LOCUS       NM_005368               1070 bp    mRNA    linear   PRI 14-APR-2024
DEFINITION  Homo sapiens myoglobin (MB), transcript variant 1, mRNA.
ACCESSION   NM_005368
VERSION     NM_005368.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1070)
  AUTHORS   Aboouf,M.A., Gorr,T.A., Hamdy,N.M., Gassmann,M. and Thiersch,M.
  TITLE     Myoglobin in Brown Adipose Tissue: A Multifaceted Player in
            Thermogenesis
  JOURNAL   Cells 12 (18), 2240 (2023)
   PUBMED   37759463
  REMARK    GeneRIF: Myoglobin in Brown Adipose Tissue: A Multifaceted Player
            in Thermogenesis.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1070)
  AUTHORS   Sackerson,C., Garcia,V., Medina,N., Maldonado,J., Daly,J. and
            Cartwright,R.
  TITLE     Comparative analysis of the myoglobin gene in whales and humans
            reveals evolutionary changes in regulatory elements and expression
            levels
  JOURNAL   PLoS One 18 (8), e0284834 (2023)
   PUBMED   37643191
  REMARK    GeneRIF: Comparative analysis of the myoglobin gene in whales and
            humans reveals evolutionary changes in regulatory elements and
            expression levels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1070)
  AUTHORS   Tupta,B., Stuehr,E., Sumi,M.P., Sweeny,E.A., Smith,B., Stuehr,D.J.
            and Ghosh,A.
  TITLE     GAPDH is involved in the heme-maturation of myoglobin and
            hemoglobin
  JOURNAL   FASEB J 36 (2), e22099 (2022)
   PUBMED   34972240
  REMARK    GeneRIF: GAPDH is involved in the heme-maturation of myoglobin and
            hemoglobin.
REFERENCE   4  (bases 1 to 1070)
  AUTHORS   Hofbauer,S., Pignataro,M., Borsari,M., Bortolotti,C.A., Di
            Rocco,G., Ravenscroft,G., Furtmuller,P.G., Obinger,C., Sola,M. and
            Battistuzzi,G.
  TITLE     Pseudoperoxidase activity, conformational stability, and
            aggregation propensity of the His98Tyr myoglobin variant:
            implications for the onset of myoglobinopathy
  JOURNAL   FEBS J 289 (4), 1105-1117 (2022)
   PUBMED   34679218
  REMARK    GeneRIF: Pseudoperoxidase activity, conformational stability, and
            aggregation propensity of the His98Tyr myoglobin variant:
            implications for the onset of myoglobinopathy.
REFERENCE   5  (bases 1 to 1070)
  AUTHORS   Quinting,T., Heymann,A.K., Bicker,A., Nauth,T., Bernardini,A.,
            Hankeln,T., Fandrey,J. and Schreiber,T.
  TITLE     Myoglobin Protects Breast Cancer Cells Due to Its ROS and NO
            Scavenging Properties
  JOURNAL   Front Endocrinol (Lausanne) 12, 732190 (2021)
   PUBMED   34671319
  REMARK    GeneRIF: Myoglobin Protects Breast Cancer Cells Due to Its ROS and
            NO Scavenging Properties.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1070)
  AUTHORS   Hubbard,S.R., Hendrickson,W.A., Lambright,D.G. and Boxer,S.G.
  TITLE     X-ray crystal structure of a recombinant human myoglobin mutant at
            2.8 A resolution
  JOURNAL   J Mol Biol 213 (2), 215-218 (1990)
   PUBMED   2342104
REFERENCE   7  (bases 1 to 1070)
  AUTHORS   Akaboshi,E.
  TITLE     Cloning of the human myoglobin gene
  JOURNAL   Gene 33 (3), 241-249 (1985)
   PUBMED   2989088
REFERENCE   8  (bases 1 to 1070)
  AUTHORS   Lundholm,K. and Schersten,T.
  TITLE     Protein synthesis in isolated human skeletal muscle tissue:
            evaluation of an experimental model
  JOURNAL   Clin Sci (Lond) 57 (2), 221-223 (1979)
   PUBMED   477257
REFERENCE   9  (bases 1 to 1070)
  AUTHORS   Romero Herrera,A.E. and Lehmann,H.
  TITLE     The myoglobin of primates. II. Pan Troglodytes (chimpanzee)
  JOURNAL   Biochim Biophys Acta 278 (1), 62-67 (1972)
   PUBMED   4627044
REFERENCE   10 (bases 1 to 1070)
  AUTHORS   Herrera,A.E. and Lehmann,H.
  TITLE     Primary structure of human myoglobin
  JOURNAL   Nat New Biol 232 (31), 149-152 (1971)
   PUBMED   5285572
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU585249.1, BQ956082.1 and
            BC014547.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005368.2.
            
            Summary: This gene encodes a member of the globin superfamily and
            is predominantly expressed in skeletal and cardiac muscles. The
            encoded protein forms a monomeric globular haemoprotein that is
            primarily responsible for the storage and facilitated transfer of
            oxygen from the cell membrane to the mitochondria. This protein
            also plays a role in regulating physiological levels of nitric
            oxide. Multiple transcript variants encoding distinct isoforms
            exist for this gene. [provided by RefSeq, May 2020].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014547.1, SRR5189655.156241.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2151741, SAMEA2153307
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: relevant for COVID-19 prognosis
            MANE Ensembl match     :: ENST00000397326.7/ ENSP00000380489.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                BU585249.1         128-140
            14-679              BQ956082.1         1-666
            680-1070            BC014547.1         684-1074
FEATURES             Location/Qualifiers
     source          1..1070
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..1070
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /note="myoglobin"
                     /db_xref="GeneID:4151"
                     /db_xref="HGNC:HGNC:6915"
                     /db_xref="MIM:160000"
     exon            1..167
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..537
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     pseudoperoxidase MB; nitrite reductase MB"
                     /codon_start=1
                     /product="myoglobin isoform 1"
                     /protein_id="NP_005359.1"
                     /db_xref="CCDS:CCDS13917.1"
                     /db_xref="GeneID:4151"
                     /db_xref="HGNC:HGNC:6915"
                     /db_xref="MIM:160000"
                     /translation="MGLSDGEWQLVLNVWGKVEADIPGHGQEVLIRLFKGHPETLEKF
                     DKFKHLKSEDEMKASEDLKKHGATVLTALGGILKKKGHHEAEIKPLAQSHATKHKIPV
                     KYLEFISECIIQVLQSKHPGDFGADAQGAMNKALELFRKDMASNYKELGFQG"
     exon            168..390
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /inference="alignment:Splign:2.1.0"
     exon            391..1070
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1047..1052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /note="hexamer: AATAAA"
     polyA_site      1070
                     /gene="MB"
                     /gene_synonym="MYOSB; PVALB"
                     /note="major polyA site"
ORIGIN      
        1 aaaccccagc tgttggggcc aggacaccca gtgagcccat acttgctctt tttgtcttct
       61 tcagactgcg ccatggggct cagcgacggg gaatggcagt tggtgctgaa cgtctggggg
      121 aaggtggagg ctgacatccc aggccatggg caggaagtcc tcatcaggct ctttaagggt
      181 cacccagaga ctctggagaa gtttgacaag ttcaagcacc tgaagtcaga ggacgagatg
      241 aaggcgtctg aggacttaaa gaagcatggt gccaccgtgc tcaccgccct gggtggcatc
      301 cttaagaaga aggggcatca tgaggcagag attaagcccc tggcacagtc gcatgccacc
      361 aagcacaaga tccccgtgaa gtacctggag ttcatctcgg aatgcatcat ccaggttctg
      421 cagagcaagc atcccgggga ctttggtgct gatgcccagg gggccatgaa caaggccctg
      481 gagctgttcc ggaaggacat ggcctccaac tacaaggagc tgggcttcca gggctaggcc
      541 cctgccgctc ccacccccac ccatctgggc cccgggttca agagagagcg gggtctgatc
      601 tcgtgtagcc atatagagtt tgcttctgag tgtctgcttt gtttagtaga ggtgggcagg
      661 aggagctgag gggctggggc tggggtgttg aagttggctt tgcatgccca gcgatgcgcc
      721 tccctgtggg atgtcatcac cctgggaacc gggagtggcc cttggctcac tgtgttctgc
      781 atggtttgga tctgaattaa ttgtcctttc ttctaaatcc caaccgaact tcttccaacc
      841 tccaaactgg ctgtaacccc aaatccaagc cattaactac acctgacagt agcaattgtc
      901 tgattaatca ctggcccctt gaagacagca gaatgtccct ttgcaatgag gaggagatct
      961 gggctgggcg ggccagctgg ggaagcattt gactatctgg aacttgtgtg tgcctcctca
     1021 ggtatggcag tgactcacct ggttttaata aaacaacctg caacatctca
//
