LOCUS       NM_024298               2294 bp    mRNA    linear   PRI 02-FEB-2025
DEFINITION  Homo sapiens membrane bound acylglycerophosphatidylinositol
            O-acyltransferase MBOAT7 (MBOAT7), transcript variant 1, mRNA.
ACCESSION   NM_024298
VERSION     NM_024298.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2294)
  AUTHORS   Varadharajan,V., Ramachandiran,I., Massey,W.J., Jain,R.,
            Banerjee,R., Horak,A.J., McMullen,M.R., Huang,E., Bellar,A.,
            Lorkowski,S.W., Gulshan,K., Helsley,R.N., James,I., Pathak,V.,
            Dasarathy,J., Welch,N., Dasarathy,S., Streem,D., Reizes,O.,
            Allende,D.S., Smith,J.D., Simcox,J., Nagy,L.E. and Brown,J.M.
  TITLE     Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid
            homeostasis and function to control alcohol-associated liver injury
  JOURNAL   Elife 12, 92243 (2024)
   PUBMED   38648183
  REMARK    GeneRIF: Membrane-bound O-acyltransferase 7 (MBOAT7) shapes
            lysosomal lipid homeostasis and function to control
            alcohol-associated liver injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2294)
  AUTHORS   Pan,Z., Alharthi,J., Bayoumi,A., George,J. and Eslam,M.
  TITLE     A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 148 (2024)
   PUBMED   38682204
  REMARK    GeneRIF: A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on
            Immune Cells.
REFERENCE   3  (bases 1 to 2294)
  AUTHORS   Nazmina,G., Khan,A., Jiang,J., Miao,Z., Khan,S.N., Khan,M.I.,
            Shah,A.H., Shah,A.H., Khisroon,M. and Haack,T.B.
  TITLE     Exome sequencing identifies homozygous variants in MBOAT7
            associated with neurodevelopmental disorder
  JOURNAL   Clin Genet 105 (4), 423-429 (2024)
   PUBMED   38088234
  REMARK    GeneRIF: Exome sequencing identifies homozygous variants in MBOAT7
            associated with neurodevelopmental disorder.
REFERENCE   4  (bases 1 to 2294)
  AUTHORS   Radwan,E., Abdelaziz,A., Mandour,M.A.M., Meki,A.M.A., El-Kholy,M.M.
            and Mohamed,M.N.
  TITLE     MBOAT7 expression is associated with disease progression in
            COVID-19 patients
  JOURNAL   Mol Biol Rep 51 (1), 79 (2024)
   PUBMED   38183501
  REMARK    GeneRIF: MBOAT7 expression is associated with disease progression
            in COVID-19 patients.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2294)
  AUTHORS   Phadnis,V.V., Snider,J., Varadharajan,V., Ramachandiran,I.,
            Deik,A.A., Lai,Z.W., Kunchok,T., Eaton,E.N., Sebastiany,C.,
            Lyakisheva,A., Vaccaro,K.D., Allen,J., Yao,Z., Wong,V., Geng,B.,
            Weiskopf,K., Clish,C.B., Brown,J.M., Stagljar,I., Weinberg,R.A. and
            Henry,W.S.
  TITLE     MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated
            phosphatidylinositol remodeling and susceptibility to ferroptosis
  JOURNAL   Cell Rep 42 (9), 113023 (2023)
   PUBMED   37691145
  REMARK    GeneRIF: MMD collaborates with ACSL4 and MBOAT7 to promote
            polyunsaturated phosphatidylinositol remodeling and susceptibility
            to ferroptosis.
REFERENCE   6  (bases 1 to 2294)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   7  (bases 1 to 2294)
  AUTHORS   Gijon,M.A., Riekhof,W.R., Zarini,S., Murphy,R.C. and Voelker,D.R.
  TITLE     Lysophospholipid acyltransferases and arachidonate recycling in
            human neutrophils
  JOURNAL   J Biol Chem 283 (44), 30235-30245 (2008)
   PUBMED   18772128
  REMARK    GeneRIF: MBOAT5 and MBOAT7 in arachidonate recycling, thus
            regulating free arachidonic acid levels and leukotriene synthesis
            in neutrophils
REFERENCE   8  (bases 1 to 2294)
  AUTHORS   Lee,H.C., Inoue,T., Imae,R., Kono,N., Shirae,S., Matsuda,S.,
            Gengyo-Ando,K., Mitani,S. and Arai,H.
  TITLE     Caenorhabditis elegans mboa-7, a member of the MBOAT family, is
            required for selective incorporation of polyunsaturated fatty acids
            into phosphatidylinositol
  JOURNAL   Mol Biol Cell 19 (3), 1174-1184 (2008)
   PUBMED   18094042
  REMARK    GeneRIF: describes the cloning of human MBOAT7
REFERENCE   9  (bases 1 to 2294)
  AUTHORS   Wende,H., Volz,A. and Ziegler,A.
  TITLE     Extensive gene duplications and a large inversion characterize the
            human leukocyte receptor cluster
  JOURNAL   Immunogenetics 51 (8-9), 703-713 (2000)
   PUBMED   10941842
  REMARK    GeneRIF: LENG4 is located in the leukocyte receptor cluster on
            chromosome 19.
            Erratum:[Immunogenetics 2001;52(3-4):308]
REFERENCE   10 (bases 1 to 2294)
  AUTHORS   Fukunaga-Johnson,N., Lee,S.W., Liebert,M. and Grossman,H.B.
  TITLE     Molecular analysis of a gene, BB1, overexpressed in bladder and
            breast carcinoma
  JOURNAL   Anticancer Res 16 (3A), 1085-1090 (1996)
   PUBMED   8702217
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA338950.1, BC003164.1,
            AK055908.1, AI032483.1 and BQ045276.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_024298.4.
            
            Summary: This gene encodes a member of the membrane-bound
            O-acyltransferases family of integral membrane proteins that have
            acyltransferase activity. The encoded protein is a
            lysophosphatidylinositol acyltransferase that has specificity for
            arachidonoyl-CoA as an acyl donor. This protein is involved in the
            reacylation of phospholipids as part of the phospholipid remodeling
            pathway known as the Land cycle. Alternative splicing results in
            multiple transcript variants. [provided by RefSeq, Mar 2009].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055908.1, SRR3476690.678194.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000245615.6/ ENSP00000245615.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               DA338950.1         303-545
            244-454             BC003164.1         77-287
            455-2213            AK055908.1         690-2448
            2214-2214           AI032483.1         83-83               c
            2215-2294           BQ045276.1         21-100              c
FEATURES             Location/Qualifiers
     source          1..2294
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.42"
     gene            1..2294
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /note="membrane bound acylglycerophosphatidylinositol
                     O-acyltransferase MBOAT7"
                     /db_xref="GeneID:79143"
                     /db_xref="HGNC:HGNC:15505"
                     /db_xref="MIM:606048"
     exon            1..243
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     exon            244..322
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     CDS             247..1665
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /EC_number="2.3.1.n4"
                     /note="isoform 1 is encoded by transcript variant 1;
                     leukocyte receptor cluster (LRC) member 4; malignant cell
                     expression-enhanced gene/tumor progression-enhanced;
                     lysophospholipid acyltransferase 7;
                     lysophosphatidylinositol acyltransferase; LPLAT 7; lyso-PI
                     acyltransferase; h-mboa-7;
                     1-acylglycerophosphatidylinositol O-acyltransferase;
                     membrane bound O-acyltransferase domain containing 7;
                     bladder and breast carcinoma-overexpressed gene 1 protein;
                     lysophosphatidylinositol acyltransferase 1;
                     lysophospholipid acyltransferase 11"
                     /codon_start=1
                     /product="lysophospholipid acyltransferase 7 isoform 1"
                     /protein_id="NP_077274.3"
                     /db_xref="CCDS:CCDS12883.1"
                     /db_xref="GeneID:79143"
                     /db_xref="HGNC:HGNC:15505"
                     /db_xref="MIM:606048"
                     /translation="MSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLF
                     TCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTN
                     AVQLLLTLKLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMETLSYSYCYV
                     GIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVR
                     EDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGP
                     TLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQWWLAQYIYK
                     SAPARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEGRLESALRGRLSPGGQ
                     KAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYWASIYFCIHFLALAALGLGLALGGG
                     SPSRRKAASQPTSLAPEKLREE"
     exon            323..452
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     exon            453..579
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     exon            580..739
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1100
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1277
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     exon            1278..2294
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2276..2281
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /note="hexamer: AATAAA"
     polyA_site      2294
                     /gene="MBOAT7"
                     /gene_synonym="BB1; hMBOA-7; LENG4; LPIAT; LPIAT1; LPLAT;
                     LPLAT11; LRC4; MBOA7; MRT57; OACT7"
                     /note="major polyA site"
ORIGIN      
        1 agtgtggacc tggactcgaa tcccgttgcc gactcgcgct ctcggcttct gctccggggc
       61 ttcttccctg cccgcccggg gccctgaccg tggcttcttc cccggcctga tctgcgcagc
      121 ccggcgggcg cccagaagga gcaggcggcg cgggggcgcg ctgggcgggg gaggcgtggc
      181 cggagctgcg gcggcaagcg ggctgggact gctcggccgc ctcctgcccg gcgagcagct
      241 cagaccatgt cgcctgaaga atggacgtat ctagtggttc ttcttatctc catccccatc
      301 ggcttcctct ttaagaaagc cggtcctggg ctgaagagat ggggagcagc cgctgtgggc
      361 ctggggctca ccctgttcac ctgtggcccc cacactttgc attctctggt caccatcctc
      421 gggacctggg ccctcattca ggcccagccc tgctcctgcc acgccctggc tctggcctgg
      481 actttctcct atctcctgtt cttccgagcc ctcagcctcc tgggcctgcc cactcccacg
      541 cccttcacca atgccgtcca gctgctgctg acgctgaagc tggtgagcct ggccagtgaa
      601 gtccaggacc tgcatctggc ccagaggaag gaaatggcct caggcttcag caaggggccc
      661 accctggggc tgctgcccga cgtgccctcc ctgatggaga cactcagcta cagctactgc
      721 tacgtgggaa tcatgacagg cccgttcttc cgctaccgca cctacctgga ctggctggag
      781 cagcccttcc ccggggcagt gcccagcctg cggcccctgc tgcgccgcgc ctggccggcc
      841 ccgctcttcg gcctgctgtt cctgctctcc tctcacctct tcccgctgga ggccgtgcgc
      901 gaggacgcct tctacgcccg cccgctgccc gcccgcctct tctacatgat ccccgtcttc
      961 ttcgccttcc gcatgcgctt ctacgtggcc tggattgccg ccgagtgcgg ctgcattgcc
     1021 gccggctttg gggcctaccc cgtggccgcc aaagcccggg ccggaggcgg ccccaccctc
     1081 caatgcccac cccccagcag tccggagaag gcggcttcct tggagtatga ctatgagacc
     1141 atccgcaaca tcgactgcta cagcacagat ttctgcgtgc gggtgcgcga tggcatgcgg
     1201 tactggaaca tgacggtgca gtggtggctg gcgcagtata tctacaagag cgcacctgcc
     1261 cgttcctatg tcctgcggag cgcctggacc atgctgctga gcgcctactg gcacggcctc
     1321 cacccgggct actacctgag cttcctgacc atcccgctgt gcctggctgc cgagggccgg
     1381 ctggagtcag ccctgcgggg gcggctgagc ccagggggcc agaaggcctg ggactgggtg
     1441 cactggttcc tgaagatgcg cgcctatgac tacatgtgca tgggcttcgt gctgctctcc
     1501 ttggccgaca cccttcggta ctgggcctcc atctacttct gtatccactt cctggccctg
     1561 gcagccctgg ggctggggct ggctttaggt gggggcagcc ccagccggcg gaaggcagca
     1621 tcccagccca ccagccttgc cccggagaag ctccgggagg agtaagctgt cacgacgctc
     1681 cctctgccag ctggtcccgg gaattctgtg aaccaggctg ctgtctcctc cccagaaaga
     1741 gtccttacct tggagagggt cctggagaga atttcctctt ccccagctaa ataccctgcc
     1801 tgcaactgaa gcagacccgg gggtgtcctc cctgccctct gcccagaggc cacctccact
     1861 cctacaaaat caaagtattg tccagacaag agtcactggc ccctgctcca gcttctgggt
     1921 atccagagag cactgcactt ccccaaaacg gaaggggccc ctgggcagtg ggttttgggc
     1981 aaattccctt tctttgcatc cacaatgtgg ggtcggagct tgggggcagg tcctgggagt
     2041 gggaagcctc ttccttgtgt ctttcgctcc acttttagct catcgcacca atattgcaga
     2101 cttggaagga agcataagct tcccatttca caaaggggaa actgaggtgc gggtgcgcgg
     2161 gcctggggac ggccgtccca tggcttccat ctgagccacc tcgggacccc agcactcctg
     2221 gcgccctctt ctcatcgctt ggcctatgac aggtcaccgt gtgtaaatct ttcccaataa
     2281 agtgttgcac aaag
//
