LOCUS       NM_203397               1226 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens metallo-beta-lactamase domain containing 1 (MBLAC1),
            mRNA.
ACCESSION   NM_203397 XM_171171 XM_379899
VERSION     NM_203397.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1226)
  AUTHORS   Pettinati,I., Grzechnik,P., Ribeiro de Almeida,C., Brem,J.,
            McDonough,M.A., Dhir,S., Proudfoot,N.J. and Schofield,C.J.
  TITLE     Biosynthesis of histone messenger RNA employs a specific 3' end
            endonuclease
  JOURNAL   Elife 7, e39865 (2018)
   PUBMED   30507380
  REMARK    GeneRIF: The cellular, genetic, biochemical, substrate selectivity,
            and crystallographic studies have been reported providing evidence
            that endoribonuclease, MBLAC1, is selective for 3' processing of
            replication-dependent histone pre-mRNA during the S-phase of the
            cell cycle.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1226)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC031288.1, BQ441096.1, AW772344.1 and AW449216.1.
            
            On Nov 22, 2018 this sequence version replaced NM_203397.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.940953.1, BC031288.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398075.4/ ENSP00000381150.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-361               BC031288.1         274-634
            362-583             BQ441096.1         378-599
            584-684             BC031288.1         857-957
            685-1222            AW772344.1         1-538               c
            1223-1226           AW449216.1         20-23               c
FEATURES             Location/Qualifiers
     source          1..1226
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q22.1"
     gene            1..1226
                     /gene="MBLAC1"
                     /note="metallo-beta-lactamase domain containing 1"
                     /db_xref="GeneID:255374"
                     /db_xref="HGNC:HGNC:22180"
                     /db_xref="MIM:620906"
     exon            1..98
                     /gene="MBLAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            99..1226
                     /gene="MBLAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..927
                     /gene="MBLAC1"
                     /EC_number="3.-.-.-"
                     /note="endoribonuclease MBLAC1"
                     /codon_start=1
                     /product="metallo-beta-lactamase domain-containing protein
                     1"
                     /protein_id="NP_981942.1"
                     /db_xref="CCDS:CCDS43620.1"
                     /db_xref="GeneID:255374"
                     /db_xref="HGNC:HGNC:22180"
                     /db_xref="MIM:620906"
                     /translation="MRTEPLCGASPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSV
                     TLVLPQTRGPASSHRESPRGSGGAEAALEEAARGPILVDTGGPWAREALLGALAGQGV
                     APGDVTLVVGTHGHSDHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGPG
                     LEVWATPGHGGQRDVSVVVAGTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRK
                     RVLVVADVVVPGHGPPFRVLREASQPETEGGGNSQQEPVVGDEEPALH"
     regulatory      1201..1206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBLAC1"
                     /note="hexamer: AATAAA"
     polyA_site      1226
                     /gene="MBLAC1"
                     /note="major polyA site"
ORIGIN      
        1 atatctgggt acacgggaac cgcagaggac aaactctcac ccgcgttttc gatttctgcg
       61 ctttcttcga gtgaggcaag acctagcaga ggcccaagcc cgtccctccc tgccaggagc
      121 agcctcatgc ggaccgagcc gctgtgcggg gcatcccctc tgctggtgcc cggcgacccc
      181 tactctgtgg tggttctgct gcagggctac gcggagccag agggtgtggg cgatgccgtg
      241 cgcgccgacg gctccgtgac cctggtccta ccccagaccc ggggcccggc ctccagccac
      301 cgagagtccc cgcgcgggag tggcggcgca gaggccgccc tggaggaggc ggcccgtggc
      361 cccatcctgg tggacaccgg gggcccctgg gctcgggagg cgctgctggg ggcgctggcg
      421 gggcagggcg tggccccggg agacgtgacg ctagtggtgg ggacccacgg gcactcggat
      481 cacatcggga acttggggct gttcccaggc gcggctctgc tggtctcgca cgacttctgc
      541 cttcccggag gccgctacct gccccacggg ctgggtgagg ggcagcccct gcgcctgggc
      601 ccggggctcg aggtgtgggc cacgccgggc cacgggggcc agcgcgacgt gagcgtggtg
      661 gtggccggca cggctctggg caccgtggtg gtggcgggag atgtgtttga gcgagatggg
      721 gacgaggatt cgtggcaggc actgagtgaa gaccccgcag cccaggagcg gagccggaag
      781 agggtcctgg tcgttgccga cgtggtcgta cctggtcacg ggcccccctt tcgagtgtta
      841 agggaagcct cgcagcccga gacggagggt ggagggaaca gccagcagga gccggtggtc
      901 ggagacgagg agcccgccct gcactaatca gcctcgagag ggactgcact cttgtcaggg
      961 aagccctaac agcgaagagc tgctggagac agagtcagag cagtcaaggg tgggagcttc
     1021 cagcccttcc aggaggccag ttttctagtg aagacagagt gcacctgaca ctgccatcac
     1081 atcgtcagta tcactgcctg tctctgccac caaactaaga tcaaaggagg ggctcagctc
     1141 cctgtgcatt ctccctgggc ctcagtaaaa tgggagaagg ttcgtgggag gggcctccaa
     1201 aataaaaatg gaaactgcat tgaaaa
//
