LOCUS       NM_001386889           12302 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens muscleblind like splicing regulator 3 (MBNL3),
            transcript variant 7, mRNA.
ACCESSION   NM_001386889 XM_005262434
VERSION     NM_001386889.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12302)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 12302)
  AUTHORS   Oladimeji,P.O., Bakke,J., Wright,W.C. and Chen,T.
  TITLE     KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma
            invasion
  JOURNAL   Sci Rep 10 (1), 1485 (2020)
   PUBMED   32001790
  REMARK    GeneRIF: KANSL2 and MBNL3 are regulators of pancreatic ductal
            adenocarcinoma invasion.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 12302)
  AUTHORS   Yuan,J.H., Liu,X.N., Wang,T.T., Pan,W., Tao,Q.F., Zhou,W.P.,
            Wang,F. and Sun,S.H.
  TITLE     The MBNL3 splicing factor promotes hepatocellular carcinoma by
            increasing PXN expression through the alternative splicing of
            lncRNA-PXN-AS1
  JOURNAL   Nat Cell Biol 19 (7), 820-832 (2017)
   PUBMED   28553938
  REMARK    GeneRIF: The MBNL3 splicing factor promotes hepatocellular
            carcinoma by increasing pacillin expression through the alternative
            splicing of lncRNA-PXN-AS1.
REFERENCE   4  (bases 1 to 12302)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 12302)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 12302)
  AUTHORS   Self,J.E., Ennis,S., Collins,A., Shawkat,F., Harris,C.M.,
            Mackey,D.A., Hodgkins,P.R., Temple,I.K., Chen,X. and Lotery,A.J.
  TITLE     Fine mapping of the X-linked recessive congenital idiopathic
            nystagmus locus at Xq24-q26.3
  JOURNAL   Mol Vis 12, 1211-1216 (2006)
   PUBMED   17102799
  REMARK    GeneRIF: We exclude MBNL3 as the causative gene in this family.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 12302)
  AUTHORS   Ho,T.H., Charlet-B,N., Poulos,M.G., Singh,G., Swanson,M.S. and
            Cooper,T.A.
  TITLE     Muscleblind proteins regulate alternative splicing
  JOURNAL   EMBO J 23 (15), 3103-3112 (2004)
   PUBMED   15257297
  REMARK    GeneRIF: MBNL proteins promote opposite splicing patterns for
            cardiac troponin T and insulin receptor alternative exons
REFERENCE   8  (bases 1 to 12302)
  AUTHORS   Squillace,R.M., Chenault,D.M. and Wang,E.H.
  TITLE     Inhibition of muscle differentiation by the novel
            muscleblind-related protein CHCR
  JOURNAL   Dev Biol 250 (1), 218-230 (2002)
   PUBMED   12297108
  REMARK    GeneRIF: results suggest that CHCR is an inhibitor of myogenesis
REFERENCE   9  (bases 1 to 12302)
  AUTHORS   Fardaei,M., Rogers,M.T., Thorpe,H.M., Larkin,K., Hamshere,M.G.,
            Harper,P.S. and Brook,J.D.
  TITLE     Three proteins, MBNL, MBLL and MBXL, co-localize in vivo with
            nuclear foci of expanded-repeat transcripts in DM1 and DM2 cells
  JOURNAL   Hum Mol Genet 11 (7), 805-814 (2002)
   PUBMED   11929853
REFERENCE   10 (bases 1 to 12302)
  AUTHORS   Miller,J.W., Urbinati,C.R., Teng-Umnuay,P., Stenberg,M.G.,
            Byrne,B.J., Thornton,C.A. and Swanson,M.S.
  TITLE     Recruitment of human muscleblind proteins to (CUG)(n) expansions
            associated with myotonic dystrophy
  JOURNAL   EMBO J 19 (17), 4439-4448 (2000)
   PUBMED   10970838
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL161442.22 and AL050310.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Sep 15, 2020 this sequence version replaced XM_005262434.3.
            
            Summary: This gene encodes a member of the muscleblind-like family
            of proteins. The encoded protein may function in regulation of
            alternative splicing and may play a role in the pathophysiology of
            myotonic dystrophy. Alternatively spliced transcript variants have
            been described. [provided by RefSeq, Dec 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038196.2531330.1,
                                           SRR14038191.4303734.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370853.8/ ENSP00000359890.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AL161442.22        46395-46582         c
            189-1068            AL050310.6         106515-107394       c
            1069-1233           AL050310.6         73308-73472         c
            1234-1425           AL050310.6         59223-59414         c
            1426-1662           AL050310.6         57927-58163         c
            1663-1813           AL050310.6         53741-53891         c
            1814-1849           AL050310.6         51743-51778         c
            1850-1944           AL050310.6         49258-49352         c
            1945-12302          AL050310.6         36400-46757         c
FEATURES             Location/Qualifiers
     source          1..12302
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="X"
                     /map="Xq26.2"
     gene            1..12302
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /note="muscleblind like splicing regulator 3"
                     /db_xref="GeneID:55796"
                     /db_xref="HGNC:HGNC:20564"
                     /db_xref="MIM:300413"
     exon            1..188
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            189..1068
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     CDS             892..1956
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /note="isoform 1 is encoded by transcript variant 7;
                     muscleblind-like protein 3; Cys3His CCG1-required protein;
                     muscleblind-like X-linked protein; muscleblind-like 3"
                     /codon_start=1
                     /product="muscleblind-like protein 3 isoform 1"
                     /protein_id="NP_001373818.1"
                     /db_xref="CCDS:CCDS14633.1"
                     /db_xref="GeneID:55796"
                     /db_xref="HGNC:HGNC:20564"
                     /db_xref="MIM:300413"
                     /translation="MTAVNVALIRDTKWLTLEVCREFQRGTCSRADADCKFAHPPRVC
                     HVENGRVVACFDSLKGRCTRENCKYLHPPPHLKTQLEINGRNNLIQQKTAAAMFAQQM
                     QLMLQNAQMSSLGSFPMTPSIPANPPMAFNPYIPHPGMGLVPAELVPNTPVLIPGNPP
                     LAMPGAVGPKLMRSDKLEVCREFQRGNCTRGENDCRYAHPTDASMIEASDNTVTICMD
                     YIKGRCSREKCKYFHPPAHLQARLKAAHHQMNHSAASAMALQPGTLQLIPKRSALEKP
                     NGATPVFNPTVFHCQQALTNLQLPQPAFIPAGPILCMAPASNIVPMMHGATPTTVSAA
                     TTPATSVPFAAPTTGNQLKF"
     exon            1069..1233
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1425
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1662
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1813
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1849
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..1944
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     exon            1945..12302
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2400..2405
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /note="hexamer: AATATA"
     polyA_site      2418
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
     regulatory      9600..9605
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /note="hexamer: AATAAA"
     polyA_site      9618
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /note="major polyA site"
     regulatory      12282..12287
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
                     /note="hexamer: AATAAA"
     polyA_site      12302
                     /gene="MBNL3"
                     /gene_synonym="CHCR; MBLX; MBLX39; MBXL"
ORIGIN      
        1 gctttaaaat ggcggcattc agtatgcacc cctgctaaag gctctcccgg caccggggcc
       61 acctcgcgca gcgctgcttt tgcttctgcc gctaacagat ggcatgtgcc gctgtcgctg
      121 ccgctgcccc tgctgctgcc gctgagagca gggcccctta gcctctgggt ttgcgctagc
      181 agcgtaaggt tctgaaaagt gccttttctg aaaactctgc tgcttggatt ctactctaga
      241 gctgtctctt tataaacccc tctccctacc ataccgttcc ctgccctctc cacctccccg
      301 ccgaacctgg tgtgcttgta gtttactgtc agcagctggt ccatttcttt tttctgtgat
      361 tctcaatttt cttagtcatt ttccctccac ttgattttgc aacgaaactt tttttgggtt
      421 ctaacatcct tcccaatctt gttatttaaa gctaataaat agggagaaaa acttttctcc
      481 ccctgatctg agaccattcc acaaatcgaa gggcagccag cagcatatgt tttttgcaag
      541 aataattgaa aacatcaact gcagagccca gaattctttt gaaagtctgc cggttattta
      601 acataaattc ggcaaaggaa caaaataaag cattcattat cttaacagtt ggcttcttaa
      661 gagttggtct ctaatttcat ttttagttat tctgatagtt tttatgattg gctttttgtt
      721 tgactagacc agatttgact ttaatgaaaa cctaagtgtt aacaaataga catttcacca
      781 aagcaacctg ttatctcttc gcacttagtt tgaattcatt tttaatcctt taatagtcca
      841 cagtaatatt gtcctaaaga gggtacattg gattttaatt ttgctttcaa tatgacggct
      901 gtcaatgttg ccctgattcg tgataccaag tggctgactt tagaagtctg tagagaattt
      961 cagagaggaa cttgctctcg agctgatgca gattgcaagt ttgcccatcc accaagagtt
     1021 tgccatgtgg aaaatggtcg tgtggtggcc tgttttgatt ctctaaaggg tcggtgtacc
     1081 cgagagaact gcaagtacct tcaccctcct ccacacttaa aaacgcagct ggagattaat
     1141 gggcggaaca atctgattca acagaagact gccgcagcca tgttcgccca gcagatgcag
     1201 cttatgctcc aaaacgctca aatgtcatca cttggttctt ttcctatgac tccatcaatt
     1261 ccagctaatc ctcccatggc tttcaatcct tacataccac atcctgggat gggcctcgtt
     1321 cctgcagaac ttgtaccaaa tacacctgtt ctgattcctg gaaacccacc tcttgcaatg
     1381 ccaggagctg ttggcccaaa actgatgcgt tcagataaac tggaggtttg ccgagaattt
     1441 cagcgtggaa attgtacccg tggggagaat gattgccgct atgctcaccc tactgatgct
     1501 tccatgattg aagcgagtga taatactgtg acaatctgca tggattacat caaaggtcga
     1561 tgctcgcggg agaaatgcaa gtactttcat cctcctgcac acttgcaagc cagactcaag
     1621 gcagctcatc atcagatgaa ccattcagct gcctctgcca tggccctgca gcctggtaca
     1681 ctgcaactga taccaaagag atcagcactg gaaaagccca atggtgccac cccggtcttt
     1741 aatcccactg ttttccactg ccaacaggct ctgactaacc tgcagctccc acagccggca
     1801 tttatccctg cagggccaat actgtgcatg gcacccgctt caaatattgt gcccatgatg
     1861 cacggtgcta cacctaccac tgtgtctgca gcaacaacac ctgccaccag cgttccgttc
     1921 gctgcaccaa ctacaggcaa tcagctgaaa ttctgaacag cagagttatg gagtatcaga
     1981 atctttccat ggaaacctcc atatggcctt tctatatata ttctcgtatg tcttattcta
     2041 ccaacacaac aataagcgtg ttgcagtcaa tgtattaagc aaagcaaacc tgccagccag
     2101 caaattcaaa taaaaaataa agcattaaaa atcaatggag atgttaaaac aacacaaata
     2161 gaaaactagt aactaccatc catcctattt gaattatcaa gcagaacatg accataaaat
     2221 ttggtaactt gttacattac tctttgtgat tttctaataa ccatgctaag tgtatttcca
     2281 cagtgagctt ttggcttact atatacattc ttggtggata aattgttcat ctgtttttga
     2341 agtgttacct tactattttg tttacaagat agtctattgg gttgattcag gatgtaacaa
     2401 atatattcag taccatttct tgtgttgtat tgtgttgtgc tgtgttaggt ttttacatac
     2461 tgtagtgttt tgctgtatat gtgtggtgtt tgatttcaac taaagtgtta ttagtgggga
     2521 acagaagtat atgtgcttaa gaacatgaca ggttcatgca aatatgctct ctttctttag
     2581 aatatttctg taggtttctt gggactgaca tttaaaacgc ctcacttttg aatgtgcaca
     2641 aaacctgctc attaacatgc atgtgtataa tttgtacctg cagatctgat gttgcataat
     2701 acaatcaaat tactagattt tttaaagaga gaaataatta cctgcacaaa gcagagaact
     2761 tcataaaaca ttaaccccta attcactctt cttaaatagc ttggcaaata agactttacc
     2821 tttaaatgaa tttctcagca tttatactaa aaattatgta aagtgctcat tagatttttt
     2881 gtgtgtgtgg cttgagaatc ccatctccta aattgagtgt ctaaaactga gccatttgtc
     2941 atcttcagct gagaaactgg tacttgggag cttaaaaata tgctaattac aagttataaa
     3001 tcaaacggag agatgggggc atggagatag tttttacgta ctggaggaaa gtgtgtaaaa
     3061 ccatggcaat gtcacctttt acacaaatgc cattttccaa atgcaaatgg ctcatgctct
     3121 ttagactact ctttgaataa caagtaagat gcaatctagc aaaagtcagt cagggtgaaa
     3181 gagaattggt tgcaaatgag gacttccctc cccaaatgga cagtcttctc tgttgatcac
     3241 agagggagcc tgagtacagg cttggagaaa tggctaggac agggaacagg gaagcactta
     3301 caattattcc ttgatttatt caaaagaact gggaaagatg gttgtagttg tctttagctt
     3361 cggttcaact gagtttcgtt ttgttaaaca gttcagtgaa ggagaaagca cctgtgatat
     3421 atggcaagtg tccccctgcc caaactttaa catcagaccc tctcacatca taaccaagcc
     3481 tcttttatgc ttgtttggat tcgtttgcct ttatatatgt ttgaaaatga caatagaaag
     3541 ggttttatca ccctttgaat gagacagagt ggctatactc cacagagctc agctgagttc
     3601 acattactaa tatttatgaa agaattttac aaccaaataa ttcctgtggt gtgtgacata
     3661 tctcatccac tctactcatt tattaatgtt attatacagt ggtggaaaca catgacattt
     3721 tacatcaagt aatagattta atattttcta gtaaataggc gctcttccac cagaaagtat
     3781 aaaaccatca tatacatata tatatatata tataatggtt tttctccttc atgaaaatga
     3841 caagtaaaaa gcaaatctga ttgaggatac cttaagctgg ctagaagtgt ttgaatcaca
     3901 gaacaatgga attagcaaaa tcctttttat agttgatgga actgaatcca ggggcatatg
     3961 acttgcccaa ggctacctta gccattgtgg gacccagaaa tatctcctgc ttcccattgt
     4021 tcctcctttt cacattgttt ttgcttcaga acatttgatg ctctcttcca aagcagaccc
     4081 atttggctca gaatataaga gagcaaaatt agctttctgg gaattgatac tctgttgatc
     4141 ttaattatcc atccaaatcc tgatcaacag tgctttctaa acagccttgc ttgtattgag
     4201 tcattgtcag ctgttgacaa tgttgcgtgg aattagagat caagagttgt cctgaccttt
     4261 acctatggac tctttgaacc agttaatttc tatttctgaa atcttaacat tgctatagaa
     4321 gaaagtagtg tatgcctttt tgaaattcat catgtatgga actgagtttt gtatgatccg
     4381 tgccagtgcc tctccagaag ggcagatctg attacatgaa tccaggaggg atgcacctga
     4441 gctagtctgg atatattcct taaaggagac aagaactttt ttgtgcaaaa tgaacttttg
     4501 tgtagtttga catctgcatg cagtgaactg tctcacttaa ctttttcaac tttgggcaaa
     4561 gatatacata aaccatagat aatagaccta cagtacagct gttttcatgt tgcgttaagc
     4621 actggaagac attaacaatg acttacctta aagtaaaagg ttccgtgagg ggtatttagg
     4681 gccactgtat ttttggtgcc acaattttct acattgttgg cattttaaaa gttgttttct
     4741 aaatgaactt aaagaaagaa agctcaaagc cctaaagttt tgatcaaatt caatagagtt
     4801 ttcagaaaaa aatacaattt taagatagca ctctttaaac tagatgtgca atgacttatt
     4861 caaattatct ttattcaaga aaagagaaaa gaagaaagat aagtcattag actataaatt
     4921 tccatttaaa aagacaagtc acaaaactaa tcagtgactc taaacaaaaa tttactggat
     4981 gaattgtata tataaaattc taatcactta tgattcttag ttaacatttt ataagctttg
     5041 tattttacag gggcctctat ttatccaaat ttattgtttt tgtccatttt tctcagcctt
     5101 ttgcaaaaaa tatgcaagag tgctgaaact tggataaaac gggtcatgta tacagagaaa
     5161 ataatctaaa agttatcttt aagagggttt tagtagtgtc aactttttaa aaaagtacta
     5221 tgtgaccata acatacgtat attttaaaga gggattaaga ttaaattaaa ataaatggat
     5281 tcataaaatt gctatttaaa tacagtattt acttttgtaa ttgaagcatg attccacaac
     5341 cagctgtggc attttatttc acttttctag atcagaggct ttaatttgta gttaatcatg
     5401 atgtggaaag tcatcttctc tctactccat caattttttt catccgtttt tgaacatgct
     5461 gaagcacttt gatcttgcca taagtgttgt cctataccac taggtggtgt tcactaatgg
     5521 gagggcctca gctcaccggc tctccaattt gggaaaaagc aagtacctcc tccctaccat
     5581 cagcagaaac tgaatgaaat taatctttgc aacttgaatc tgttttaagt agcattacca
     5641 ataagcatag tggtatctga ataaggaatg acatttacat tacattttat taaataagag
     5701 agaaagttaa tgtgctactt gaaatgttat ttggttcttt gtccccctca ttgcagagta
     5761 tagataagga tgctcttagg taaaatgcag ccacaagttt tccgagttcc tttagtctgt
     5821 agggtaggct atgaggtaca gaatgattag aaactgaaat cctcattatt tttctctcaa
     5881 atacatttca catacattga aacagaaata ggcaaaattt atgagggaaa tctgatttcc
     5941 caattctgat gaatagatat actaagacag tagccttgtt taaccagtgc ctgtagaagg
     6001 cactagaata aatagcatgt ccaagagtat aacaactttt tttgtaaatt tagttactag
     6061 cctaatcaaa ctgtaaatat aactcactaa ttggtaccat attttcattt ttcttattgt
     6121 tcatctttaa ggtttcattt tattgctttt ttgtagctct aagtaactaa tcaatttaat
     6181 ttcaaaggaa agttaaagaa agtttaagct tttactgcat ggattctgcc cgcctagcta
     6241 ggttctgaac tgacactgaa gtatgacaag atacagatta tagtccaaaa ctatccttta
     6301 cagttcacaa tttaagaaca aatttaactt tatatacaaa taataattgt tatctaatta
     6361 tatttagttg ttgctttggc aacaaaatta caacatggct acctttagac atttgtgtat
     6421 gtgaacattt tacttgtaaa ctataggtga tttgtgacag tatgagcctg tagaaaatac
     6481 agctcaaaac tatgaaaaca gacatggttg agttcttttt taatcccaaa ggcccatata
     6541 taaaagctga atttgtgtcc ttgtgtgact ttttgtgaaa aagtttataa cacatggatt
     6601 ctagaatcag gctttatagt ttatagaatt tgttgtgtgg atagggttat tccacagtat
     6661 ttagacttca aaacgcaatc attgcatttt taatacatta cctaactttt tttataactt
     6721 aattcaaaat taccccattc aagtggcata gctgtagctg caaaaattct gttttctgga
     6781 attacatgag caaatatagc tatatgagga ttaatgtatg actaaagcct cttttgaaat
     6841 taattcatat ttttaaaact atacataaag atactgtgga atgacccctt aacagtgttt
     6901 aagaaacata tgctgcagtt aattgactgt ctcagttagg gtgcggatgt gtgagacaca
     6961 ccttttttgc acttatgtac atagtccatg aaagcaatcc ttggagcttt ttttaaatgt
     7021 aagaagtctg tgataatagt ggaaaagtta gtaagagaga gttatttcta aggctttgaa
     7081 aaggagggtg tttttgctct aagacttaac taaagcataa tgttgctttg ctgttacgga
     7141 ggctttctag tttgctacag gtcaccaaaa gagaaggcta gtaacaggta acaggtcagc
     7201 ctcagctaac agcactgaac aagagtagaa taacttcatc ttttaacaag atcattagca
     7261 aagattgttt gctttttaaa ttaatccccc ctataaacac acacacacgt gtgcacacac
     7321 acacacacac acacacaccg ggcagtttct agaacaagtt ttcctttttc agtggttgta
     7381 agcagtgaaa tacctcatgt attacaagat agatattacc gttatgatag aataagattt
     7441 catctttcac agaaagtgat cagctgatat atgtgtcagt taaaatgttt atcaattaat
     7501 aggtatttaa gtgacaaatt gttaatgttg accattgttc ctcctttaag atccagtaac
     7561 caaaaccaaa tcggtaacca ttgaaagatg atatttaaca gttaaggatg gccagcatag
     7621 ggccgttcat tcccttcaac aaagggaaaa aaaatgctcc tggcacaact ttataactgg
     7681 cttcatttac attatacctg ttcagtggaa gctgtttttt gacctacctt taccagatta
     7741 caaagtagtt aactgtgcca cttcagcctc ccactgtttt gttttaacta aacagaagag
     7801 aaccagccaa aatcttacgt aacacaggag ctggaagaca atgtttcaat ctgaccatct
     7861 ctgccaattt tagctcccac gccacctata gatagccagt taactttctt tttgccccca
     7921 ggcaatgagg cctagaagag gtcaaggtta gaaaggttaa gcatttgatc actacaggta
     7981 cttgtagtac ctagagaagg aacccatcct ggggttggtg gagttggtat tgctactcgt
     8041 tttgatagtt ctcatttaca gagaaagaaa aataagccaa agccagaaag caatccaagc
     8101 cttacagttg tccaatacct cagggccagt tggctagaat tttcttttcc ctcagcccat
     8161 aatcacttag agttagccat acaacaaaca gcctgacaat ctgaccagca tttccattga
     8221 tataaaatgt aagcattcct tcattctgta gttaggaact ccaacttcag ccttatctcc
     8281 aacataattt cccaatttaa cctatgtact gatatggaca tttctttgtg aatatgccag
     8341 attcaagaat gtatttttct aaggtcaata gagatacgac attttaagtc aggaaaaatc
     8401 acctataaat tagtaggaat aactgtagaa gcatcacaaa agatacccca tgaatagatg
     8461 gcatggtgtg catgctgaca gccacggggt catactctgg agtttcaaca tagaggctgt
     8521 gtttcaataa ataagacaaa ttggggaatt aagtaaaaca aatggatgta actgaggccc
     8581 ccccccaaaa aaagccctct attactaacc tcaagaaaat atttagtttg actaatttgt
     8641 gcagtttcca gctcttctac ttgttcttgc ctgtaagaga atcactaata ctcaaaagct
     8701 ggattattga agagaaattt tatctttaaa tagaatccat ccacaattat ggtatatgta
     8761 aaaaaaatgt atgactatga aataagtcgc agctctttgc agatattgca aaatccttgc
     8821 taggcatcta catcatatta gttttttaaa aaatacctct gtaacaagac ctaaaagtaa
     8881 cctaactatt aagcagtgct tttttctctg aaaacacaca acctaaagat ttatctgtca
     8941 taaaactgca tggttccaga gctttatttc tgtgtagaga tgctatttgt tagtgatgga
     9001 aacaaattac tttgttgcta tgtcttttgt gtctagcagt tgagagaatg atatgaccat
     9061 catatcactg gattatggga atgaatgccc ttttcaaaat aaacttattt attaatattt
     9121 taatattatt ttaatattat aatattaata atattttaat attattgttg ctgctttaac
     9181 agaaaatgag ccatttgtcc ccatgctccc aaattacaat gatttaaatt aaaaaacttt
     9241 tgaaggattt tcctaaatat attctttttt aaaggactaa ctttgtgcat tcatataaca
     9301 acaatttgga ataatgtgaa aaatggaggc acataatttg ggtggaaaat ggcgattaaa
     9361 aatatatata agaaaattat tagccatgtg taacatattt aaataatgac cagaatattt
     9421 catgagtacc aactcttccc atagtaattt tcctccaaaa tgcaatagct cattccctca
     9481 actgcagacg ctttgatttt ttttcaagtt atagtgctgt agtgcttgtt tatgtttaaa
     9541 agtgcacatt atgcagctca ttttagtatg ctacttctat gtttattttt tgttcttcta
     9601 ataaaatgca taaacttctt ggttatgtct ttttttatga atccatattc acacattagg
     9661 agttcacttg aaggctattc atgctctagt atattaatcc taatatttag taattctaaa
     9721 atgaaattta aatttctgat ttggctcaat gttatatttc atacatagag taaatttatt
     9781 tccaaatata ccatcagtat tttgaattat gtagataata tatccgttgt gttagaccta
     9841 ttactcttat aagattgaag ttactgacac aagaaaaaca cttctatttt aataaaagaa
     9901 tacttaaaat tttgagagaa tgcttactag tttctcttgt gcctcagaaa tcctgaggca
     9961 tattctaaga tgcattatta gaagtttctc tttcccagtt attcatgtct atcctgcatc
    10021 cctagtgtaa catatgaaac cagtgttgtt tatttcatac tttccagatg ggcatcaatc
    10081 atttcataac aatgagatgc atgaattttt ccattaaaat gttttctctc acttaaaatt
    10141 ggttatcttc aacaaatggc acagtaataa aaggatgatc atttttgttc tttaagaaag
    10201 taaatgtaat ttagtaatac tttattctgc cttatttcaa aatgcttcaa aaatgcgaat
    10261 ctggaacttc tctgcattga ccactgttct ggagttgggc tgatagaaaa ctgcggtgaa
    10321 gagagtttag atcagaggct atggcagagc aaagtattac tgatgtgtct cttaacagtg
    10381 aagagggtcg gggaggaggt tgggtccttg tcaagtgtca gctgccctat acatagttct
    10441 cttgcccctt gtgccctgtt ttactatttc taaggtggtt cccatgatgg catttcttga
    10501 taagcccact ttgagccgtt taatgttttg taggtgtttc tgtgagtctg ataataccag
    10561 cactaaaaac agttcagtat atagacattt acaagaggtc ttaggcctct tcagaattca
    10621 gttaatgtct ttctctttga ggctgctgaa tgttaggtaa gaattcaggg caagcattcc
    10681 cgaccatcat caaattggag acttggagtt tctattggct ggaagaaagt tgacccacag
    10741 gcaaaaccag atgtaaacca agtttgtctt gggtactttt caaattcttt tcacagcatc
    10801 cttttctcat ccctcatggt ggcctctggc cctggaaaat cctcatgata gcaacttatc
    10861 aggcctgttt cctctgatag atctggactt ttccccttaa gtgctttcct gttgggcttc
    10921 tcagactatg gagaactgct catagttgag atctaagaga caaattaccc tatggtgttc
    10981 aagaatggcc gtatttagta tactgcctgt cctggaagtg ttcacattta aaaaggcatg
    11041 actttccaat gggcaaatat cagacaccta catgcataga taagggaaat atgttttact
    11101 taagcaaact tctaggcatt gaatctcagt gtttaggtgc agagatggaa ttcctataag
    11161 caatgcagtc attcaccaca tcaggaaggc caaaaaatga acactctcgt aattttgtta
    11221 ttatctggaa agttctgata tgataatgaa cctaaaatac tgaatagata gtgaacatcc
    11281 taaaattcca ctgaccagaa tccattccca tggtcatcat ctgtagaggg catgatacaa
    11341 tgacaggcct gaggtatgat tataattctg gagtaattta aagcctatat ttgttaaact
    11401 ttaacagatg gacacacatt ctctgatttt ctacttggct ctttcctgta ctagaaatgc
    11461 gcatttaact aaaccttccc agcttttctg ttcagtgcct gacttacact actcccttag
    11521 gcaggaggac agtgggtgtc tggggaataa aagccaagag ctccaaacag aggattttgg
    11581 atacaaaggg cagccaccag gaaatagctt tgtgagaggg acagactatc tgattcccat
    11641 ttgtacaaac atgtccaaag caaaagcaca gcattctaaa gtggatgcag aaattagtat
    11701 acaatggcag ttctggccag tgcagcccag catttttctg ttgtgcatgg aaagaacaca
    11761 gtgaaaaggc aggcagggca tccggtgcaa agtgcaacag acatagacac acaaatccag
    11821 ttttcctgat gagagaggga gctatctctt cataagtgat gcaatgcaat gcaggcatgt
    11881 acaagtacaa ggaaagattt atttttaaaa aatcatagtg taactggatg aataccagca
    11941 acagcacctg ctaaagcaaa cagcctgttc attaaaaact ggacttgagg gaatggagaa
    12001 agaatctgag gagcctgcag tcagcatgct tgcagagacc ttatggctac agaagacgat
    12061 gattaaccca tagaggttca atgtagtttt caagaagagg gtgggaaagc ataagatggg
    12121 gactaagact ttgcctttaa ccttcatgac atgaagaatt gaatgactct ttgttggaaa
    12181 aaatggcagt tatgagataa ttggatccat gttaattata tatatttctg tatatatagt
    12241 aagtggttat tgatgtgcct ttgttaacca tttcactatt taataaatgt gtgtgtagtt
    12301 ta
//
