LOCUS       NM_002383               2540 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens MYC associated zinc finger protein (MAZ), transcript
            variant 1, mRNA.
ACCESSION   NM_002383
VERSION     NM_002383.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2540)
  AUTHORS   Zeng,J., Zhang,L., Huang,L., Yu,X., Han,L., Zheng,Y., Wang,T.,
            Zhang,N. and Yang,M.
  TITLE     MAZ promotes thyroid cancer progression by driving transcriptional
            reprogram and enhancing ERK1/2 activation
  JOURNAL   Cancer Lett 602, 217201 (2024)
   PUBMED   39197582
  REMARK    GeneRIF: MAZ promotes thyroid cancer progression by driving
            transcriptional reprogram and enhancing ERK1/2 activation.
REFERENCE   2  (bases 1 to 2540)
  AUTHORS   Han,L., Huo,Y., Huang,L., Zheng,Y., Yu,X., Zhang,N. and Yang,M.
  TITLE     Genome-wide functional integration identified MAZ-controlled RPS14
            dysregulation in hepatocellular carcinoma
  JOURNAL   Arch Toxicol 98 (3), 985-997 (2024)
   PUBMED   38189915
  REMARK    GeneRIF: Genome-wide functional integration identified
            MAZ-controlled RPS14 dysregulation in hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2540)
  AUTHORS   Wang,W., Li,D., Xu,Q., Cheng,J., Yu,Z., Li,G., Qiao,S., Pan,J.,
            Wang,H., Shi,J., Zheng,T. and Sui,G.
  TITLE     G-quadruplexes promote the motility in MAZ phase-separated
            condensates to activate CCND1 expression and contribute to
            hepatocarcinogenesis
  JOURNAL   Nat Commun 15 (1), 1045 (2024)
   PUBMED   38316778
  REMARK    GeneRIF: G-quadruplexes promote the motility in MAZ phase-separated
            condensates to activate CCND1 expression and contribute to
            hepatocarcinogenesis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2540)
  AUTHORS   Zheng,C., Wu,H., Zhang,S., Tian,R., Long,H., Zhang,H., Guo,X.,
            Li,D., Tan,S. and Zhu,X.
  TITLE     Myc-Associated Zinc Finger Protein Promotes Metastasis of Papillary
            Thyroid Cancer
  JOURNAL   Front Biosci (Landmark Ed) 28 (8), 162 (2023)
   PUBMED   37664917
  REMARK    GeneRIF: Myc-Associated Zinc Finger Protein Promotes Metastasis of
            Papillary Thyroid Cancer.
REFERENCE   5  (bases 1 to 2540)
  AUTHORS   Deen,D., Butter,F., Daniels,D.E., Ferrer-Vicens,I.,
            Ferguson,D.C.J., Holland,M.L., Samara,V., Sloane-Stanley,J.A.,
            Ayyub,H., Mann,M., Frayne,J., Garrick,D. and Vernimmen,D.
  TITLE     Identification of the transcription factor MAZ as a regulator of
            erythropoiesis
  JOURNAL   Blood Adv 5 (15), 3002-3015 (2021)
   PUBMED   34351390
  REMARK    GeneRIF: Identification of the transcription factor MAZ as a
            regulator of erythropoiesis.
            Erratum:[Blood Adv. 2022 Mar 22;6(6):1854. doi:
            10.1182/bloodadvances.2021006651.. PMID: 35298619]
REFERENCE   6  (bases 1 to 2540)
  AUTHORS   Song,J., Murakami,H., Tsutsui,H., Tang,X., Matsumura,M.,
            Itakura,K., Kanazawa,I., Sun,K. and Yokoyama,K.K.
  TITLE     Genomic organization and expression of a human gene for
            Myc-associated zinc finger protein (MAZ)
  JOURNAL   J Biol Chem 273 (32), 20603-20614 (1998)
   PUBMED   9685418
REFERENCE   7  (bases 1 to 2540)
  AUTHORS   Tsutsui,H., Sakatsume,O., Itakura,K. and Yokoyama,K.K.
  TITLE     Members of the MAZ family: a novel cDNA clone for MAZ from human
            pancreatic islet cells
  JOURNAL   Biochem Biophys Res Commun 226 (3), 801-809 (1996)
   PUBMED   8831693
REFERENCE   8  (bases 1 to 2540)
  AUTHORS   Parks,C.L. and Shenk,T.
  TITLE     The serotonin 1a receptor gene contains a TATA-less promoter that
            responds to MAZ and Sp1
  JOURNAL   J Biol Chem 271 (8), 4417-4430 (1996)
   PUBMED   8626793
REFERENCE   9  (bases 1 to 2540)
  AUTHORS   Bossone,S.A., Asselin,C., Patel,A.J. and Marcu,K.B.
  TITLE     MAZ, a zinc finger protein, binds to c-MYC and C2 gene sequences
            regulating transcriptional initiation and termination
  JOURNAL   Proc Natl Acad Sci U S A 89 (16), 7452-7456 (1992)
   PUBMED   1502157
REFERENCE   10 (bases 1 to 2540)
  AUTHORS   Pyrc,J.J., Moberg,K.H. and Hall,D.J.
  TITLE     Isolation of a novel cDNA encoding a zinc-finger protein that binds
            to two sites within the c-myc promoter
  JOURNAL   Biochemistry 31 (16), 4102-4110 (1992)
   PUBMED   1567856
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC009133.7.
            
            On Nov 23, 2018 this sequence version replaced NM_002383.3.
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            3' coding region which results in a frameshift, compared to variant
            2. It encodes isoform 1 which has a distinct C-terminus and is
            shorter than isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M94046.1, SRR1163657.476647.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322945.11/ ENSP00000313362.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-365               AC009133.7         58496-58860         c
            366-1216            AC009133.7         57561-58411         c
            1217-1280           AC009133.7         57096-57159         c
            1281-1452           AC009133.7         56648-56819         c
            1453-2540           AC009133.7         54225-55312         c
FEATURES             Location/Qualifiers
     source          1..2540
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..2540
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /note="MYC associated zinc finger protein"
                     /db_xref="GeneID:4150"
                     /db_xref="HGNC:HGNC:6914"
                     /db_xref="MIM:600999"
     exon            1..365
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..1607
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /note="isoform 1 is encoded by transcript variant 1; serum
                     amyloid A activating factor 2; purine-binding
                     transcription factor; serum amyloid A activating factor 1;
                     zinc-finger protein, 87 kilodaltons; MAZI; zinc finger
                     protein 801; transcription factor Zif87"
                     /codon_start=1
                     /product="myc-associated zinc finger protein isoform 1"
                     /protein_id="NP_002374.2"
                     /db_xref="CCDS:CCDS42143.1"
                     /db_xref="GeneID:4150"
                     /db_xref="HGNC:HGNC:6914"
                     /db_xref="MIM:600999"
                     /translation="MFPVFPCTLLAPPFPVLGLDSRGVGGLMNSFPPPQGHAQNPLQV
                     GAELQSRFFASQGCAQSPFQAAPAPPPTPQAPAAEPLQVDLLPVLAAAQESAAAAAAA
                     AAAAAAVAAAPPAPAAASTVDTAALKQPPAPPPPPPPVSAPAAEAAPPASAATIAAAA
                     ATAVVAPTSTVAVAPVASALEKKTKSKGPYICALCAKEFKNGYNLRRHEAIHTGAKAG
                     RVPSGAMKMPTMVPLSLLSVPQLSGAGGGGGEAGAGGGAAAVAAGGVVTTTASGKRIR
                     KNHACEMCGKAFRDVYHLNRHKLSHSDEKPYQCPVCQQRFKRKDRMSYHVRSHDGAVH
                     KPYNCSHCGKSFSRPDHLNSHVRQVHSTERPFKCEKCEAAFATKDRLRAHTVRHEEKV
                     PCHVCGKMLSSAYISDHMKVHSQGPHHVCELCNKGTGEVCPMAAAAAAAAAAAAAAVA
                     APPTAVGSLSGAEGVPVSSQPLPSQPW"
     exon            366..1216
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1280
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1452
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..2540
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2518..2523
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /note="hexamer: AATAAA"
     polyA_site      2540
                     /gene="MAZ"
                     /gene_synonym="Pur-1; PUR1; SAF-1; SAF-2; SAF-3; ZF87;
                     Zif87; ZNF801"
                     /note="major polyA site"
ORIGIN      
        1 ctcttttcct ccctcccgcc ggccggggtg cgcgggcggc ggggcggccc gcgggccatg
       61 cgttcggcgc ggcccagccc ggccggccgg gggcggcgcc ccgagcccgg gccccgcgcg
      121 gcccgcgccc ccggcccccg ctgagccccg ggggccccgc tgcggccgag gccatgttcc
      181 cggtgtttcc ttgcacgctg ctggcccccc ccttccccgt gctgggcctg gactcccggg
      241 gggtgggcgg cctcatgaac tccttcccgc cacctcaggg tcacgcccag aaccccctgc
      301 aggtcggggc tgagctccag tcccgcttct ttgcctccca gggctgcgcc cagagtccat
      361 tccaggccgc gccggcgccc ccgcccacgc cccaggcccc ggcggccgag cccctccagg
      421 tggacttgct cccggtgctc gccgccgccc aggagtccgc cgcggctgct gcggccgctg
      481 ccgccgctgc tgccgccgtc gctgccgcgc ccccggcccc tgccgccgcc tctacggtgg
      541 acacagcggc cctgaagcag cctccggcgc cccctccgcc acccccgcca gtgtcggcgc
      601 ccgcggccga ggccgcgccc cccgcctccg ccgccactat cgccgcggcg gcggccaccg
      661 ccgtcgtagc cccaacctcg acggtcgccg tggccccggt cgcgtctgcc ttggagaaga
      721 agacaaagag caaggggccc tacatctgcg ctctgtgcgc caaggagttc aagaacggct
      781 acaatctccg gaggcacgaa gccatccaca cgggagccaa ggccggccgg gtcccctcgg
      841 gtgctatgaa gatgccgacc atggtgcccc tgagcctcct gagcgtgccc cagctgagcg
      901 gagccggcgg gggaggggga gaggcgggtg ccggcggcgg cgctgccgca gtggccgccg
      961 gtggcgtggt gaccacgacc gcctcgggga agcgcatccg gaagaaccat gcctgcgaga
     1021 tgtgtggcaa ggccttccgc gacgtctacc acctgaaccg acacaagctg tcgcactcgg
     1081 acgagaagcc ctaccagtgc ccggtgtgcc agcagcgctt caagcgcaag gaccgcatga
     1141 gctaccacgt gcgctcacat gacggcgctg tgcacaagcc ctacaactgc tcccactgtg
     1201 gcaagagctt ctcccggccg gatcacctca acagtcacgt cagacaagtg cactcaacag
     1261 aacggccctt caaatgtgag aaatgtgagg cagctttcgc cacgaaggat cggctgcggg
     1321 cgcacacagt acgacacgag gagaaagtgc catgtcacgt gtgtggcaag atgctgagct
     1381 cggcttatat ttcggaccac atgaaggtgc acagccaggg tcctcaccat gtctgtgagc
     1441 tctgcaacaa aggtactggt gaggtttgtc caatggcggc ggcagcggca gcggcggcag
     1501 cggcagcagc ggcagcagta gcagcccctc ccacagctgt gggctccctc tcgggggcgg
     1561 agggggtgcc tgtgagctct cagccacttc cctcccaacc ctggtgagct ccaagttggt
     1621 tgcgggggag aggggagaat ggagtagagt cccttggtac aagctcctct cccccctctt
     1681 ttcccaccaa ctcctatttc cctaccaacc aaggagcctc cagaaggaaa ggaggaagaa
     1741 atgttttctt aggggaattc gctaggtttt aacgatttgt ttctcctgct cctcttctgt
     1801 cagacctgac cccacacaaa cctgtcccct cggttgtgtt gaagtcccct ggacagtggg
     1861 caggggtggc agaggacacg agcagccact gcccgtaccc cctctcctct ctgtaagccc
     1921 atgccctgtc ttcccaggga cttgtgagcc tcttccctcg acggtcctct tctctccttc
     1981 cagtcctctc cccctgctgt ctgcagcccc tccccgggga gttggtgctt tcttttcctt
     2041 tttttttttt ttccaggggg agggaggaga ggaaggaggg ggatcagagc tgtcccaaag
     2101 agggaaagcg gtgaggtttg aggaggggca gaagcagggc cggcaaaggt tgtaccttca
     2161 taaggtggta tggggggttg gggtcaggcc ctgaacatcg tcctacttga gaatctgtca
     2221 ggggaaaaag tcaaggggag caggaggaag agccaggagg gccagaggca gagaagagat
     2281 ggagtcttag gggccagggt gagcgagggg tccagggcct agaggtgctt cctgggggcg
     2341 ggggaatgca gccagtgtcc ccctcccctc ttccacccca gctccagccc tggtcttgtc
     2401 ttttcatccc tcttccccac gacagaagaa gttgtggccc tggccatgtc atcgtgttcc
     2461 tgtgtcccct gcatgtaccc caccctccac cccttccttt tgcgcggacc ccattacaat
     2521 aaattttaaa taaaatcctg
//
