LOCUS       NM_178496               3063 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens Mab-21 domain containing 2 (MB21D2), mRNA.
ACCESSION   NM_178496
VERSION     NM_178496.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3063)
  AUTHORS   Liu,H., Yan,Z., Zhu,D., Xu,H., Liu,F., Chen,T., Zhang,H., Zheng,Y.,
            Liu,B., Zhang,L., Zhao,W. and Gao,C.
  TITLE     CD-NTase family member MB21D2 promotes cGAS-mediated antiviral and
            antitumor immunity
  JOURNAL   Cell Death Differ 30 (4), 992-1004 (2023)
   PUBMED   36681781
REFERENCE   2  (bases 1 to 3063)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3063)
  AUTHORS   Gracilla,D.E., Korla,P.K., Lai,M.T., Chiang,A.J., Liou,W.S. and
            Sheu,J.J.
  TITLE     Overexpression of wild type or a Q311E mutant MB21D2 promotes a
            pro-oncogenic phenotype in HNSCC
  JOURNAL   Mol Oncol 14 (12), 3065-3082 (2020)
   PUBMED   32979859
  REMARK    GeneRIF: Overexpression of wild type or a Q311E mutant MB21D2
            promotes a pro-oncogenic phenotype in HNSCC.
REFERENCE   4  (bases 1 to 3063)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 3063)
  AUTHORS   Kranzusch,P.J.
  TITLE     cGAS and CD-NTase enzymes: structure, mechanism, and evolution
  JOURNAL   Curr Opin Struct Biol 59, 178-187 (2019)
   PUBMED   31593902
  REMARK    Review article
REFERENCE   6  (bases 1 to 3063)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3063)
  AUTHORS   Ahmed,S.M., Theriault,B.L., Uppalapati,M., Chiu,C.W., Gallie,B.L.,
            Sidhu,S.S. and Angers,S.
  TITLE     KIF14 negatively regulates Rap1a-Radil signaling during breast
            cancer progression
  JOURNAL   J Cell Biol 199 (6), 951-967 (2012)
   PUBMED   23209302
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC045582.1 and BC013123.1.
            
            On Nov 22, 2018 this sequence version replaced NM_178496.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC013123.1, SRR1803616.227037.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392452.3/ ENSP00000376246.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BC045582.1         306-322
            18-3063             BC013123.1         1-3046
FEATURES             Location/Qualifiers
     source          1..3063
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..3063
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /note="Mab-21 domain containing 2"
                     /db_xref="GeneID:151963"
                     /db_xref="HGNC:HGNC:30438"
                     /db_xref="MIM:620914"
     exon            1..227
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..1492
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /note="protein MB21D2; mab-21 domain-containing protein 2;
                     DANGER family member 2A"
                     /codon_start=1
                     /product="nucleotidyltransferase MB21D2"
                     /protein_id="NP_848591.2"
                     /db_xref="CCDS:CCDS3302.2"
                     /db_xref="GeneID:151963"
                     /db_xref="HGNC:HGNC:30438"
                     /db_xref="MIM:620914"
                     /translation="MKMAAPTANKAASLGCNNKPAFPELDFRSGARVEELNKLIQEFT
                     KHDQREYDDQRALEIHTAKDFIFSMLGMVQKLDQKLPVANEYLLLSGGVREGVVDLDL
                     DELNVYARGTDYDMDFTLLVPALKLHDRNQPVTLDMRHSALCHSWLSLRLFDEGTISK
                     WKDCCTIVDHINGATNYFFSPTKVADWFYDSISIVLSEIQKKPQRGMPKVEKVEKNGT
                     IISIILGVGSSRMLYDIVPVVSFKGWPAVAQSWLMENHFWDGKITEEEVISGFYLVPA
                     CSYKGKKDNEWRLSFARSEVQLKKCISSSLMQAYQACKAIIIKLLSRPKAISPYHLRS
                     MMLWACDRLPANYLAQEDYAAHFLLGLIDDLQHCLVNKMCPNYFIPQCNMLEHLSEET
                     VMLHARKLSSVRSDPAEHLRTAIEHVKAANRLTLELQRRGSTTSIPSPQSDGGDPNQP
                     DDRLAKKLQQLVTENPGKSISVFINPDDVTRPHFRIDDKFF"
     exon            228..3063
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3034..3039
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /note="hexamer: AATAAA"
     regulatory      3042..3047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /note="hexamer: AAGAAA"
     polyA_site      3051
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
     polyA_site      3063
                     /gene="MB21D2"
                     /gene_synonym="C3orf59; D2A; hMB21D2"
                     /note="major polyA site"
ORIGIN      
        1 actcggcgcg ttttgcatga agatggcggc tcccaccgcc aacaaggcag cctccctggg
       61 ctgtaacaac aagcctgcgt tcccggagct ggatttcagg tcgggagctc gggtggagga
      121 attgaacaaa ctcatccaag aatttacgaa gcacgaccag cgggaatacg acgaccagag
      181 agcgctggag attcacacag ccaaggattt catcttttcc atgctgggaa tggtgcaaaa
      241 gctggaccaa aagcttccag tggctaatga atacctgttg ctctctggag gtgtccggga
      301 aggcgtggtg gacctggact tagatgagct taatgtctat gcccggggta ctgactatga
      361 tatggacttt accctcttgg tgccagccct caagctgcat gaccgtaatc agcctgtgac
      421 actcgacatg cgccactcag ccttgtgcca ctcttggctg agccttcggc tctttgatga
      481 ggggacaatc agtaaatgga aagactgctg caccattgta gatcacatca atggtgccac
      541 caactacttc ttctcaccta ccaaagtggc tgactggttc tatgactcta tcagcattgt
      601 cctatcagaa atacagaaga aaccccagcg agggatgcca aaggtagaaa aggtggaaaa
      661 aaatgggacc atcatctcca tcattctggg tgtagggagt agtcgcatgt tgtatgatat
      721 tgtccctgtg gtatctttca aaggttggcc tgcagtggcc cagagctggc tcatggagaa
      781 ccacttttgg gatgggaaga ttactgagga agaggtcatc agtgggtttt acttggtgcc
      841 tgcttgctcc tacaagggta agaaggacaa tgaatggcgg ctgtcctttg ccaggagcga
      901 ggtgcagttg aagaagtgca tctccagcag cctcatgcag gcctatcagg cctgcaaagc
      961 catcatcatt aaactgctgt cccggcccaa ggctattagc ccctatcacc tgcggagcat
     1021 gatgctctgg gcctgcgaca gacttcctgc caactacttg gctcaagaag actatgcagc
     1081 ccactttttg ctgggcctca tcgatgacct gcaacactgt ctggtcaaca agatgtgccc
     1141 caattatttc atccctcagt gcaacatgct ggaacatctg tctgaggaga cagtcatgct
     1201 tcacgcccgg aagctgtcct ctgtgcgctc agacccggca gagcacttgc gcaccgccat
     1261 tgagcatgtc aaggcagcca accggctgac actggagctc cagaggcgag gtagcaccac
     1321 cagcatcccc tctccacagt ctgacggagg ggaccccaac cagcctgatg accgtttggc
     1381 aaaaaaactg cagcagctag tgactgagaa cccgggaaag tcaatctctg tctttatcaa
     1441 tcctgacgat gtcacaaggc cccatttcag aattgatgac aaatttttct gagtgttagc
     1501 tgactttttt ttttcctgat tcttaaactc tgataatgtg tcgtgtggtt tgtgatgcta
     1561 tctttctgtt ttttacatat ccagcctaga ttggatttgt taagaacaaa ttttaagttt
     1621 cctggttctg caggatggtg caggctctga aacagtatat tactatttca tattctgcct
     1681 ctgatttcgt tgtttacttt ttgtagttat tgtcatgctc tttagtttgt tggagttttt
     1741 tttcttttta aggagatctt aagccataga tgaaaatgcc catgaatcct cttgcttttt
     1801 tctgtttcat acttggtgca aatttgttca tgggtatggg gaaacaaatc tctttctgat
     1861 gcttaacgat tctatcctat tatttttatt attttgtttt tgtctttttt cttatgagct
     1921 ttcaccacta ctgatatttg agaatcatat gaacctggga actacttggc atgttagctg
     1981 gatttattta ttttggccag tgaccagagt agtttccccc cttttccacc aaacaatgta
     2041 aactttgaaa gtgataatac tacaaattgt gttttggagc aacttcattg aatgtaattg
     2101 tcctcaaatc agagaacact gggtggtttg aagggtgtct ttgacagttt tccaagcaga
     2161 attaaggttt ccaaatgtta attttagcat atgtaattat ttgaagcctt atttaaatcc
     2221 tattaaagaa cataccatta taattattat ttgcactaat ctttgccatt gtcagaattg
     2281 caaagtgtgt ttcaatataa attaacaacc actctcgaaa ttctatcatt ttttcatttt
     2341 gcccatttct atcagtgaaa tgattctttg catttgctta gttctccttc agttgtgggg
     2401 tcctgctttg ccctctttga tattcctggt tcctgtctta ctgagagaag ttgttaaagc
     2461 tttatacatg ttgaccccat ctaaagctgg ggaaaatata cacttgatga agtaggtgtc
     2521 tttgtattta tttcttttgg ggtcatagag gtaagctttt ttgtaaaatc tctactcttc
     2581 ctgagagttt tgagaaaaac tggcaggaag aacttataat ccccaaatag aagataccac
     2641 gtctgttcaa aagcaggtat tgctatagag cagcacccag gaaatatctg tgggtggcag
     2701 ccttggtata gaggtgtcct gtcttcatga gtgaagttac ttgcctgatt aggtgctgga
     2761 aggtattggc tccctgtttt ggtgtggact catggcaagc tggtgtttaa gaggtcagga
     2821 ggcctgctga tctttcaaag gacacccatg atgtctactc atagaaaggg caagtaacgt
     2881 gttcattttg gtcttgaatg tccaaactca agggttggat tttggccaat tgaaatcaga
     2941 catatgcgat cttgggtttt tgcatggaaa ttaatgtaat gcttataaat gaaaaatgaa
     3001 aacatttcaa ccatctaagt caaacacaaa aataataaaa aaagaaacat actggccttg
     3061 aaa
//
