaca tgcgggctgg gcagctgtta gagtccaacg
     1741 tggggcagca cagagagggg gccacctccc caggccgtgg ctgcccacac accccaatta
     1801 gctgaattcg cgtgtggcag agggaggaaa aggaggcaaa cgtgggctgg gcaatggcct
     1861 cacataggaa acagggtctt cctggagatt tggtgatgga gatgtcaagc aggtggcctc
     1921 tggacgtcac cgttgccctg catggtggcc ccagagcagc ctctatgaac aacctcgttt
     1981 ccaaaccaca gcccacagcc ggagagtcca ggaagacttg cgcactcaga gcagaagggt
     2041 aggagtcctc tagacagcct cgcagccgcg ccagtcgccc atagacactg gctgtgaccg
     2101 ggcgtgctgg cagcggcagt gcacagtggc cagcactaac cctccctgag aagataaccg
     2161 gctcattcac ttcctcccag aagacgcgtg gtagcgagta ggcacaggcg tgcacctgct
     2221 cccgaattac tcaccgagac acacgggctg agcagacggc cccgtggatg gagacaaaga
     2281 gctcttctga ccatatcctt cttaacaccc gctggcatct cctttcgcgc ctccctccct
     2341 aacctactga cccacctttt gattttagcg cacctgtgat tgataggcct tccaaagagt
     2401 cccacgctgg catcaccctc cccgaggacg gagatgagga gtagtcagcg tgatgccaaa
     2461 acgcgtcttc ttaatccaat tctaattctg aatgtttcgt gtgggcttaa taccatgtct
     2521 attaatatat agcctcgatg atgagagagt tacaaagaac aaaactccag acacaaacct
     2581 ccaaattttt cagcagaagc actctgcgtc gctgagctga ggtcggctct gcgatccata
     2641 cgtggccgca cccacacagc acgtgctgtg acgatggctg aacggaaagt gtacactgtt
     2701 cctgaatatt gaaataaaac aataaacttt taatggta
//
