LOCUS       NM_016586               1603 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens MAP3K12 binding inhibitory protein 1 (MBIP),
            transcript variant 1, mRNA.
ACCESSION   NM_016586
VERSION     NM_016586.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Ochieng,J.K., Kundu,S.T., Bajaj,R., Leticia Rodriguez,B.,
            Fradette,J.J. and Gibbons,D.L.
  TITLE     MBIP (MAP3K12 binding inhibitory protein) drives NSCLC metastasis
            by JNK-dependent activation of MMPs
  JOURNAL   Oncogene 39 (43), 6719-6732 (2020)
   PUBMED   32963352
  REMARK    GeneRIF: MBIP (MAP3K12 binding inhibitory protein) drives NSCLC
            metastasis by JNK-dependent activation of MMPs.
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Shareefi,G., Turkistani,A.N., Alsayyah,A., Kussaibi,H., Abdel
            Hadi,M. and Alkharsah,K.R.
  TITLE     Pathway-Affecting Single Nucleotide Polymorphisms (SNPs) in RPS6KA1
            and MBIP Genes are Associated with Breast Cancer Risk
  JOURNAL   Asian Pac J Cancer Prev 21 (7), 2163-2168 (2020)
   PUBMED   32711446
  REMARK    GeneRIF: Pathway-Affecting Single Nucleotide Polymorphisms (SNPs)
            in RPS6KA1 and MBIP Genes are Associated with Breast Cancer Risk.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Guelman,S., Kozuka,K., Mao,Y., Pham,V., Solloway,M.J., Wang,J.,
            Wu,J., Lill,J.R. and Zha,J.
  TITLE     The double-histone-acetyltransferase complex ATAC is essential for
            mammalian development
  JOURNAL   Mol Cell Biol 29 (5), 1176-1188 (2009)
   PUBMED   19103755
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Wang,Y.L., Faiola,F., Xu,M., Pan,S. and Martinez,E.
  TITLE     Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel
            NC2-like histone fold module that interacts with the TATA-binding
            protein
  JOURNAL   J Biol Chem 283 (49), 33808-33815 (2008)
   PUBMED   18838386
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Fukuyama,K., Yoshida,M., Yamashita,A., Deyama,T., Baba,M.,
            Suzuki,A., Mohri,H., Ikezawa,Z., Nakajima,H., Hirai,S. and Ohno,S.
  TITLE     MAPK upstream kinase (MUK)-binding inhibitory protein, a negative
            regulator of MUK/dual leucine zipper-bearing kinase/leucine zipper
            protein kinase
  JOURNAL   J Biol Chem 275 (28), 21247-21254 (2000)
   PUBMED   10801814
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Daley,M.D., Olee,T., Peng,H.Q., Soto-Gil,R.W., Chen,P.P. and
            Siminovitch,K.A.
  TITLE     Molecular characterization of the human immunoglobulin V lambda I
            germline gene repertoire
  JOURNAL   Mol Immunol 29 (9), 1031-1042 (1992)
   PUBMED   1495496
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137226.3, AK315290.1 and AA761503.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016586.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038523.1, SRR3476690.1162714.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000416007.9/ ENSP00000399718.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AL137226.3         77938-78052         c
            116-1084            AK315290.1         156-1124
            1085-1269           AL137226.3         56313-56497         c
            1270-1603           AA761503.1         20-353              c
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q13.3"
     gene            1..1603
                     /gene="MBIP"
                     /note="MAP3K12 binding inhibitory protein 1"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
     exon            1..178
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1084
                     /gene="MBIP"
                     /note="isoform 1 is encoded by transcript variant 1;
                     MUK-binding inhibitory protein; MAPK upstream
                     kinase-binding inhibitory protein"
                     /codon_start=1
                     /product="MAP3K12-binding inhibitory protein 1 isoform 1"
                     /protein_id="NP_057670.2"
                     /db_xref="CCDS:CCDS9658.1"
                     /db_xref="GeneID:51562"
                     /db_xref="HGNC:HGNC:20427"
                     /db_xref="MIM:609431"
                     /translation="MAAATELNRPSSGDRNLERRCRPNLSREVLYEIFRSLHTLVGQL
                     DLRDDVVKITIDWNKLQSLSAFQPALLFSALEQHILYLQPFLAKLQSPIKEENTTAVE
                     EIGRTEMGNKNEVNDKFSIGDLQEEEKHKESDLRDVKKTQIHFDPEVVQIKAGKAEID
                     RRISAFIERKQAEINENNVREFCNVIDCNQENSCARTDAIFTPYPGFKSHVKVSRVVN
                     TYGPQTRPEGIPGSGHKPNSMLRDCGNQAVEERLQNIEAHLRLQTGGPVPRDIYQRIK
                     KLEDKILELEGISPEYFQSVSFSGKRRKVQPPQQNYSLAELDEKISALKQALLRKSRE
                     AESMATHHLP"
     exon            179..298
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            299..523
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            524..620
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            621..686
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            687..839
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            840..937
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            938..976
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1603
                     /gene="MBIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1581..1586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MBIP"
                     /note="hexamer: AATAAA"
     polyA_site      1603
                     /gene="MBIP"
                     /note="major polyA site"
ORIGIN      
        1 gtgagcaaat cttggtggtg gtggtggtgg ggcggcctga gaagatatca tggctgctgc
       61 cacggagctt aatcgcccga gcagcggtga caggaacctg gagcgaagat gcagacccaa
      121 cctctcccga gaggtgctct acgaaatctt tcgctcccta cacaccctgg ttggacagct
      181 tgacctcaga gatgatgtgg tgaaaattac aatcgattgg aacaagctcc agagcctctc
      241 ggcattccag cctgcattgc tctttagtgc acttgaacaa cacattttat atttacagcc
      301 ttttttagca aaacttcagt ctccgattaa agaggagaat acaactgctg ttgaagagat
      361 aggaagaaca gaaatgggga acaaaaatga agtaaatgac aaattttcca ttggcgacct
      421 acaagaggaa gaaaagcaca aagaaagtga tttaagagat gtgaaaaaga cacagatcca
      481 ttttgatcca gaagtagttc agataaaggc tggaaaagca gaaattgaca gacgaatatc
      541 tgcatttatt gaaagaaagc aagctgaaat caatgaaaac aacgtcaggg aattttgcaa
      601 tgttattgat tgtaatcaag aaaatagttg tgcaagaact gatgcgattt ttacccctta
      661 ccccggattt aaaagtcacg taaaagtttc tagagttgtg aatacatacg gaccacagac
      721 tagacctgaa ggaattccag ggtcaggtca taaacctaac agcatgcttc gagactgtgg
      781 taatcaggct gtagaagaac gactacaaaa tattgaggcc cacttgcggt tacagacagg
      841 tggtccagtg ccaagagaca tttatcagag aattaaaaaa cttgaggata aaatccttga
      901 attggaaggc atctctcctg aatattttca gtctgtaagc ttttctggaa aaagaagaaa
      961 agttcaacca cctcaacaga actattcact ggctgaactt gatgagaaaa ttagtgccct
     1021 caaacaagcc ctcctcagaa aatcaagaga agcagaatcc atggcaaccc accaccttcc
     1081 atgaaaaact cctctcatcc ttgtcatttt acttttttgt atacatatgt gtaacttaca
     1141 ctgttattaa ttcaacggat atatatttat caatgtagac ttctctgtga agtcaaggtt
     1201 tattttcaca tgagtccagc ttgcagcaag taatcttcaa atattccagt aagttttgaa
     1261 ataatgaatg cattgaaaat agcattgttg gaatttattc ccttctgttt taaaggaggt
     1321 attttggaaa ttgaaaaact taatttacaa gtgctggtac atcttttttc ttttgtggac
     1381 cacaggaagg aagatttatt ttgatattga tactttaaaa ggactttata tttgtaacat
     1441 tgatgttaac cagtttatta gtttaaatca gtactttgca tataataagc attcaacaaa
     1501 aatttattga ctgaaatgaa ttttaaatgc atgtgtatga acttgttttt cttaatcttt
     1561 aagatgtcag tattcatgta aataaacaat agatccagct tta
//
