LOCUS       NM_015329               4845 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens MAU2 sister chromatid cohesion factor (MAU2), mRNA.
ACCESSION   NM_015329 XM_048457
VERSION     NM_015329.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4845)
  AUTHORS   Parenti,I., Diab,F., Gil,S.R., Mulugeta,E., Casa,V., Berutti,R.,
            Brouwer,R.W.W., Dupe,V., Eckhold,J., Graf,E., Puisac,B., Ramos,F.,
            Schwarzmayr,T., Gines,M.M., van Staveren,T., van IJcken,W.F.J.,
            Strom,T.M., Pie,J., Watrin,E., Kaiser,F.J. and Wendt,K.S.
  TITLE     MAU2 and NIPBL Variants Impair the Heterodimerization of the
            Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome
  JOURNAL   Cell Rep 31 (7), 107647 (2020)
   PUBMED   32433956
  REMARK    GeneRIF: MAU2 and NIPBL Variants Impair the Heterodimerization of
            the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome.
REFERENCE   3  (bases 1 to 4845)
  AUTHORS   Zheng,G., Kanchwala,M., Xing,C. and Yu,H.
  TITLE     MCM2-7-dependent cohesin loading during S phase promotes
            sister-chromatid cohesion
  JOURNAL   Elife 7, e33920 (2018)
   PUBMED   29611806
  REMARK    GeneRIF: Here, the authors show that, in human cells, cohesin
            loading onto chromosomes during early S phase requires the
            replicative helicase MCM2-7 and the kinase DDK. Cohesin and its
            loader SCC2/4 (NIPBL/MAU2 in humans) associate with DDK and
            phosphorylated MCM2-7.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4845)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 4845)
  AUTHORS   Hein,M.Y., Hubner,N.C., Poser,I., Cox,J., Nagaraj,N., Toyoda,Y.,
            Gak,I.A., Weisswange,I., Mansfeld,J., Buchholz,F., Hyman,A.A. and
            Mann,M.
  TITLE     A human interactome in three quantitative dimensions organized by
            stoichiometries and abundances
  JOURNAL   Cell 163 (3), 712-723 (2015)
   PUBMED   26496610
REFERENCE   6  (bases 1 to 4845)
  AUTHORS   Braunholz,D., Hullings,M., Gil-Rodriguez,M.C., Fincher,C.T.,
            Mallozzi,M.B., Loy,E., Albrecht,M., Kaur,M., Limon,J., Rampuria,A.,
            Clark,D., Kline,A., Dalski,A., Eckhold,J., Tzschach,A.,
            Hennekam,R., Gillessen-Kaesbach,G., Wierzba,J., Krantz,I.D.,
            Deardorff,M.A. and Kaiser,F.J.
  TITLE     Isolated NIBPL missense mutations that cause Cornelia de Lange
            syndrome alter MAU2 interaction
  JOURNAL   Eur J Hum Genet 20 (3), 271-276 (2012)
   PUBMED   21934712
  REMARK    GeneRIF: specific novel mutations at the N-terminus of the
            MAU2-interacting domain of NIBPL result in markedly reduced MAU2
            binding.
            Erratum:[Eur J Hum Genet. 2012 Mar;20(3):366]
REFERENCE   7  (bases 1 to 4845)
  AUTHORS   Seitan,V.C., Banks,P., Laval,S., Majid,N.A., Dorsett,D., Rana,A.,
            Smith,J., Bateman,A., Krpic,S., Hostert,A., Rollins,R.A.,
            Erdjument-Bromage,H., Tempst,P., Benard,C.Y., Hekimi,S.,
            Newbury,S.F. and Strachan,T.
  TITLE     Metazoan Scc4 homologs link sister chromatid cohesion to cell and
            axon migration guidance
  JOURNAL   PLoS Biol 4 (8), e242 (2006)
   PUBMED   16802858
REFERENCE   8  (bases 1 to 4845)
  AUTHORS   Watrin,E., Schleiffer,A., Tanaka,K., Eisenhaber,F., Nasmyth,K. and
            Peters,J.M.
  TITLE     Human Scc4 is required for cohesin binding to chromatin,
            sister-chromatid cohesion, and mitotic progression
  JOURNAL   Curr Biol 16 (9), 863-874 (2006)
   PUBMED   16682347
  REMARK    GeneRIF: Human MAU-2 family member has weak similarity to yeast
            Scc4 and is associated with Scc2, bound to chromatin from telophase
            until prophase, and required for association of cohesin with
            chromatin during interphase
REFERENCE   9  (bases 1 to 4845)
  AUTHORS   Choy,K.W., Wang,C.C., Ogura,A., Lau,T.K., Rogers,M.S., Ikeo,K.,
            Gojobori,T., Lam,D.S. and Pang,C.P.
  TITLE     Genomic annotation of 15,809 ESTs identified from pooled early
            gestation human eyes
  JOURNAL   Physiol Genomics 25 (1), 9-15 (2006)
   PUBMED   16368877
REFERENCE   10 (bases 1 to 4845)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC022543.3, AB020699.1, BY795974.2 and AC003030.1.
            
            On Nov 22, 2018 this sequence version replaced NM_015329.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.41081.1,
                                           SRR1660803.123380.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262815.13/ ENSP00000262815.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AC022543.3         12696-12701
            7-330               AB020699.1         1-324
            331-520             BY795974.2         307-496
            521-2366            AB020699.1         515-2360
            2367-4845           AC003030.1         25586-28064
FEATURES             Location/Qualifiers
     source          1..4845
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..4845
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /note="MAU2 sister chromatid cohesion factor"
                     /db_xref="GeneID:23383"
                     /db_xref="HGNC:HGNC:29140"
                     /db_xref="MIM:614560"
     exon            1..307
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..1873
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /note="cohesin loading complex subunit SCC4 homolog;
                     protein MAU-2; sister chromatid cohesion 4"
                     /codon_start=1
                     /product="MAU2 chromatid cohesion factor homolog"
                     /protein_id="NP_056144.3"
                     /db_xref="CCDS:CCDS32969.2"
                     /db_xref="GeneID:23383"
                     /db_xref="HGNC:HGNC:29140"
                     /db_xref="MIM:614560"
                     /translation="MAAQAAAAAQAAAAQAAQAEAADSWYLALLGFAEHFRTSSPPKI
                     RLCVHCLQAVFPFKPPQRIEARTHLQLGSVLYHHTKNSEQARSHLEKAWLISQQIPQF
                     EDVKFEAASLLSELYCQENSVDAAKPLLRKAIQISQQTPYWHCRLLFQLAQLHTLEKD
                     LVSACDLLGVGAEYARVVGSEYTRALFLLSKGMLLLMERKLQEVHPLLTLCGQIVENW
                     QGNPIQKESLRVFFLVLQVTHYLDAGQVKSVKPCLKQLQQCIQTISTLHDDEILPSNP
                     ADLFHWLPKEHMCVLVYLVTVMHSMQAGYLEKAQKYTDKALMQLEKLKMLDCSPILSS
                     FQVILLEHIIMCRLVTGHKATALQEISQVCQLCQQSPRLFSNHAAQLHTLLGLYCVSV
                     NCMDNAEAQFTTALRLTNHQELWAFIVTNLASVYIREGNRHQEVLYSLLERINPDHSF
                     PVSSHCLRAAAFYVRGLFSFFQGRYNEAKRFLRETLKMSNAEDLNRLTACSLVLLGHI
                     FYVLGNHRESNNMVVPAMQLASKIPDMSVQLWSSALLRDLNKACGNAMDAHEAAQMHQ
                     NFSQQLLQDHIEACSLPEHNLITWTDGPPPVQFQAQNGPNTSLASLL"
     exon            308..325
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            326..391
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            392..487
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            488..582
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            583..610
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            611..766
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..913
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1004
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1108
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1186
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1252
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1339
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1389
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1390..1467
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1579
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1580..1670
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1798
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     exon            1799..4845
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3827..3832
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /note="hexamer: ATTAAA"
     polyA_site      3848
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /note="major polyA site"
     regulatory      4823..4828
                     /regulatory_class="polyA_signal_sequence"
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /note="hexamer: AGTAAA"
     polyA_site      4845
                     /gene="MAU2"
                     /gene_synonym="KIAA0892; mau-2; MAU2L; SCC4"
                     /note="major polyA site"
ORIGIN      
        1 gtggcggcgg cttgttgttg tggaggccaa aatggcggct caggcggcgg cagcggccca
       61 ggcggcggcg gcccaggctg cgcaggccga ggcggccgac tcgtggtacc tggcgcttct
      121 gggcttcgct gagcacttcc gcacttccag cccgcccaaa atccgcctgt gcgtgcactg
      181 cctgcaggcc gtgttcccct tcaagccgcc gcagcgcatc gaggcccgta cacacctgca
      241 gctgggctcc gttctctatc accacaccaa gaacagcgag caggcgcgca gccacctgga
      301 gaaggcgtgg ttgatatcac agcaaatccc gcagttcgaa gatgttaaat ttgaagcagc
      361 aagtctgttg tctgaattgt actgtcaaga gaattccgtt gatgcagcaa agccgctgct
      421 gcggaaggcg atccagatct cacagcagac cccatattgg cactgccgcc tgctcttcca
      481 gctcgctcaa ctgcacacgc ttgagaagga cctggtgtcg gcctgtgacc tcctgggtgt
      541 aggggccgag tacgcccggg tggtgggatc tgaatacaca cgggcgctgt tcctcctcag
      601 caaggggatg ctgctgctga tggagcgaaa gctgcaggag gtgcacccgc tgctgaccct
      661 ctgcgggcag atcgtggaga actggcaggg gaaccccatc cagaaggagt cgctgcgtgt
      721 cttcttcctg gtgctccagg tcacccacta tctggatgcc gggcaggtga agagcgtgaa
      781 gccgtgtctg aagcagctgc agcagtgcat ccagaccatc tccacactgc acgatgatga
      841 gatcctgccc agcaaccccg ctgacctctt ccactggctg cccaaggagc acatgtgtgt
      901 gcttgtctac ctggtgactg tgatgcactc catgcaggcc ggctacctgg agaaggcgca
      961 gaagtacacg gacaaggccc tcatgcagct ggagaagctc aagatgctgg actgcagccc
     1021 catcctgtca tccttccaag tgatcctgct ggagcacatc atcatgtgcc gccttgtcac
     1081 gggtcacaag gccacggcgc tgcaggagat ctcccaggtc tgccagctgt gccagcagtc
     1141 cccccggctc ttctccaacc atgcagcaca gctgcacaca ttgctgggcc tgtactgtgt
     1201 ctctgtcaac tgcatggaca acgcggaagc ccagttcacc acggccctgc ggctcaccaa
     1261 ccaccaggag ctgtgggcct tcatcgtcac caacctggcg agtgtgtata tacgggaagg
     1321 aaatagacac caagaggtac tctacagtct gctggagagg atcaacccgg accacagctt
     1381 ccctgtcagc tcgcactgcc tccgagcagc cgccttctat gtgcgtgggc tcttctcctt
     1441 cttccaggga cgctacaacg aggccaagcg atttctgcgg gaaactctga agatgtccaa
     1501 tgctgaggac ctgaaccggc tcacagcctg ctccctcgtg cttctgggcc acatcttcta
     1561 tgtgctggga aaccacaggg agagtaacaa catggtggtg cctgccatgc agctcgccag
     1621 caagatcccg gacatgtcgg tacagctgtg gtcgtcagca ctgctgagag acctgaataa
     1681 agcctgtggg aacgccatgg atgcccatga agccgcccag atgcaccaga acttctcgca
     1741 gcagctgctc caggaccaca ttgaggcctg cagcctcccc gaacacaacc tcatcacgtg
     1801 gacagacggt ccaccccccg tgcagttcca agctcagaat ggacccaaca ccagcctggc
     1861 cagcctcctg tgaggccttg atggggccat ccagctccgc agggcctgcg cgtctccggc
     1921 ttccacccag acggcactca agcctgcccc cgaggcgtgc ttccttcctg attgtctcta
     1981 gagcttccaa gtcctgggaa tgtgcggggc cagtccctgc cctcccagga ggggtggtag
     2041 ccgttcccac ctcgcagcag gacccccagt gcagaggctc acaggtggca cacaggcgct
     2101 gtctctccag agccatcctt cagagtggac ctcagtgcca gtcctgcctc agcatctggg
     2161 tcacgtcggc caggagtagg gtgcaggcct ccagcaggtc ctaatcctgt gtgccagggc
     2221 aggcagtgcc ccaggggcac cacgcctgac tctccatcac ccaggccttg atgccgagcg
     2281 ggagtagagt gtttcctctg ctcaaggcaa tttccagagc ccggatgcca gtttctggcc
     2341 tgaatttgga gggaagaagt aatggcgcta gtgtgggacg aagcacagat cccagcactt
     2401 ttcccagctt tctctccagc atcagtccct gcagcagctg gggcctctgg tcaggaaccc
     2461 tcagggaccc aggaactcag cttccaaaca tctgcacctt gaccggactc gccatcccgc
     2521 cgtgggggtg caggtgattg taaacacggg tgtgcatgtg gatgcacacg ggtgtgcggt
     2581 gaagatctgt ggagatggag ctgggagctg aggctcctgt tgcaccagcc accttccccc
     2641 atcttgtggc tgctgagggg caggaagcgg gggagtgggc tcgtctccta aatttaagat
     2701 cacctcctca gctagcttag agtgcgtggc acgggccccc cgcccccgag atctggagcc
     2761 cagggacttt cttcctggca gatctgtggc cttccctgct cagcctcttg gtccccccac
     2821 tccctccacc gcctcacctt ccctgctggg tctctggggc acagtgtgaa acccgcaccc
     2881 tagccaggcc ccagggagcc tccgctgggc ccagacagca gcgtttggtt ttatccactt
     2941 ttcttggata atcaggaggt gccccagtgg tcacagtgtg gcattccgag ttggggcggg
     3001 tggtcgggtc aagatagcag cagcaggtgt cagggctcaa gacaccaccc cctccagctt
     3061 ctggggccca ggagcctctc cctgctacag ggggtggggg tcctgctcag cagggtaggt
     3121 ggtggtttta ggtcttgtca ccctcactca gtggaactgc ctctgggagc tttggcgtct
     3181 gtgactaaag ggacgctgga ttgctcaggt cagctgcttg gggctcccag gctgggtgtg
     3241 ccttagccac aggcagggct gtcaataacc cccttcctca ctggccacca cctgacatca
     3301 gcaccagtga caggctggtc agagggcggg gctggtgagg gtttgtccta agaggaccac
     3361 cgccatctct gggtctccag ggggagagcc tggccctgtc ctttgctacc cagggctgcc
     3421 cccaggccca tgaagccaat aggagagcgt gtggcactgg cccacaaact gtccctgtcc
     3481 tgtcttcctc ccgagccatg gcctctgcta gctccacctt gaaggagccc cccacatcct
     3541 cccctacatc ccagagatgc caccacttgt gtctccacaa tgtgctcctg cccacccggg
     3601 ttccgcactg tccgacccct gcacaccact catgtcacca cggcgtgcat catgttcatc
     3661 cccatctatt tatttaagcc tttctttgct tgtagggcat tttgtatgta gagcagttga
     3721 aaacagaacc tcagaactta acatctgtcc tgatgttaaa gtgcttttca tgaccaccct
     3781 gttatctatg tatatgtaaa gttaaggatg agatcttaag tttacaatta aaaactcagt
     3841 actcaatatt taatattcta ctcgagcttt atggaagcca aatcatgtgc atgtgtgtgt
     3901 gtgcgtgtgt gcaagctttg aacctccttc cacagccgca tcttctcatg acacaaagct
     3961 tttgataagt actttcctgt gggtcgctca gcgcctcata gcatctcatt caattgcaag
     4021 aatagaggcc agacacggtg gcgcatgcct gtagtcccag ctaactggga ggctgaggca
     4081 ggaggatcac ttgagcccag gagattgagg ctgcagtgag catgatcgcg acactgcact
     4141 ccagcctggg tgacggtgag actttgtctc aaaaaaaaaa aaaaaaacaa tggaaggcag
     4201 acagcaagtc cctgaggaca catcacacag tgtcctgtag ctaagtgtct aggaaaaaac
     4261 aaaaactcca aacccttcag tggatgagga caaggtcgca gaaaggcatt ctgttgacag
     4321 atgaacagcc gaaagctggc cagaccctcc tgtatgcctc tgcccttgtc ctgtgggttg
     4381 agggggtctg accaggaggc cacctacagc aggaagtgag gctgccatgt ttccttgaga
     4441 cacagctgcc tctccccagc tctgtccctg tagtcacctg ccggtgggcg aggatcctct
     4501 ccctgggata agcactccca gccccgttta tcagaaacac aggcaaggaa attggaactg
     4561 ccacccagcc cagcatggtg gctcaattgg ttggttgcgt tgtcagttgt ctcttcgttt
     4621 tgttaaggtt tttaataagt acgtttggca taatgtcttt taatgggttt gtaatatttg
     4681 taacggtttt agcagcctat aacttttcag ctggtgcttt tacttaggga aaaaaacaat
     4741 ttgtaaatac agaacattgt ttaaaagaca taaccataga acatagcttc ctgtttgtgg
     4801 attttgtttc ctatatattc aaagtaaaat gacttacagg agcca
//
