LOCUS       NM_144614                793 bp    mRNA    linear   PRI 11-JUN-2024
DEFINITION  Homo sapiens methyl-CpG binding domain protein 3 like 2 (MBD3L2),
            mRNA.
ACCESSION   NM_144614 XM_001131059
VERSION     NM_144614.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Peng,L., Li,Y., Xi,Y., Li,W., Li,J., Lv,R., Zhang,L., Zou,Q.,
            Dong,S., Luo,H., Wu,F. and Yu,W.
  TITLE     MBD3L2 promotes Tet2 enzymatic activity for mediating
            5-methylcytosine oxidation
  JOURNAL   J Cell Sci 129 (5), 1059-1071 (2016)
   PUBMED   26769901
  REMARK    GeneRIF: MBD3L2 is more effective than MBD3 in promoting Tet2
            enzymatic activity through strengthening the binding affinity
            between Tet2 and the methylated DNA target.
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Walavalkar,N.M., Gordon,N. and Williams,D.C. Jr.
  TITLE     Unique features of the anti-parallel, heterodimeric coiled-coil
            interaction between methyl-cytosine binding domain 2 (MBD2)
            homologues and GATA zinc finger domain containing 2A
            (GATAD2A/p66alpha)
  JOURNAL   J Biol Chem 288 (5), 3419-3427 (2013)
   PUBMED   23239876
  REMARK    GeneRIF: These factors lead to a binding affinity hierarchy of
            p66alpha for the different MBD2 homologues (MBD2 approximately MBD3
            > MBD3L1 approximately MBD3L2).
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Jin,S.G., Jiang,C.L., Rauch,T., Li,H. and Pfeifer,G.P.
  TITLE     MBD3L2 interacts with MBD3 and components of the NuRD complex and
            can oppose MBD2-MeCP1-mediated methylation silencing
  JOURNAL   J Biol Chem 280 (13), 12700-12709 (2005)
   PUBMED   15701600
  REMARK    GeneRIF: MBD3L2 interacts with MBD3 and components of the NuRD
            complex and can oppose MBD2-MeCP1-mediated methylation silencing
REFERENCE   5  (bases 1 to 793)
  AUTHORS   Jiang,C.L., Jin,S.G., Lee,D.H., Lan,Z.J., Xu,X., O'Connor,T.R.,
            Szabo,P.E., Mann,J.R., Cooney,A.J. and Pfeifer,G.P.
  TITLE     MBD3L1 and MBD3L2, two new proteins homologous to the
            methyl-CpG-binding proteins MBD2 and MBD3: characterization of
            MBD3L1 as a testis-specific transcriptional repressor
  JOURNAL   Genomics 80 (6), 621-629 (2002)
   PUBMED   12504854
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC010606.7 and AF503919.2.
            
            On Aug 14, 2020 this sequence version replaced NM_144614.3.
            
            Summary: This gene encodes a protein that is related to
            methyl-CpG-binding proteins but lacks the methyl-CpG binding
            domain. The protein has been found in germ cell tumors and some
            somatic tissues. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF503919.2, BE281376.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMN03465418
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000381393.3/ ENSP00000370800.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                AC010606.7         75821-75839         c
            20-22               AC010606.7         75818-75820         c
            23-422              AF503919.2         5-404
            423-690             AC010606.7         73528-73795         c
            691-793             AF503919.2         672-774
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..793
                     /gene="MBD3L2"
                     /note="methyl-CpG binding domain protein 3 like 2"
                     /db_xref="GeneID:125997"
                     /db_xref="HGNC:HGNC:18532"
                     /db_xref="MIM:607964"
     exon            1..98
                     /gene="MBD3L2"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..680
                     /gene="MBD3L2"
                     /note="MBD3-like protein 2; CTB-25J19.1"
                     /codon_start=1
                     /product="methyl-CpG-binding domain protein 3-like 2"
                     /protein_id="NP_653215.2"
                     /db_xref="CCDS:CCDS42483.1"
                     /db_xref="GeneID:125997"
                     /db_xref="HGNC:HGNC:18532"
                     /db_xref="MIM:607964"
                     /translation="MGEPAFTSFPSLPVLGKLKRNMMPWALQKKREIHMAKAHRRRAA
                     RSALPMRLTSCIFRRPVTRIRSHPDNQVRRRKGDEHLEKPQQLCAYRRLQALQPCSSQ
                     GEGSSPLHLESVLSILAPGTAGESLDRAGAERVRSPLEPTPGRFPAVAGGPTPGMGCQ
                     LPPPLSGQLVTPADIRRQARRVKKARERLAKALQADRLARRAEMLTGG"
     exon            99..793
                     /gene="MBD3L2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaagggctg tctgtgcctc aggagtgggg tcagcaggag gaactctaca gctatgggag
       61 aacctgcgtt cacctctttt ccaagcctgc ctgttctggg gaagctcaaa aggaacatga
      121 tgccctgggc tttacagaag aaacgagaaa tccacatggc caaggcccat cggagacgag
      181 ctgcgaggtc tgctctcccc atgagactca ccagctgcat cttccggagg ccggtgacaa
      241 ggatcaggtc tcatcctgac aaccaggtca gacgcagaaa aggggacgag cacctggaga
      301 agccgcagca actctgcgcc taccggagac tgcaggccct gcagccctgc agcagccaag
      361 gagaaggttc aagtccactg catttggaga gcgtcttaag tatccttgca ccggggacgg
      421 ccggtgaatc tctggacaga gctggtgctg agcgtgtgcg cagcccgctt gagcccaccc
      481 ctgggcggtt tccagctgtg gcaggggggc caaccccagg aatgggttgt cagctcccac
      541 cgcccctctc tggccaattg gtgactcctg cagatatccg gagacaggcc aggagggtga
      601 agaaagccag ggagagactg gccaaggcct tgcaggcaga caggctggcc aggcgggcag
      661 aaatgctgac aggtggatga agctcagtct tgggctttcg gtccctttct tttaatgccc
      721 atcctcattc ctactctgaa ttgtcacact tttcccttcc ccaccagttc tttaataaaa
      781 gtatttgaaa ggc
//
