LOCUS       NM_203406               4277 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens metallo-beta-lactamase domain containing 2 (MBLAC2),
            mRNA.
ACCESSION   NM_203406 XM_087657
VERSION     NM_203406.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4277)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4277)
  AUTHORS   Malgapo,M.I.P., Safadi,J.M. and Linder,M.E.
  TITLE     Metallo-beta-lactamase domain-containing protein 2 is
            S-palmitoylated and exhibits acyl-CoA hydrolase activity
  JOURNAL   J Biol Chem 296, 100106 (2021)
   PUBMED   33219126
REFERENCE   3  (bases 1 to 4277)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4277)
  AUTHORS   Diene,S.M., Pinault,L., Keshri,V., Armstrong,N., Khelaifia,S.,
            Chabriere,E., Caetano-Anolles,G., Colson,P., La Scola,B.,
            Rolain,J.M., Pontarotti,P. and Raoult,D.
  TITLE     Human metallo-beta-lactamase enzymes degrade penicillin
  JOURNAL   Sci Rep 9 (1), 12173 (2019)
   PUBMED   31434986
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4277)
  AUTHORS   Buschow,S.I., van Balkom,B.W., Aalberts,M., Heck,A.J., Wauben,M.
            and Stoorvogel,W.
  TITLE     MHC class II-associated proteins in B-cell exosomes and potential
            functional implications for exosome biogenesis
  JOURNAL   Immunol Cell Biol 88 (8), 851-856 (2010)
   PUBMED   20458337
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093510.2.
            
            On Nov 23, 2018 this sequence version replaced NM_203406.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.246008.1,
                                           SRR1660807.71450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000316610.7/ ENSP00000314776.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-933               AC093510.2         11403-12335
            934-4277            AC093510.2         24622-27965
FEATURES             Location/Qualifiers
     source          1..4277
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q14.3"
     gene            1..4277
                     /gene="MBLAC2"
                     /note="metallo-beta-lactamase domain containing 2"
                     /db_xref="GeneID:153364"
                     /db_xref="HGNC:HGNC:33711"
                     /db_xref="MIM:620907"
     exon            1..933
                     /gene="MBLAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             480..1319
                     /gene="MBLAC2"
                     /EC_number="3.1.2.2"
                     /EC_number="3.5.2.6"
                     /note="metallo-beta-lactamase domain-containing protein 2;
                     beta-lactamase MBLAC2; acyl-CoA thioesterase MBLAC2;
                     palmitoyl-coenzyme A thioesterase MBLAC2"
                     /codon_start=1
                     /product="acyl-coenzyme A thioesterase MBLAC2"
                     /protein_id="NP_981951.2"
                     /db_xref="CCDS:CCDS4067.1"
                     /db_xref="GeneID:153364"
                     /db_xref="HGNC:HGNC:33711"
                     /db_xref="MIM:620907"
                     /translation="MSALEWYAHKSLGDGIFWIQERFYESGNRANIWLVRGSEQDVVI
                     DTGLGLRSLPEYLYSSGLLQDREAKEDAARRPLLAVATHVHFDHSGGLYQFDRVAVHH
                     AEAEALARGDNFETVTWLSDSEVVRTPSPGWRARQFRVQAVQPTLILQDGDVINLGDR
                     QLTVMHMPGHSRGSICLHDKDRKILFSGDVVYDGSLIDWLPYSRISDYVGTCERLIEL
                     VDRGLVEKVLPGHFNTFGAERLFRLASNYISKAGICHKVSTFAMRSLASLALRVTNSR
                     TSP"
     exon            934..4277
                     /gene="MBLAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1960..1965
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBLAC2"
                     /note="hexamer: AGTAAA"
     polyA_site      1967
                     /gene="MBLAC2"
     regulatory      4258..4263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBLAC2"
                     /note="hexamer: AATAAA"
     polyA_site      4277
                     /gene="MBLAC2"
                     /note="major polyA site"
ORIGIN      
        1 gtacaacccg cgaggcccca cactttctgc gccagctggg agtgcgcgcc ctgcagagcc
       61 agtgggtggg cggttctagc tcttcccacc ctcactgcgg gcctctgctg tcacacgccc
      121 ggggtggcga aacggtcgcc acctgagtct ccattctgct gcagtggccc ctgcgttaaa
      181 gctctctcgt ggtgcggctg ccgaggctgc ggtagctcct gcgcccccgt gctggtggcg
      241 cagcctctgc ttgctgccga cctggcggaa gggtgcggga gcgcacgcta cgggcagcgt
      301 cggtctgcgt ccttcctcct cctattccga cccccgcatc ccacgccccc gcctcgctct
      361 acgcctcctc cctggctgca ggcagaccgc ttcacacagc cgcagtgccc tgtgtgtgga
      421 cagcctgtgg gagactcgca cgcccacact caccccgcct ggctgcaccc ctgcccagca
      481 tgtcggcgct cgagtggtac gcccacaagt ctctaggcga tggtatcttc tggattcaag
      541 aacgtttcta cgagtcgggc aaccgtgcca acatctggct ggtgcgcggc tccgagcagg
      601 acgtggtgat cgatacaggc ctggggctgc gcagcctccc ggagtacctg tactcctccg
      661 gcctcttgca ggaccgagag gccaaagagg acgcggcgcg ccggccactg cttgccgtgg
      721 ccacccacgt gcacttcgac cactccggcg gcctctacca gttcgaccgc gtggcagtgc
      781 accacgccga ggccgaggcg ctggctcgcg gggacaactt tgagaccgtg acctggcttt
      841 ccgatagcga ggtggtgcgg acgcccagcc ccggctggag ggccagacag ttccgggtac
      901 aggcggtgca gcccaccctc atcctgcagg atggggatgt gatcaacctt ggtgacagac
      961 agctcactgt tatgcacatg ccaggtcact ccaggggcag tatttgctta catgacaaag
     1021 accgaaagat tctcttcagt ggagacgtcg tgtatgatgg atcactgatt gactggctcc
     1081 catacagcag gataagtgac tatgttggaa cttgtgaacg tctaatagaa ttagtggaca
     1141 gaggtctggt agagaaggtg cttcctgggc acttcaatac ctttggtgct gaaaggcttt
     1201 ttcgattggc ttctaactat atttcaaaag ctgggatatg tcacaaagtt tctacttttg
     1261 ccatgcgatc tcttgcaagt ttagctctac gtgtaacaaa ttctaggacc tcgccctagt
     1321 atctatactg ataatatatt ttgattaatt atatacatta attcattctg tgctatttaa
     1381 ctgattaata gtgagcattt catgaagtgc ttttatacca ctattatata tcagagaaag
     1441 attgagaatg aataagccaa aaagaaaatt gttagtttaa attgttttct ttcttccaag
     1501 aaagaagcca cttaaataag cttatacttt gccaaagctg tcatcttgta atatatgctc
     1561 tagaaatgac ataaaggttt atggggaagc aaagagagat tttgtggcaa gagaactgcc
     1621 cttgcctctg tttttcttgt tttattccct tgatgaccta gggaaaaaaa ggcatgtaga
     1681 gtattatgtt tatactttaa acttgatatt tttagtgtat tatttaaaga taaaggttct
     1741 tgggtttaaa atacattaga acttaatgca gacatataaa gtaacattga gaatgacaac
     1801 taaaacattc cattgttatg gtcctgaatt ttttatgctt catttcatgt atttattctt
     1861 tgtataatta tagcatacat gttatgtaat ataacttatg aaaagtacag tgaattttgc
     1921 tttattgcaa agctttaaat ataaatttca gagtgcttca gtaaaaagct actatatatt
     1981 gttgtttgtt attgtgtagg taatattttc aattatgaaa gtgaaatgca aatgtctgtt
     2041 atctaactac aaattgtcag atttcttaaa aggacactgt caggcaaatt tgaaaatata
     2101 cacattgaga ataatttttt attattatat cctattttaa tattaacagc tattatgaac
     2161 aaaatttttc ctgttaaata gcgacttcag tattgtgtta tgttttacag cgttaaaaca
     2221 actatgaaga tctgcagcta ttcttttact taacatgcat atgtactaca gagggatttt
     2281 taaattaatt gcaaaatgtg cattagctat tgacttagag tgaattgcct tttgtatcct
     2341 gattcacaac acctattcct gttcagtatt ctttgtcttg aatagagaag tctatgttcg
     2401 taaagtcata taaaaggtta taccactatt tagtaaaaag ttttagtttg gtgctgttaa
     2461 taataatttg ctaaaaggcc ttttagaata tttcataaag ggttttaaac agttttttcc
     2521 cactgccttt ttattattga catatctaaa accaaactga aatcgctttg gaaatcagat
     2581 tttttaatgt taggaagatc cagcaatttt ggtttctgaa aaattacaaa acttttctac
     2641 cctacagatg cccaggttct ttagtttttt attcattcaa ctcacacaca cataaacata
     2701 tacatacaca aacacaatcc cacatgcaaa cacacacagc cacatatata catgtgtagc
     2761 acagcgctaa acactgtgga ggctaaaaaa agtcaaagac aacattataa ctaaaagtcg
     2821 aaagcacaca aaatataaat aatagtgtat gcaagttaat gtacattata catgcgtgta
     2881 agggacataa atggaggggt gtgaactttg gttaggcaaa gtttactgga ggaggggttt
     2941 ttgagtcaaa tttggaagga tgaacttgtt agatagtcag agttggaaac aaaacaatcc
     3001 aagaataggg atataagcat tgctagtcta gaatagtcta ttccttgtga aaatataaat
     3061 ttaattttca ggaatccagt atattccaaa catcacatat ttagcatgag aaaaattgat
     3121 ttgtgattgt gtatatgagt cattgttaat gggagacaag ctgaactgcc acatgccacc
     3181 aaatgaacct ttacttcaat caaaaaggag ggtatgattg gttcaattat attaacagaa
     3241 tatcatgggc atttctctat gatggtcatt caaggtagta ggtctctttc aactgagtgc
     3301 aacattgaga ataatgattt ggttcagggc aactacaaat aatcacttac taagccttaa
     3361 ataaagccat tatttttata tcaatagcac aaaggaaaac caaaagtcct taaccactga
     3421 ccatttttat catattttag gccttttttt aaaaaatcag ggtatagtag gcactaagtt
     3481 ttattaggaa atatttaaac ctgctgaagg atttatttat aaaaagtgca atttttcaaa
     3541 acacattatt attttttaat ttcccaattt tttcagtttt tcaaattgta ccacaacata
     3601 gaactgtgat attttgctat tacttcaatg tgaataaata aggtaaagta tatcatttat
     3661 tgagtgccca tgctgtacat ttaaaatatg cattatttaa tttaatctta ctcccagcac
     3721 caaaaggtaa ttgaccagcc tcaacacaat tttggacaaa gctagtaact gaacacaggt
     3781 ctgtctgccc cacacttctc tttctcttgt aactgcacaa tagcagaaaa ttggcaagat
     3841 gtatttttac tttccaagat gccgtgtgtg ccaagaataa atgaaatgat gttaaagcat
     3901 aataataaca tatctttaaa aagcttttca aaatatattt tcaccctgac agtgaccctt
     3961 gtaacttaaa tgatttttgg aaatattagt atgtaagtat aattcaaagt tgtcaaaatg
     4021 taagacattt agaagtaatt tttattattt atattgttaa tacttaatca ctggaaattc
     4081 attttcctta ctcgatgttt tctttcaact gagaagccta aaacaaacaa aaaccttgtg
     4141 tgttatcctg atatagttga ctaaatgtat ttgttcttat atggatagta atatgaatgt
     4201 gacatgcacc aattgtccta ttataatttt cagataagtg taactaagca cttgtgtaat
     4261 aaatattagt catttta
//
